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This study focuses on 15 foreign-born students majoring in physics who are also racial/ethnic minorities. We address the research question: What are the acculturation experiences of foreign-born Students of Color majoring in physics? Berry's (2003) theory of acculturation and Bandura's (1994) theory of self-efficacy were substantive frameworks for analyzing the data. The findings illustrate participants' cultural, educational, and social adjustments. Emphasis is placed on how participants navigate and achieve success in this process. [ABSTRACT FROM AUTHOR]

Context: Since no specific treatment exists in case of cutaneous contamination by radionuclides such as uranium, a nanoemulsion comprising calixarene molecules, known for their good chelation properties, was previously designed. However, this fluid topical form may be not suitable for optimal application on the skin or wounds. Objective: To develop a texturing pharmaceutical form for the treatment of wounded skins contaminated by uranium. Materials and methods: The formulations consisted in oil-in-water (O/W) nanoemulsions, loaded with calixarene molecules. The external phase of the initial liquid nanoemulsion was modified with a combination of thermosensitive gelifying polymers: Poloxamer and HydroxyPropylMethylcellulose (HPMC) or methylcellulose (MC). These new formulations were characterized then tested by ex vivo experiments on Franz cells to prevent uranyl ions diffusion through excoriated pig ear skin explants. Results: Despite strong changes in rheological properties, the physico-chemical characteristics of the new nanoemulsions, such as the size and the zeta potential as well as macroscopic aspect were preserved. In addition, on wounded skin, diffusion of uranyl ions, measured by ICP-MS, was limited to less than 5% for both HPMC and MC nanoemulsions. Conclusions: These results demonstrated that a hybrid formulation of nanoemulsion in hydrogel is efficient to treat uranium skin contamination. [ABSTRACT FROM AUTHOR]

Spirituality and meaning in life are important pathways to well-being. Research has conceptually and empirically linked spirituality, religiousness and meaning in life. The present study was concerned with investigating presence of meaning (MLQ-P) and search for meaning (MLQ-S) as mediators between spirituality (religious and existential well-being) and hedonic and eudaimonic well-being. A multi-cultural sample of 326 South African students completed the Meaning in Life Questionnaire (MLQ), Spiritual Well-Being Scale (SWBS), Questionnaire for Eudaimonic Well-Being (QEWB) and the Mental Health Continuum Short-Form (MHC-SF). Structural equation modelling in Mplus was used to study direct and indirect effects. Findings show that the presence of meaning in life explains more paths between spirituality and psychological well-being than search for meaning. MLQ-P mediated the paths between existential well-being and four of the five indices of psychological well-being. MLQ-S did not mediate any path between spirituality (existential and religious well-being) and psychological well-being outcomes. [ABSTRACT FROM AUTHOR]

This tool is a unique comprehensive scale and methodology to measure the psychosocial acuity of patients and families across a health care continuum. Coupled with other measures, psychosocial acuity can tell a complete and compelling story of social work contributions and aid in resource alignment. Accurately conveying the full scope of social work value to anyone, especially health system leadership, requires that the psychosocial acuity of the patient and family be measured and factored into the equation, along with productivity, time spent, and services provided. The development and utilization of the Psychosocial Acuity Tool is the focus of this publication. [ABSTRACT FROM AUTHOR]

The use of highly active antiretroviral therapy against human immunodeficiency virus (HIV) can lead to rare instances of treatment failure and the emergence of drug resistance. HIV drug-resistant strains are archived in cellular reservoirs, and this can exclude the future efficacy of drugs or drug classes against which resistance has emerged. In addition, drug-resistant viruses can be transmitted between individuals. HIV drug resistance has been countered through the constant development of new antiretroviral drugs. Integrase strand transfer inhibitors, that actively block the integration of the HIV genome into the host DNA, represent the most recent antiretroviral drugs. Of these, raltegravir, elvitegravir, and dolutegravir are the only integrase strand transfer inhibitors that have been approved for human therapy by the US Food and Drug Administration. Dolutegravir is unique in its ability to seemingly evade HIV drug resistance in treatment-naïve individuals. Here, we review the use of integrase strand transfer inhibitors in the management of HIV, focusing on HIV resistance. [ABSTRACT FROM AUTHOR]

Background and purpose: Many individuals with stroke express desires to resume activities involving deep knee flexion, such as daily living, work-related, and sports activities. However, training methods for improving deep flexion activities have not commonly been reported in the stroke rehabilitation literature. The purpose of this case report is to describe the development of a task-oriented training program and demonstrate its use in improving deep flexion activities in an individual with sub-acute hemiplegia. Case description: The patient was a 55-year-old shoe salesman diagnosed with ischemic stroke 6 weeks before physical therapy evaluation. His primary concerns were functional activities that required deep flexion, such as the inability to squat and to maintain a squatting position in the Eastern toilet and difficulty in performing work-related activities (e.g. fitting shoes for customers while sitting on a low stool). Intervention: We developed a task-oriented training program that specifically targeted deep flexion activities. The first phase of training consisted primarily of practicing sit-to-stand on a low stool and the second phase consisted of practicing squatting. Outcomes: After 6 weeks of intervention, the patient achieved more than the expected outcome on the Goal Attainment Scale (score = +2) for both primary goals and reported positive changes in social participation, such as visiting his friends and relatives and praying at the temple. Discussion: The task-oriented deep flexion activity intervention was associated with positive changes in functional activity and social participation in a patient recovering from stroke. [ABSTRACT FROM AUTHOR]

Research regarding valued occupations following stroke has been carried out almost exclusively with stroke survivors who have returned to their own homes following hospital discharge. We explored engagement in personally valued occupations following stroke and discharge to an assisted living facility. Four women aged 72-87 were followed at 6, 9, and 12 months post stroke. All of the women desired to engage in personally valued occupations to continue to: (1) develop skills and knowledge and contribute to others through occupations of personal interest and (2) improve their health, mobility and function. Opportunities to engage in such occupations were generally present within the AL facilities. However, there were barriers to making use of these opportunities. Challenges for AL facilities wishing to make changes that would allow for enhanced engagement in personally valued occupations included recognition of residents' individual skills and desires to use these skills and identification of individualized information regarding residents' interests. [ABSTRACT FROM AUTHOR]

We report a theoretical study of the structural and electronic properties of thercccandrcttconformers of several pyrogallol[4]arenes, R-Pyg[4]arenes (i.e. R =  fluoroethyl, methyl,t-butyl, phenyl, tolyl andp-fluorophenyl) carried out by employing the HF-DFT hybrid B3LYP functional. Comparison of the B3LYP energies of the two stereoisomers showed that thercccconformer is more stable than itsrcttcounterpart for all the derivatives considered. However, calculations made with the double-hybrid Grimme's B97D functional confirmed the experimental observation that the relative stability depends on the type of the R substituents. These results clearly suggest that the B97D functional together with large enough basis sets (i.e. split-valence plus polarisation and diffuse functions) is sufficiently accurate for the purpose of describing the conformational features of these compounds. Computed electrostatic potential maps of thercccof the different R-Pyg[4]arenes showed that a negative potential is present within the cavity of these compounds. In addition, it is observed that the size of this negative electrostatic potential depends on the electron-donating or electron-withdrawing character of the R substituents. [ABSTRACT FROM AUTHOR]

Enhancing primary health care to incorporate mental health services is a key strategy for closing the treatment gap for people with mental disorders. The integration of psychological care into primary health care is a critical step in addressing poor access to mental health specialists. As the psychology profession is increasingly called upon to prepare psychologists for primary health care settings, an international experts' consensus is valuable in guiding the development of a high-quality curriculum for psychologists working in the primary health care context. A Delphi method was used to gain a consensus on the most appropriate roles and training for psychologists. Initial constructs and themes were derived from a detailed literature review and sent to 114 international experts in primary mental health care from five continents. Overall, 52 experts who participated agreed that psychologists should have wide-ranging roles and skills including clinical, health promotion and advocacy skills. This study has identified the specific roles and training needed by psychologists to enable them to work more effectively in primary health care settings. The consensus will inform the development of a curriculum for psychologists working in primary health care in Indonesia, and is part of a broader suite of studies. [ABSTRACT FROM AUTHOR]

Mental health is a critical issue in Indonesia, since its population ranks among the top five in the world and the prevalence of common mental disorders is 11.6% of the adult population. However, the need to build an effective mental health-care system that is accessible to the whole population has only been recently addressed. The Aceh tsunami in 2004 brought to the forefront an unexpected window of opportunity to build a mental health-care system. Integration of mental health care into primary health care is a key strategy to close the treatment gap for people with mental disorders. Existing integration of psychologists into primary health care is a big step to meet the shortage of mental health-care specialists. As primary mental health care is an emerging field, the perspectives of Indonesian experts on Indonesian mental health care are needed to develop a curriculum for training psychologists to work in primary health care. In this study, data have been collected through semi-structured interviews with 24 Indonesian mental health experts, and three focus group discussions with 26 psychologists. Overall, experts agreed that to be able to work in primary health-care psychologists should have roles and training ranging from clinical to advocacy skills. Participants also agreed that psychologists should work in the community and contribute to primary health care as service providers and that strong collaborations between psychologists and other primary health-care providers are the key; these can be developed partly through referral and by respecting each other's unique strengths. [ABSTRACT FROM AUTHOR]

Copyright of Australian Social Work is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Despite the ubiquity of biofilms in natural and man-made environments, research on surface-associated cells has focused primarily on solid–liquid interfaces. This study evaluated the extent to which bacterial cells persist on inanimate solid–air interfaces. The desiccation tolerance of bacterial strains isolated from indoor air, as well as of a test strain (Pseudomonas aeruginosa), was determined at different levels of relative humidity (RH) using the large droplet inoculation method in an aerosol chamber. The cells survived longer at lower (25 and 42%) than at high RH (95%). Four of the seven indoor strains selected for further study showed extended period of survival following deposition as 0.05–0.1 ml of washed culture followed by desiccation, each with different effects on the survival of the test strain,P.aeruginosa. A strain closely related toArthrobacterspecies afforded the highest level of protection to the test strain. Even though the desiccation-tolerant strains survived when they were deposited as bioaerosols, the protective role towards the test strain was not observed when the latter was deposited as a bioaerosol. These, which are often-unculturable, bacteria may go undetected during routine monitoring of biofouling, thereby allowing them to act as reservoirs and extending the habitat range of undesired microorganisms. [ABSTRACT FROM AUTHOR]

Up until 10 years ago, basic and clinical HIV-1 research was mainly performed on HIV-1 subtype B that predominated in resource-rich settings. Over the past decade, HIV-1 care and therapy has been scaled up substantially in Latin America, Africa and Asia. These regions are largely dominated by non-B subtype infections, and especially the African continent is affected by the HIV pandemic. Insight on the potency of antiviral drugs and regimens as well as on the emergence of drug resistance in non-B subtypes was lacking triggering research in this field, also partly driven by the introduction and spreading of HIV-1 non-B subtypes in Europe. The scope of this article was to review and discuss the state-of-the-art on the impact of HIV-1 genetic variation on the in vitro activity of antiviral drugs and in vivo response to antiviral therapy; as well as on the in vitro and in vivo emergence of drug resistance. [ABSTRACT FROM AUTHOR]

Traumatic workplace events (critical incidents) occur with unfortunate regularity and with significant repercussions for affected organizations. Critical incident stress management (CISM) units, often a specialty component of employee assistance programs, provide consultation and support for workplace incidents. While CISM seeks to support both individual and organizational outcomes, trauma research oriented toward individual traumatic stress dominates the literature, mirroring practitioner training that tends to emphasize clinical over organizational practice. This research contributes to less-prevalent studies that explore organizational-level outcomes. Despite the facts that social workers play a central role in critical incident response and CISM units collect massive amounts of practice data, there are no published social work studies capitalizing on the potential of existing critical incident data. Employing the methodology of clinical data mining, this practice-based, exploratory research examines the propositions that incident severity level associates with several post-incident organizational outcomes. Several findings translate into considerations for evidence-informed CISM practice in the areas of intake assessment, organizational consultation, and incident response planning. [ABSTRACT FROM AUTHOR]

Due to new challenges, new extraction solvents based on innovative extractants are needed in hydrometallurgy for specific tasks. Thus, the aim of the present article is to discuss the potential and limits of Quantitative Structure–Properties Relationship (QSPR) and molecular modeling for identifying new extractants. QSPR methods may have useful applications in such a complex problem as the design of ligands for metal separation. Nevertheless, the degree of reliability of the predictions is still limited and, in the present state of the art, these techniques are likely more useful for optimization within a given family of extractants than to build in-silico new reagents. The molecular modeling techniques provide binding energies between target metals and given ligands, as well as optimized chemical structures of the formed complexes. Thus, in principle, the information, which can be deduced from the molecular modeling computations are richer than that provided by QSPR methods. Nevertheless, an effort should be made to establish more tangible links between the calculated binding energies and the physical parameters used by the hydrometallurgists, such as the complexation constants in aqueous phase (βMAn) or better the extraction constants (Kex). [ABSTRACT FROM AUTHOR]

Purpose: This study was designed to explore the concept of recovery from the perspectives of stroke survivors and informal carers. The aim of this qualitative study was to identify the main factors that are perceived to contribute to recovery after stroke. Method: Data were obtained via focus groups using semistructured questionnaires. One focus group included all participants (n = 14). This was followed by separate focus groups for stroke survivors (n = 8) and informal carers (n = 6). The data from the three focus groups were analysed using thematic analysis, whereby themes and sub-themes were identified and summarised via dual coding. Results: The main theme identified was 'individual recovery expectations'. The contributing sub-themes were: 'essential elements of recovery', 'returning home' and 'the environment of rehabilitation'. The predominant factors to arise from this study surround the concepts of 'returning to normality' for the stroke survivor and the 'tension of providing care' for informal carers. Conclusions: This study provides a current description of stroke survivor and carer expectations of recovery. There are diverse and ongoing concerns that can be encountered into the chronic phase poststroke. Models of community-based care should adopt targeted interventions that concurrently consider stroke survivor and carer's individual concepts of recovery. [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editor discusses the projects undertaken in a collaborative partnership structured around practice research between the health social work community in Melbourne and the academic community at the University of Melbourne.

Elderly patients presenting to St. Vincent's Health Emergency Department (ED) constitute approximately one third of presentations. A significant proportion of these involve preexisting conditions including depression that, within elderly patients, is associated with social isolation, physical and mental health problems, and barriers to accessing community services. It is also often overlooked as a clinical diagnosis among the elderly. This study aimed to assess the efficacy of a brief depression screening tool and examine the change over time in quality of life and social factors for elderly patients who present to ED. Patients aged 65 years and over were screened for depression using a short form of the Geriatric Depression Scale (GDS-15). Participants were randomized into control (usual care) and intervention (an assertive outreach community management program) groups and assessed in relation to depression, quality of life, and social support/functioning at recruitment and 6 weeks post discharge. Approximately one in four participants experienced mild to moderate depression that was related to medical factors and associated reduced mobility. This study suggests that an assertive outreach program, with the inclusion of community intervention and links to social supports and services, could improve the management of depression in the elderly and associated health outcomes. [ABSTRACT FROM AUTHOR]

Perinatal mental health has become the focus for policymakers, government, research, the acute health sector, and health practitioners. The aim of this clinical data-mining study (Epstein, 2010) was to undertake a retrospective exploration into the primary mental health and psychosocial issues experienced by women who were pregnant and accessing obstetric care at one of the largest maternity hospitals in Australia. The study also investigated service pathways and gaps. Aboriginal women were overrepresented, demonstrating their ongoing disadvantage, whereas other linguistically and culturally diverse women were underrepresented, suggesting the existence of barriers to service. Although psychosocial factors tend to be underreported (Buist et al., 2002), the findings highlighted the integral rather than peripheral nature of these factors during pregnancy (Vilder, 2006) and suggest the need for change to systems that work to support women's perinatal mental health. [ABSTRACT FROM AUTHOR]

There is a striking absence of literature articulating and evaluating clinical social work contributions to suicide prevention, despite considerable practice in this important field. This article reports on a model of assertive brief psychotherapeutic intervention and facilitated linkage to community services utilized in a prospective cohort study of emergency department suicide attempt aftercare. A key outcome measure, the Manchester Short Assessment of Quality of Life (MANSA), was used with 65 patients to assess psychosocial domains at initial presentation, 4-weeks, 3-months, and 6-months. There were significant improvements in the domains of work, finance, leisure, social life, living situation, personal safety and health by 3 months. There were highly significant correlations between psychosocial improvements and improved depression scores. [ABSTRACT FROM AUTHOR]

Conventional wisdom holds that the ‘brain drain’ of health professionals from Africa is deeply damaging to the continent. Recently, a group of North American and European neoliberal economists has challenged this view, variously arguing that the negative consequences are highly exaggerated and the compensating benefits many. The benefits include various forms of diaspora engagement in which those who have left then engage in a variety of activities and actions that bring substantial benefits to their country of origin. This article examines the case of South African physicians in Canada to test this argument. The study on which the article is based found that these physicians constitute a profoundly disengaged diaspora. The quantitative evidence shows that while they continue to assert a South African identity and take some interest in events in the country, they do not participate significantly in any of the activities that typify diaspora engagement. The article then uses the qualitative narratives of the physicians to discuss how they justify this situation to themselves. As we show, at the heart of these narratives is a dystopic set of images that show nothing of value and nothing praiseworthy in post-apartheid South Africa. [ABSTRACT FROM PUBLISHER]

A growing body of evidence points to the important role of spirituality and meaning in life in treating people with medical and psychological conditions. The purpose of the present study was twofold: first, to examine the relationship among meaning in life, spirituality, and their dimensions to alcoholism and depressive symptomatology; and second, to explore the differences in spirituality and meaning of life among individuals of low, moderate, and high depressive symptomatology. Results indicated that spirituality and meaning in life were statistically significantly associated to alcoholism and depressive symptoms. In particular, depression was statistically significantly correlated with the onset of alcohol use and the dimensions of spirituality and meaning in life. Implications for counseling and psychotherapy are discussed. [ABSTRACT FROM PUBLISHER]

The potential for para-occupational (or 'take-home') exposure to a number of chemicals has been recognized for over 60 years. We conducted a literature review in order to characterize reported cases of asbestos-related disease among household contacts of workers occupationally exposed to asbestos. Over 200 published articles were evaluated. Nearly 60 articles described cases of asbestos-related disease thought to be caused by para-occupational exposure. Over 65% of these cases were in persons who lived with workers classified as miners, shipyard workers, insulators, or others involved in the manufacturing of asbestos-containing products, with nearly all remaining workers identified as craftsmen. 98% of the available lung samples of the persons with diseases indicated the presence of amphibole asbestos. Eight studies provided airborne asbestos concentrations during (i) handling of clothing contaminated with asbestos during insulation work or simulated use of friction products; (ii) ambient conditions in the homes of asbestos miners; and (iii) wearing previously contaminated clothing. This review indicates that the literature is dominated by case reports, the majority of which involved household contacts of workers in industries characterized, generally, by high exposures to amphiboles or mixed mineral types. The available data do not implicate chrysotile as a significant cause of disease for household contacts. Also, our analysis indicates that there is insufficient information in the published literature that would allow one to relate airborne asbestos concentrations in a workplace to those that would be generated from subsequent handling of contact with clothing that had been contaminated in that environment. Ideally, a simulation study could be conducted in the future to better understand the relationships between the airborne concentrations in the workplace and the fiber characteristics that influence retention on fabric, as well as the concentrations that can be generated by handling the contaminated clothing by the persons in the home. [ABSTRACT FROM AUTHOR]

Fourteen Azotobacter chroococcum strains isolated from soils of Southern Poland were studied concerning resistance to various xenobiotics: heavy metal ions: Cd2+, Cu2+, Fe3+, Mn2+, Pb2+, Zn2+, pesticides: herbicides linuron (3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea) and combination of mecoprop ((RS)-2-(4-chloro-2-methylphenoxy)propanoic acid), dicamba (3,6-dichloro-2-methoxybenzoic acid) and MCPA (2-methyl-4-chlorophenoxyacetic acid), fungicide copper oxychloride, insecticide fenitrothion (O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate) and eight antibiotics commonly used against Gram-negative bacteria. The tested soils were divided into seven groups of land use: forest, field crop, park, urban lawn, industrial area, garden and fallow land, and were analyzed for the following heavy metal ion concentrations using the atomic absorption spectrometry (AAS) technique: Cd2+, Cu2+, Fe3+, Mn2+, Pb2+, Zn2+. All strains were resistant to Pb2+, whereas other metals caused the growth inhibition of the analyzed strains. There was no significant relationship between metal concentrations in the analyzed soils and metal resistance of the isolates. Herbicide linuron did not inhibit the growth of A. chroococcum in any of the concentrations. All other pesticides caused the growth inhibition only in the concentrate forms. All isolates were sensitive to β-lactam antibiotic Meropenem, however high intraspecies differentiation was observed concerning resistance to other antibiotics. The obtained results require further study regarding resistance mechanisms and possible use of the xenobiotic-resistant strains in land rehabilitation. [ABSTRACT FROM PUBLISHER]

Purpose. To conduct a systematic review to explore the effectiveness of community-based rehabilitation interventions delivered by allied health professionals and/or nursing staff in reducing depression, facilitating participation and improving health-related quality of life (HRQoL) post-inpatient stroke rehabilitation. Method. A search was conducted in the databases of MEDLINE, PEDro, CINAHL and the Cochrane Library. Publications were classified into categories based on the type of the interventions. Best evidence synthesis and meta-analysis were utilised to determine the level of evidence. Results. Fifty-four studies were included in the review, and divided into nine broad intervention categories. Meta-analysis demonstrated significant reduction in depression with exercise interventions ( n == 137; effect estimate SMD: −−2.03, 95%%CI: −−3.22, −−0.85). Community-based interventions targeting participation and leisure domains showed moderate evidence for improvement in global participation measures and HRQoL. Comprehensive rehabilitation demonstrated limited evidence for depression and participation, and strong evidence for HRQoL Conclusions. There is limited to moderate evidence supporting some rehabilitation interventions in affecting the outcomes of depression, participation and HRQoL post-stroke. Heterogeneity of the studies made evidence synthesis difficult. Further consideration needs to be given to the type and timing of outcome measures selected to represent the domains of participation and HRQoL. [ABSTRACT FROM AUTHOR]

Level of ability within rock climbing is generally expressed in terms of a 'best ascent', rated using various grading systems within the sport. The most common method of obtaining this information is via self-report. The aim of this study was to examine the validity of self-reported climbing grades. Twenty-nine competitive rock climbers (17 males, 12 females) were first asked to report their current (defined as within the last 12 months) best on-sight lead ascent grade (Aus/NZ). The participants then climbed a specifically designed indoor route, under on-sight conditions (one attempt, no route practice or preview), to obtain an assessed grade. The route increased in difficulty, and was such that the distance achieved by the climber corresponded to a particular grade. The mean (±standard deviation) self-reported and assessed grade was 22.6 ± 3.4 and 22.0 ± 3.0 (Aus/NZ) respectively. Despite slight over- and underestimations in males and females respectively, there was no statistically significant difference between self-reported and assessed on-sight climbing grades. The results of this study suggest that self-reported climbing grades provide a valid and accurate reflection of climbing ability. [ABSTRACT FROM AUTHOR]

Background: Evaluation of the dynamics of enfuvirtide (ENF) resistance mutations after ENF withdrawal in patients with virological failure under salvage therapy may be helpful to optimize the management of ENF in human immunodeficiency virus (HIV)-infected patients. Methods: Seven patients with a failing ENF-containing regimen, initiated for at least 3 months (median 6.4 months, range 3--14), were included and followed up prospectively at the time of virological failure. Genotypic analysis of the gp41 region by bulk sequencing and clonal analysis was performed in plasma and/or peripheral blood mononuclear cells to detect ENF resistance mutations. Results: Genotypic profiles of ENF-resistant variants at ENF discontinuation were as follows: V38A in 3 patients, V38A++N42T++N43D in 1 patient, N43D in 2 patients, and N43K in 1 patient. Clonal analysis showed that maintaining ENF treatment after virological failure has an impact on both (1) the number of resistance profiles detected, and (2) the time of persistence of ENF-resistant variants. ENF-resistant variants were archived in HIV DNA in 5/7 patients. At 1 month after ENF withdrawal, no significant increase in HIV-1 viral load was observed. Conclusion: The persistence of ENF-resistant variants was found to be correlated to exposure time to failing drug. ENF withdrawal should be considered in patients with virological failure to preserve the possible efficacy of ENF recycling or upcoming entry inhibitors. [ABSTRACT FROM AUTHOR]

Objective. This study aimed to assess self-reported well-being in a clinical sample of stroke patients and to identify possible associations with prevalence, severity and bother of lower urinary tract symptoms (LUTS). Material and methods. A cross-sectional, clinical survey was initiated whereby stroke patients were invited to complete The WHO-Five Well-Being Index (WHO-5) and a LUTS instrument, the Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire. Of 519 stroke patients invited, 482 subjects were eligible and 407 (84%) respondents answered the questionnaires. Results. Poor well-being (sum score <13) was reported by 22% of all stroke patients, for women 29% and for men 14%. Depression (sum score <8) was reported by 10%, for women 11% and for men 8%. Poor well-being was significantly ( p < 0.01) associated with severity and bother of LUTS. Likewise, poor well-being was significantly ( p < 0.001) associated with the prevalence of four different symptom groups of LUTS. Conclusions. The results indicate that poor well-being is present in stroke patients with LUTS, especially in women. Likewise, the data showed significant association between poor well-being and LUTS. Screening for well-being and LUTS in stroke patients is strongly recommended. [ABSTRACT FROM AUTHOR]

To better understand biofouling of seawater reverse osmosis (SWRO) membranes, bacterial diversity was characterized in the intake water, in subsequently pretreated water and on SWRO membranes from a full-scale desalination plant (FSDP) during a 9 month period. 16S rRNA gene fingerprinting and sequencing revealed that bacterial communities in the water samples and on the SWRO membranes were very different. For the different sampling dates, the bacterial diversity of the active and the total bacterial fractions of the water samples remained relatively stable over the sampling period whereas the bacterial community structure on the four SWRO membrane samples was significantly different. The richness and evenness of the SWRO membrane bacterial communities increased with usage time with an increase in the Shannon diversity index of 2.2 to 3.7. In the oldest SWRO membrane (330 days), no single operational taxonomic unit (OTU) dominated and the majority of the OTUs fell into the Alphaproteobacteria or the Planctomycetes. In striking contrast, a Betaproteobacteria OTU affiliated to the genus Ideonella was dominant and exclusively found in the membrane used for the shortest time (10 days). This suggests that bacteria belonging to this genus could be one of the primary colonizers of the SWRO membrane. Knowledge of the dominant bacterial species on SWRO membranes and their dynamics should help guide culture studies for physiological characterization of biofilm forming species. [ABSTRACT FROM AUTHOR]

Serotonin receptors are the product of 15 distinct genes, 14 of which are G protein-coupled receptors. These receptors are expressed in a wide range of cell types, including distinct neuronal populations, and promote diverse functional responses in multiple organ systems. These receptors are important for mediating the in vivo effects of their cognate neurotransmitter, serotonin, as well as the endogenous tryptamines. In addition, the actions of many drugs are mediated, either directly or indirectly, through serotonin receptors, including antidepressants, antipsychotics, anxiolytics, sleep aids, migraine therapies, gastrointestinal therapeutics and hallucinogenic drugs. It is becoming increasingly evident that serotonin receptors can engage in differential signaling that is determined by the chemical nature of the ligand and that ligands that demonstrate a predilection for inducing a particular signaling cascade are considered to have 'functional selectivity'. The elucidation of the cellular signaling pathways that mediate the physiological responses to serotonin and other agonists is an active area of investigation and will be an onward-looking focal point for determining how to effectively and selectively promote beneficial serotonergic mimicry while avoiding unwanted clinical side effects. This review highlights the modulation of serotonin 2A, 2C, and four receptors by β-arrestins, which may represent a fulcrum for biasing receptor responsiveness in vivo. [ABSTRACT FROM AUTHOR]

Video-taping clinical sessions is a common practice among social workers so that the tapes may be used for clinical supervision and reviewed with the individuals or families involved. They are usually underused for research purposes. This article reports on an innovative research method using such tapes as a basis for clinical data mining to explore the bereavement experience of Chinese people in Hong Kong. Using this data, a rich item pool, containing both negative and positive reactions, was generated to allow the development of a culturally relevant measurement tool of grief reactions. The data also facilitated theory building in the area of grief and bereavement. This study extended the use of video-tapes in clinical sessions for research purposes and helped to collect reliable and timely data in a non-intrusive way. It has also advanced the use of quantitative data in the clinical data-mining approach. The study encouraged collaboration between clinicians and researchers to develop knowledge and skills about their special target group of clients. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate the development of resistance to raltegravir (RAL) in patients with viraemia between 40 and 400 copies/ml. All HIV-1-infected patients with multidrug-resistant virus, plasma HIV-1 RNA >1000 copies/ml and starting RAL were enrolled in this observational study and followed up until week 48. Sixty-seven patients with median plasma HIV-1 RNA at 4.3 log10 copies/ml and CD4 at 177 cells/mm3 were included. At week 24, 43 achieved full viral suppression (FVS; plasma HIV-1 RNA <40 copies/ml), 18 had incomplete viral suppression (IVS; plasma HIV-1 RNA 40–≤400 copies/ml) and 6 experienced virological failure (VF; plasma HIV-1 RNA >400 copies/ml). At week 48, all the FVS were sustained, 16 of the IVS patients retained a plasma HIV-1 RNA <400 copies/ml and only 2 of the IVS at week 24 experienced VF. No RAL resistance was detected in the persistent low viraemia. In contrast, integrase mutation was detected in 6 of the patients with VF. A genotypic sensitivity score equal to 0 was associated with plasma HIV-1 RNA >40 copies/ml at week 24 (OR 20.9, 95% CI 2.0–215.1) and with RAL resistance (OR 14.2, 95% CI 2.1–94.7). This study confirmed the high efficacy of a RAL-containing regimen under routine clinical conditions in infections caused by multidrug-resistant virus. If persistent low viraemia is observed over more than 48 weeks without the emergence of resistance, RAL should never be given as functional monotherapy, as it is associated with a maximal risk of VF and the emergence of RAL resistance. [ABSTRACT FROM AUTHOR]

The profession of social work is becoming increasingly involved in empowerment for its members as employers become more invested in promoting employee satisfaction. This is occurring at a crucial time in which predictions are that the profession will be heading into a shortage of workers (NASW Center for Workforce Studies, 2006; U.S. Department of Labor Profession Report 2008-09). The experiences of the social work staff at Virginia Commonwealth University Medical Center in Richmond, Virginia, illustrate the process as efforts combine to create new paths to career development for “frontline” clinicians. The work of the Retention Committee in the Department of Care Coordination began due to staff members' dissatisfaction with opportunity for advancement, pay disparity, and inequitable distribution of workload. This article will present the history, efforts, and outcome of the Social Work Retention Committee at VCU Medical Center. [ABSTRACT FROM AUTHOR]

Australian community arts and mental health is described through its 40-year history with peaks of activity coinciding with federal labor governments and the establishment of four independent health promotion agencies from the late 1980s. The paper then takes a thematic approach to discussing the development of national approaches to supporting arts and health practice, data sources, current research and evaluation and advocacy challenges. The paper concludes by suggesting that under the current federal labor government arts and health may benefit from increasing recognition of the intrinsic benefits of arts participation and cultural rights. [ABSTRACT FROM AUTHOR]

An introduction is presented in which the editor discusses various reports within the issue on topics including the effectiveness and impact of social work programs, 2018 Excellence in Research Australia (ERA) and the Australian Research Council (ARC).

Social work students' responses to research tend to reflect their anxiety about the acquisition of competency in statistics and research methods. Their desires to attain social work education and subsequently become practitioners are viewed by them as at odds with research as taught. Yet, within the current quantocentric culture—which the authors define as one in which quantitative research methods are privileged over other lines of inquiry—social work education is increasingly emphasizing research as a central component of practice. Using a 'culture as disability' framework to understand quantocentric culture and its impact on the educational environment, we suggest an educational approach designed to interest students in a broad view of research allowing for the wholehearted inclusion of non-quantitative and practice-related facets of research. The approach encourages students to: (a) fully articulate their perceptions of research, both positive and negative; (b) link these views and experiences to the anti-oppressive social work literature and to examine research methods from the perspective of quantocentrism; and (c) develop an inclusive typology of research that integrates qualitative approaches encompassing historical, philosophical, narrative and other avenues that are relevant to their future social work practice careers. [ABSTRACT FROM AUTHOR]

Understanding differences in the recapture rate between different tags (A-, B- and C-types), capture methods (rock-and-surf anglers, scientific divers and Natal Sharks Board protection nets) and life-history stages (juvenile and adult) is critical in evaluating the results obtained from cooperative tagging programmes (CTPs). A generalised linear modelling approach, using a log-linear model, was used to determine significant differences in the probability of recapture between these various factors using data from the Oceanographic Research Institute and Port Elizabeth Museum CTPs. Between 1984 and 2004, a total of 3 385 raggedtooth sharks Carcharias taurus was tagged by volunteers from both programmes along the east coast of South Africa. A likelihood ratio test indicated significant differences in the probability of recapture between A- and C-type and B- and C-type tags (p < 0.01), between different capture methods (p < 0.05) and between juvenile and adult sharks (p < 0.01). A comparison of recapture rates between members of the CTPs also indicated a marked variability in the performance of individual taggers. The study highlights important data-quality issues inherent in large CTPs. [ABSTRACT FROM AUTHOR]

This article identifies dualisms in the continuing and sometimes acrimonious discourse concerning the relationship between social work practice and research. In so doing, it describes the epistemological assumptions of and differences between evidence-based practice, research-based practice, practice-based research, and reflective practice. In the spirit of the Hong Kong conference, the author extends McNeill's concept of “evidence-informed practice” to suggest a more inclusive and harmonious conception of practice-research integration. The article concludes by considering what such a model might look like. [ABSTRACT FROM AUTHOR]

A discussion about the importance of research for social work practitioners and the nature of academic-practitioner partnerships set the scene in this article for a discussion about an innovative academic-practitioner partnership. This partnership, aimed at strengthening research mindedness and research activity in social service settings, has been fuelled by a belief in the power of groups to achieve what individuals cannot. The authors reflect on the range of inputs and synergistic group processes that allowed for a series of outcomes that would not have been possible within an individualized initiative. In conclusion, lessons learned from the use of groups to advance practice-based research are outlined. [ABSTRACT FROM AUTHOR]

We evaluate by simulation three model-based methods to test the influence of a single nucleotide polymorphism on a pharmacokinetic parameter of a drug: analysis of variance (ANOVA) on the empirical Bayes estimates of the individual parameters, likelihood ratio test between models with and without genetic covariate, and Wald tests on the parameters of the model with covariate. Analyses are performed using the FO and FOCE method implemented in the NONMEM software. We compare several approaches for model selection based on tests and global criteria. We illustrate the results with pharmacokinetic data on indinavir from HIV-positive patients included in COPHAR 2-ANRS 111 to study the gene effect prospectively. Only the tests based on the EBE obtain an empirical type I error close to the expected 5%. The approximation made with the FO algorithm results in a significant inflation of the type I error of the LRT and Wald tests. [ABSTRACT FROM AUTHOR]

Crystal chemical analysis of several large sets of topologically related structures confirms earlier suggestions that within the same cell content, space group, and Wyckoff site occupancies, there may exist several structure types of sometimes quite different coordination chemistry and bonding arrangement. The original Flahaut's suggestion of demarcating anti-Cu2Sb and PbFCl structure types has been extended to an analysis of structures of over 350 compounds in terms of various structural characteristics as free parameters. For the Cu2Sb family, structural field maps indicate formation of at least three distinct structure types: Cu2Sb, PbFCl, CeFeSi (anti-type of PbFCl) and UAs2 (which is not an anti-type of Cu2Sb). The formerly suggested ternary ZrSiS structure type is in fact an ordered version of UAs2. Extension of this approach to "filled" versions of these structure types permits clear demarcation of two other topologically related structure types, LaOAgS and HfCuSi2, the latter being a derivative of UAs2 but not Cu2Sb. Very similar relationships have been observed for several smaller structural families. Perspectives of using different structural parameters as free coordinates are discussed. [ABSTRACT FROM AUTHOR]

The trends emerging in the natural language processing (NLP) of African languages spoken in South Africa, are explored in order to determine whether research in and development of such NLP is keeping abreast of international developments. This is done by investigating the past, present and future of NLP of African languages, keeping especially the multidisciplinary nature of the field and the role of the linguist in mind. A Human Sciences Research Council (HSRC) report of 1986, expressed concern about the backlog in South Africa regarding NLP, and celled for dynamic action. As computational power increased and became less expensive, more interest began to be shown in NLP in South Africa. Pockets of expertise that have developed at various institutions over the past 20 years are discussed and the importance of cooperation in the field, across disciplines, is illustrated in this paper. In order to facilitate coordinated action and prevent the duplication of language resources and the development of basic enabling technologies, the implementation of the concept of the Basic Language Resource Kit (BLARK) is recommended, while a new project, which aims to create a platform for WordNet development for African languages, is cited as prime example of international collaboration. [ABSTRACT FROM AUTHOR]

[(C6H6)Ru(1,2,4-triazole)3](CF3SO3)2 has been prepared and studied by IR, electronic and 1H NMR spectroscopy and X-ray crystallography. The complex was prepared by reaction of [(C6H6)RuCl2]2 with 1,2,4-triazole in the presence of AgCF3SO3 in methanol. The electronic spectrum of the compound has been calculated using the TDDFT method. [ABSTRACT FROM AUTHOR]

Advances in laboratory methods have driven improvements in the management and treatment of HIV infection. The methods to accurately and rapidly diagnose HIV infection in infants and children have been outlined in the previous article. In this review, the laboratory evaluation of infected children is described and methods to monitor progression of disease and response to therapy outlined. [ABSTRACT FROM AUTHOR]

G protein-coupled receptors (GPCRs) are integral membrane proteins that mediate cellular responses to a variety of ligands and represent major drug targets. Despite their medical importance, detailed structural information is limited because only one GPCR has been crystallized and its structure determined. To develop tools to aid in the formation of well-ordered crystals, we generated monoclonal antibodies with high affinity to the rat neurotensin receptor. All antibodies bound to the C-terminus of the receptor, which may reflect the selection strategy used to identify high-affinity binders. Further characterization revealed that some antibodies bound to the receptor in a sodium chloride sensitive manner, but others did not. Epitope mapping revealed distinct antigenic regions within the receptor C-terminus. Tight binding of Fab fragments to the receptor was verified by size exclusion chromatography. [ABSTRACT FROM AUTHOR]

Introduction . Recently, the identification of the SEN virus as a possible etiological agent of parental transmission hepatitis led to the study of the prevalence of such pathogen agents, particularly SENV-H, in our population. This paper compares the rate prevalence in high-risk subjects, such as dialysis patients, and low-risk subjects, such as blood donors. Material and Methods . The study was carried out on SEN virus DNA extracted from serum of dialysis patients and blood donors, and the presence of viral genomes was performed by the nested PCR method. Results . The results showed a higher prevalence in male blood donors, supporting the hypothesis of an epidemiological role for sexual and also parental transmission, as is clearly demonstrated by the high prevalence in dialysis patients. The result reduced the importance of the possible etiological role of the SEN virus due to the high percentage of positivity in healthy population, and it induces one to consider poorly significant the pathogenicity of such viral agents. Conclusion . For this instance, the authors, in agreement with the phylogenically related TT virus, described SEN viruses as absolutely not pathogens and considered them as “simple guests.” [ABSTRACT FROM AUTHOR]