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In der eigenen Häuslichkeit versorgt zu werden, ist für viele pflegebedürftige Menschen von großer Bedeutung. Neben Angehörigen gewährleisten ambulante Pflegedienste die häusliche Versorgung. In Deutschland wird ein Viertel der zu Hause betreuten pflegebedürftigen Menschen von ambulanten Pflegediensten versorgt. Das Thema der Qualität der ambulanten Pflege ist zunehmend Gegenstand pflegefachlicher und politischer Diskussionen. Eine Möglichkeit zur Messung von Versorgungsqualität ist die Nutzung von Routinedaten von Kranken- bzw. Pflegekassen. Für die ambulante Pflege gab es hierzu bislang keine Überlegungen. Im Rahmen der Forschungsarbeit wurde daher die generelle Nutzbarkeit von Routinedaten für die ambulante Pflege untersucht. Im Ergebnis zeigt sich, dass eine Reihe von qualitätsrelevanten Versorgungsaspekten in der ambulanten Pflege anhand von Routinedaten operationalisierbar ist. Die Mehrzahl der relevanten Versorgungsaspekte ist jedoch nicht über Routinedaten abbildbar. Hierfür wären unter anderem grundlegende Anpassungen der gesetzlichen Rahmenbedingungen erforderlich.

This book will serve as a complete reference guide for the totality of salivary gland (SG) disease. Focusing on the clues available to the practitioner during the patient examination, it will completely review and update the available data concerning all manner of SG conditions. Looking beyond the perspectives of surgery, imaging, pathology, or sialendoscopy in diagnosis and therapy, this book will provide all professionals interested in the head and neck extensive and detailed diagnostic information about each SG entity. Achieving an accurate diagnosis involves the use of multiple clinical tools (history, physical examination, imaging, serology, biopsy etc). The indication for and significance of each of these investigative procedures will be discussed, integrated and photographically illustrated in tandem with the diagnostic review of the relevant SG entity. Besides a diagnostic review of readily diagnosed SG entities (Sjogren's, sialolithiasis, infection etc), the book willcover subjects whose diagnoses have been inadequately described (juvenile recurrent parotitis, sarcoid, radioactive iodine for thyroid cancer, pediatric Sjogren's, etc) or never reviewed (middle ear surgery and saliva, Stensen's duct dilatation, first bite syndrome, HIV paraparotid fat, etc) in other published texts. It will be organized by diagnosis. Written by an expert in the field with over six decades of clinical experience, Clinical Management of Salivary Gland Disorders will call attention to the large number of presenting patients who can be categorized as'false-positives.'This includes a psychosomatic group with perceptual salivary complaints, patients with masseteric hypertrophy, paraglandular opacities misdiagnosed as sialoliths, dental caries thought to have a salivary origin and more. Finally, this book will offer thorough methodology for identifying and diagnosing these initially confusing problems. An exhaustive resource for the field of salivary gland complaints, this book will be useful to otolaryngologists, head/neck surgeons, plastic surgeons, oral medicine/oral pathology practitioners and residents, oral and maxillofacial surgeons, and dentists. Internists concerned with physical diagnosis of head/neck problems, neuroradiologists concerned with relating imaging results to a clinical salivary gland condition and nurse practitioners and dental hygienists will also find this book most helpful.

This book constitutes the refereed proceedings of the 23rd IFIP WG 6.1 Conference on e-Business, e-Services and e-Society, I3E 2024, held in Heerlen, The Netherlands, during September 11–13, 2024. The 28 full papers and 8 short papers presented in this volume were carefully reviewed and selected from 77 submissions. They were organized in topical sections as follows: Artificial Intelligence Adoption and Impact; Digital Transformation and Organizational Innovation; Healthcare, Social Well-being, and Ethics.

This book explores key factors long-term care recipients have identified as impacting their quality of life and offers programmatic and policy recommendations to enhance well-being within long-term care communities. Leadership and staff who work in nursing homes and other residential care communities serve as gatekeepers to resident well-being, often without recognizing how residents'quality of life is impacted by their decision-making. This book takes a life domain approach to build on research-based studies that document key drivers of care recipients'quality of life, including relationships, autonomy and respect, activities and meals, environment, and care. Using a framework that enhances understanding of resident quality of life, it outlines practical, programmatic, and policy suggestions for long-term care stakeholders, such as administrators, managers, front-line staff, family members, and policy-makers, whose directives and actions impact the lived experience of long-term care residents. As such, this book serves as a roadmap for leaders and managers of long-term care communities, along with policymakers who regulate health and human services, to best structure care environments to maximize quality of life and well-being for long-term care recipients.

This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies.Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds.Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.

The sixth edition of Contact Dermatitis covers in detail every conceivable aspect of irritant and allergic contact dermatitis and its modern-day management. The 1st edition of this book was published in 1992 and has served as the main reference book of contact dermatitis. In this new edition special emphasis is given to immunological mechanisms, molecular aspects of sensitizers, atypical clinical forms, patch test methodology, reactions to medicaments, and occupational and environmental factors. In order to optimize the diagnostic approach, a wide range of information is provided, including a dictionary of contact allergens and detailed information on exposure assessment. Retained chapters from the previous edition have been thoroughly revised to reflect the latest knowledge. Furthermore, completely new chapters have been added on a variety of topics, including contact allergy to medical implants, relevant allergens in gloves and immediate reactions to occupational materials. The editors and authors are all leading practitioners in the field. The comprehensive but approachable text is supplemented by a large number of full colour illustrations and tables. Core messages highlight the most important information and will help the reader to gain a better understanding of the subject and greater competence in everyday practice.

This landmark book is the most extensive and complete oculofacial plastic surgery guide available in the market. Updated and broadened from the three previous editions, it includes advances in the use of surgical navigation systems, and new techniques and treatments for diseases involving the eyelid, orbital and lacrimal system.Organized across 11 sections of in-depth, expertly written text, Smith and Nesi's Ophthalmic Plastic and Reconstructive Surgery, Fourth Edition has taken the best of the field's classic reference text and expanded upon it. Detailed chapters cover a multitude of topics relating to various ocular surgeries, pediatric considerations, ocular traumas, and anatomy.Supplemented with a myriad of high-quality illustrations, Smith and Nesi's Ophthalmic Plastic and Reconstructive Surgery, Fourth Edition is an indispensable reference for oculoplastics surgeons and physicians in other fields.

This edited volume is a compilation of 30 articles discussing what constitutes food for health and longevity. The aim is to provide up-to-date information, insights, and future tendencies in the ongoing scientific research about nutritional components, food habits and dietary patterns in different cultures. The health-sustaining and health-promoting effects of food are certainly founded in its overall composition of macronutrients and micronutrients. However, the consumption of these nutrients is normally in the form of raw or prepared food from the animal and plant sources. The book is divided into four parts and a conclusion, and successfully convenes the well-established information and knowledge, along with the personal views of a diversified group of researchers and academicians on the multifaceted aspects of nutrition, food and diet. The first part reviews the scientific information about proteins, carbohydrates, fats and oils, micronutrients, pro- and pre-biotics, and hormetins, along with a discussion of the evolutionary principles and constraints about what is optimal food, if any. The second part discusses various kinds of foods and food supplements with respect to their claimed benefits for general health and prevention of some diseases. The third part brings in the cultural aspects, such as what are the principles of healthy eating according to the traditional Chinese and Indian systems, what is the importance of mealing times and daily rhythms, and how different cultures have developed different folk wisdoms for eating for health, longevity and immortality. In the part four, various approaches which are either already in practice or are still in the testing and research phases are discussed and evaluated critically, for example intermittent fasting and calorie restriction, food-based short peptides, senolytics, Ayurvedic compounds, optimal food for old people, and food for the prevention of obesity and other metabolic disorders. The overreaching aim of this book is to inform, inspire and encourage students, researchers, educators and medical health professionals thinking about food and food habits in a holistic context of our habits, cultures and patterns. Food cannot be reduced to a pill of nutritional components. Eating food is a complex human behavior culturally evolved over thousands of years. Perhaps the old adage “we are what we eat” needs to be modified to “we eat what we are”.

This book is intended as a manual and offers an essential tool for practicing and occupational dermatologists, for postgraduates training in dermatology and allergo-immunology, and for allergologists and occupational physicians. Moreover, the authors include information from the world literature, addressing the needs of those who work in industrial fields and are concerned about the dermatological safety of products. The book provides a handy update on this complex, rapidly evolving research area, and in particular, an in-depth analysis of its clinical aspects. It will enable dermatologists to recognize the various clinical manifestations of the condition, make a prompt diagnosis and choose the most effective treatment.Contact dermatitis, a vast and fascinating field of study, has a high frequency of occurrence worldwide in both children and adults of both sexes, and during their daily routine, dermatologists invariably encounter many patients with this disease. To ensure the proper management of these patients it is necessary first of all to formulate a clinical diagnosis on accurate morphological grounds, since it is the most clinically polymorphic disease in dermatology and hence very demanding in terms of differential diagnosis. Then, to achieve properly targeted prevention for each patient, it is essential to isolate the causes among the numerous etiological chemical agents present in both working and leisure time activities and environments. The aim of this book is therefore two-fold: firstly to provide information on the various clinical features of contact dermatitis and review their differential diagnosis, and secondly to provide a comprehensive etiological overview. Particular attention has been paid to the methodologies and importance of patch tests and other diagnostic tools, as well as to the principles of prognosis, treatment and rehabilitation, together with considerations on some preventive aspects underlying contact dermatitis. A wealth of color clinical images, as well as tables and explanatory diagrams, round out the book.

This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related disorders and conditions affecting the oral and maxillofacial region. The pathophysiology, clinical presentation, diagnostic evaluation, and treatment of all relevant diseases and disorders are described with the aid of a wealth of clinical cases and illustrations that enable the reader to appreciate the diversity and potential complexity of Oral Medicine. In addition to the wide-ranging coverage of oral conditions, separate sections are devoted to bone and cutaneous pathology and to orofacial pain and its management, in addition to dental sleep medicine. The clinician who treats Oral Medicine patients will find this book to be an excellent aid to optimal management grounded in a sound knowledge of basic science and the dental and medical aspects ofeach disorder. In addition, it will serve as an outstanding textbook for undergraduate and postgraduate students.

Practical Head and Neck Pathology: Frequently Asked Questions centers around frequently asked questions, but it is not meant to be comprehensive in its approach. Instead, it aims to touch on all major or commonly encountered entities. Each chapter begins with a list of questions typically ordered from basic histologic knowledge, to inflammatory processes, primary tumors, and secondary tumor types. Strategies for the diagnosis of salivary gland, metastatic head and neck cancers and thyroid disease using ancillary testing is highlighted. Small biopsy dilemmas in undifferentiated tumors of the sinonasal and nasopharyngeal tracts are undertaken with emphasis on differential diagnosis and ancillary techniques. The tables are the foundation of the book, offering a quick reference guide for salient features of various entities and differential diagnoses. A comprehensive set of references after each question can be used to supplement the information provided and give the reader a foundation for further learning. This book answers some of the difficult, prevailing and emerging questions in head and neck pathology that arise in everyday practice. While such challenges may not always be frequent, they have tremendous impact on clinical practice. Clinically pertinent, molecular advances in treatment and diagnosis for the practicing and junior pathologist are covered.

This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management.

This book aims to address the major aspects of future drug product development and therapy for older adults, giving practical guidance for the rational product and clinical development and prescribing of drug products to this ever growing segment of the population. With authors coming from key “aging” markets such as Europe, the USA, China and Japan, the book will provide valuable information for students, scientists, regulators, practitioners, and other healthcare professionals from academia, industry and regulatory bodies.

This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful “one-stop information shop” for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.

Entscheidendes Anliegen dieses Standardwerkes ist die klinisch-pathologische Korrelation: Bereits klinisch sichtbare, strukturelle Veränderungen am Auge werden den entsprechenden mikroskopischen Schnitten in über 1000 Abbildungen und schematischen Skizzen gegenübergestellt. Außerdem wird die Differentialdiagnose definierter Befunde in 188 Tabellen erläutert. Nach einleitenden Kapiteln über die Anatomie und einer Übersicht des Untersuchungsmaterials in einem ophthalmologischen Labor folgen Kapitel über Mißbildungen, intraokulare Entzündungen, Folgen von Trauma und chirurgischen Eingriffen sowie Glaukome. Anschließend werden die einzelnen Gewebeabschnitte systematisch abgehandelt: Konjunktiva, Kornea, Uvea, Linse, Glaskörper, Retina, Optikus und kursorisch die okulären Adnexe. Die Voraussetzungen für die Leitstrukturen und Elemente des ophthalmoskopischen Bildes werden getrennt erörtert. Abschließend folgt eine Übersicht der morphologischen Augenveränderungen bei Allgemeinerkrankungen und als Therapie-Folge. 4500 Literaturstellen erleichtern den Einstieg in vorhandenes Schrifttum.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

It is indeed a pleasure to write a foreword for this spectacular book which represents a landmark in the history of ocular pathology. Not since the three volumes of the Henke-Lubarsch handbook appeared forty years ago has anything like this come on the market. This book represents a compre­ hensive, thorough and up-to-date clinically oriented textbook on ocular pathology. We are all indebted to the senior author, who is now professor of ophthal­ mology at the University of Erlangen, who presents us here with the fruit of decades of industrious endeavors. We also have to be grateful to the American ophthalmic pathologist, Dr. David Apple, who, as one of the main collaborators of the German edition, has now provided us with the English translation. The book has a twofold purpose: First, it is meant to be a source of instruction for ophthalmologists and pathologists. For that purpose it is beautifully illustrated both by clinical pictures and by excellent photomicro­ graphs and electromicroscopic pictures. Most valuable from a didactic point of view are the colored schematic drawings and the many tables. These two features are practically unique and should help any neophyte in grasp­ ing the principles of ocular pathology.

The past 10 years have seen a remarkable change in the approach to cardiac arrhythmias, from a position of confidence and a feeling of well-being about pharmacological treatment to a situation in which there is now marked uncertainty and general apprehension about the role of antiarrhythmic drugs. Until relatively recently the prevailing concept in antiarrhythmic therapy was that arrhythmias could be controlled by drugs which slowed conduction or suppressed automaticity, goals well served by the sodium channel-blocking drugs and glycosides. Drug re­ search was based largely on the development of agents mimicking those already available, but with greater efficacy, fewer side effects or a more favourable phar­ macokinetic profile. The CAST trial stands out as a landmark in the evolution of arrhytmia manage­ ment; rarely has a single trial had such a profound impact not only on clinical prac­ tice, but also on the whole approach of those involved in the research, development and regulation of antiarrhythmic drugs. The results of the CAST trial, designed to redress the shortcomings of earlier trials which had failed to demonstrate the anticipated improvement in mortality post-myocardial infarction with the use of class I agents, are well known. The CAST and CAST II showed an increase in mor­ tality associated with the active agent (encainide, flecainide or morizicine) com­ pared to placebo treatment. They firmly established the potential danger in the use of class I drugs.

When faced with a challenging dermatologic problem, physicians are often required to perform a time-consuming search through large dermatologic texts in order to find information that will assist in the necessary differential diagnosis. This comprehensive and concise handbook is designed to simplify this process dramatically, permitting rapid identification of the correct diagnosis. Hundreds of dermatologic diagnoses, morphologic features, drug-induced disorders, extracutaneous manifestations, histologic findings, and random other findings are listed in alphabetical order and in a homogeneous, reader-friendly structure. The differential diagnoses are shown under each main diagnosis, sorted according to similarity with that diagnosis. Since the first edition, approaching 50 new diagnoses have been added, and many new images included. This easily portable book will be of great value for dermatologists and all who deal with dermatologic diseases.

The fifth edition delivers up-to-date coverage of every conceivable aspect in modern-day management of contact dermatitis. Leading experts have thoroughly updated the previous edition, while adding new chapters on genetics, the skin barrier, respiratory symptoms to chemicals and an extensive section on prevention. Both irritant and allergic contact dermatitis are covered with special emphasis on immunological mechanisms, molecular aspects of sensitizers, atypical clinical forms, reactions to medicaments, occupational and environmental aspects. The comprehensive yet approachable text is supplemented by numerous color illustrations and tables. Core messages and case reports highlight the most important information and help in gaining better understanding of the topic and greater competence in daily practice. An extensive dictionary of allergens gives quick access to specific information.

Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.

Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.

This updated volume provides a “user-friendly” reference for dermatologists, dermatology residents and students, as well as for health care workers in related fields to better understand immune-mediated skin diseases and their therapies.The focus is on what is needed by the physician/resident or student for betting understanding the pathophysiology of the disease as well as the mechanisms of action of the therapies. The reader can easily read about groups of related diseases as well as groups of related therapies.The level of complexity of the book is such that it has practical applications on a daily basis but can also be used by the resident as a teaching tool and as a handy source of review for the boards. In addition, it can be used the practicing dermatologist to study for recertification.The scope of the book is immunology, immunogenetics, immunopathology and immunopharmacology as they relate to clinical dermatology.

Tis book originated as a small reference manual that I created to serve as an educational supplement for the dermatology residents a-t Loui siana State University Health Sciences Center. Deeming the compiled information to be useful for all dermatologists, I decided to expand the text and publish it. Every major category of the patient evaluation, from the chief complaint to the diagnosis, is addressed with regard to the dermatological diferential diagnosis. Te establishment of a precise diferential diagnosis for a gi- ven cu taneous problem is the fundamental challenge that the dermatologist faces with every patient. Tis unique exercise is very intellectual; in a short period of time the clinician must select from a list of perhaps several hundred diseases a few possibilities that match the clinic-al pre sentation. Tis is performed while also negotiating the patient - interac tion, examining the patient, and beginning to formulate a pla- n of ac tion. Profciency in the formulation of a diferential diagnosis that is brief and simultaneously thorough allows for consideration of- all pos sibilities, proper evaluation, and, hopefully, rapid diagnosis. We hope to provide the target readers (dermatologists and dermatologists- -in-train ing) with some assistance in carrying out this frequently complicated task. For the confrontation with an atypical presentation of a common disease or the classic presentation of an uncommon disease, the reader will hopefully fnd this book very useful.

Springer Handbook of Enzymes provides data on enzymes sufficiently well characterized. It offers concise and complete descriptions of some 5,000 enzymes and their application areas. Data sheets are arranged in their EC-Number sequence and the volumes themselves are arranged according to enzyme classes. This new, second edition reflects considerable progress in enzymology: many enzymes are newly classified or reclassified. Each entry is correlated with references and one or more source organisms. New datafields are created: application and engineering (for the properties of enzymes where the sequence has been changed). The total amount of material contained in the Handbook has more than doubled so that the complete second edition consists of 39 volumes as well as a Synonym Index. In addition, starting in 2009, all newly classified enzymes are treated in Supplement Volumes. Springer Handbook of Enzymes is an ideal source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences, as well as for medicinal applications.

It is an unusual event for a textbook covering such a national and international networks and the use of highly specialized field as contact dermatitis to be standardized methodology, a highly differentiated published in its fourth edition within a time period picture can now be painted; we know the major p- of 13 years. When the European and Environmental fessions at risk, as well as the influences of age and Contact Dermatitis Research Group was founded in various cofactors. This is a solid basis for preventive 1985,one of the major goals was to edit a textbook of measures. A new allergen, described in one center, high scientific standard written by renown experts can now be tested on a large scale in a short time and keep it regularly updated. The greatest danger period. If the data evaluation shows an unacceptably for a textbook is to become outdated – then it stays high rate of sensitization in the exposed population, on the bookshelf and is rarely consulted. The contin- regulatory measures will be undertaken to protect uous flow of new medicaments, the fascinating the consumer. A recent example is the “methyldib- improvements in diagnostic image analysis and ever- mo glutaronitrile story. ” changing operative procedures are the reasons for These and other issues of importance are covered considerable knowledge deficits in old textbooks, in depth in the newest edition of this textbook.

Atopic eczema (atopic dermatitis, neurodermitis diffusa, endogenous eczema) is one of the most common skin diseases of our time and is still increasing in prevalence dramatically all over the world. The reasons for this increase are not known. It occurs at any age, not only in childhood, approximately 2/3 of children affected will suffer from this disease when they are grown-up. Written by leading experts of their field, this second edition comprises the state of the art in pathophysiology, clinical medicine and therapeutic management. It demonstrates that there is no simple'miracle'cream, pill or diet for this disease, but that a disturbed barrier function can only be repaired by adequate and individualized skin care and it shows how unspecific anti-inflammatory treatment has to be individually tailored according to body area affected, patient age and acuity of skin lesions. All physicians will find this book most helpful in the painstaking search for the individual causal or eliciting factors.

Seit 1985 wird der deutsche Arzneimittelmarkt im Arzneiverordnungs-Report analysiert. Datengrundlage ist die Vollerfassung von 400 Millionen Rezepten für die Patienten der gesetzlichen Krankenversicherung. Die Arzneimittelausgaben nahmen 2004 erstmals seit 12 Jahren um 2,5 Mrd. € auf 21,7 Mrd. € durch das GKV-Modernisierungsgesetz ab. Wesentliche Elemente der Kostensenkung waren der Ausschluss rezeptfreier Arzneimittel aus der vertragsärztlichen Versorgung, erhöhte Rabatte der Arzneimittelhersteller an die Krankenkassen, erhöhte Patientenzuzahlungen und die Einführung einer Praxisgebühr. Aktuelle Verordnungstrends werden an 3000 Arzneimitteln in 46 Indikationsgruppen dargestellt. Besonders eingegangen wird auf: Bewertung von 33 Neueinführungen des Jahres 2004, Einsparerfolge bei Generika und umstrittenen Arzneimitteln, Verordnungsprofil rezeptfreier Arzneimittel. Als Schwerpunkthema werden die Arzneiverordnungen pharmazeutischer Hersteller und ihr Produktsortiment im Kindesalter dargestellt. Immer noch problematisch ist hier die Anwendung von Arzneimitteln außerhalb der Zulassung (Off label). Noch häufiger werden bei Kindern Arzneimittel mit umstrittener Wirkung verordnet. Presseecho zum Arzneiverordnungs-Report 2004:'Bei Medikamenten droht neue Kostenlawine'Süddeutsche Zeitung 16.10.2004'Medikamente werden 2005 teurer'Tagesspiegel 16.10.2004'Rezeptfrei oft billiger als verordnet'Stuttgarter Nachrichten 16.10.2004'Kosten sinken - vorübergehend'Deutsches Ärzteblatt 22.10.2004

Die Fortbildungswoche für praktische Dermatologie und Venerologie ist zur zentralen Fortbildungsveranstaltung der deutschsprachigen Dermatologen geworden. Alle zwei Jahre wird hier ein für die Praxis aufbereiteter, aktueller Überblick über den Wissensstand und die Entwicklung des gesamten Faches gegeben. In diesem Band finden sich die Themen der 19. Fortbildungswoche für praktische Dermatologie und Venerologie 2004 als sorgfältig bearbeitete und mit aktuellen, weiterführenden Literaturhinweisen versehene Übersichten. Weiterhin sind auch in diesem Band die Kasuistiken der'Diaklinik'enthalten.

Zu dick – was steckt dahinter? Die Zahl der Kinder und Jugendlichen mit zu hohem Körpergewicht hat sich in den letzten zwanzig Jahren mehr als verdoppelt – und steigt stetig weiter an. Fast 7% aller Schulkinder leiden bereits an Übergewicht! Welche unterschiedlichen Ursachen bedingen die Entstehung von Adipositas? Welche vielfältigen Folgen kann die Adipositas verursachen? Kinder und Jugendliche mit Übergewicht und ihre Familien benötigen Ihre Kompetenz in Diagnostik, Beratung und Therapie, um diese Erkrankung zu bewältigen! Hier finden Sie das Wissen zur Adipositas! Ausführlich und verständlich aufbereitet: Entstehung der Adipositas Komorbiditäten Zusammenhang zwischen Umweltfaktoren und genetischer Veranlagung Diagnostischen Verfahren Möglichkeiten der Prävention verschiedene therapeutische Konzepte Alles, was Sie bei Ihrer täglichen Arbeit über Adipositas bei Kindern und Jugendlichen wissen müssen!

Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The second edition has been extended by chapters on autoimmune pigmentary disorders (vitiligo), hairloss (alopecia areata) and cutaneous symptoms of rheumatic disorders.

This book is the third in aseries of publications devoted to the biogeographieal and ecological research in the Southern Hemisphere, published in the'Monographiae Biologicae'. After dealing with Australia (vol. VIII) and Southern Africa (Vol. XIV) it was thought essential to include Antarctiea in this series. Ever since the expedition of the'Belgiea'made the first suc­ cessful wintering within the antarctie circle in 1898 and brought back a very rieh harvest of scientific data, Belgium kept a vivid interest in Antarctiea and took an active part in the modern and international exploration of this vast continent. As part of their programs for the International Geophysieal Year (I. G. Y.) twelve nations established permanent or semi-permanent bases on the Antarctie Continent or on subantarctie islands. Thus a new era of vast and free international scientific collaboration in the Antarctie was opened and it culminated in the formulation and the signing of the Antarctic Treaty (Washington 1959). It was recognized and accepted that'Antarctiea'shall be used for peaceful purposes only and'Freedom of scientific investigation in Antarctiea and coopera­ tion toward that end, as applied during the I. G. Y., shall continue..'In order to organize this collaboration e. g. by full exchange of programs and resuIts a'Special Committee on Antarctie Research'(S. C. A. R.) was founded in 1957.