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This book comprehensively reviews the fundamentals of biomarker discovery using mass-spectrometry-based proteomic and glycoproteomic methods. It also provides case studies of proteomic and glycoproteomic molecular signatures to illustrate the design and use of various mass spectrometry modes such as selected reaction monitoring (SRM), parallel reaction monitoring (PRM), and sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS). In turn, the book presents the challenges of the proteomic methods in biomarker discovery and approaches for overcoming these challenges by extending the performance by improving the sensitivity, throughput, and selectivity of the method. It also addresses the bottleneck of deriving useful biological interpretations from large multi-dimensional datasets emanating from these experiments by discussing data analysis pipelines and appropriate statistical analysis. Finally, a detailed discussion on the design, characterization, and application of protein/glycoprotein-based biosensors for clinical diagnostics is discussed. The book is intended to serve as a reliable resource for the students and researchers working in the area of biomarker discovery and validation using mass spectrometry-based methods and their subsequent applications for biosensor design. ​

This book provides a comprehensive study of major issues of moral psychology throughout history, from ancient to early modern philosophy. The volume focuses primarily on the Western history of philosophy but also deals with Jewish and Islamic heritage. The Introduction chapter lays out the historical background in broad strokes, giving the reader the “lay of the land” when it comes to the terms of analysis and their overall development within the Western tradition of moral psychology. The book continues by studying and analyzing moral anthropology, moral agency and motivation, virtues and social and political commitments, taking a thematic approach in a specific time-period and focus on the most unique and/or fruitful discussions about a particular historically situated discussion when it comes to thinking about questions and/or ‘problems'in the field of moral psychology. Aimed at both a layman and academic audience, this book is of great interest to a broad readership.

This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitablefor antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers. ​

An international panel of experts have contributed to create the first comprehensive guide to spiritual care focussing on the palliative care setting from neonatal to aged care, combining the theoretical underpinnings of spirituality research with practical applications for its introduction into patient care. This book is structured to give a detailed understanding of the importance of spirituality for patients approaching the end of life as well as the impact of spiritual care on patients, families and carers. As the first step towards reaching this goal, the need for spiritual care training of clinicians is outlined, including the crucial step of nurturing one's own spiritual life. Ways to identify and assess patients'spiritual needs are explained. The experience of existential suffering is explored along with discussion of the ways it can manifest and how it can be addressed. The implementation of spiritual care in the clinical setting is detailed with illustrations of the roleof each member of the palliative care team and the benefits of an institutional approach. This valuable resource provides not only empirical evidence for the importance of spiritual care but also practical guidance for those wishing to practice it. It is ideal for all those caring for patients of all ages at the end of life, including palliative care clinicians, spiritual care professionals, students and researchers, and anyone interested in creating meaning in the face of imminent death.

The book elaborates on microplastics as a global concern, prompting the need for comprehensive understanding and effective management. It thoroughly explores the various aspects of microplastics, addressing their detection, separation, and contamination in diverse ecosystems. The introductory chapter highlights the global risks associated with microplastics while presenting the challenges and opportunities in tackling this issue. It focuses on the detection techniques employed to identify microplastics, providing insights into the analytical methods and technologies utilized in their characterization. It delves into the separation techniques used to extract microplastics from complex environmental matrices, aiding in their accurate quantification and analysis. The subsequent chapters examine the presence and impact of microplastics in specific ecosystems, including aquatic and terrestrial. It investigates the prevalence of microplastics in water bodies and their detrimental effects on aquatic organisms and elucidates their distribution, transport, and ecological implications on land-dwelling organisms. The book further explores microplastics'occurrence in foods, cosmetics, and air pollution and associated health hazards. It delves into the lesser-known aspects of microplastics influence on nitrogen cycling and nitrous oxide emissions, offering valuable insights into their impact on biogeochemical processes. It discusses microplastics environmental risks and hazards, covering the ecological, biodiversity, and ecosystem-level impacts caused by these persistent pollutants. The concluding chapters focus on sustainable management strategies for mitigating and controlling microplastics proliferation and associated risks. This book provides a comprehensive and multidisciplinary approach for understanding and addressing the challenges posed by microplastics. It serves as a valuable resource for researchers, policymakers, environmentalists, and anyone concerned about the impact of microplastics on planet. This book aims to foster sustainable management practices and contribute to a cleaner and healthier environment by unraveling microplastics complexities.

This book presents a comprehensive introduction to the field of bilingualism and multilingualism with focus on education. It compiles various sub-themes such as minority and majority languages, childhood bilingualism, and the historical aspects of bilingualism. Each chapter is carefully structured and includes clear themes with introductory notes by the editor. The main focus is on the cognitive development of bilinguals and how they promote cultural diversity, presenting how bilingual education and second language teaching within the socio-political and multicultural landscape are interconnected. It discusses significant concepts such as translanguaging, an innovative approach that transcends traditional language boundaries, and the role of Multilingual Education (MLE) in shaping the future of learning. Research also focusses on macro-level issues, such as globalization and minority language preservation, and micro-level strategies for bilingual classrooms. In addition, it explores topics such as Dual Language schools, the economic benefits of bilingualism, and debates on language loss and bilingual education policy in different countries. These well-organized topics promote a holistic understanding of bilingualism and encourage a positive view of linguistic diversity and its role in creating a more inclusive, multicultural world. For educators, researchers and language enthusiasts, it is an invaluable resource that provides a thorough understanding of the nuances of bi/multilingual education. The auto-summaries have been generated by a recursive clustering algorithm via the Dimensions Auto-summarizer by Digital Science handled by Subject Matter Experts and the editor of this book. The editor of this book selected which Springer Nature content should be auto-summarized and decided its order of appearance. Please be aware that these are extractive auto-summaries, which consist of original sentences, but are not representative of its original paper, since we do not show the full length of the publication. Please note that only published SN content is represented here, and that machine-generated books are still at an experimental stage.

This book gathers research papers presented at the 4th edition of the International Research and Innovation Conference—CI3 2023, that took place from August 30 to September 1, 2023, at the facilities of the Instituto Tecnológico Universitario Rumiñahui, located in the city of SangolquÍ, Pichincha, Ecuador. The conference was organized by the Red de Investigación, Innovación y Transferencia de Tecnología—RIT2, made up of the most relevant university institutes in Ecuador, among which are ITCA, BOLIVARIANO, ARGOS, VIDA NUEVA, ESPÍRITU SANTO, SUDAMERICANO, ISMAC, SAN ISIDRO, ARTES GRÁFICAS, ORIENTE, HUMANE, SUCRE, CENTRAL TÉCNICO, POLICÍA NACIONAL and RUMIÑAHUI. Additionally, the event is sponsored by the Secretaría de Educación Superior, Ciencia, Tecnología e Innovación—SENESCYT, Labortorio de Comunicación Visual de la Universidad Estatal de Campinas—Brazil, Universidad Ana G. Méndez—Puerto Rico, Centro de Investigaciones Psicopedagógicas y Sociológicas—Cuba, Instituto Superior de Diseño de la Universidad de La Habana—Cuba, GDEON and the Corporación Ecuatoriana para el Desarrollo de la Investigación y la Academia—CEDIA. The main objective of CI3 2023 is to generate a space for dissemination and collaboration, where academia, industry and government can share their ideas, experiences and results of their projects and research. “Research as a pillar of higher education and business improvement” is the motto of the Conference and suggests how research, innovation and academia must coincide with the productive sector to leverage social and economic development. CI3 2023 had 145 papers submitted, of which 52 were accepted for publication and presentation. To guarantee the quality of the publications, the event has a staff of more than 70 experts, from different countries such as Spain, Argentina, Chile, Mexico, Peru, Brazil, Ecuador, among others, who carry out an exhaustive review of each proposal sent. The content of this proceeding is related to the following topics: • Smart Cities • Innovation and Development • Applied Technologies • Economics and Management • ICT for Educations

This book compiles cutting-edge research and innovative practices in the field of naval architecture and marine engineering, presented during the IV Iberoamerican Congress of Naval Engineering and 27th Pan-American Congress of Naval Engineering, Maritime Transportation and Port Engineering (COPINAVAL). It covers an extensive array of topics, from reverse ship design procedures to the impact of climate change on port facilities, providing readers with a wide breadth of knowledge within the maritime engineering domain. Each chapter offers in-depth technical insights supported by empirical data and advanced computational models, ensuring a thorough understanding of the discussed subjects. With a strong emphasis on practical applications, solutions and improvements to real-world challenges in ship design, construction, and operation are presented. The content adopts an interdisciplinary approach, spanning naval architecture, hydrodynamics, materials science, and more, allowing for a holistic comprehension of maritime engineering. Furthermore, the book delves into sustainable technologies, including eco-friendly electric boats, wave energy farms, and offshore photovoltaic panels, contributing to global efforts for a more environmentally responsible maritime industry. It also highlights the integration of cutting-edge technologies like virtual reality, robotics, and simulation modeling in shipbuilding processes, offering insights into the future of the industry.

This book explores open educational resources and open education through research conducted on this topic globally. This book engages with intersections between open educational resources, social justice and equality, as well as policy in terms of open educational resources. Numerous examples of open praxis are also included, ranging from open educational resources courses to the affordances of artificial intelligence, data-driven learning, and open textbooks in this context. Furthermore, chapters range from providing a broad overview of open educational resources international and regional initiatives in Africa, to cases of work done in the United States, New Zealand, Israel, and Hong Kong. The role of Wikipedia and Wikidata is also prominent. Finally, this book includes unique contributions, focusing on open educational resources and feminist pedagogy, as well as disabled learners'motivations for participating in Massive Open Online Courses (MOOCs). Academics and researchers workingin the field of open education and higher education in general will understand the importance of this work.

This book uses real-world examples from the aquaculture industry to demonstrate how deep technology is assisting farmers and vulnerable communities. Works conducted by Poseidon-AI (a deep tech company involved in the aquaculture sector) in different countries are presented as case studies to show the positive impacts of deep tech involvement in the aquaculture sector. Primary industries, such as fisheries and aquaculture, rely heavily on labor. Furthermore, the manual practices of these farming methods increase material waste and reduce yields, resulting in higher costs and lower revenues. Poikilotherms make up the majority of aquatic animals, and environmental changes have a significant impact on them. This means that, due to climate change, farming of these animals cannot continue in the same way that it has for centuries. Artificial intelligence, machine learning, image processing, sensing, and automation are approaches that can assist these farms in dealing with rapid environmental changes while also assisting farmers in growing their businesses sustainably. This book is of interest to climate change scientists, entrepreneurs, investors, civil workers, and policymakers. Furthermore, the book is a great complimentary material for graduate students of fisheries, aquaculture, ecology, soil science, water management and environmental sciences. All national and international policymakers working in implementation of UNSDGs and sustainability, will find this book a useful read.

This book examines the effect of trade policy on language which represents an underrecognized area in the field of language policy and planning. It argues that trade policies like Japan's Economic Partnership Agreements (EPAs) have important consequences for national language (education) policies and for discourses about language and nation. Since 2008, Japan has signed the EPAs with Indonesia, the Philippines and Vietnam to recruit migrant nurses and eldercare workers and manage their mobility by means of pre-employment language training and the Japanese-medium licensure examinations. Through the analysis of these language management devices, this book demonstrates that the EPAs are a manifestation and representation of contemporary language issues intertwined particularly with pressing issues of Japan's social aging and demographic change. As the EPAs are intertwined with welfare, economy, social cohesion, and international political and economic relations and competitiveness, the book presents a far more complex picture of and a richer potential of language policy.

This book delves into the realm of effective language education programs, examining them from both macro and micro-policy-making perspectives. It unravels the distinguishing features of exemplary language programs and explores how these programs are implemented in diverse international contexts. The book comprehensively explores various facets of language education programs, encompassing well-crafted language education policies, robust curriculum and syllabus design, impactful teaching materials, effective approaches to English for specific purposes (ESP), English as a medium of instruction (EMI), content and language integrated learning (CLIL), and English as a Lingua Franca (ELF)-informed instruction. The book also delves into fruitful school/institute-university partnerships, the judicious use of technology, strategies for teacher recruitment and professional development, as well as efficient policies for learner assessment, among other topics of significance. The contributions within this book are firmly grounded in data, incorporating findings from empirical studies. The insights provided draw upon valuable data obtained from a range of diverse contexts in which effective language education programs have been implemented.

This is the third, completely updated edition of a comprehensive book in which many of the world's leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists.

This book offers an international account of the use of linguistic landscapes to promote multilingual education, from primary school to the university, and in teacher education programs. It brings linguistic landscapes to the forefront of multilingual education in school settings and teacher education, expanding the disciplinary domains through which they have been studied. Drawing on multidisciplinarity and placing linguistic landscapes in the field of language (teacher) education, this book presents empirical studies developed in eleven countries: Australia, France, Germany, Israel, Japan, Mozambique, The Netherlands, Portugal, Russia, Spain, and The United States. The chapters illustrate how multilingual pedagogies can be enhanced using linguistic landscapes in mainstream education and are written by partners of the Erasmus Plus project LoCALL “LOcal Linguistic Landscapes for global language education in the school context”.

This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.

The book is an excellent reference collection of the research conducted by different workers on induced mutagenesis, worldwide, for more than 80 years. One can get almost all mutation breeding references at one place. The book gives a coherent and concise account of all the important and relevant aspects related to induced mutagenesis with an emphasis on recent developments in the field of crop improvement. The references have been arranged crop wise and important topic wise which deal with not only classical mutation breeding but also spontaneous mutations, somaclonal variations, nanoparticles, and relevant modern aspects. The book highlights 22 chapters covering holistic information on almost all important components such as radiosensitivity, chromosomal and morphological abnormalities, detection of mutation, management of chimera, present status of mutation etc.) of Mutation Breeding. Chapters are very informative, and one can follow the references on crop and aspect basis sincethe start of mutation breeding work. This book is an excellent resource for researchers and students for understanding proper applications of induced mutations in crop improvement and biological research. It is of interest and useful to graduate and postgraduate students, horticulturists, floriculturists, agricultural scientists, and breeders related to crop improvement program.

This book heightens readers'awareness of the importance of emotional intelligence and how it impacts our lives. It inspires parents, teachers and school leaders to learn more about emotional intelligence as a process of self-improvement, relational skills, and to help our students to develop emotional intelligence from an early stage of their lives. There are four parts in the book. Part 1 explains the importance of emotional intelligence in every aspect of our lives. It presents models and theories of emotional intelligence and explains how our emotions control our mind, body and spirit. Part 2 gives insights into how emotions play a significant role in our relationships with others. Part 3 takes the reader from family to the workplace and highlights the importance of becoming more aware of our emotions at work and how we relate to others. Part 4 emphasises the importance of helping our students to develop essential emotional intelligence to face this increasingly complex and challenging world.

The second edition of the handbook reflects the expanding growth and sophistication in research on student engagement. Editorial scope and coverage are significantly expanded in the new edition, including numerous new chapters that address such topics as child and adolescent well-being, resilience, and social-emotional learning as well as extending student engagement into the realm of college attendance and persistence. In addition to its enhanced focus on student engagement as a means for promoting positive youth development, all original chapters have been extensively revised and updated, including those focusing on such foundational topics related to student engagement as motivation, measurement, high school dropout, school reform, and families. Key areas of coverage include:Demography and structural barriers to student engagement.Developmental and social contexts of student engagement.Student engagement and resilience.Engaging students through effective academic instruction and classroom management.Social-emotional learning and student mental health and physical well-being.Student engagement across the globe, languages, and cultures. The second edition of the Handbook of Research on Student Engagement is the definitive resource for researchers, scientist-practitioners and clinicians as well as graduate students in such varied fields as clinical child and school psychology, social work, public health, educational psychology, teaching and teacher education, educational policy, and all interrelated disciplines.

This proceedings volume results from the NATO Advanced Research Workshop on'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)'. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation.The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop:· Techniques for biomarker development· Low-dose effect mechanisms· Biomarkers for risk evaluation· Biomarkers in wildlife· Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.

This two-volume textbook provides a comprehensive review of both adult and pediatric gastrointestinal, hepatobiliary and pancreatic pathology. The 1st volume is dedicated to gastrointestinal tract pathology. The second volume of this book covers liver, biliary system, and pancreatic pathology. This book covers each aspect of gastrointestinal tract pathology in detail, including clinical presentation, endoscopic appearance, disease pathogenesis, gross and microscopic details of each lesion. Ancillary diagnostic methods, molecular subtypes, and prognostic workup have been detailed adequately. The book also covers diseases relevant to South-East Asia, in addition to diseases prevalent worldwide. It contains 24 chapters, categorized into four sections. Section I covers the general aspects of gastrointestinal pathology including normal anatomy of the gastrointestinal tract, endoscopic details relevant for gastrointestinal pathologists and histopathologists, grossing techniques, utility of and details of ancillary tests needed; section II covers all benign diseases in different anatomical parts of the gastrointestinal tract; section III covers preneoplastic lesions and malignancies of the gastrointestinal tract, including a separate chapter on updated molecular classifications of gastrointestinal tract tumors arising from different segments; section IV includes a unique chapter on setting up a gastrointestinal pathology laboratory. This textbook has been written and edited by experts in the field with proven academic and research excellence and include curated contents to provide lucid and updated information to the readers. The book features more than 800 photographs, line diagrams, endoscopic and radiology pictures, gross and microscopic images. It includes'Chapter Summary'at the end of each chapter and ‘Learning Tips'summarized after each major segment that helps the readers to reinforce the knowledge gained fromeach chapter. Chapters also contain case studies and/ or multiple-choice questions to enable readers to self-assess and learn from the explanations added. The textbook includes many unique chapters. It also covers cytological details and techniques relevant to gastrointestinal pathology. This comprehensive review of gastrointestinal pathology is a valuable resource for the faculties, gastrointestinal pathologists, cytologists, histopathologists, practicing pathologists, gastroenterologists, gastrointestinal surgeons, pathology fellows, postgraduates, clinical gastrointestinal fellows, and researchers in related fields.

The book brings together into a single text the interrelated but different research efforts to translate the current evidence on risk and outcome of severe mental disorders into a preventive perspective. The book also introduces a holistic approach to prevention in mental health, by combining biological, psychological and environmental evidence that attempts to blunt the risk and reduce the number of individuals with mental health vulnerabilities who eventually progress to the manifestation of a severe mental disorder. Finally, the book wants also to highlight the possibility to overcome the single disorder-oriented preventive approach in an attempt to intercept a wider at-risk youth population and explore clinical research areas underperformed where future efforts will have to concentrate. Mental health problems have their peak of incidence during the transition from childhood to young adulthood, interesting up to 20% adolescents. Half of those eventually developing such difficulties experience clinically relevant mental distress by the age of 14. Even more importantly, the symptomatic onset is generally anticipated by non-specific warning signs of psychosocial impairment potentially evolving in any severe mental disorder. This is of crucial importance, as almost one in two health problems contributing to the global disease burden across the 0-25 age span is a mental disorder. The search for preventive strategies among youth has developed over the past 2-3 decades, invigorated by a rethinking of mental disorders'ineluctable prodromal phase into a period where the trajectory of illness can be slowed down, blunted, or even halted. The paradigms for implementing preventing approaches in mental health have often developed independent of each other. This book aims at summarizing the available evidence and make a step towards a more mature vision of the potentialities of promotion and prevention in mental health.

This reference work presents an authoritative review of microplastics as vectors of environmental contaminants and provides a comprehensive coverage of their ecotoxicological and toxicological effects. Divided into four sections, this book outlines the current analytical techniques and applications for sampling, processing analysis, and data reporting of microplastics pollution in the environment, explores microplastics degradation and interaction with chemical pollutants, discusses the fate and behaviour of microplastics in the environment, and provides valuable insights about prevention, regulation and remediation of microplastics pollution. Written by interdisciplinary expert academics and practitioners, this reference work will appeal to a wide readership of students, researchers and professionals interested in this field, including marine scientists, environmental scientists, analytical chemists, organic chemists, biochemists, biologists, polymer scientists, and toxicologists.

This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives2) Regulation and Oversight3) Basic Trial Designs4) Advanced Trial Designs5) Analysis6) Trial Publication7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.

This is the first international and interdisciplinary handbook to offer a comprehensive and an in-depth overview of findings from contemporary research, theory, and practice in early childhood language education in various parts of the world and with different populations. The contributions by leading scholars and practitioners are structured to give a survey of the topic, highlight its importance, and provide a critical stance. The book covers preschool ages, and looks at children belonging to diverse ethno-linguistic groups and experiencing different histories and pathways of their socio-linguistic and socio-cultural development and early education. The languages under the scope of this handbook are identified by the contributors as immigrant languages, indigenous, endangered, heritage, regional, minority, majority, and marginalized, as well as foreign and second languages, all of which are discussed in relation to early language education as the key concept of the handbook. In thisvolume, “early language education” will refer to any kind of setting, both formal and informal (e.g. nursery, kindergarten, early childhood education centers, complementary early schooling etc.) in which language learning within a context of children's sociolinguistic diversity takes place before elementary school.

This book reports on research and developments in human-technology interaction. A special emphasis is given to human-computer interaction, and its implementation for a wide range of purposes such as healthcare, manufacturing, transportation, and education, among others. The human aspects are analyzed in detail. Innovative studies related to human-centered design, wearable technologies, augmented, virtual and mixed reality simulation, as well as developments and applications of machine learning and AI for different purposes, represent the core of the book. Emerging issues in business, security, and infrastructure are also critically examined, thus offering a timely, scientifically-grounded, but also professionally-oriented snapshot of the current state of the field. The book is based on contributions presented at the 4th International Conference on Human Interaction and Emerging Technologies: Future Applications, IHIET-AI 2021, held on April 28-30, 2021, in Strasbourg, France. Itoffers a timely survey and a practice-oriented reference guide to researchers and professionals dealing with design and/or management of the new generation of service systems.

This book addresses practical issues that reflect the current landscape of GI pathology practice and is organized in such a way that fits the fast-pacing daily life of practicing pathologists. It contains more than 540 questions that address difficult, prevailing and controversial issues in GI pathology that are frequently encountered in daily practice and consult service. For most questions, answers are straightforward with ample literature support. However, true diagnostic controversies and clinical dilemma cannot be easily resolved with current knowledge and available information. To such challenges, an expert approach regarding how to synthesize complicated topics and clearly communicate the thinking process is valuable to readers and can help guide clinicians making optimal treatment plans for their patients. The latter types of answers are highly enriched throughout the book. Distinct from other existing GI pathology textbooks, this book is primarily organized according to disease entities and pathological processes instead of specific organs and anatomic locations. Guided by chapter titles and listed questions, readers should be able to look up a disease or a pathological feature and find the most important and relevant diagnostic criteria and pertinent differential diagnoses. Written by experts in the field, Practical Gastrointestinal Pathology provides easy and quick access to concise, evidence-based and up-to-date information to aid accurate diagnosis and serves as a useful resource for practicing pathologists, pathology trainees and GI clinicians as well as allied health professionals who frequently deal with GI pathology.

This is the first ever handbook on giftedness and talent development for the Asia-Pacific region. It discusses important issues for an important group of students, addresses a gap in the current understanding of gifted students in the region, traverses substantial intellectual terrain, and draws on past and present research literature.The handbook brings together contributions from 18 countries, providing a diverse, unique and comprehensive contemporary research and practice on giftedness and talent development in the Asia-Pacific region. It highlights contemporary issues and incorporates important topics such as conceptions, identification, curriculum, and programs. Chapters in the book will include a stronger focus on pedagogy that could assist researchers, academics and educators, post-graduate students, families, advocates, teachers and practitioners, and other stakeholders to support gifted students. It also informs pre-service education programs in gifted education, in-service professional learning programs, and future research and practice in this region of the world.