13 results on '"Sendo T"'
Search Results
2. Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit
- Author
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Iida, A., Hiromichi Naito, Yorifuji, T., Zamami, Y., Yamada, A., Koga, T., Imai, T., Sendo, T., Nakao, A., and Ichiba, S.
- Subjects
Extracorporeal Membrane Oxygenation ,Midazolam ,sedatives ,pharmacodynamics ,Humans ,Hypnotics and Sedatives ,polyvinyl chloride ,ECMO ,pharmacokinetics - Abstract
Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
- Published
- 2019
3. Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice.
- Author
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Wada Y, Ushio S, Kitamura Y, Zamami Y, and Sendo T
- Subjects
- Animals, Mice, Male, Hippocampus drug effects, Hippocampus metabolism, K Cl- Cotransporters, Hypnotics and Sedatives pharmacology, Inflammation chemically induced, Frontal Lobe drug effects, Frontal Lobe metabolism, Zolpidem pharmacology, Lipopolysaccharides, Pyridines pharmacology, Receptors, GABA-A metabolism, Receptors, GABA-A drug effects, Symporters genetics, Symporters metabolism, Reflex, Righting drug effects
- Abstract
Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl- cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl- cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2024
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4. Factors Associated with Work Efficiency in Home Health Care by Pharmacists.
- Author
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Sugiura S, Kitamura Y, Izushi Y, Ushio S, and Sendo T
- Subjects
- House Calls, Humans, Pharmacists, Retrospective Studies, Community Pharmacy Services, Home Care Services
- Abstract
In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2022
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5. Retrospective Cohort Study of Clinical Efficacy and Safety of Cefozopran for Treating Febrile Neutropenia during Chemotherapy in Patients with Lung Cancer.
- Author
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Higashionna T, Ushio S, Esumi S, Murakawa K, Kitamura Y, and Sendo T
- Subjects
- Anti-Bacterial Agents adverse effects, Cefepime adverse effects, Cephalosporins adverse effects, Humans, Retrospective Studies, Treatment Outcome, Cefozopran, Febrile Neutropenia chemically induced, Febrile Neutropenia drug therapy, Lung Neoplasms drug therapy
- Abstract
Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2022
- Full Text
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6. Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance.
- Author
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Tatebe Y, Kanamitsu K, Kanzaki H, Ishida H, Fujiwara K, Washio K, Kitamura Y, Sendo T, Shimada A, and Tsukahara H
- Subjects
- Antimetabolites, Antineoplastic administration & dosage, Antimetabolites, Antineoplastic blood, Child, Humans, Liver-Specific Organic Anion Transporter 1, Male, Methotrexate administration & dosage, Methotrexate blood, Methylenetetrahydrofolate Reductase (NADPH2), Polymorphism, Single Nucleotide genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Antimetabolites, Antineoplastic pharmacokinetics, Methotrexate pharmacokinetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
- Abstract
Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2020
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7. Immobility-reducing Effects of Ketamine during the Forced Swim Test on 5-HT1A Receptor Activity in the Medial Prefrontal Cortex in an Intractable Depression Model.
- Author
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Takahashi K, Kitamura Y, Ushio S, and Sendo T
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- Animals, Depression drug therapy, Disease Models, Animal, Humans, Ketamine administration & dosage, Rats, Rats, Wistar, Swimming, Behavior, Animal drug effects, Ketamine pharmacology, Prefrontal Cortex drug effects, Receptors, Serotonin drug effects
- Abstract
Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats' immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2020
- Full Text
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8. A Multidisciplinary Approach to the Management of Chronic Pain through a Self-managed Behavioral Exercise Program : A Pilot Study in Japan.
- Author
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Nishie H, Tetsunaga T, Kanzaki H, Oda K, Inoue S, Ryuo Y, Ota H, Miyawaki T, Arakawa K, Tetsunaga T, Kitamura Y, Sendo T, Morimatsu H, Ozaki T, and Nishida K
- Subjects
- Chronic Pain psychology, Humans, Pain Measurement, Pilot Projects, Quality of Life, Chronic Pain therapy, Exercise Therapy, Pain Management methods, Patient Care Team, Self-Management
- Abstract
We conducted this study to determine the short-term treatment outcomes of multidisciplinary approaches to chronic pain management for outpatients in Japan. We evaluated pain reduction and improvement in quality of life (QOL) after treatment. We analyzed 32 patients who had experienced intractable chronic pain for > 3 months. The patients received multidisciplinary therapeutic self-managed exercise instructions and then underwent evaluations 1 and 3 months after the treatment. We used the Pain Disability Short Form-36 (SF-36), Pain Catastrophizing Scale (PCS), and Pain Disability Assessment Scale (PDAS) to evaluate QOL. Although the pain levels were the same before and after the physical exercise program, the patients showed significant improvements in physical function on the SF-36 (48.5 vs. 54.5, 3 months vs. 1 month; p=0.0124), the magnification subscale on the PCS (6.8 vs. 5.9, 1 month vs. before; p=0.0164) and the PDAS (29.2 vs. 23.4, 3 months vs. before; p=0.0055). Chronic pain should be treated with a biopsychosocial approach, but time constraints and costs have limited the implementation of multidisciplinary and behavioral approaches to chronic pain management. Our findings demonstrate that clinical improvements are possible for patients with chronic pain, using multidisciplinary team resources widely available in Japanese clinical practice., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2018
- Full Text
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9. Characteristics of the runway model of intracranial self-stimulation behavior and comparison with other motivated behaviors.
- Author
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Esumi S, Kawasaki Y, Gomita Y, Kitamura Y, and Sendo T
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- Animals, Brain physiology, Causality, Dopamine physiology, Dopaminergic Neurons physiology, Models, Animal, Rats, Reward, Running psychology, Behavior, Animal physiology, Learning physiology, Models, Biological, Motivation physiology, Running physiology, Self Stimulation physiology
- Abstract
Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors.
- Published
- 2014
- Full Text
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10. Preparation of enteric-coated capsules of beclomethasone dipropionate for patients with intestinal graft-versus-host disease and a case study.
- Author
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Murakawa K, Sato T, Maeda Y, Kitamura Y, Tanimoto M, and Sendo T
- Subjects
- Aged, Beclomethasone chemistry, Capsules chemistry, Glucocorticoids chemistry, Graft vs Host Disease etiology, Humans, Intestinal Diseases etiology, Male, Transplantation, Homologous, Beclomethasone administration & dosage, Glucocorticoids administration & dosage, Graft vs Host Disease drug therapy, Hematopoietic Stem Cell Transplantation adverse effects, Intestinal Diseases drug therapy, Leukemia-Lymphoma, Adult T-Cell therapy, Tablets, Enteric-Coated
- Abstract
Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
- Published
- 2013
- Full Text
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11. Evaluation of motivational effects induced by intracranial self-stimulation behavior.
- Author
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Sagara H, Sendo T, and Gomita Y
- Subjects
- Animals, Electric Stimulation, Methamphetamine pharmacology, Models, Animal, Motivation drug effects, Nicotine pharmacology, Rats, Behavior, Animal physiology, Brain physiology, Motivation physiology, Self Stimulation physiology
- Abstract
In the runway model of intracranial self-stimulation (ICSS) experimentation, the experimental animal is timed in running a fixed distance to depress a lever that releases electrical stimulation to an electrode implanted along its medial forebrain bundle. This ICSS has both a reward and a motivational component. Using the runway method and priming stimulation, we designed an experimental method for directly measuring motivation. An assessment of pharmacological agents that are known to influence motivational states was also undertaken. Using the experimental methods that we created, we observed prominent changes in running speed when animals were exposed to methamphetamine and nicotine. According to these data, the runway method employing intracranial self-stimulation behavior may be useful for the evaluation of substances that act on motivation. We review the underlying neuropharmacological and anatomical functions associated with our experimental methods. We hope that this technique will be used to scientifically evaluate the impact of drugs and/or therapeutic interventions on human motivation.
- Published
- 2010
- Full Text
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12. Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats.
- Author
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Doi M, Miyazaki I, Nagamachi T, Shinomiya K, Matsunaga H, Sendo T, Kawasaki H, Asanuma M, Gomita Y, and Kitamura Y
- Subjects
- Animals, Antidepressive Agents, Tricyclic pharmacology, Antimanic Agents pharmacology, Dentate Gyrus drug effects, Depression pathology, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Resistance, Male, Rats, Rats, Wistar, Sodium Chloride pharmacology, Adrenocorticotropic Hormone pharmacology, Cell Proliferation drug effects, Dentate Gyrus cytology, Imipramine pharmacology, Lithium pharmacology
- Abstract
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
- Published
- 2010
- Full Text
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13. Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior.
- Author
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Sagara H, Kitamura Y, Esumi S, Sendo T, Araki H, and Gomita Y
- Subjects
- Animals, Male, Medial Forebrain Bundle drug effects, Medial Forebrain Bundle physiology, Rats, Rats, Wistar, Reward, Running, Behavior, Animal drug effects, Conditioning, Operant drug effects, Motivation, Nicotine pharmacology, Nicotinic Agonists pharmacology, Self Stimulation drug effects
- Abstract
It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation(ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 microA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs.
- Published
- 2008
- Full Text
- View/download PDF
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