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Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats.
- Source :
-
Acta medica Okayama [Acta Med Okayama] 2010 Aug; Vol. 64 (4), pp. 219-23. - Publication Year :
- 2010
-
Abstract
- We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
- Subjects :
- Animals
Antidepressive Agents, Tricyclic pharmacology
Antimanic Agents pharmacology
Dentate Gyrus drug effects
Depression pathology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Resistance
Male
Rats
Rats, Wistar
Sodium Chloride pharmacology
Adrenocorticotropic Hormone pharmacology
Cell Proliferation drug effects
Dentate Gyrus cytology
Imipramine pharmacology
Lithium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0386-300X
- Volume :
- 64
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta medica Okayama
- Publication Type :
- Academic Journal
- Accession number :
- 20802538
- Full Text :
- https://doi.org/10.18926/AMO/40129