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Preparation of enteric-coated capsules of beclomethasone dipropionate for patients with intestinal graft-versus-host disease and a case study.
- Source :
-
Acta medica Okayama [Acta Med Okayama] 2013; Vol. 67 (5), pp. 319-24. - Publication Year :
- 2013
-
Abstract
- Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.
- Subjects :
- Aged
Beclomethasone chemistry
Capsules chemistry
Glucocorticoids chemistry
Graft vs Host Disease etiology
Humans
Intestinal Diseases etiology
Male
Transplantation, Homologous
Beclomethasone administration & dosage
Glucocorticoids administration & dosage
Graft vs Host Disease drug therapy
Hematopoietic Stem Cell Transplantation adverse effects
Intestinal Diseases drug therapy
Leukemia-Lymphoma, Adult T-Cell therapy
Tablets, Enteric-Coated
Subjects
Details
- Language :
- English
- ISSN :
- 0386-300X
- Volume :
- 67
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta medica Okayama
- Publication Type :
- Academic Journal
- Accession number :
- 24145732
- Full Text :
- https://doi.org/10.18926/AMO/51868