Search

The article discusses a study by Duksung Women's University that developed a novel HPLC-ESI-MS/MS method to analyze phospholipids and sphingolipids in plasma samples from colorectal cancer patients and healthy individuals. Topics discussed include the differentiation of lipid metabolite concentrations between cancer and healthy subjects, the use of statistical models like PLS-DA and random forest classification, and the potential of identified lipids as biomarkers for colorectal cancer.

A study conducted at Yazd University in Iran has developed a new method for detecting breast cancer-derived exosomes using a flexible electrochemical paper-based device. Exosomes are biomarkers that are released by tumor cells and can be found in various biological fluids. The device, called Exo-sensing paper, is a three-electrode system that utilizes a nanocomposite of nickel nanofoam, graphene oxide, and gold nanoparticles to increase antibody loading on the sensor surface. The device has a wide linear range of detection and shows potential for use as a point-of-care testing tool for minimally invasive liquid biopsy. [Extracted from the article]

Lunit, a provider of AI-powered solutions for cancer diagnostics, has achieved a significant milestone by publishing 100 peer-reviewed papers in scientific journals featuring its Lunit INSIGHT suite. These papers, which focus on lung abnormalities and breast cancer, have been published in prestigious journals such as The Lancet Digital Health, JAMA Oncology, and Radiology. The research demonstrates the safety, effectiveness, efficiency, and reliability of Lunit INSIGHT products, and highlights the potential of AI to replace traditional methods of medical image analysis. Lunit's achievement reflects its commitment to advancing AI applications in medical settings and improving patient outcomes. [Extracted from the article]

Researchers at the University of Naples Federico II in Italy have developed a paper-based electrochemical device that can detect a specific microRNA, miRNA-652, associated with triple-negative breast cancer (TNBC). TNBC is a particularly aggressive and difficult-to-diagnose form of breast cancer, and current diagnostic methods are invasive and expensive. The device, which is customizable and selective in its recognition of miRNA-652, has shown promising results in detecting the microRNA in standard solutions and human serum. This development represents a significant step towards a non-invasive and TNBC-specific diagnostic platform that could improve patient prognosis and quality of life. [Extracted from the article]

A study examining the prevalence of problematic papers in non-coding RNA (ncRNA) research found that around 1.79% of papers have been retracted and an additional 5.68% have raised concerns on PubPeer. The number of problematic papers has steadily increased, with concerning and retraction rates peaking in 2019 at nearly 10.8% and 3.7% respectively. These unreliable papers have been widely cited in academic literature, patents, clinical trials, and policy documents, posing a threat to research integrity and public health. The main issues identified include image manipulation, data falsification, fake peer reviews, and ethical lapses. The study calls for urgent scrutiny of ncRNA publications and broader reforms to address systemic problems in research. [Extracted from the article]

Researchers from Chaudhary Charan Singh University in India have developed a paper-based analytical device for the early detection of ovarian cancer. The device uses silver nanoparticles coated on paper to detect lysophosphatidic acid (LPA), a biomarker for ovarian cancer, through surface enhanced Raman spectroscopy (SERS). The study found that patients with ovarian cancer had higher levels of LPA compared to those with benign ovarian tumors or healthy individuals. The researchers believe that this point-of-care device could be a simple, effective, and cost-effective tool for early diagnosis of ovarian cancer. [Extracted from the article]

Researchers at Ajman University in the United Arab Emirates have conducted a study on enhancing the efficacy of photodynamic therapy (PDT) for breast cancer treatment. The study focuses on the use of silica nanoparticles (SiNPs) to encapsulate a photosensitizer called Temoporfin, which aims to improve its delivery and reduce toxicity. The researchers found that encapsulated Temoporfin demonstrated greater effectiveness in eliminating cancer cells compared to its naked form. This research highlights the potential of SiNPs as an efficient drug delivery system in PDT and sets the groundwork for more advanced strategies in cancer treatment. [Extracted from the article]

Researchers at Old Dominion University have developed a paper-based DNA biosensor for the rapid and selective detection of miR-21, a key biomarker overexpressed in various cancers. This innovative biosensor leverages gold inkjet printing to immobilize single-stranded DNA-21 on electrodeposited gold nanoparticles, allowing for specific miR-21 capture. The biosensor exhibited a linear detection range from 1 fM to 1 nM miR-21 with a sensitivity of 7.69 fM A-1 cm2 and a rapid response time of 15 minutes, making it a promising tool for cost-effective cancer diagnostics in underserved areas. [Extracted from the article]

A recent research study conducted at the University of Rochester in New York has focused on the importance of geriatric assessment and management (GAM) in older adults with cancer. As the aging population continues to grow, understanding the diverse health status and vulnerabilities of older adults becomes crucial for guiding treatment decisions and supportive care interventions. The study, supported by the European Society for Medical Oncology, provides recommendations and future directions based on existing evidence and key trials. This research paper offers valuable insights into the role of geriatric assessment and management in improving care for older adults with cancer. [Extracted from the article]

Researchers from China Pharmaceutical University have developed a new sensor array for the quantification and identification of biothiols and cancer cells. The sensor array utilizes three different Ag-based nanomaterials loaded onto filter paper to create three sensing channels. These channels generate specific fingerprint patterns for each biothiol, allowing for precise identification and quantification. The sensor array has potential applications in disease diagnosis, including the differentiation of normal and cancer cells and the identification of different types of tumor cells. [Extracted from the article]

A consensus paper by the Italian Sarcoma Group provides clinical recommendations for the treatment of localized angiosarcoma, a rare and aggressive vascular sarcoma. The paper highlights the unique challenges in managing angiosarcoma compared to other sarcomas and emphasizes the need for dedicated clinical recommendations. The Italian Sarcoma Group organized a consensus meeting to develop these recommendations, aiming to standardize and harmonize clinical practices for the optimal approach to localized angiosarcoma. The research concludes that further investigation through clinical trials is necessary to address uncertainties in the management of the disease. [Extracted from the article]

Researchers from Third Military Medical University - Army Medical University have developed a novel biosensor for the detection of small extracellular vesicle-derived microRNAs (sEV-miRNAs), which are promising biomarkers for early cancer diagnosis. The biosensor utilizes a molecular probe based on multiarmed DNA tetrahedral jumpers (mDNA-Js) and a disposable paper-based electrode modified with a Zr-MOF-rGO-Au NP nanocomplex. The bioplatform achieved sensitive detection of sEV-miR-21 with a detection limit of 34.6 aM and a dynamic range from 100 aM to 0.2 M. The biosensor shows potential for fast, easy, low-cost, and highly sensitive detection of various nucleic acids, making it suitable for point-of-care biosensing. [Extracted from the article]

Keywords: Paris; France; Europe; Antibodies; Blood Proteins; Breast Cancer; Cancer; Diagnostics and Screening; Drug Conjugates; Drug Development; Drugs and Therapies; Health and Medicine; Immunoglobulins; Immunology; Interstitial Lung Disease; Lung Diseases and Conditions; Oncology; Proteins; Respiratory Tract Diseases and Conditions; Risk and Prevention; Women's Health EN Paris France Europe Antibodies Blood Proteins Breast Cancer Cancer Diagnostics and Screening Drug Conjugates Drug Development Drugs and Therapies Health and Medicine Immunoglobulins Immunology Interstitial Lung Disease Lung Diseases and Conditions Oncology Proteins Respiratory Tract Diseases and Conditions Risk and Prevention Women's Health 434 434 1 09/25/23 20230926 NES 230926 2023 SEP 26 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Respiratory Tract Diseases and Conditions - Lung Diseases and Conditions are presented in a new report. The mechanisms of ILD induced by many chemotherapy drugs, other drug classes and ADCs used in cancer, including breast cancer, are not clearly elucidated.". [Extracted from the article]

New Delhi, India, Asia, Biomarkers, Cancer, Cancer Biomarkers, Carcinoma Biomarkers, Chemicals, Diagnostics and Screening, Electrochemicals, Emerging Technologies, Gynecology, Health and Medicine, Nanoparticles, Nanotechnology, Oncology, Ovarian Cancer, Women's Health Keywords: New Delhi; India; Asia; Biomarkers; Cancer; Cancer Biomarkers; Carcinoma Biomarkers; Chemicals; Diagnostics and Screening; Electrochemicals; Emerging Technologies; Gynecology; Health and Medicine; Nanoparticles; Nanotechnology; Oncology; Ovarian Cancer; Women's Health EN New Delhi India Asia Biomarkers Cancer Cancer Biomarkers Carcinoma Biomarkers Chemicals Diagnostics and Screening Electrochemicals Emerging Technologies Gynecology Health and Medicine Nanoparticles Nanotechnology Oncology Ovarian Cancer Women's Health 1007 1007 1 09/19/23 20230922 NES 230922 2023 SEP 19 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Data detailed on Diagnostics and Screening - Cancer Biomarkers have been presented. [Extracted from the article]

A clinical trial, NCT06474611, has been launched to evaluate the impact of sending electronic reminder messages to patients who qualify for lung cancer screening. The trial aims to determine if these reminders increase engagement in screening among eligible patients who have not previously been screened and have an upcoming appointment with their doctor. The trial is being conducted by Kaiser Permanente and is part of their efforts to expand lung cancer screening participation. The primary objective of the trial is to evaluate the effectiveness of a 2-arm electronic message outreach intervention. [Extracted from the article]

Researchers at the University of Napoli have developed a paper-based electrochemical device for the early detection of integrin avb6 expressing tumors. Current technologies for tumor detection have limitations such as invasiveness, toxicity, inaccuracy, lengthy testing duration, and high cost. The biosensor developed in this study was able to recognize avb6-containing Small Extracellular Vesicles (S-EVs) derived from cancer cell lines, with a limit of detection of 0.7103 S-EVs/mL and a linear range up to 105 S-EVs/mL. This innovative diagnostic technique may provide a novel opportunity for the detection of avb6 expressing cancers. [Extracted from the article]

Padua, Italy, Europe, Breast Cancer, Cancer, Diagnostics and Screening, Drugs and Therapies, Health and Medicine, Oncology, Women's Health Keywords: Padua; Italy; Europe; Breast Cancer; Cancer; Diagnostics and Screening; Drugs and Therapies; Health and Medicine; Oncology; Women's Health EN Padua Italy Europe Breast Cancer Cancer Diagnostics and Screening Drugs and Therapies Health and Medicine Oncology Women's Health 877 877 1 06/19/23 20230620 NES 230620 2023 JUN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on Oncology - Breast Cancer. [Extracted from the article]

Keywords: Breast Cancer; Cancer; Circadian Rhythms; Drugs and Therapies; Health and Medicine; Oncology; Women's Health EN Breast Cancer Cancer Circadian Rhythms Drugs and Therapies Health and Medicine Oncology Women's Health 539 539 1 06/12/23 20230616 NES 230616 2023 JUN 13 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on breast cancer is the subject of a new report. Breast Cancer, Cancer, Circadian Rhythms, Drugs and Therapies, Health and Medicine, Oncology, Women's Health. [Extracted from the article]

Keywords: Houston; State:Texas; United States; North and Central America; Cancer; Cervical Cancer; Health and Medicine; Oncology; Women's Health EN Houston State:Texas United States North and Central America Cancer Cervical Cancer Health and Medicine Oncology Women's Health 2023 FEB 7 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on Oncology - Cervical Cancer are discussed in a new report. The paper HPV DNA test correctly identified eight of eight HPV-negative clinical samples and seven of eight HPV-positive clinical samples. [Extracted from the article]

HanxBio has published a research paper titled "Narazaciclib, a novel multikinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models" in the journal Scientific Reports. The paper describes the preclinical evaluation of Narazaciclib (HX301) for the treatment of acute myeloid leukemia (AML). The researchers conducted comprehensive pharmacology characterization of HX301 using various preclinical experimental AML models, demonstrating its strong anti-leukemia activity and potential mechanisms of action. The study also investigated the pharmacodynamics and pharmacokinetics of HX301, providing valuable information for clinical dosage selection. The results of this study will guide the clinical development strategies for HX301 in the treatment of AML. [Extracted from the article]

Biosensors, Biotechnology, Cancer, Health and Medicine, Nanotechnology, Oncology For more information on this research see: Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications. Keywords: Biosensors; Biotechnology; Cancer; Health and Medicine; Nanotechnology; Oncology EN Biosensors Biotechnology Cancer Health and Medicine Nanotechnology Oncology 1039 1039 1 07/17/23 20230717 NES 230717 2023 JUL 18 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- A new study on biosensors is now available. [Extracted from the article]

A study conducted by researchers at NOVA Southeastern University explores the stigma surrounding cervical cancer in the Caribbean. The study aimed to describe the cervical cancer stigma and evaluate the influence of prevention practices among the non-patient population in Jamaica, Grenada, and Trinidad and Tobago. The research found that cultural background and social norms are closely linked to the stigma of cervical cancer in these countries. The study highlights the need for increased cervical cancer prevention practices in the Caribbean. [Extracted from the article]

In particular, the tumor cells may be selected from a group consisting of human cervical cancer cells, human breast cancer cells, human prostate cancer cells, and human seminoma cells. The method of claim 1, further comprising: obtaining a suspension of isolated tumor cells in a cell culture medium comprising a cryoprotectant, wherein the cell culture medium is free of a hydrogel. The method of claim 10, wherein the tumor cells may be selected from a group consisting of human cervical cancer cells, human breast cancer cells, human prostate cancer cells, and human seminoma cells. [Extracted from the article]

Keywords: Zhejiang; People's Republic of China; Asia; Cancer; Carcinomas; Enzymes and Coenzymes; Health and Medicine; Oncology; Oral Squamous Cell Carcinoma; Oxidase; Squamous Cell Carcinoma EN Zhejiang People's Republic of China Asia Cancer Carcinomas Enzymes and Coenzymes Health and Medicine Oncology Oral Squamous Cell Carcinoma Oxidase Squamous Cell Carcinoma 312 312 1 06/26/23 20230627 NES 230627 2023 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Fresh data on Oncology - Oral Squamous Cell Carcinoma are presented in a new report. Zhejiang, People's Republic of China, Asia, Cancer, Carcinomas, Enzymes and Coenzymes, Health and Medicine, Oncology, Oral Squamous Cell Carcinoma, Oxidase, Squamous Cell Carcinoma. [Extracted from the article]

Keywords: Tokyo; Japan; Asia; Cancer; Drugs and Therapies; Genetics; Health and Medicine; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Oncology EN Tokyo Japan Asia Cancer Drugs and Therapies Genetics Health and Medicine Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Oncology 960 960 1 06/19/23 20230620 NES 230620 2023 JUN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Data detailed on Oncology - Non-Small Cell Lung Cancer have been presented. For more information on this research see: Paper Serum-derived Exosomal Mir-125a-3p Predicts the Response To Anti-programmed Cell Death-1/programmed Cell Death-ligand 1 Monotherapy In Patients With Non-small Cell Lung Cancer. [Extracted from the article]

For more information on this research see: Imaging of Pediatric Brain Tumors: a Cog Diagnostic Imaging Committee/spr Oncology Committee/aspnr White Paper. Keywords: Philadelphia; State:Pennsylvania; United States; North and Central America; Brain Cancer; Cancer; Diagnostic Imaging; Diagnostics and Screening; Health and Medicine; Oncology; Pediatrics EN Philadelphia State:Pennsylvania United States North and Central America Brain Cancer Cancer Diagnostic Imaging Diagnostics and Screening Health and Medicine Oncology Pediatrics 2023 JAN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Oncology - Brain Cancer. [Extracted from the article]

This work builds on the concept of detecting cancer biomarkers, such as proteins or circulating tumor cells, in a patient's blood sample. Keywords: Biomarkers; Cancer; Diagnostics and Screening; Emerging Technologies; Engineering; Enzymes and Coenzymes; Genetics; Health and Medicine; Massachusetts Institute of Technology; Nanoparticles; Nanotechnology; Oncology; Protease; Technology; Tumors EN Biomarkers Cancer Diagnostics and Screening Emerging Technologies Engineering Enzymes and Coenzymes Genetics Health and Medicine Massachusetts Institute of Technology Nanoparticles Nanotechnology Oncology Protease Technology Tumors 18 18 1 05/08/23 20230508 NES 230508 2023 MAY 8 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Vaccine Week -- CAMBRIDGE, MA - MIT engineers have designed a new nanoparticle sensor that could enable early diagnosis of cancer with a simple urine test. [Extracted from the article]

Keywords: Uttar Pradesh; India; Asia; Cancer Research; Beverage; Cancer; Chemicals; Electrochemicals; Food; Food Products; Health and Medicine; Oncology; Risk and Prevention EN Uttar Pradesh India Asia Cancer Research Beverage Cancer Chemicals Electrochemicals Food Food Products Health and Medicine Oncology Risk and Prevention 825 825 1 04/10/23 20230413 NES 230413 2023 APR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Food Weekly News -- Investigators publish new report on Cancer Research. Keywords for this news article include: Uttar Pradesh, India, Asia, Cancer Research, Beverage, Cancer, Chemicals, Electrochemicals, Food, Food Products, Health and Medicine, Oncology, Risk and Prevention, CSIR - Indian Institute of Toxicology Research. Uttar Pradesh, India, Asia, Cancer Research, Beverage, Cancer, Chemicals, Electrochemicals, Food, Food Products, Health and Medicine, Oncology, Risk and Prevention. [Extracted from the article]

Dallas, State:Texas, United States, North and Central America, Cancer, Carcinomas, Health and Medicine, Liver Cancer, Oncology, Risk and Prevention Keywords: Dallas; State:Texas; United States; North and Central America; Cancer; Carcinomas; Health and Medicine; Liver Cancer; Oncology; Risk and Prevention EN Dallas State:Texas United States North and Central America Cancer Carcinomas Health and Medicine Liver Cancer Oncology Risk and Prevention 399 399 1 08/14/23 20230814 NES 230814 2023 AUG 15 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Oncology - Liver Cancer have been published. As with other cancers, surveillance programmes aim to detect tumours at an early stage, facilitate curative-intent treatment, and reduce cancer-related mortality.". [Extracted from the article]

A recent study conducted by researchers at Qingdao University in China analyzed the global research landscape and trends of cancer stem cells (CSCs) from 1997 to 2023. The study found that CSCs, a subset of cells with self-renewal ability and tumor generating potential, play a significant role in tumorigenesis, metastasis, recurrence, and resistance to chemoradiotherapy. The research focused on the development process, research hotspots, and trends in the CSCs field. It revealed that the research focus has shifted from basic biology to clinical transformation, with emerging issues such as transcription, inhibition, and chemoresistance gaining attention. The study suggests that future research should prioritize the tumor microenvironment and chemoresistance. [Extracted from the article]

A study conducted by researchers at the University of Sydney examined the presence of wrongly identified nucleotide sequences in high-impact-factor cancer research journals. The study found that 3.8% of nucleotide sequences in Molecular Cancer papers and 4.0% in Oncogene papers were wrongly identified. These wrongly identified sequences were distributed across a significant number of papers, including those from 2020. The study highlights the risks of relying on journal impact factors or citations as indicators of research quality. [Extracted from the article]

A recent study conducted by researchers at Sharda University in Greater Noida, India, explores the use of machine learning and non-machine learning approaches in the categorization of brain tumors. The researchers compiled and reviewed 169 research papers on brain tumor detection from 2013 to 2023, evaluating the efficacy of different methodologies based on criteria such as accuracy, sensitivity, specificity, and computing efficiency. The study provides a comprehensive summary of the current state of brain tumor categorization and highlights the application and development of machine learning methods in this field. The research has significant implications for brain tumor classification research. [Extracted from the article]

A new editorial paper titled "The double-edge sword of CRISPR application for in vivo studies" discusses the challenges and potential of using CRISPR technology for in vivo cancer studies. The paper highlights a previous study that demonstrated the ability to generate cancer in mice using CRISPR, but notes that few studies have utilized this method in the past decade. The imperfection of mutations introduced by CRISPR is identified as a challenge, as it can result in clone-to-clone variation and tumors with different mutation profiles. However, the paper concludes that despite these challenges, the in vivo application of CRISPR is likely to become more common in the future. [Extracted from the article]

A study conducted by researchers at the Dana-Farber Cancer Institute in Boston, Massachusetts aimed to determine the best method for obtaining sensitive information from young adult cancer survivors (YACS). The study compared two methods of item administration, paper surveys and telephone automated computer-assisted structured interviews (TACASI), to assess the acceptability of asking about sensitive topics such as suicidal ideation and sexual health. The results showed that the proportion of participants reporting symptoms did not significantly vary between the two methods, and the majority of participants felt comfortable answering sensitive items regardless of the administration mode. The study suggests that screening for these sensitive topics can be integrated into clinical care for YACS using either paper or technology-assisted methods. [Extracted from the article]

A recent report from Chulalongkorn University discusses the concept of breast self-examination (BSE) as a vital screening method for early detection and diagnosis of breast cancer. The paper uses the Walker and Avant analysis method to define BSE and identify its attributes, antecedents, consequences, and empirical referents. BSE is particularly important in developing countries with limited resources, as it is a cost-effective technique for detecting abnormal cells in normal breast tissue. The report also explores factors that influence BSE, such as knowledge and perception about BSE, personal and family history of breast cancer, health literacy campaigns, education level, increasing age, obesity, and reproductive factors. The paper provides various tools for measuring and assessing BSE, including structured questionnaires, scales based on health belief models, knowledge tests, and health action process approaches. [Extracted from the article]

A new review paper published in Aging explores the concept of using senescent cell-derived vaccines as a potential immune response against cancer and aging. The paper discusses the role of tumor-associated senescent cells in cancer progression and regression and highlights the potential use of senolytics, drugs that eliminate senescent cells, in cancer treatment. The researchers also propose the idea of designing an adaptive anti-aging vaccine. The paper provides valuable insights into the current knowledge in this field. [Extracted from the article]

Mercy BioAnalytics, Inc. has published two companion papers in the Journal of Molecular Diagnostics, describing a novel technology platform and clinical verification of an ovarian cancer test. The technology platform, called the Mercy Halo, utilizes tumor-derived extracellular vesicles (EVs) as biomarkers for early-stage cancer detection. The test has shown high sensitivity and specificity in detecting high-grade serous carcinoma (HGSC), the most common and deadly subtype of ovarian cancer. These publications provide promising evidence of progress towards the development of a safe and effective ovarian cancer screening test for postmenopausal women. [Extracted from the article]

A research paper published in Oncotarget discusses the development of a nanodrug called MN-anti-miR10b, which delivers anti-miR-10b antisense oligomers to cancer cells. The paper highlights the poor prognosis for metastatic breast cancer and the role of miR-10b in driving metastasis. The researchers found that inhibiting miR-10b with MN-anti-miR10b activates developmental processes in cancer cells and decreases their stemness. In mouse models, MN-anti-miR10b was shown to prevent the onset of metastasis and eliminate existing metastases when combined with chemotherapy. The study suggests that MN-anti-miR10b could be a potential therapy for metastatic breast cancer. [Extracted from the article]

The Arthur and Elizabeth Schlesinger Library on the History of Women in America in Cambridge, Massachusetts, will receive the collection of papers and articles from Dr. Susan Love, a renowned breast cancer surgeon and researcher. Dr. Love is known for her pioneering work in breast cancer surgery and her advocacy for women's health. She also played a significant role in expanding the rights of same-sex couples as parents. The addition of Dr. Love's papers to the library's collection is seen as a highly significant contribution to the field of breast cancer research and patient advocacy. [Extracted from the article]

A systematic review conducted by researchers at the University of Leeds examined how overall survival is assessed in randomized clinical trials for cancer and whether subsequent treatment lines are considered. The review found that overall survival is a key endpoint in cancer clinical trials, but it has shifted from being a primary to a secondary endpoint over time. The review also highlighted a methodological gap in how researchers should address the effect of subsequent anti-cancer treatments received by trial participants during follow-up. Future research will aim to address this gap and gather stakeholder opinions on the matter. [Extracted from the article]

A recent report from the Second Clinical College explores the relationship between iron metabolism imbalance and esophageal cancer. The research highlights the significant correlation between iron overload and an increased risk of esophageal cancer. The paper discusses the physiological mechanisms that regulate cellular iron homeostasis and the multifaceted roles of iron in tumorigenesis, progression, and metastasis. The study also suggests that further research is needed to understand the specific role of iron metabolism in esophageal cancer pathogenesis and to develop more effective treatment strategies. [Extracted from the article]

A new report from Central South University in China presents fresh data on thyroid cancer, specifically focusing on lymph node metastasis in papillary thyroid carcinoma (PTC). The study conducted a comprehensive bibliometric analysis of approximately 3,292 publications from 2012 to 2022 to understand the research trends and impact of lymph node metastasis in PTC. The analysis revealed a pattern of growth in the number of publications per year, with China having the highest number of papers. The study concludes by outlining the current state of research on lymph node metastasis in PTC and highlighting significant contributions, trends, and future research directions. [Extracted from the article]

A new research perspective published in Oncoscience presents the rationale for adding five already approved and marketed generic drugs to the current standard chemotherapy for pancreatic ductal adenocarcinoma (PDAC). The regimen, called IPIAD, includes an angiotensin receptor blocker, an antimicrobial drug, an antifungal drug, a broad-spectrum antibiotic, and an antibiotic. The researcher suggests that this augmentation regimen may slow the growth of PDAC and provide clinical benefit. The full paper provides more detailed information on the drugs and their potential impact on PDAC. [Extracted from the article]

A research perspective published in Oncoscience discusses the use of blood-based liquid biopsies for prostate cancer management. The paper provides an overview of three types of liquid biopsies: circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor-derived exosomes. The authors highlight the advances in molecular characterization of these biopsies and their potential to predict recurrence, improve treatment responses, and evaluate prognosis in prostate cancer patients. While there is currently full clinical validation for only one CTC-based and one ctDNA-based liquid biopsy, the adoption of additional methods is expected as they undergo standardization and validation. The paper also outlines the advantages and disadvantages of different blood-based liquid biopsy approaches and suggests that the utilization of these biopsies, with the assistance of artificial intelligence, will enhance patient stratification and facilitate timely therapeutic decision-making. [Extracted from the article]

A research paper published in Aging (Albany NY) and Aging-US explores the prevalence of frailty in breast cancer and hematopoietic cell transplant survivors and its impact on physical performance and quality of life. The study, conducted by researchers from the University of Minnesota, Amgen, and Columbia University Medical Center, found a high prevalence of frailty in these survivor groups, with detrimental effects on physical functioning and overall well-being. The study also identified an association between frailty and the senescence marker p16INK4a, suggesting the need for further research on senolytic trials in cancer survivors. [Extracted from the article]

Researchers from Universiti Kebangsaan Malaysia have conducted a study on brain tumor diseases and the use of machine learning techniques for their classification. The study highlights the impact of brain tumor diseases worldwide and the need for accurate classification methods. The researchers utilized various data mining techniques, including wavelet analysis and spatial pixel modulation, as well as feature extraction and reduction techniques. The study concludes that machine learning schemes are crucial for brain tumor detection and classification, providing a comprehensive analysis of different methods. This research serves as a valuable starting point for future work in this field. [Extracted from the article]

A review of 49 previously published papers suggests that vegetarian and vegan diets are generally associated with better cardiovascular health and lower risk of cancer, cardiovascular diseases, and death. These diets have been linked to reduced risk of ischemic heart disease, gastrointestinal and prostate cancer, and death from cardiovascular disease. However, the benefits of plant-based diets for pregnant women in terms of gestational diabetes and hypertension are unclear. The researchers caution against widespread recommendation of plant-based diets due to variations in study methodologies and the potential for vitamin and mineral deficiencies. [Extracted from the article]