1. Hippocampal intracerebral evoked potentials as a marker of its functionality in drug-resistant epilepsy
- Author
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Daniela de Andrade Morange, Virginie Laguitton, Romain Carron, Daniele Schön, Christian-George Bénar, Bernard Giusiano, Fabrice Bartolomei, Agnès Trébuchon, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital Professor Edgard Santos, Hôpital de la Timone [CHU - APHM] (TIMONE), and ANR-16-CONV-0002,ILCB,ILCB: Institute of Language Communication and the Brain(2016)
- Subjects
marker ,Drug Resistant Epilepsy ,Epilepsy ,iEEG ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,[SCCO.NEUR]Cognitive science/Neuroscience ,General Medicine ,Neuropsychological Tests ,temporal lobe epilepsy ,event-related potentials ,Hippocampus ,Magnetic Resonance Imaging ,MTL-P300 ,Neurology ,Epilepsy, Temporal Lobe ,Seizures ,Physiology (medical) ,Humans ,Neurology (clinical) ,oddball ,Evoked Potentials - Abstract
International audience; Objectives: To assess hippocampal function during stereoelectroencephalography (SEEG) investigations through the study of the medial temporal lobe event-related potential (ERP) MTL-P300. Methods: We recorded the MTL-P300 during a visual oddball task, using hippocampal electrodes implanted for SEEG in 71 patients, in a preoperative epilepsy investigation. The presence of an MTL-P300 and its amplitude were correlated with hippocampal involvement during seizures and memory function. Results: Analysis using ROC curves revealed that an MTL-P300 amplitude below-46 µV, has a specificity of 93.3% in detecting the epileptogenic zone, and absence of the MTL-P300 in the left hippocampus of patients with typical language organization was associated with marked alteration of verbal memory scores. There was a significant correlation between performance in non-verbal memory tests and the amplitude of the MTL-P300 in the right hippocampus of patients with left hemispheric seizures (immediate visual recall: r=0.67, p=0.005; delayed visual recall: r=0.56, p=0.025). Using a linear regression, we confirmed that the absence of the MTL-P300 in the left hippocampus, the involvement of the left hippocampus during seizures, and the duration of epilepsy were predictors of verbal memory deficits. Conclusion: Analysis of the MTL-P300 during SEEG recording provides relevant information for the analysis of hippocampal functionality and can help to localize the epileptogenic zone.
- Published
- 2022