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Hippocampal intracerebral evoked potentials as a marker of its functionality in drug-resistant epilepsy
- Source :
- Neurophysiologie Clinique = Clinical Neurophysiology, Neurophysiologie Clinique = Clinical Neurophysiology, Elsevier Masson, 2022, 52 (4), pp.323-332. ⟨10.1016/j.neucli.2022.07.001⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- International audience; Objectives: To assess hippocampal function during stereoelectroencephalography (SEEG) investigations through the study of the medial temporal lobe event-related potential (ERP) MTL-P300. Methods: We recorded the MTL-P300 during a visual oddball task, using hippocampal electrodes implanted for SEEG in 71 patients, in a preoperative epilepsy investigation. The presence of an MTL-P300 and its amplitude were correlated with hippocampal involvement during seizures and memory function. Results: Analysis using ROC curves revealed that an MTL-P300 amplitude below-46 µV, has a specificity of 93.3% in detecting the epileptogenic zone, and absence of the MTL-P300 in the left hippocampus of patients with typical language organization was associated with marked alteration of verbal memory scores. There was a significant correlation between performance in non-verbal memory tests and the amplitude of the MTL-P300 in the right hippocampus of patients with left hemispheric seizures (immediate visual recall: r=0.67, p=0.005; delayed visual recall: r=0.56, p=0.025). Using a linear regression, we confirmed that the absence of the MTL-P300 in the left hippocampus, the involvement of the left hippocampus during seizures, and the duration of epilepsy were predictors of verbal memory deficits. Conclusion: Analysis of the MTL-P300 during SEEG recording provides relevant information for the analysis of hippocampal functionality and can help to localize the epileptogenic zone.
- Subjects :
- marker
Drug Resistant Epilepsy
Epilepsy
iEEG
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[SCCO.NEUR]Cognitive science/Neuroscience
General Medicine
Neuropsychological Tests
temporal lobe epilepsy
event-related potentials
Hippocampus
Magnetic Resonance Imaging
MTL-P300
Neurology
Epilepsy, Temporal Lobe
Seizures
Physiology (medical)
Humans
Neurology (clinical)
oddball
Evoked Potentials
Subjects
Details
- Language :
- English
- ISSN :
- 09877053
- Database :
- OpenAIRE
- Journal :
- Neurophysiologie Clinique = Clinical Neurophysiology, Neurophysiologie Clinique = Clinical Neurophysiology, Elsevier Masson, 2022, 52 (4), pp.323-332. ⟨10.1016/j.neucli.2022.07.001⟩
- Accession number :
- edsair.doi.dedup.....cf88612d56ea7c3dba140b48eff3fc9f