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Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges
- Source :
- Journal of Neurophysiology, Journal of Neurophysiology, American Physiological Society, 2016, 115 (3), pp.1157-1169. ⟨10.1152/jn.00994.2014⟩, Journal of Neurophysiology, 2016, 115 (3), pp.1157-1169. ⟨10.1152/jn.00994.2014⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; Interpretation of hemodynamic responses in epilepsy is hampered by an incomplete understanding of the underlying neurovascular coupling, especially the contributions of excitation and inhibition. We made simultaneous multimodal recordings of local field potentials (LFPs), firing of individual neurons, blood flow, and oxygen level in the somatosensory cortex of anesthetized rats. Epileptiform discharges induced by bicuculline injections were used to trigger large local events. LFP and blood flow were robustly coupled, as were LFP and tissue oxygen. In a parametric linear model, LFP and the baseline activities of cerebral blood flow and tissue partial oxygen tension contributed significantly to blood flow and oxygen responses. In an analysis of recordings from 402 neurons, blood flow/tissue oxygen correlated with the discharge of putative interneurons but not of principal cells. Our results show that interneuron activity is important in the vascular and metabolic responses during epileptiform discharges.
- Subjects :
- 0301 basic medicine
Male
Interneuron
genetic structures
Physiology
Hemodynamics
Local field potential
Somatosensory system
Bicuculline
03 medical and health sciences
0302 clinical medicine
Oxygen Consumption
Interneurons
Evoked Potentials, Somatosensory
medicine
Animals
Rats, Wistar
Epilepsy
Chemistry
General Neuroscience
musculoskeletal, neural, and ocular physiology
[SCCO.NEUR]Cognitive science/Neuroscience
Blood flow
Somatosensory Cortex
Rats
Electrophysiology
030104 developmental biology
medicine.anatomical_structure
Cerebral blood flow
nervous system
Cerebrovascular Circulation
Call for Papers
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00223077 and 15221598
- Database :
- OpenAIRE
- Journal :
- Journal of Neurophysiology, Journal of Neurophysiology, American Physiological Society, 2016, 115 (3), pp.1157-1169. ⟨10.1152/jn.00994.2014⟩, Journal of Neurophysiology, 2016, 115 (3), pp.1157-1169. ⟨10.1152/jn.00994.2014⟩
- Accession number :
- edsair.doi.dedup.....ed836877a1c90c6dca9a8183dbbb3ce1