1. Acute Cocoa Supplementation Increases Postprandial HDL Cholesterol and Insulin in Obese Adults with Type 2 Diabetes after Consumption of a High-Fat Breakfast
- Author
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Dongxu Fu, Nancy M. Betts, Timothy J. Lyons, Arpita Basu, Christopher E. Aston, and Misti J. Leyva
- Subjects
Male ,medicine.medical_specialty ,Nutrition and Disease ,medicine.medical_treatment ,Medicine (miscellaneous) ,Type 2 diabetes ,Diet, High-Fat ,Placebo ,Body Mass Index ,Beverages ,chemistry.chemical_compound ,Vascular Stiffness ,Insulin resistance ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Insulin ,Obesity ,Breakfast ,Flavonoids ,Cacao ,Meal ,Cross-Over Studies ,Nutrition and Dietetics ,Cholesterol ,business.industry ,Cholesterol, HDL ,food and beverages ,Middle Aged ,Postprandial Period ,medicine.disease ,Endocrinology ,Postprandial ,Diabetes Mellitus, Type 2 ,chemistry ,Female ,Sample collection ,Insulin Resistance ,business ,Diabetic Angiopathies - Abstract
Background: Dietary cocoa is an important source of flavonoids and is associated with favorable cardiovascular disease effects, such as improvements in vascular function and lipid profiles, in nondiabetic adults. Type 2 diabetes (T2D) is associated with adverse effects on postprandial serum glucose, lipids, inflammation, and vascular function. Objective: We examined the hypothesis that cocoa reduces metabolic stress in obese T2D adults after a high-fat fast-food–style meal. Methods: Adults with T2D [n = 18; age (mean ± SE): 56 ± 3 y; BMI (in kg/m2): 35.3 ± 2.0; 14 women; 4 men] were randomly assigned to receive cocoa beverage (960 mg total polyphenols; 480 mg flavanols) or flavanol-free placebo (110 mg total polyphenols
- Published
- 2015
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