45 results on '"Luca Salvatore"'
Search Results
2. Non-invasive ventilation for acute hypoxemic respiratory failure, including COVID-19
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Rosà, Tommaso, primary, Menga, Luca Salvatore, additional, Tejpal, Ambika, additional, Cesarano, Melania, additional, Michi, Teresa, additional, Sklar, Michael C., additional, and Grieco, Domenico Luca, additional
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- 2023
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3. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS
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Tommaso Mauri, Giuseppe Foti, Carla Fornari, Giacomo Grasselli, Riccardo Pinciroli, Federica Lovisari, Daniela Tubiolo, Carlo Alberto Volta, Savino Spadaro, Roberto Rona, Egle Rondelli, Paolo Navalesi, Eugenio Garofalo, Rihard Knafelj, Vojka Gorjup, Riccardo Colombo, Andrea Cortegiani, Jian-Xin Zhou, Rocco D’Andrea, Italo Calamai, Ánxela Vidal González, Oriol Roca, Domenico Luca Grieco, Tomas Jovaisa, Dimitrios Bampalis, Tobias Becher, Denise Battaglini, Huiqing Ge, Mariana Luz, Jean-Michel Constantin, Marco Ranieri, Claude Guerin, Jordi Mancebo, Paolo Pelosi, Roberto Fumagalli, Laurent Brochard, Antonio Pesenti, null Plug working group of ESICM, Alessandra Papoff, Raffaele Di Fenza, Stefano Gianni, Elena Spinelli, Alfredo Lissoni, Chiara Abbruzzese, Alfio Bronco, Silvia Villa, Vincenzo Russotto, Arianna Iachi, Lorenzo Ball, Nicolò Patroniti, Rosario Spina, Romano Giuntini, Simone Peruzzi, Luca Salvatore Menga, Tommaso Fossali, Antonio Castelli, Davide Ottolina, Marina García-de-Acilu, Manel Santafè, Dirk Schädler, Norbert Weiler, Emilia Rosas Carvajal, César Pérez Calvo, Evangelia Neou, Yu-Mei Wang, Yi-Min Zhou, Federico Longhini, Andrea Bruni, Mariacristina Leonardi, Cesare Gregoretti, Mariachiara Ippolito, Zelia Milazzo, Lorenzo Querci, Serena Ranieri, Giulia Insom, Jernej Berden, Marko Noc, Ursa Mikuz, Matteo Arzenton, Marta Lazzeri, Arianna Villa, Bruna Brandão Barreto, Marcos Nogueira Oliveira Rios, Dimitri Gusmao-Flores, Mandeep Phull, Tom Barnes, Hussain Musarat, and Sara Conti
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Pulmonary and Respiratory Medicine ,ARDS ,business.industry ,Pressure support ventilation ,Critical Care and Intensive Care Medicine ,medicine.disease ,Spontaneous breathing trial ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Randomized controlled trial ,law ,Anesthesia ,Breathing ,Medicine ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Respiratory minute volume ,Positive end-expiratory pressure ,Tidal volume - Abstract
Background Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant. Research Question Is the clinical application of sigh during pressure support ventilation (PSV) feasible? Study Design and Methods We conducted a multicenter noninferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or ARDS undergoing PSV. Patients were randomized to the no-sigh group and treated by PSV alone, or to the sigh group, treated by PSV plus sigh (increase in airway pressure to 30 cm H2O for 3 s once per minute) until day 28 or death or successful spontaneous breathing trial. The primary end point of the study was feasibility, assessed as noninferiority (5% tolerance) in the proportion of patients failing assisted ventilation. Secondary outcomes included safety, physiologic parameters in the first week from randomization, 28-day mortality, and ventilator-free days. Results Two-hundred and fifty-eight patients (31% women; median age, 65 [54-75] years) were enrolled. In the sigh group, 23% of patients failed to remain on assisted ventilation vs 30% in the no-sigh group (absolute difference, –7%; 95% CI, –18% to 4%; P = .015 for noninferiority). Adverse events occurred in 12% vs 13% in the sigh vs no-sigh group (P = .852). Oxygenation was improved whereas tidal volume, respiratory rate, and corrected minute ventilation were lower over the first 7 days from randomization in the sigh vs no-sigh group. There was no significant difference in terms of mortality (16% vs 21%; P = .337) and ventilator-free days (22 [7-26] vs 22 [3-25] days; P = .300) for the sigh vs no-sigh group. Interpretation Among hypoxemic intubated ICU patients, application of sigh was feasible and without increased risk. Trial Registry ClinicalTrials.gov ; No.: NCT03201263 ; URL: www.clinicaltrials.gov
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- 2021
4. Safety of low intensity oral anticoagulant therapy in patients with bileaflet mechanical aortic valve prosthesis: A propensity weighted study
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Marisa De Feo, Michele Torella, Alessandro Della Corte, Denise Galbiati, Ester Della Ratta, Luca Salvatore De Santo, Ciro Bancone, Antonino S. Rubino, Rubino, Antonino S., Torella, Michele, Della Ratta, Ester E., Galbiati, Denise, Corte, Alessandro Della, Bancone, Ciro, De Santo, Luca S., and De Feo, Marisa
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medicine.medical_specialty ,medicine.medical_treatment ,Population ,030204 cardiovascular system & hematology ,Prosthesis ,03 medical and health sciences ,0302 clinical medicine ,Aortic valve replacement ,Thromboembolism ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,030212 general & internal medicine ,Adverse effect ,education ,Stroke ,Heart Valve Prosthesis Implantation ,education.field_of_study ,business.industry ,Anticoagulants ,Mechanical Aortic Valve ,medicine.disease ,Regimen ,Aortic Valve ,Heart Valve Prosthesis ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Scarce data are available on the long-term outcomes of different regimens of oral anticoagulation in an all comer population of patients undergoing aortic valve replacement with a bileaflet mechanical heart valve. Methods Outcomes of 88 patients discharged with a target INR of 2.0 (LOW-INR) were compared to 147 contemporary patients who have been recommended a target INR of 2.5 (CONV). Primary outcome was the composite of any thromboembolic or haemorrhagic events. Secondary outcomes were the individual components of the primary outcome, cardiovascular mortality and stroke. To reduce selection bias, a propensity weighted analysis was performed. Results After inverse probability of treatment weighting, the primary endpoint occurred in 0.7% of patient in the LOW-INR group and in 7.0% in the CONV group (p = .0255). Linearized event rate were significantly lower in the LOW-INR group (primary endpoint: rate difference − 12.0 per 1000 patient/years, p = .0052; haemorrhage: −5.8 per 1000 patient/years, p = .0330; neurological events: −7.6 per 1000 patient/years, p = .0140). Conventional target INR was associated with an increased hazard of the composite endpoint (HR 11.193, 95% CI 1.424–88.003, p = .0217). Conclusions Lowering the intensity of oral anticoagulation resulted in a relevant clinical benefit of reduced rates of haemorrhagic and neurological adverse events in the mid-term follow-up. This report confirms the safety profile of the low INR regimen in an all comer population undergoing aortic valve replacement with an Abbott mechanical valve.
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- 2020
5. An insight on type I collagen from horse tendon for the manufacture of implantable devices
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Mohammed Hasan, Maria Lucia Natali, Lorena Campa, Marta Madaghiele, Nunzia Gallo, Loredana Capobianco, Luca Salvatore, Alessandro Sannino, Paola Lunetti, Ludovico Valli, Gabriele Giancane, Anna Napoli, Laura Blasi, Donatella Aiello, Victor V. Borovkov, Amilcare Barca, Simona Bettini, Salvatore, L., Gallo, N., Aiello, D., Lunetti, P., Barca, A., Blasi, L., Madaghiele, M., Bettini, S., Giancane, G., Hasan, M., Borovkov, V., Natali, M. L., Campa, L., Valli, L., Capobianco, L., Napoli, A., and Sannino, A.
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EQUINE COLLAGEN ,Biocompatible Materials ,02 engineering and technology ,Biochemistry ,Collagen Type I ,Tendons ,Mice ,03 medical and health sciences ,Tissue engineering ,Structural Biology ,medicine ,Animals ,Horses ,Type I collagen ,Molecular Biology ,030304 developmental biology ,0303 health sciences ,Tissue Engineering ,Tissue Scaffolds ,Equine ,Chemistry ,Horse ,Biomaterial ,General Medicine ,021001 nanoscience & nanotechnology ,Tendon ,medicine.anatomical_structure ,NIH 3T3 Cells ,Immune reaction ,0210 nano-technology ,Biomedical engineering - Abstract
Type I collagen is the most abundant protein of the human body. Due to its favourable properties, collagen extracted from animal tissues is adopted to manufacture a wide range of devices for biomedical applications. Compared to bovine and porcine collagens, which are the most largely used, equine collagen is free from the risk of zoonosis, has no reported immune reactions, and has not religious constraints. In this work, a recently available type I collagen extracted from horse tendon was evaluated and compared with a commercially available collagen isoform derived from the same species and tissue. Detailed physical, chemical and biological investigations were performed, in agreement with the requirements of the current standard for the characterization of type I collagen to be used for the manufacture of Tissue Engineering Medical Products. To the best of our knowledge, this is the first report on the complete primary structure of the investigated collagen.
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- 2020
6. A Prospective Observational Study on the Variables Affecting the Risk of Inferior Alveolar Nerve Damage During Lower Third Molar Surgery With Nerve/Root Proximity
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Pippi, Roberto, primary, De Luca, Salvatore, additional, and Pietrantoni, Alessandra, additional
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- 2022
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7. Exploring the effects of the crosslink density on the physicochemical properties of collagen-based scaffolds
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Nunzia Gallo, Alessandro Sannino, Luca Salvatore, Maria Lucia Natali, Marta Madaghiele, Valentina Bonfrate, Deborah Pedone, and Emanuela Calò
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endocrine system ,Scaffold ,Materials science ,Polymers and Plastics ,Dimethyl Suberimidate ,macromolecular substances ,02 engineering and technology ,urologic and male genital diseases ,010402 general chemistry ,01 natural sciences ,Degradation ,chemistry.chemical_compound ,Tissue engineering ,polycyclic compounds ,Thermal stability ,Polymers and polymer manufacture ,Carbodiimide ,Crosslinking ,urogenital system ,Organic Chemistry ,technology, industry, and agriculture ,021001 nanoscience & nanotechnology ,Crosslink density ,0104 chemical sciences ,TP1080-1185 ,chemistry ,Genipin ,Biophysics ,Degradation (geology) ,Collagen ,Glutaraldehyde ,0210 nano-technology ,hormones, hormone substitutes, and hormone antagonists - Abstract
The optimization of collagen-based scaffolds for tissue engineering goes through the careful selection of the crosslinking method(s), which should impart the prerequisite mechanical and degradation properties without impairing the cell/tissue response. Here, we investigated the chemically effective (ρxch) and the elastically effective (ρxel) crosslink density of collagen-based scaffolds, induced by various crosslinking methods. The aim was to get a deeper insight into the influence of intramolecular and intermolecular crosslinks on several scaffold properties. Freeze-dried collagen matrices were crosslinked via a dehydrothermal treatment (DHT), and then treated with different chemical agents, including carbodiimide (EDC), glutaraldehyde (GTA), formaldehyde (FA), genipin (GP) and dimethyl suberimidate (DMS). Quantification of primary amines and stress-relaxation compressive tests were performed to evaluate ρxch and ρxel, respectively. Scaffolds were then assessed for their water uptake, thermal stability and in vitro resistance to enzymatic degradation. Interestingly, for the various crosslinking treatments ρxch was found to increase in the order DHT
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- 2021
8. Commentary: Open surgery for descending thoracic aortic disease: 'Pride and prejudice'
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Luca Salvatore De Santo
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pride ,Aortic Aneurysm, Thoracic ,business.industry ,Open surgery ,General surgery ,media_common.quotation_subject ,Aorta, Thoracic ,Blood Vessel Prosthesis Implantation ,Humans ,Medicine ,Surgery ,Thoracic aortic disease ,Cardiology and Cardiovascular Medicine ,business ,Prejudice ,Prejudice (legal term) ,media_common - Published
- 2019
9. Effects of vildagliptin, a DPP-4 inhibitor, in elderly diabetic patients with mild cognitive impairment
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Borzì, Antonio Maria, primary, Condorelli, Giovanni, additional, Biondi, Antonio, additional, Basile, Francesco, additional, Vicari, Enzo Saretto Dante, additional, Buscemi, Carola, additional, Luca, Salvatore, additional, and Vacante, Marco, additional
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- 2019
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10. Commentary: Open surgery for descending thoracic aortic disease: “Pride and prejudice”
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De Santo, Luca Salvatore, primary
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- 2019
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11. Prosthesis-Patient Mismatch in the Elderly: Survival, Ventricular Mass Regression, and Quality of Life
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Alessandro Della Corte, Mariano Vicchio, Giuseppe Caianiello, Maurizio Cotrufo, Luca Salvatore De Santo, Marisa De Feo, Michelangelo Scardone, Vicchio, M, DELLA CORTE, Alessandro, DE SANTO, Luca Salvatore, DE FEO, Marisa, Caianiello, G, Scardone, M, and Cotrufo, M.
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Body Surface Area ,Heart Ventricles ,medicine.medical_treatment ,Population ,Kaplan-Meier Estimate ,Prosthesis Design ,Risk Assessment ,Severity of Illness Index ,Prosthesis ,Cohort Studies ,Quality of life ,Aortic valve replacement ,Reference Values ,Prosthesis Fitting ,Severity of illness ,medicine ,Humans ,education ,Geriatric Assessment ,Aged ,Probability ,Retrospective Studies ,Aged, 80 and over ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,Body surface area ,education.field_of_study ,business.industry ,Aortic Valve Stenosis ,Organ Size ,Prognosis ,medicine.disease ,Survival Analysis ,Echocardiography, Doppler ,Surgery ,Treatment Outcome ,Italy ,Case-Control Studies ,Heart Valve Prosthesis ,Quality of Life ,Population study ,Female ,Cardiology and Cardiovascular Medicine ,business ,Cohort study - Abstract
Background Evaluation of the impact of prosthesis-patient mismatch (PPM) on long-term outcome and quality of life (QOL) in elderly patients who underwent implantation of small size bileaflet prostheses for aortic stenosis. Methods Between September 1988 and September 2006, 377 patients aged greater than 70 years underwent aortic valve replacement with a small size bileaflet prosthesis (17, 19, and 21 mm) in one Institution. The study population's survivors (345 patients) were divided into three groups according to the indexed effective orifice area (EOAI): Group A included patients with EOAI less than 0.60 cm 2 /m 2 ; group B included patients with EOAI ranging between 0.61 and 0.84 cm 2 /m 2 ; and group C included patients with EOAI 0.85 cm 2 /m 2 or greater. Cumulative and comparative analyses of long-term outcomes and of left ventricular mass regression were performed. The QOL was evaluated with the 36-Item Short Form Health Survey (SF-36) questionnaire. Results Overall hospital mortality was 8.5% (32 patients). Group A included 33 patients (9.6%), group B 175 (50.7%), and group C 137 (39.7%). Actuarial survival was 88.8% ± 0.016 at 1 year, 82.1% ± 0.022 at 5 years, and 76.7% ± 0.032 at 10 years. No difference emerged among the three groups. A significant reduction in left ventricular mass was observed in all groups and in all patient subsets of prosthetic size. The scores obtained in the SF-36 test were similar in the three groups and significantly higher than those of the general population ( p Conclusions Incidence of severe PPM is low after aortic valve replacement. Presence of severe or moderate PPM, did not influence long-term outcome, left ventricular mass regression and QOL in a population of septuagenarians.
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- 2008
12. Acute hemodynamic and functional effects of surgical ventricular restoration and heart transplantation in patients with ischemic dilated cardiomyopathy
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Luca Salvatore De Santo, Marisa De Feo, Gianantonio Nappi, Gianpaolo Romano, Cristiano Amarelli, Michelangelo Scardone, Giuseppe Santarpino, Maurizio Cotrufo, Alessandro Della Corte, Cotrufo, M, DE SANTO, Luca Salvatore, DELLA CORTE, Alessandro, Romano, G, Amarelli, C, DE FEO, Marisa, Santarpino, G, Scardone, M, and Nappi, Gianantonio
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Adult ,Cardiomyopathy, Dilated ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Heart disease ,Heart Ventricles ,medicine.medical_treatment ,Myocardial Ischemia ,transplantation ,Ventricular Dysfunction, Left ,Oxygen Consumption ,Internal medicine ,Humans ,Medicine ,Prospective Studies ,Exercise ,ntilatory efficiency ,Aged ,Cardiac catheterization ,Heart transplantation ,Ejection fraction ,business.industry ,Hemodynamics ,Dilated cardiomyopathy ,Recovery of Function ,Middle Aged ,maximal VO2 ,medicine.disease ,Transplantation ,Heart failure ,Cardiology ,congestive heart failure ,Heart Transplantation ,Female ,Surgery ,business ,Cardiology and Cardiovascular Medicine ,Respiratory minute volume - Abstract
Objectives Peak oxygen uptake (Vo 2 ) and ventilatory efficiency have prognostic implications in the population with congestive heart failure. This study evaluated quality-of-life functional capacity after the 2 treatment strategies of surgical ventricular restoration and transplantation for severe left ventricular dysfunction of ischemic cause. Methods The 75-patient study population (between 2004 and 2006) with severe heart failure included 35 patients undergoing surgical ventricular restoration (mean age, 62.6 ± 8.7 years), sometimes together with coronary artery bypass grafting or mitral surgery, and 40 cardiac transplant recipients (mean age, 55.6 ± 7.7 years). Preoperative and 6-month postoperative function (peak Vo 2 , the anaerobic threshold, and the slope of minute ventilation/carbon dioxide uptake), cardiac catheterization parameters (left and right), and hospital and early outcomes were evaluated. Results The 2 groups had comparable baseline functional impairment and experienced similar hospital stay and early outcomes. They also showed similar improvements in left ventricular volume indexes and hemodynamic parameters and sustained significant improvements of median Vo 2 , anaerobic threshold, and minute ventilation/carbon dioxide uptake values. Conclusions Both surgical strategies resulted in a significant and comparable improvement of functional capacity at the 6-month evaluation. These early studies must be repeated to determine the long-term benefits of surgical ventricular restoration because maximal Vo 2 and ventilatory efficiency lose their prognostic survival role after transplantation.
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- 2008
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13. Tissue Versus Mechanical Prostheses: Quality of Life in Octogenarians
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Giuseppe Caianiello, Mariano Vicchio, Luca Salvatore De Santo, Michelangelo Scardone, Maurizio Cotrufo, Alessandro Della Corte, Marisa De Feo, Vicchio, M, DELLA CORTE, Alessandro, DE SANTO, Luca Salvatore, DE FEO, Marisa, Caianiello, G, Scardone, M, and Cotrufo, M.
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Bypass grafting ,medicine.medical_treatment ,Prosthesis Design ,Risk Assessment ,Sensitivity and Specificity ,Severity of Illness Index ,Prosthesis ,Cohort Studies ,Aortic valve replacement ,Quality of life ,medicine ,Humans ,Geriatric Assessment ,Stroke ,Probability ,Retrospective Studies ,Aged, 80 and over ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,Postoperative Care ,business.industry ,Significant difference ,Aortic Valve Stenosis ,medicine.disease ,Survival Analysis ,Echocardiography, Doppler ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Heart Valve Prosthesis ,Concomitant ,Quality of Life ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,Artery - Abstract
The aim of this study was to determine whether changes in prognosis and quality of life (QOL) after aortic valve replacement (AVR) in octogenarians differ depending on the choice of mechanical (MP) or tissue (BP) valves.Between July 1992 and September 2006, 160 consecutive octogenarians underwent AVR with (18.8%) or without concomitant coronary artery bypass grafting. At follow-up (mean 3.4 +/- 2.8 years, 552 patient-years, 98.3% complete), 121 were still alive and answered the Medical Outcomes Study Short-Form 36 Health Survey (SF-36) QOL questionnaire.Group BP had 62 patients. Group MP had 98 patients. Preoperative risk factors were comparable except group BP was older. Global hospital mortality was 8.8%. There were 21 late deaths, 61.9% of which were not valve- or anticoagulation-related. A significant difference emerged in 1-, 3-, 5- and 8-year actuarial survival rates (BP: 86.4% +/- 0.04%, 76.9% +/- 0.06%, 58.1% +/- 0.1%, 46.5% +/- 0.14%, respectively, vs MP: 91.3% +/- 0.03%, 88.6% +/- 0.03%, 81.6% +/- 0.05%, 70% +/- 0.67%; p = 0.025) but not in terms of 8-year freedom from valve-related complications (82.6% +/- 0.1% vs 87% +/- 0.053%, p = 0.55). One anticoagulant-related hemorrhage occurred in group MP; one stroke occurred in group BP. Survivors had significant improvement in New York Heart Association functional class compared with preoperatively (1.1 vs 2.8, p0.001) Mean QOL scores were satisfactory and substantially comparable between the two groups; in seven domains, scores were higher than those of the age- and sex-matched general Italian population.Long-term survival after AVR in selected octogenarians was similar to that of the general elderly population. The device type exerted no influence on QOL.
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- 2008
14. New biomaterials alternative to small intestinal submucosa (SIS) for urethral stricture repair
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F. Gervaso, Fabio Sallustio, Luca Salvatore, C. Divella, Anna Gallone, N. Gallo, C. Curci, P. Ditonno, M. Vulpi, A. Sannino, and A. Vitarelli
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medicine.medical_specialty ,Urethral stricture ,business.industry ,Urology ,medicine ,medicine.disease ,business ,Surgery ,Small intestinal submucosa - Published
- 2019
15. Acute aortic dissection: The conundrum of severity of disease, extent of surgery and end-organ function
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De Santo, Luca Salvatore, primary
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- 2018
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16. Treatment of recurrent staphylococcal mediastinitis: still a controversial issue
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Marisa De Feo, Attilio Renzulli, Maurizio Cotrufo, Luca Salvatore De Santo, Riccardo Utili, Alessandro Della Corte, Gianpaolo Romano, DE FEO, Marisa, DE SANTO, Luca Salvatore, Romano, G, Renzulli, A, DELLA CORTE, Alessandro, Utili, Riccardo, and Cotrufo, M.
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Carbohydrates ,Group A ,Surgical Flaps ,Group B ,Leukocyte Count ,Recurrence ,White blood cell ,medicine ,Humans ,Surgical Wound Infection ,Cardiac Surgical Procedures ,Aged ,Retrospective Studies ,Debridement ,business.industry ,Incidence (epidemiology) ,Perioperative ,Middle Aged ,Staphylococcal Infections ,medicine.disease ,Bandages ,Mediastinitis ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Although surgical management with early debridement and closed mediastinal irrigation has proved successful in reducing early mortality following poststernotomy deep sternal wound infection, recurrence rates are still up to 20%. This study compared the effectiveness and safety of wound dressing with granulated sugar versus early muscle flap surgery in the management of recurrent postoperative Staphylococcal mediastinitis. Methods Between January 1995 and January 2002, 25 patients with severe recurrent staphylococcal mediastinitis were treated with granulated sugar wound dressing (group A) or with wound debridement, v-shape sternectomy and associated muscle flap surgery (group B). Clinical outcomes and perioperative data were analyzed. Outcomes were compared between the groups evaluating the length of time for normalization of white blood cell (WBC) count and of body temperature and length of hospital stay. Patient characteristics determining best treatment option were identified. Survival and incidence of recurrence at follow-up were also analyzed. Results Study groups proved homogenous as to preoperative characteristics. Complete cure was achieved earlier in group A than in group B (defervescence: p = 0.0005; WBC normalization: p = 0.0001, respectively). Hospital stay was shorter in group A. A statistically significant difference was found in hospital mortality (16% overall) between the two groups with better outcomes in group A ( p = 0.039). In the patient subset with the most severe preoperative profile (hemodialysis, tracheostomy, inotropic support) surgical treatment produced worse results than the sugar dressing method ( p = 0.048). No case of recurrence was observed. Conclusions Both treatments proved effective in recurrent type IV A Staphylococcal mediastinitis. Granulated sugar proved a safer option in severely compromised patients.
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- 2003
17. Continuous Positive Airway Pressure in the Cardiac Surgery Setting: Always and Everywhere? First, Start With the Basics
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Luca Salvatore De Santo, Carlo Zebele, Antonio M. Esquinas, Esquinas, Antonio M, Zebele, Carlo, and De Santo, Luca Salvatore
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medicine.medical_specialty ,Continuous Positive Airway Pressure ,business.industry ,medicine.medical_treatment ,030208 emergency & critical care medicine ,030204 cardiovascular system & hematology ,Cardiac surgery ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,Cardiac Surgical Procedure ,Humans ,Medicine ,Non-invasive ventilation ,Continuous positive airway pressure ,Cardiac Surgical Procedures ,Cardiology and Cardiovascular Medicine ,business ,Intensive care medicine ,Human - Published
- 2017
18. Adaptive support ventilation weaning protocols in cardiac surgical patients: Complex speculations with little practical impact
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João Cravo, Antonio M. Esquinas, Luca Salvatore De Santo, Esquinas, Antonio M, Cravo, João, and De Santo, Luca Salvatore
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medicine.medical_specialty ,Minute ventilation ,Adaptive support ,Coronary artery bypass grafting ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Adaptive support ventilation ,law ,Humans ,Cardiac Surgical Procedure ,Medicine ,Weaning ,Cardiac Surgical Procedures ,Coronary Artery Bypass ,Intensive care medicine ,business.industry ,Coronary Artery Bypa ,Respiration ,030208 emergency & critical care medicine ,Postoperative ventilation ,Ventilation (architecture) ,business ,Ventilator Weaning ,Respiratory minute volume ,Human ,Surgical patients - Published
- 2017
19. Mechanical Aortic Valve Replacement in Young Women Planning on Pregnancy
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Alessandro Della Corte, Veronica D'Oria, Salvatore Giordano, Luca Salvatore De Santo, Gianpaolo Romano, Maurizio Cotrufo, Gianantonio Nappi, and Marisa De Feo
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Pregnancy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Warfarin ,Mechanical Aortic Valve ,Gestational age ,medicine.disease ,Valve replacement ,medicine ,Observational study ,Pregnancy Trimesters ,business ,Intensive care medicine ,Prospective cohort study ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
Objectives This pilot prospective observational study aimed to evaluate the maternal and fetal outcomes of pregnancies under low-dose oral anticoagulation therapy after aortic mechanical replacement. Background Need for valve replacement is still an issue for young women with native valve disease who are planning on future pregnancy. Choice of replacement device is a challenging clinical task. Methods A comprehensive pre-operative counseling protocol to guide choice of replacement device was developed. The pre-operative anticoagulation trial to determine the warfarin daily dosage needed to reach target international normalized ratio (INR) represented the main stem of such protocol. Pregnancies on low-dose anticoagulation therapy (target INR: 1.5 to 2.5) were allowed in a highly selected subset of mechanical aortic valve recipients. Results Twenty-two patients of 40 originally referred for native valve disease surgery requiring valve replacement, safely underwent the pre-operative anticoagulation challenge. No maternal or fetal complications were detected in 16 pregnancies under low oral anticoagulation. Patterns of warfarin daily dosage and induced INRs were characterized during pregnancy. Conclusions In this small sample observational study, a pre-operative anticoagulation therapy trial helped young women scheduled for valve replacement to acquire complete information as to the choice of prosthetic device. In selected third-generation mechanical aortic prosthesis recipients, low-dose anticoagulation therapy seems safe and feasible for both mother and fetus. Further studies are needed to validate this approach.
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- 2012
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20. Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves
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Luca Salvatore De Santo, Nicola Vitale, Marisa De Feo, Maurizio Cotrufo, Nicola Tedesco, Alessio Pollice, Vitale, N, DE FEO, Marisa, DE SANTO, Luca Salvatore, Pollice, A, Tedesco, N, and Cotrufo, M.
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Male ,medicine.drug_class ,Pregnancy Complications, Cardiovascular ,Pregnancy ,medicine ,Humans ,International Normalized Ratio ,cardiovascular diseases ,Fetal Death ,Full Term ,Heart Valve Prosthesis Implantation ,Dose-Response Relationship, Drug ,Cesarean Section ,business.industry ,Vaginal delivery ,Anticoagulant ,Infant, Newborn ,Warfarin ,Abnormalities, Drug-Induced ,Anticoagulants ,Thrombosis ,medicine.disease ,Prosthesis Failure ,Anesthesia ,Gestation ,Female ,Caesarian section ,Cardiology and Cardiovascular Medicine ,business ,Complication ,medicine.drug - Abstract
OBJECTIVESThe purpose of this study was to assess the incidence of warfarin fetal complications and whether they are dose-dependent.BACKGROUNDGravid patients with mechanical heart valves require long-term anticoagulant therapy. Controversy exists concerning the appropriate treatment of these patients.METHODSForty-three women on warfarin carrying out 58 pregnancies were studied. For each patient with full-term pregnancy a caesarian section was scheduled for the 38th week during brief warfarin discontinuation. Maternal and fetal complications were evaluated. Fetal complications were divided according to the warfarin dosage ≤5 mg and >5 mg necessary to keep an international normalized ratio (INR) of 2.5 to 3.5, and analyzed subsequently.RESULTSA total of 58 pregnancies were observed: 31 healthy babies (30 full term, 1 premature) and 27 fetal complications (22 spontaneous abortions, 2 warfarin embryopathies, 1 stillbirth, 1 ventricular septal defect, 1 growth retardation) were recorded. Two maternal valve thromboses occurred. No fetal or maternal bleeding was observed during caesarian sections or premature vaginal delivery. Patients whose warfarin doses during pregnancy were >5 mg had 22 fetal complications, whereas those taking a dose ≤5 mg had only five fetal complications (p = 0.0001). For an increase of the warfarin dose there was a substantially increased probability of fetal complications (p < 0.0001; ρ < 0.7316).CONCLUSIONSThere is a close dependency between warfarin dosage and fetal complications. Patients on warfarin anticoagulation may be delivered by planned caesarian section at the 38th week while briefly interrupting anticoagulation.
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- 1999
21. LOWERing the INtensity of oral anticoaGulant Therapy in patients with bileaflet mechanical aortic valve replacement: Results from the 'LOWERING-IT' Trial
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Gianantonio Nappi, Marco Franciulli, Giampaolo Romano, Michele Torella, Teresa Salvatore, Marisa De Feo, Daniele Torella, Ciro Indolfi, Maurizio Cotrufo, Paolo Chiodini, Ferdinando Carlo Sasso, Luca Salvatore De Santo, Georgina M. Ellison, Cristiano Amarelli, Torella, Michele, Torella, D, Chiodini, Paolo, Franciulli, M, Romano, G, De Santo, L, DE FEO, Marisa, Amarelli, C, Sasso, Ferdinando Carlo, Salvatore, Teresa, Ellison, Gm, Indolfi, C, Cotrufo, M, and Nappi, Gianantonio
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Adult ,Male ,Aortic valve ,endocrine system ,medicine.medical_specialty ,Administration, Oral ,Moderate anticoagulation ,Postoperative Hemorrhage ,Prosthesis Design ,law.invention ,Young Adult ,Randomized controlled trial ,Risk Factors ,law ,health services administration ,Antithrombotic ,medicine ,Humans ,heterocyclic compounds ,Prospective Studies ,cardiovascular diseases ,Prospective cohort study ,Dose-Response Relationship, Drug ,business.industry ,Incidence ,fungi ,Anticoagulants ,Mechanical Aortic Valve ,Thrombosis ,Aortic Valve Stenosis ,Middle Aged ,Prognosis ,medicine.disease ,antithrombotic regimen ,Surgery ,coumarine ,Regimen ,medicine.anatomical_structure ,Italy ,Heart Valve Prosthesis ,Aortic valve stenosis ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Backgrou nd Moderate anticoagulation after mechanical heart valve replacement has been proposed to reduce the risk of bleeding related to lifelong anticoagulation. However, the efficacy of such reduced antithrombotic regimens is still unknown. The present prospective open-label, single-center, randomized controlled trial aimed to evaluate the safety and feasibility of reduced oral anticoagulation after isolated mechanical aortic valve replacement. Metho ds Low-risk patients undergoing bileaflet mechanical aortic valve replacement were randomized to a low International normalized ratio (INR) target (1.5-2.5; LOW-INR group) or to the standard currently recommended INR (2.0-3.0; CONVENTIONAL-INR group) through daily coumarine oral therapy. No aspirin was added. Median follow-up was 5.6 years. Th e pr imar y out co me was a sse ss me nt of no ni nfe ri ori ty of t he lo w ov er the s tan dar d an t ico agu l ati on reg imen on thromboembolic events. Secondary end point was the superiority of the reduced INR target strategy on bleeding events. Results We analyzed 396 patients (197 in the LOW-INR group and 199 in the CONVENTIONAL-INR group). The mean of INR was 1.94 ± 0.21 and 2.61 ± 0.25 in the LOW-INR and CONVENTIONAL-INR groups, respectively (P b .001). One versus three thromboembolic events occurred in the LOW-INR and CONVENTIONAL-INR, respectively, meeting the noninferiority criterion ( P = .62). Total hemorrhagic events occurred in 6 patients in the LOW-INR group and in 16 patients in the CONVENTIONAL-INR group (P = .04). Conclusio ns LOWERING-IT trial established that the proposed LOW-INR target is safe and feasible in low-risk patients after bileaflet aortic mechanical valve replacement. It results in similar thrombotic events and in a significant reduction of bleeding occurrence when compared to the conventional anticoagulation regimen.
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- 2010
22. Shock Waves Activate In Vitro Cultured Progenitors and Precursors Of Cardiac Cell Lineages from the Human Heart
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Maurizio Cotrufo, Luca Salvatore De Santo, S. Russo, Franca Di Meglio, Alessandro Arcucci, Clotilde Castaldo, Stefania Montagnani, Ernst Marlinghaus, Bruno Corrado, Daria Nurzynska, Francesco Baldascino, Nurzynska, DARIA ANNA, DI MEGLIO, Franca, Castaldo, Clotilde, Arcucci, Alessandro, Marlinghaus, E, Russo, Sergio, Corrado, Bruno, de Santo, L, Baldascino, F, Cotrufo, M, Montagnani, Stefania, D, Nurzynska, F, DI MEGLIO, C, Castaldo, A, Arcucci, E, Marlinghau, S, Russo, B, Corrado, DE SANTO, L., F, Baldascino, M, Cotrufo, and S, Montagnani
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Adult ,Cardiomyopathy, Dilated ,Male ,Pathology ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Cellular differentiation ,Biophysics ,Cardiomyopathy ,chemistry.chemical_compound ,Lithotripsy ,medicine ,Humans ,Cell Lineage ,Radiology, Nuclear Medicine and imaging ,Progenitor cell ,Receptor ,Cells, Cultured ,Cell Proliferation ,Radiological and Ultrasound Technology ,Cell growth ,business.industry ,Myocardium ,Stem Cells ,Cell Differentiation ,Middle Aged ,medicine.disease ,Vascular endothelial growth factor ,chemistry ,Heart failure ,Female ,Stem cell ,business ,Biomarkers - Abstract
Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It is currently accepted that the isolation, expansion and application of resident cardiac stem cells may hold therapeutic promise for the future. Recently, it has been demonstrated that shock waves (SW) could enhance the expression of vascular endothelial growth factor (VEGF) and its receptor, Flt-1. As the development of angiogenic noninvasive therapy is very important for future therapeutic strategies in cardiovascular diseases, we examined in vitro, the effects of SW treatment on adult resident cardiac primitive cells isolated from bioptic fragments of normal human hearts and from explanted pathologic hearts with postischemic cardiomyopathy. This study demonstrates that SW have positive influence on both the proliferation and the differentiation of cardiomyocytes, smooth muscle and endothelial cells precursors, with a more obvious effect being evident in the cells from normal heart than in those taken from pathologic hearts. Our results suggest that SW treatment could inhibit or retard the pathologic remodeling and functional degradation of the heart if applied during the early stages of heart failure.
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- 2008
23. Hybrid aortic arch repair: Facts and hints beyond the statistical truth
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De Santo, Luca Salvatore, primary
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- 2017
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24. Continuous Positive Airway Pressure in the Cardiac Surgery Setting: Always and Everywhere? First, Start With the Basics
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Esquinas, Antonio M., primary, Zebele, Carlo, additional, and De Santo, Luca Salvatore, additional
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- 2017
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25. The effects of adaptive servo-ventilation in the management of acute cardiogenic pulmonary edema: Definitely more than a blurb
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Esquinas, Antonio M., primary and De Santo, Luca Salvatore, additional
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- 2017
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26. Adaptive support ventilation weaning protocols in cardiac surgical patients: Complex speculations with little practical impact
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Esquinas, Antonio M., primary, Cravo, João, additional, and De Santo, Luca Salvatore, additional
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- 2017
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27. How to delineate obstructive sleep apnea and continuous positive airway pressure link in postoperative atrial fibrillation conundrum?
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De Santo, Luca Salvatore, primary and Esquinas, Antonio M., additional
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- 2016
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28. Biomechanical implications of the congenital bicuspid aortic valve: A finite element study of aortic root function from in vivo data
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Ciro Bancone, Alberto Redaelli, Luca Del Viscovo, Emiliano Votta, Carlo Angelo Conti, Luca Salvatore De Santo, Alessandro Della Corte, Conti, Ca, DELLA CORTE, Alessandro, Votta, E, DEL VISCOVO, Luca, Bancone, C, DE SANTO, Luca Salvatore, and Redaelli, A.
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Adult ,Heart Defects, Congenital ,Male ,Aortic valve ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,Finite Element Analysis ,Diastole ,Young Adult ,Imaging, Three-Dimensional ,Bicuspid aortic valve ,Bicuspid valve ,medicine.artery ,Internal medicine ,medicine ,Humans ,Computer Simulation ,cardiovascular diseases ,Systole ,Aorta ,business.industry ,Models, Cardiovascular ,Anatomy ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Biomechanical Phenomena ,Kinetics ,Stenosis ,medicine.anatomical_structure ,Aortic Valve ,Circulatory system ,Cardiology ,cardiovascular system ,Female ,Surgery ,Stress, Mechanical ,business ,Cardiology and Cardiovascular Medicine - Abstract
Objective Congenital bicuspid aortic valves frequently cause aortic stenosis or regurgitation. Improved understanding of valve and root biomechanics is needed to achieve advancements in surgical repair techniques. By using imaging-derived data, finite element models were developed to quantify aortic valve and root biomechanical alterations associated with bicuspid geometry. Methods A dynamic 3-dimensional finite element model of the aortic root with a bicuspid aortic valve (type 1 right/left) was developed. The model's geometry was based on measurements from 2-dimensional magnetic resonance images acquired in 8 normotensive and otherwise healthy subjects with echocardiographically normal function of their bicuspid aortic valves. Numeric results were compared with those obtained from our previous model representing the normal root with a tricuspid aortic valve. The effects of raphe thickening on valve kinematics and stresses were also evaluated. Results During systole, the bicuspid valve opened asymmetrically compared with the normal valve, resulting in an elliptic shape of its orifice. During diastole, the conjoint cusp occluded a larger proportion of the valve orifice and leaflet bending was altered, although competence was preserved. The bicuspid model presented higher stresses compared with the tricuspid model, particularly in the central basal region of the conjoint cusp (+800%). The presence of a raphe partially reduced stress in this region but increased stress in the other cusp. Conclusions Aortic valve function is altered in clinically normally functioning bicuspid aortic valves. Bicuspid geometry per se entails abnormal leaflet stress. The stress location suggests that leaflet stress may play a role in tissue remodeling at the raphe region and in early leaflet degeneration.
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- 2010
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29. Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: Focus on cell–matrix signaling
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Franca Di Meglio, Ciro Bancone, Michelangelo Scardone, Marisa De Feo, Daria Nurzynska, Luca Salvatore De Santo, Alessandro Della Corte, Cesare Quarto, Clotilde Castaldo, Stefania Montagnani, Maurizio Cotrufo, Della Corte, A, Quarto, C, Bancone, C, Castaldo, Clotilde, DI MEGLIO, Franca, Nurzynska, DARIA ANNA, De Santo, L, De Feo, M, Scardone, M, Montagnani, Stefania, Cotrufo, M., DELLA CORTE, Alessandro, Bancone, Castaldo, C, DI MEGLIO, F, Nurzynska, D, DE SANTO, Luca Salvatore, DE FEO, Marisa, and Montagnani, S
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Adult ,Male ,Pulmonary and Respiratory Medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Myocytes, Smooth Muscle ,Aortic Diseases ,Tenascin ,Apoptosis ,Bicuspid aortic valve ,medicine.artery ,Internal medicine ,Ascending aorta ,medicine ,Humans ,Myocyte ,cardiovascular diseases ,Aorta ,Aged ,Extracellular Matrix Proteins ,biology ,apoptotic indexe ,business.industry ,Aortic Valve Stenosis ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Aortic Aneurysm ,Extracellular Matrix ,Stenosis ,Bcl-2-modifying factor-Bcl-2 binding ,Aortic valve stenosis ,Circulatory system ,cardiovascular system ,biology.protein ,Cardiology ,Female ,Surgery ,business ,Cardiology and Cardiovascular Medicine ,bicuspid nonaneurysmal aorta ,Dilatation, Pathologic ,Signal Transduction - Abstract
OBJECTIVE: The present study examined temporal and spatial patterns of extracellular matrix and smooth muscle cell changes in the ascending aorta with bicuspid and tricuspid aortic valve stenosis. METHODS: Wall specimens were retrieved from both the greater and the lesser curvature ("convexity" and "concavity") of 14 nonaneurysmal and 12 aneurysmal aortas (aortic ratios 1.2 and 1.5, respectively) and from 3 heart donors (normal). Immunochemistry was performed for detection of apoptotic (terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling [TUNEL]-positive) and proliferating (Ki-67-positive) smooth muscle cells and for semiquantification of matrix proteins (collagens, fibronectin, tenascin, laminin). Co-immunoprecipitation assessed the extent of Bcl-2-modifying factor binding to Bcl-2, indicating a matrix-derived cytoskeleton-mediated proapoptotic signaling. Polymerase chain reaction allowed for quantification of messenger RNA expression for Bcl-2. RESULTS: In both bicuspid and tricuspid aneurysms, fibrillar collagens were reduced, whereas fibronectin and tenascin were increased compared with those in normal conditions. These matrix alterations were already evident in bicuspid nonaneurysmal aortas at the convexity, with significant elevation of apoptotic indexes (P = .02 bicuspid vs normal; P = .48 tricuspid vs normal). Apoptotic indexes correlated with aortic dimensions only in tricuspid aortas (P = .01). No significant increase in Ki-67 was found. Higher levels of Bcl-2-modifying factor-Bcl-2 binding were found in bicuspid nonaneurysmal aorta versus tricuspid (P = .03) and normal aortas (P = .01). Bcl-2 messenger RNA expression was reduced in the bicuspid aorta versus normal (P = .08). CONCLUSIONS: Smooth muscle cell apoptosis with bicuspid aortic valve stenosis occurred before overt aortic dilation, mainly at the convexity, where wall stress is expectedly higher. In this setting, a matrix-dependent proapoptotic signaling was evidenced by increased Bcl-2-modifying factor-Bcl-2 binding. Stress-dependent bicuspid aortic valve matrix changes may trigger early apoptosis by inducing cytoskeletal rearrangement.
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- 2008
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30. Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: Preliminary results
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Germano Guerra, Michelangelo Scardone, Luca Salvatore De Santo, Alessandro Della Corte, Cesare Quarto, Giampaolo Romano, Clotilde Castaldo, Cristiano Amarelli, Maurizio Cotrufo, Serena Vitale, Franca Di Meglio, Maria Scarano, Stefania Montagnani, Marisa De Feo, Cotrufo, M, Della Corte, A, De Santo, L, Quarto, C, De Feo, M, Romano, G, Amarelli, C, Scardone, M, DI MEGLIO, Franca, Guerra, G, Scarano, M, Vitale, S, Castaldo, Clotilde, Montagnani, Stefania, Cotrufo, M., DELLA CORTE, Alessandro, DE SANTO, Luca Salvatore, Quarto, C., DE FEO, Marisa, Romano, GIOVANNI PIERO, Amarelli, C., Scardone, M., DI MEGLIO, F., Guerra, G., Scarano, M., Vitale, S., Castaldo, C., and Montagnani, S.
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Thorax ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,bicuspid-associated aortic dilation ,Bicuspid aortic valve ,extracellular matrix ,Aortic Valve Insufficiency ,Aortic Diseases ,Regurgitation (circulation) ,Concavity site ,Collagen Type I ,Extracellular matrix ,Pathogenesis ,Bicuspid aortic valve, extracellular matrix, Immunohistochemistry, Concavity site, Convexity site ,medicine.artery ,Internal medicine ,Convexity site ,Ascending aorta ,medicine ,Humans ,Aorta ,Aged ,Extracellular Matrix Proteins ,business.industry ,Aortic Valve Stenosis ,Middle Aged ,aortic dilatation ,medicine.disease ,Stenosis ,Collagen Type III ,Aortic Valve ,immunohistochemistry ,Cardiology ,cardiovascular system ,Surgery ,business ,Cardiology and Cardiovascular Medicine ,Dilatation, Pathologic - Abstract
OBJECTIVE: This study aimed to assess extracellular matrix protein expression patterns at the convexity (right anterolateral wall) and the concavity of the dilated ascending aorta in patients with bicuspid aortic valve disease. METHODS: Aortic wall specimens were retrieved from the convexity and the concavity in 27 bicuspid aortic valve patients (12 with stenosis and 15 with regurgitation) and 6 heart donors (controls). Morphometry, immunohistochemistry, Western blot, and polymerase chain reaction were performed, focusing on matrix proteins involved in vascular remodeling. RESULTS: Type I and III collagens were significantly decreased in bicuspid-associated dilated aortas versus controls (P < .001), particularly at the convexity (P < .05 vs concavity). Expression of messenger RNA for collagens was lower than normal only in the regurgitant subgroup. At immunohistochemistry, proteins whose overproduction has been demonstrated in response to abnormal wall stress, such as tenascin and fibronectin, were more expressed in the convexity than in the concavity, especially in the stenosis subgroup. Tenascin, which is produced by smooth muscle cells in the synthetic phenotype, was nearly undetectable in controls. Fewer smooth muscle cells (stenosis, P = .017; regurgitation, P = .008) and more severe elastic fiber fragmentation (P = .029 and P < .001) were observed in the convexity versus the concavity. CONCLUSIONS: In bicuspid-associated aortic dilations, an asymmetric pattern of matrix protein expression was found that was consistent with the asymmetry in wall-stress distribution reported previously. Differences exist between patients with stenosis and those with regurgitation in terms of protein expression and content in the aortic wall. Further studies could clarify the relations between these findings and the pathogenesis of aortic dilatation in bicuspid aortic valve patients.
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- 2005
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31. Achilles Tendon for Sternal Synthesis in the Treatment of Mediastinitis
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Cesare Quarto, Antonio Carozza, Maurizio Cotrufo, Luca Salvatore De Santo, Alessandro Della Corte, Marisa De Feo, Michele Torella, Gianantonio Nappi, DE FEO, Marisa, Carozza, A., DELLA CORTE, Alessandro, Quarto, C., Torella, M., DE SANTO, L. S., Nappi, Gianantonio, and Cotrufo, M.
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Male ,Pulmonary and Respiratory Medicine ,Thorax ,Sternum ,medicine.medical_specialty ,Transplantation, Heterotopic ,medicine.medical_treatment ,Achilles Tendon ,Computed tomographic ,Postoperative Complications ,medicine ,Humans ,Surgical Wound Infection ,Transplantation, Homologous ,Cardiac Surgical Procedures ,Device Removal ,Aged ,Achilles tendon ,Surgical approach ,Debridement ,business.industry ,Middle Aged ,musculoskeletal system ,medicine.disease ,Mediastinitis ,Surgery ,Transplantation ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Bone Wires ,Follow-Up Studies - Abstract
Surgical approaches to postoperative mediastinitis that imply wire removal achieve earlier infection recovery but leave the patient with sternal instability. In 10 patients after wound surgical debridement, my colleagues and I achieved sternal synthesis by using Achilles tendons retrieved from multiorgan donors and stored in glutaraldehyde. Three tendons were used in each patient; they were passed through the bone at the manubrium and parasternally at the midsternum and the lower sternum. Thirty-day computed tomographic scan results, infection recovery, and quality of life were satisfactory.
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- 2005
32. Leukoreduction program for red blood cell transfusions in coronary surgery: Association with reduced acute kidney injury and in-hospital mortality
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Romano, Gianpaolo, primary, Mastroianni, Ciro, additional, Bancone, Ciro, additional, Della Corte, Alessandro, additional, Galdieri, Nicola, additional, Nappi, Gianantonio, additional, and De Santo, Luca Salvatore, additional
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- 2010
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33. Changes of the quality-of-life under the treatment of severe senile osteoporosis with teriparatide
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Maugeri, Domenico, primary, Russo, Enzo, additional, Luca, Salvatore, additional, Leotta, Carmelo, additional, Mamazza, Grazia, additional, Sorace, Rosaria, additional, Rizzotto, Maurizio, additional, Manuele, Sara, additional, Fiore, Valentina, additional, Taverna, Giuseppe, additional, Castiglia, Biagio, additional, and Calitro, Michele, additional
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- 2009
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34. Elevated chromogranin A (CgA) serum levels in the patients with advanced pancreatic cancer
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Malaguarnera, Michele, primary, Cristaldi, Erika, additional, Cammalleri, Lisa, additional, Colonna, Valentina, additional, Lipari, Helga, additional, Capici, Alessandra, additional, Cavallaro, Andrea, additional, Beretta, Massimiliano, additional, Alessandria, Innocenza, additional, Luca, Salvatore, additional, and Motta, Massimo, additional
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- 2009
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35. Prosthesis-Patient Mismatch in the Elderly: Survival, Ventricular Mass Regression, and Quality of Life
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Vicchio, Mariano, primary, Della Corte, Alessandro, additional, De Santo, Luca Salvatore, additional, De Feo, Marisa, additional, Caianiello, Giuseppe, additional, Scardone, Michelangelo, additional, and Cotrufo, Maurizio, additional
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- 2008
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36. Acute hemodynamic and functional effects of surgical ventricular restoration and heart transplantation in patients with ischemic dilated cardiomyopathy
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Cotrufo, Maurizio, primary, De Santo, Luca Salvatore, additional, Corte, Alessandro Della, additional, Romano, GianPaolo, additional, Amarelli, Cristiano, additional, De Feo, Marisa, additional, Santarpino, Giuseppe, additional, Scardone, Michelangelo, additional, and Nappi, Gianantonio, additional
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- 2008
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37. Tissue Versus Mechanical Prostheses: Quality of Life in Octogenarians
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Vicchio, Mariano, primary, Della Corte, Alessandro, additional, De Santo, Luca Salvatore, additional, De Feo, Marisa, additional, Caianiello, Giuseppe, additional, Scardone, Michelangelo, additional, and Cotrufo, Maurizio, additional
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- 2008
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38. Mitral mechanical replacement in young rheumatic women: Analysis of long-term survival, valve-related complications, and pregnancy outcomes over a 3707-patient-year follow-up
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De Santo, Luca Salvatore, primary, Romano, Gianpaolo, additional, Corte, Alessandro Della, additional, Tizzano, Francesco, additional, Petraio, Andrea, additional, Amarelli, Cristiano, additional, De Feo, Marisa, additional, Dialetto, Giovanni, additional, Scardone, Michelangelo, additional, and Cotrufo, Maurizio, additional
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- 2005
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39. Successful subtotal tracheal replacement (using a skin/omental graft) for dehiscence after a resection for thyroid cancer
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Spaggiari, Lorenzo, primary, Calabrese, Luca Salvatore, additional, D’Aiuto, Massimiliano, additional, Veronesi, Giulia, additional, Galetta, Domenico, additional, Venturino, Marco, additional, and Chiesa, Fausto, additional
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- 2005
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40. Achilles Tendon for Sternal Synthesis in the Treatment of Mediastinitis
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De Feo, Marisa, primary, Carozza, Antonio, additional, Della Corte, Alessandro, additional, Quarto, Cesare, additional, Torella, Michele, additional, De Santo, Luca Salvatore, additional, Nappi, Gianantonio, additional, and Cotrufo, Maurizio, additional
- Published
- 2005
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41. Surgical repair of acute type a aortic dissection: continuous pulmonary perfusion during retrograde cerebral perfusion prevents lung injury in a pilot study
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De Santo, Luca Salvatore, primary, Romano, Gianpaolo, additional, Amarelli, Cristiano, additional, Onorati, Francesco, additional, Torella, Michele, additional, Renzulli, Attilio, additional, Galdieri, Nicola, additional, and Cotrufo, Maurizio, additional
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- 2003
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42. Treatment of recurrent staphylococcal mediastinitis: still a controversial issue
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De Feo, Marisa, primary, De Santo, Luca Salvatore, additional, Romano, Gianpaolo, additional, Renzulli, Attilio, additional, Della Corte, Alessandro, additional, Utili, Riccardo, additional, and Cotrufo, Maurizio, additional
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- 2003
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43. Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves
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Vitale, Nicola, primary, De Feo, Marisa, additional, De Santo, Luca Salvatore, additional, Pollice, Alessio, additional, Tedesco, Nicola, additional, and Cotrufo, Maurizio, additional
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- 1999
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44. Role of Sildenafil in Acute Posttransplant Right Ventricular Dysfunction: Successful Experience in 13 Consecutive Patients
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L.S. De Santo, Cristiano Amarelli, C. Mastroianni, N. Galdieri, Maurizio Cotrufo, Giuseppe Caianiello, C. Marra, A. Della Corte, Ciro Maiello, Gianpaolo Romano, DE SANTO, Luca Salvatore, Mastroianni, C, Romano, G, Amarelli, C, Marra, C, Maiello, C, Galdieri, N, DELLA CORTE, Alessandro, Cotrufo, M, and Caianiello, G.
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Adult ,Cardiac Catheterization ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Heart disease ,Sildenafil ,Hypertension, Pulmonary ,Vasodilator Agents ,Ventricular Dysfunction, Right ,medicine.medical_treatment ,Piperazines ,Sildenafil Citrate ,chemistry.chemical_compound ,Postoperative Complications ,Internal medicine ,medicine ,Humans ,Sulfones ,Child ,Retrospective Studies ,Cardiac catheterization ,Heart transplantation ,Transplantation ,business.industry ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Surgery ,Radiography ,Treatment Outcome ,medicine.anatomical_structure ,chemistry ,Purines ,Circulatory system ,cardiovascular system ,Vascular resistance ,Cardiology ,Heart Transplantation ,Female ,Vascular Resistance ,Heart-Assist Devices ,business ,Phosphodiesterase 5 inhibitor ,Echocardiography, Transesophageal - Abstract
Background. Superimposed acute right ventricular dysfunction in the setting of preexisting pulmonary hypertension is a nearly fatal complication after heart transplantation. The optimal treatment modality remains a matter of debate. Recently, sildenafil citrate, a nonselective pulmonary vasodilator, has gained popularity in the treatment of pulmonary hypertension in transplant candidates. Methods. Herein we have presented a series of 13 patients in whom sildenafil was used to treat right ventricular dysfunction and pulmonary hypertension as detected by transesophageal echocardiography and Swan-Ganz right heart catheterization after heart transplant. Their characteristics were mean age 49 11.4 years; 38.4% with previous cardiac procedures, 30.8% status I, basal pulmonary vascular resistance index 10.4 4.6 WoodU, mean transpulmonary gradient 18.7 5.4 mmHg. In addition to conventional inodilator support, we administered 1 to 3 mg per kilogram of sildenafil. Complete hemodynamic measurements were obtained before and after the institution of the therapy and at 1-month follow-up. Results. Within the first 72 hours, acute right ventricular dysfunction resolved in all cases without untoward side effects or significant systemic impact. Sildenafil significantly decreased the transpulmonary gradient and pulmonary vascular resistance index relative to baseline values; 5.6 1.82 versus 10.4 4.6 WU, (P .05), 13.5 3.4 mm Hg versus 18.7 5.4 mm Hg (P .05), respectively. Improved indices of right ventricular function were observed on echocardiographic monitoring. After 1 month, sildenafil treatment was discontinued. Conclusion. Management of acute right ventricular dysfunction in heart transplant recipients with pulmonary hypertension using sildenafil proved safe and effective.
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- 2008
45. Bioelectrical impedance analysis in heart transplantation: Early and late changes
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STELLATO D, CIRILLO M, DE SANTO LS, FRANGIOSA A, COTRUFO M, DE SANTO NG, DI IORIO BRELATED ARTICLES, LINKS, ANASTASIO, Pietro, D, Stellato, Cirillo, M., SANTO LS, De, P, Anastasio, A, Frangiosa, M, Cotrufo, SANTO NG, De, B, DI IORIO, Stellato, D, Cirillo, M, DE SANTO, Luca Salvatore, Anastasio, Pietro, Frangiosa, A, Cotrufo, M, DE SANTO, Ng, DI IORIO BRELATED, Article, and Links
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Body water ,Reactance ,Biology ,Body Water ,Heart Conduction System ,Internal medicine ,Extracellular fluid ,Electric Impedance ,medicine ,Humans ,Heart Failure ,Heart transplantation ,Analysis of Variance ,Body Weight ,Normal level ,Middle Aged ,Surgery ,Transplantation ,Membrane function ,Nephrology ,Cardiology ,Heart Transplantation ,Female ,Extracellular Space ,Bioelectrical impedance analysis - Abstract
The objectives of this study were to perform bioelectrical impedance analysis before and after heart transplantation with comparison to healthy subjects. Eight patients (7 men, 1 woman) before (day 0) and after transplantation (day 3, 7, 12, 15, and 180) and 24 healthy controls, matched for sex, age, and body mass were studied. Data collection included bioelectrical impedance analysis (resistance, reactance, and estimates of body water), clinical, and laboratory measurements. Compared with controls, patients had at baseline significantly higher reactance, not significantly different resistance, body weight, total body water, and intra- to extracellular water ratio. After surgery, for reactance, there was an acute decrease followed by a slow, progressive increase up to normal level by day 15. Resistance and body weight did not significantly change; the intra- to extracellular water ratio significantly decreased with stable total body water. Changes in reactance are the main effects induced on bioelectrical impedance by heart transplantation. Acutely, there is a large decrease which likely reflects changes both in water distribution and in cell membrane function. The late changes more likely reflect the shift of body water from the extra- to the intracellular space with stable total body water.
- Published
- 2001
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