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Shock Waves Activate In Vitro Cultured Progenitors and Precursors Of Cardiac Cell Lineages from the Human Heart
- Source :
- Ultrasound in Medicine & Biology. 34:334-342
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Postischemic cardiomyopathy remains one of the disorders in urgent need of effective noninvasive therapy. It is currently accepted that the isolation, expansion and application of resident cardiac stem cells may hold therapeutic promise for the future. Recently, it has been demonstrated that shock waves (SW) could enhance the expression of vascular endothelial growth factor (VEGF) and its receptor, Flt-1. As the development of angiogenic noninvasive therapy is very important for future therapeutic strategies in cardiovascular diseases, we examined in vitro, the effects of SW treatment on adult resident cardiac primitive cells isolated from bioptic fragments of normal human hearts and from explanted pathologic hearts with postischemic cardiomyopathy. This study demonstrates that SW have positive influence on both the proliferation and the differentiation of cardiomyocytes, smooth muscle and endothelial cells precursors, with a more obvious effect being evident in the cells from normal heart than in those taken from pathologic hearts. Our results suggest that SW treatment could inhibit or retard the pathologic remodeling and functional degradation of the heart if applied during the early stages of heart failure.
- Subjects :
- Adult
Cardiomyopathy, Dilated
Male
Pathology
medicine.medical_specialty
Acoustics and Ultrasonics
Cellular differentiation
Biophysics
Cardiomyopathy
chemistry.chemical_compound
Lithotripsy
medicine
Humans
Cell Lineage
Radiology, Nuclear Medicine and imaging
Progenitor cell
Receptor
Cells, Cultured
Cell Proliferation
Radiological and Ultrasound Technology
Cell growth
business.industry
Myocardium
Stem Cells
Cell Differentiation
Middle Aged
medicine.disease
Vascular endothelial growth factor
chemistry
Heart failure
Female
Stem cell
business
Biomarkers
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Medicine & Biology
- Accession number :
- edsair.doi.dedup.....2533ff9aa6dc2273f8616a29301a0661