1. Phytoconstituents from Vitex agnus-castus fruits.
- Author
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Chen SN, Friesen JB, Webster D, Nikolic D, van Breemen RB, Wang ZJ, Fong HH, Farnsworth NR, and Pauli GF
- Subjects
- Diterpenes chemistry, Drugs, Chinese Herbal chemistry, Flavonoids isolation & purification, Fruit chemistry, Lignans isolation & purification, Magnetic Resonance Spectroscopy, Molecular Structure, Phenols isolation & purification, Spectrometry, Mass, Electrospray Ionization, Terpenes isolation & purification, Diterpenes isolation & purification, Vitex chemistry
- Abstract
A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
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