1. p63 immunoexpression in hair follicles of normal and alopecia X-affected skin of Pomeranian dogs.
- Author
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Della Salda L, Bongiovanni L, Massimini M, Romanucci M, Vercelli A, Colosimo A, Di Matteo R, and Defourny SVP
- Subjects
- Dogs, Animals, Alopecia genetics, Alopecia veterinary, Skin pathology, Biopsy veterinary, Gene Expression Regulation, Hair Follicle pathology, Dog Diseases pathology
- Abstract
Background: Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes., Hypothesis/objectives: The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin., Animals: Skin biopsies from 19 alopecia X-affected and six control Pomeranians were analysed., Materials and Methods: Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples., Results: Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles., Conclusions and Clinical Relevance: The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle., (© 2023 ESVD and ACVD.)
- Published
- 2023
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