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Apoptosis and anti-apoptotic heat shock proteins in canine cutaneous infundibular keratinizing acanthomas and squamous cell carcinomas.
- Source :
-
Veterinary dermatology [Vet Dermatol] 2008 Oct; Vol. 19 (5), pp. 271-9. Date of Electronic Publication: 2008 Aug 18. - Publication Year :
- 2008
-
Abstract
- Cell stress and death are linked in the neoplastic process, and heat shock proteins appear to play an important role by inhibiting apoptotic pathways. The apoptotic rates in 9 canine infundibular keratinizing acanthomas (IKAs) and 17 canine squamous cell carcinomas (SCCs) were correlated with the immunohistochemical expression of caspase-3 and the antiapoptotic heat shock proteins Hsp27, 72 and 73. Apoptosis was evaluated using the terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling (TUNEL) method. The absence of a correlation between the TUNEL index and active-caspase-3 expression, a paucity of active-caspase-3-positive cells and Hsp72 over-expression were considered to be indicative of inhibition of apoptosis, and suggestive that inhibition of cell death plays a key role in oncogenesis and tumour growth of some canine skin neoplasms.
- Subjects :
- Acanthoma pathology
Animals
Apoptosis genetics
Carcinoma, Squamous Cell pathology
Dogs
Gene Expression Regulation
Heat-Shock Proteins genetics
Immunohistochemistry veterinary
In Situ Nick-End Labeling
Acanthoma veterinary
Apoptosis physiology
Carcinoma, Squamous Cell veterinary
Dog Diseases metabolism
Heat-Shock Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3164
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Veterinary dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 18803621
- Full Text :
- https://doi.org/10.1111/j.1365-3164.2008.00687.x