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A recent preprint abstract discusses a cryopreservation strategy for storing myoblasts, which are cells involved in skeletal muscle health, in paper-based scaffolds. The goal of this research is to make it easier for the broader biology community to use three-dimensional tissue-engineered models for studying skeletal muscle pathophysiology and developing therapeutic agents. The researchers developed a protocol using commercially available reagents that allows myoblasts to be cryopreserved in a format that can be easily transferred to users without expertise in skeletal muscle cell culture. The study validates that the cryopreserved myoblasts maintain cell viability, differentiation, and function, and demonstrates successful shipping and use of the tissues by collaborators. The researchers also applied their method to study muscle endogenous repair. This research has not yet undergone peer review. [Extracted from the article]

Researchers from Mustansiriyah University in Baghdad, Iraq have developed a spectrophotometric method and a paper-based microfluidic device for the quantitative determination of Amoxicillin in pure form and pharmaceutical preparations. The detection method involves a coupling reaction of Amoxicillin with diazotized sulfadimidine in an alkaline medium, and the reaction product is measured at a specific wavelength. The paper-based microfluidic device can be used for the semi-quantitative determination of Amoxicillin in pure solution and commercial pharmaceutical products for rapid screening. This research provides a low-cost and portable method for analyzing active pharmaceutical ingredients in the pharmaceutical industry. [Extracted from the article]

A recent study conducted by researchers at Beijing Normal University explores the use of drawing paper as a therapeutic tool in drama counseling. The study focuses on a case study involving a Chinese primary school student who used drawing paper as a stage to act out a drama, allowing for emotional catharsis and expression. The research suggests that this approach could lead to a new therapeutic model in individual mental health counseling. The study also highlights the cultural significance of the drawing in drama counseling model within the Chinese culture. For more information, the full article can be accessed through the provided link. [Extracted from the article]

A study conducted by researchers at the University at Buffalo found that people with opioid use disorder who also have hepatitis C virus (HCV) were twice as likely to be successfully treated and cured from HCV if they received telemedicine treatment at their opioid treatment program (OTP) rather than being referred off-site. The study, published in the Journal of the American Medical Association (JAMA), is one of the few randomized controlled trials that have examined the effectiveness of telemedicine in improving healthcare access for vulnerable populations. The researchers found that 90.3% of participants in the telemedicine arm were cured of HCV infection compared to 39.4% of participants referred to an off-site specialist. The use of telemedicine also resulted in subsequent improvements in health and well-being for participants, including reductions in substance use. The study suggests that telemedicine should be further explored as an approach to increase healthcare access for underserved populations with other health conditions. [Extracted from the article]

Researchers from Yangzhou University in China have developed a new method for detecting tumor-derived extracellular vesicles (T-EVs) using a paper-based lipid bilayer magnetic interface. T-EVs are important biomarkers for predicting immunotherapy response, but traditional bioassays have limited detection specificity. The new biosensor combines the use of magnetic beads covered with liposome bilayers and aptamers to isolate and amplify the signals of T-EVs. The biosensor demonstrated high sensitivity, with a detection limit as low as 5.0 EVs/μL, and has potential applications in predicting immunotherapy response and point-of-care disease diagnosis. [Extracted from the article]

A recent study conducted by researchers at the Harbin Institute of Technology in Shenzhen, China, has developed a paper-based microfluidic sensor array for the discrimination of tetracycline antibiotics. The sensor array utilizes lanthanide metal-carbon quantum dots composite ink and inkjet printing technology to create a portable and cost-effective device. The platform successfully differentiated six different tetracycline antibiotics and demonstrated its practicality in real samples. This research has potential applications in disease diagnosis, food safety, and environmental contamination. [Extracted from the article]

Researchers at the University of Karachi in Pakistan have developed a highly stable and sensitive colorimetric sensor using silver nanoparticles (AgNPs) for the detection of omeprazole at trace levels. The sensor combines AgNPs-based paper technology with smartphone technology for real-time analysis of omeprazole. The sensor demonstrated high stability, sensitivity, and versatility, making it suitable for on-site and point-of-care omeprazole detection in various samples. This research provides a promising solution for real-time omeprazole analysis with potential applications beyond pharmaceutical formulations. [Extracted from the article]