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Researchers from COMSATS University in Lahore, Pakistan have developed a cellulose paper-based aptasensing protocol for the detection of the cancer biomarker mucin 1 (MUC1). The paper surface was modified using polydopamine modified carbon nanotubes (PDA@CNTS) to create a strong adhesion and binding interface. The researchers used dynamic laser speckle (DLS) analysis to analyze the speckle patterns generated from the cellulose-based paper surface, providing sensitive and accurate analysis of the target biomarker. The paper-based aptasensor demonstrated sensitive and selective detection of MUC1, making it a promising tool for low-cost and portable biological applications. [Extracted from the article]

Researchers from Tufts University in Medford, Massachusetts have developed a distance-based paper analytical device (dPAD) that can simultaneously quantify cytokine biomarkers in human biological samples. The dPAD uses carbon dots (CDs) and molecularly imprinted polymers (MIPs) to achieve high selectivity and sensitivity. The device is cost-effective, user-friendly, and has the potential for point-of-care diagnostics of cytokine-related disorders. The research was funded by the Uniformed Services University of the Health Sciences, the Henry Jackson Foundation, and the DoD Peer Review Medical Research Program. [Extracted from the article]

Researchers at Vancouver Island University have developed a new method for detecting chronic kidney disease (CKD) using paper spray mass spectrometry (PS-MS) combined with machine learning. The protocol is rapid and simple, based on analyzing metabolic profile changes in urine. The study found that the PS-MS combined with machine learning approach had a diagnostic performance of over 96% accuracy for CKD. This research suggests that PS-MS combined with machine learning could be a valuable tool for the rapid and simple diagnosis of CKD. [Extracted from the article]

A study conducted by researchers at Chulalongkorn University in Bangkok, Thailand, has explored the use of molecularly imprinted polymer paper-based analytical devices (MIP-PADs) for biomarker detection. MIP-PADs have the potential to improve the selectivity and specificity of paper-based analytical devices, making them more effective in complex analysis conditions and samples. The study highlights the fabrication and characterization processes of MIP-PADs, discusses their applications in biological samples, and evaluates their potential for commercialization. This research is the first of its kind to assess MIP-PADs for biomarker analysis. [Extracted from the article]

A recent study conducted at the University of Aquila in L'Aquila, Italy, compared the accuracy of nursing diagnoses using a computerized system versus a traditional paper-based approach. The study found that the computer-based system resulted in significantly higher accuracy in solving cancer and stroke clinical scenarios, but no significant difference in acute myocardial infarction scenarios. The use of the electronic system also increased the number of correct diagnostic indicators. However, the study highlighted the need to make electronic documentation systems more user-friendly. This research has been peer-reviewed and published in CIN Computers Informatics Nursing. [Extracted from the article]

A recent report from researchers at Birmingham Women's and Children's NHS Foundation Trust discusses the diagnosis and treatment of progressive familial intrahepatic cholestasis (PFIC), a rare liver disorder that primarily affects children. The researchers aimed to provide recommendations for the management of PFIC in clinical practice. They developed an algorithm for the diagnosis and treatment of children with suspected PFIC, which includes the use of licensed inhibitors of ileal bile acid transporters as the first-line treatment. The authors hope that these recommendations will help standardize the management of PFIC and raise awareness of current developments in the field. [Extracted from the article]

A report from the State University of Campinas (UNICAMP) in Brazil provides recommendations for the diagnosis and treatment of post-extubation laryngitis (PEL) in children. The research involved a multidisciplinary expert-based opinion and used a modified Delphi method. The report highlights the importance of airway endoscopy in making treatment decisions, although there is no consensus on the dosage and length of treatment. The study also recommends the use of systemic corticosteroids, specifically dexamethasone, as part of the medical treatment for PEL. The management of post-extubation laryngitis is challenging and can benefit from a multidisciplinary approach. [Extracted from the article]