151 results on '"Actinic Damage"'
Search Results
2. Canfield Reveal Image changes following sun exposure
- Author
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Alexa Carboni, BS, Jessica Marie Kirk, BS, Nathaniel Marroquin, BS, Garrett Furth, BS, James M. Small, MD, PhD, and Robert P. Dellavalle, MD, PhD, MSPH
- Subjects
actinic damage ,acute sun damage ,Canfield Imager ,skin imaging ,sun damage ,sun exposure imaging ,Dermatology ,RL1-803 - Published
- 2023
- Full Text
- View/download PDF
3. Frontal Fibrosing Alopecia and Sunscreen Use: A Cross-sectional Study of Actinic Damage
- Author
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María Librada Porriño-Bustamante, Trinidad Montero-Vílchez, Fernando Javier Pinedo-Moraleda, Ángel Fernández-Flores, María Antonia Fernández-Pugnaire, and Salvador Arias-Santiago
- Subjects
frontal fibrosing alopecia ,sunscreens ,actinic damage ,histopathology ,trichoscopy ,Dermatology ,RL1-803 - Abstract
Patients with frontal fibrosing alopecia report higher rates of sunscreen use than control subjects. However, it is not known whether the higher use of sunscreens is a cause or a consequence of the alopecia. A greater use of sunscreens should be associated with a lower incidence of signs of actinic damage. The aim of this study is to assess the presence of actinic damage in patients with frontal fibrosing alopecia. A cross-sectional study was carried out on 101 patients with frontal fibrosing alopecia and 40 control subjects. The presence of actinic damage, in the form of solar lentigines, actinic keratoses, and basal and squamous cell carcinomas, was recorded in both groups, together with sunscreen use. Trichoscopy and skin biopsy were performed on patients. Actinic damage was present more frequently in patients with frontal fibrosing alopecia (69.3%) than in control subjects (50%) (p = 0.031). Patients used sunscreens more frequently than did control subjects (83.2% vs 62.5%, p = 0.008). However, the prevalence of trichoscopic inflammatory signs, peripheral alopecia, and inflammatory infiltrate and sebaceous gland involvement in skin biopsy, were similar in patients who used sunscreens and those who did not use them. In conclusion, patients with frontal fibrosing alopecia had greater actinic damage than did control subjects, and this is hypothesized as a reason for the higher use of sunscreens among patients. Thus, use of sunscreens may not be the trigger for frontal fibrosing alopecia that dermatologists have proposed.
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- 2022
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4. Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo).
- Author
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van der Weyden, Louise, O'Dell, Nicolize, Avenant, Alida, Pazzi, Paolo, and Koeppel, Katja N.
- Subjects
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SQUAMOUS cell carcinoma , *RADIOTHERAPY , *TREATMENT effectiveness , *SNOW leopard , *DYSPLASIA , *CHRONIC kidney failure , *FELIDAE , *LIONS - Abstract
Cutaneous squamous cell carcinoma (SCC) is a slow growing but locally invasive neoplasm, most commonly caused by prolonged exposure to ultraviolet (UV) radiation. Whilst SCC accounts for 15% of skin tumours in domesticated cats, cutaneous SCC in non-domesticated felids (apart from captive snow leopards) appears to be uncommon, with only three reports in the literature to date. In this report, a captive African lion (Panthera leo) presented with two ulcerative lesions on the nasal planum. Histopathology of the lesions revealed epidermal keratinocyte dysplasia and neoplastic basal- and supra-basal epithelial cells with dyskeratosis and evidence of basement membrane breaching and dermal invasion, consistent with a diagnosis of SCC. There was also evidence of laminar fibrosis and inflammation of the subjacent dermis suggesting that the SCC most likely resulted from UV-induced neoplastic transformation of the epidermal squamous epithelium following actinic keratosis. The lion was treated with hypofractionated radiation therapy and remained in remission until his death (euthanised 17 months later because of age-related chronic renal failure). This is the first report of cutaneous SCC in a lion with evidence of actinic damage and resolution after radiation therapy. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
5. Field cancerization: Definition, epidemiology, risk factors, and outcomes.
- Author
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Willenbrink, Tyler J., Ruiz, Emily S., Cornejo, Christine M., Schmults, Chrysalyne D., Arron, Sarah T., Jambusaria-Pahlajani, Anokhi, Cornejo, Christine, and Arron, Sarah
- Abstract
Field cancerization was first described in 1953 when pathologic atypia was identified in clinically normal tissue surrounding oropharyngeal carcinomas. The discovery of mutated fields surrounding primary tumors raised the question of whether the development of subsequent tumors within the field represented recurrences or additional primary tumors. Since this initial study, field cancerization has been applied to numerous other epithelial tissues, including the skin. Cutaneous field cancerization occurs in areas exposed to chronic ultraviolet radiation, which leads to clonal proliferations of p53-mutated fields and is characterized by multifocal actinic keratoses, squamous cell carcinomas in situ, and cutaneous squamous cell carcinomas. In the first article in this continuing medical education series, we define field cancerization, review the available grading systems, and discuss the epidemiology, risk factors, and outcomes associated with this disease. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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6. Favre-Racouchot Syndrome
- Author
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Pugliese, Silvina, Smith, Andrea, Epstein, Rachel, Torres, Abel, and Zeichner, Joshua, editor
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- 2014
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7. Predictors of Beagley-Gibson skin cast grade in older adults.
- Author
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Thompson, M. J. W., Aitken, D. A., Mei, I. A., Otahal, P., Cicolini, J., Winzenberg, T. M., and Jones, G.
- Subjects
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HEALTH of older people , *SKIN examination , *TOPOGRAPHY , *PHYSIOLOGICAL effects of ultraviolet radiation , *BACK , *RADIOIMMUNOASSAY - Abstract
Background and purpose The Beagley-Gibson ( BG) grading system utilizes microtopographical skin changes to generate an individualized, objective estimate of cumulative, lifetime ultraviolet radiation ( UVR) exposure. However, predictors of BG grade are ill-defined, particularly in older populations. The aim of this cross-sectional study was to describe the factors associated with skin damage as measured by the BG method in 835 community-dwelling older adults. Methods Study participants aged 53-83 years had silicone casts taken from the dorsum of both hands and graded by the BG method. Lifetime sun exposure, skin phenotypic traits and smoking status were assessed by questionnaire. 25-hydroxyvitamin D and melanin density were measured using radioimmunoassay and spectrophotometry, respectively. Ordered logistic regression was used to compute a single odds ratio ( OR) by taking BG grade as the outcome variable. Results Higher 25-hydroxyvitamin D was associated with increasing BG grade ( OR = 1.39, P = 0.02) in adjusted analysis. Age ( OR = 1.14, P < 0.001), occupational sun exposure ( OR = 1.62, P < 0.001), ability to tan ( OR = 1.40, P < 0.001), melanin density ( OR=0.79, P = 0.001), lifetime leisure time sun exposure ( OR = 1.21, P = 0.004), current smoking ( OR = 1.82, P = 0.007), propensity to sunburn ( OR = 1.18, P = 0.016), and waist-hip ratio ( OR = 1.10, P = 0.02) were independent predictors of BG grade. Hair colour, number of sunburns, body mass index and gender were not independent predictors of BG grade. Conclusions Beagley-Gibson skin cast grade is a biologically relevant marker of UVR exposure in older adults influenced by both intrinsic and extrinsic factors. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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8. Comparison of Grenz ray and photodynamic therapy for field treatment of actinic keratoses on the forearm: A case series
- Author
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W. Harris Green, Christopher M. Wolfe, Lauren Angnardo, and Armand B. Cognetta
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Male ,Dorsum ,medicine.medical_specialty ,Actinic Damage ,medicine.medical_treatment ,Photodynamic therapy ,Dermatology ,X-Ray Therapy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Forearm ,medicine ,Humans ,Aged ,Aged, 80 and over ,business.industry ,Actinic keratosis ,Actinic keratoses ,Middle Aged ,medicine.disease ,Keratosis, Actinic ,Radiation therapy ,medicine.anatomical_structure ,Photochemotherapy ,030220 oncology & carcinogenesis ,Grenz ray therapy ,Dry Needling ,Female ,business - Abstract
Background Actinic Keratosis is an intraepidermal neoplasm that represents the second most common reason for dermatologic visits in the United States. Sustained clearance with existing therapies is highly variable. Objective To assess the effects of combination and monotherapy with photodynamic therapy (PDT), grenz ray therapy, and PDT with microneedling (microchannel skin system) for actinic damage of the dorsal forearms and hands. Methods Full ethics approval was obtained through a Human Subjects Committee. Four patients with diffuse actinic field damage on their forearms and hands were recruited for the study. The dorsal forearm and hand from the elbow to the metacarpophalangeal joint were divided into four equal sections. Section 1 was treated with PDT. Section 2 was treated with grenz ray. Section 3 was treated with PDT plus microneedling. Section 4 was treated with grenz ray and PDT with microneedling. Lesion counts were recorded with transparent grids, photographed and evaluated by the same investigator at baseline, 1, 2, 3 and 6 months. Results At month 6 post treatment, lesion counts, as a per cent reduction from baseline, were 91.7% in section 1 (PDT); 97.3% in section 2 (grenz ray); 92.9% in section 3 (PDT + microneedle); and 93.9% in section 4 (grenz ray + PDT + microneedle). Conclusion The greatest reduction occurred in the grenz ray monotherapy section and the second greatest reduction in the grenz ray, PDT, microneedling section. Further research on the efficacy of grenz ray therapy for field treatment of actinic keratosis of the forearms and hands is needed.
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- 2020
9. ¿Reconoce esta clave diagnóstica? Parte 2
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Karen M. Buitrago, Juan P. Ospina, Javier Canedo, Juan Botero, and Daniela Bertel
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Quality of evidence ,medicine.medical_specialty ,Management strategy ,Actinic Damage ,business.industry ,Leukocytoclastic vasculitis ,Etiology ,medicine ,General Medicine ,Disease ,business ,Dermatology - Abstract
Se trata de una enfermedad cutánea inflamatoria, benigna e infrecuente que corresponde a una vasculitis leucocitoclástica de vasos pequeños. Típicamente compromete el rostro, de etiología desconocida, aunque se ha planteado daño actínico, entre otras posibles causas. Se manifiesta como pápulas, placas o nódulos de color marrón rojizo a violáceo, bien definidas, infiltradas, de superficie brillante, que muestran acentuación folicular y telangiectasias. Esta entidad tiene un curso indolente y benigno, los pacientes suelen buscar tratamiento por estética y por su curso crónico. No existen guías de manejo ni buena calidad de evidencia con respecto al tratamiento, por lo que la estrategia de manejo debe individualizarse.
- Published
- 2019
10. Assessment of Actinic Elastosis by 20-MHz Sonography
- Author
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Dirschka, Th., Hoffmann, K., Altmeyer, P., Altmeyer, Peter, editor, Hoffmann, Klaus, editor, and Stücker, Markus, editor
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- 1997
- Full Text
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11. Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia
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Amy R. Williams, Sabina Bashir, Davina A. Lewis, Robert R Hoopes, Michael G. Kemp, Michael P. Markey, Jonathan Weyerbacher, Mathew M. Loesch, Kenneth Y. Tsai, David H. Southern, Dan F. Spandau, Matthew Kuhar, Jeffrey J. Wargo, Christina Knisely, Elizabeth Cates, Sunil S. Tholpady, Jeffrey B. Travers, Amber J. Castellanos, Angela Zhang, Craig A Rohan, Ryan D. Gabbard, and Roy Chen
- Subjects
Male ,medicine.medical_specialty ,Skin Neoplasms ,Actinic Damage ,Ultraviolet Rays ,Human skin ,Receptor, IGF Type 1 ,law.invention ,Mice ,Randomized controlled trial ,law ,medicine ,Animals ,Humans ,Aged ,Aged, 80 and over ,integumentary system ,business.industry ,Actinic keratosis ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Skin Aging ,Keratosis, Actinic ,Increased risk ,Cohort ,Female ,Laser Therapy ,Clinical Medicine ,Skin cancer ,business ,UVB Radiation - Abstract
BACKGROUND: The loss of insulin-like growth factor 1 (IGF-1) expression in senescent dermal fibroblasts during aging is associated with an increased risk of nonmelanoma skin cancer (NMSC). We tested how IGF-1 signaling can influence photocarcinogenesis during chronic UVB exposure to determine if fractionated laser resurfacing (FLR) of aged skin, which upregulates dermal IGF-1 levels, can prevent the occurrence of actinic keratosis (AK) and NMSC. METHODS: A human skin/immunodeficient mouse xenografting model was used to test the effects of a small molecule inhibitor of the IGF-1 receptor on chronic UVB radiation. Subsequently, the durability of FLR treatment was tested on a cohort of human participants aged 65 years and older. Finally, 48 individuals aged 60 years and older with considerable actinic damage were enrolled in a prospective randomized clinical trial in which they underwent a single unilateral FLR treatment of one lower arm. Numbers of AKs/NMSCs were recorded on both extremities for up to 36 months in blinded fashion. RESULTS: Xenografting studies revealed that chronic UVB treatment with a topical IGF-1R inhibitor resulted in a procarcinogenic response. A single FLR treatment was durable in restoring appropriate UVB response in geriatric skin for at least 2 years. FLR resulted in sustained reduction in numbers of AKs and decreased numbers of NMSCs in the treated arm (2 NMSCs) versus the untreated arm (24 NMSCs). CONCLUSION: The elimination of senescent fibroblasts via FLR reduced the procarcinogenic UVB response of aged skin. Thus, wounding therapies are a potentially effective prophylaxis for managing high-risk populations. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03906253). FUNDING: National Institutes of Health, Veterans Administration.
- Published
- 2021
12. Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)
- Author
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Alida Avenant, Paolo Pazzi, Nicolize O'Dell, Louise van der Weyden, and Katja Natalie Koeppel
- Subjects
Lions ,Male ,medicine.medical_specialty ,Pathology ,skin ,Hypofractionated Radiation Therapy ,Skin Neoplasms ,040301 veterinary sciences ,medicine.medical_treatment ,Veterinary medicine ,Nose Neoplasms ,Case Report ,radiation therapy ,030308 mycology & parasitology ,0403 veterinary science ,03 medical and health sciences ,laminar fibrosis ,SF600-1100 ,medicine ,Animals ,cancer ,Neoplastic transformation ,actinic damage ,0303 health sciences ,lion ,General Veterinary ,business.industry ,Actinic keratosis ,Cancer ,04 agricultural and veterinary sciences ,General Medicine ,medicine.disease ,Dyskeratosis ,uv ,Radiation therapy ,stomatognathic diseases ,Dysplasia ,Carcinoma, Squamous Cell ,Histopathology ,Radiation Dose Hypofractionation ,business - Abstract
Cutaneous squamous cell carcinoma (SCC) is a slow growing but locally invasive neoplasm, most commonly caused by prolonged exposure to ultraviolet (UV) radiation. Whilst SCC accounts for 15% of skin tumours in domesticated cats, cutaneous SCC in non-domesticated felids (apart from captive snow leopards) appears to be uncommon, with only three reports in the literature to date. In this report, a captive African lion (Panthera leo) presented with two ulcerative lesions on the nasal planum. Histopathology of the lesions revealed epidermal keratinocyte dysplasia and neoplastic basal- and supra-basal epithelial cells with dyskeratosis and evidence of basement membrane breaching and dermal invasion, consistent with a diagnosis of SCC. There was also evidence of laminar fibrosis and inflammation of the subjacent dermis suggesting that the SCC most likely resulted from UV-induced neoplastic transformation of the epidermal squamous epithelium following actinic keratosis. The lion was treated with hypofractionated radiation therapy and remained in remission until his death (euthanised 17 months later because of age-related chronic renal failure). This is the first report of cutaneous SCC in a lion with evidence of actinic damage and resolution after radiation therapy.
- Published
- 2021
13. Canfield Reveal Image changes following sun exposure.
- Author
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Carboni A, Kirk JM, Marroquin N, Furth G, Small JM, and Dellavalle RP
- Abstract
Competing Interests: Dr Dellavalle is a member of the Colorado Skin Cancer Task Force. Authors Carboni, Kirk, Marroquin, Furth, and Small have no conflicts of interest to declare.
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- 2023
- Full Text
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14. Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin.
- Author
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Jaimes, Natalia, Marghoob, Ashfaq A., Rabinovitz, Harold, Braun, Ralph P., Cameron, Alan, Rosendahl, Cliff, Canning, Greg, and Keir, Jeffrey
- Abstract
Background Melanomas on chronically sun-damaged skin (CSDS) can be difficult to identify and often manifest morphologic features that overlap with benign lesions. Objective We describe and analyze the clinical and dermoscopic characteristics of melanomas on nonfacial CSDS. Methods Melanoma cases on nonfacial CSDS were retrospectively identified from the biopsy specimen logs of 6 melanoma clinics. Clinical and dermoscopic images were combined into 1 database. Demographics, clinical, dermoscopic, and histopathologic information were analyzed. Descriptive frequencies were calculated. Results One hundred eighty-six cases met the inclusion criteria: 142 melanomas in situ (76%) and 39 invasive (21%; mean thickness, 0.49 mm). Lentigo maligna was the most common histopathologic subtype (n = 76; 40.9%). The most frequent dermoscopic structures were granularity (n = 126; 67.7%) and angulated lines (n = 82; 44%). Vascular structures were more frequent in invasive melanomas (56% vs 12% of in situ melanomas). Most manifested 1 of 3 dermoscopic patterns: patchy peripheral pigmented islands, angulated lines, and tan structureless with granularity pattern. Limitations This was a retrospective study, and evaluators were not blinded to the diagnosis. In addition, interobserver concordance and sensitivity and specificity for dermoscopic structures were not evaluated. Conclusion Outlier lesions manifesting dermoscopic structures, such as granularity, angulated lines, or vessels and any of the 3 described dermoscopic patterns should raise suspicion for melanoma. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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15. Steatocystomas of the head and neck are associated with actinic damage
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Melissa Butt, Christopher Chu, Deep Patel, Klaus F. Helm, and Yesul Kim
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medicine.medical_specialty ,Keratosis ,Epidermal Cyst ,Actinic Damage ,business.industry ,Dermatology ,medicine.disease ,Keratosis, Actinic ,medicine ,Head (vessel) ,Humans ,Head and neck ,business ,Steatocystomas ,Head ,Neck - Published
- 2020
16. Field cancerization: Looking to the future.
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Willenbrink, Tyler J., Ruiz, Emily S., Cornejo, Christine M., Schmults, Chrysalyne D., Arron, Sarah T., and Jambusaria-Pahlajani, Anokhi
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- 2021
- Full Text
- View/download PDF
17. Field cancerization: Looking to the future
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Sarah T. Arron, Tyler J. Willenbrink, Christine M. Cornejo, Chrysalyne D. Schmults, Anokhi Jambusaria-Pahlajani, and Emily S. Ruiz
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medicine.medical_specialty ,Cutaneous squamous cell carcinoma ,Actinic Damage ,business.industry ,Actinic keratosis ,Medicine ,Field cancerization ,Dermatology ,Actinic keratoses ,business ,medicine.disease - Published
- 2021
18. Severe widespread actinic damage and squamous cell carcinoma: could hydrochlorothiazide be implicated? A report of two cases
- Author
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Grant Wylie and Amrita Randhawa
- Subjects
Aged, 80 and over ,medicine.medical_specialty ,Skin Neoplasms ,Actinic Damage ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Dermatology ,Hydrochlorothiazide ,medicine ,Carcinoma ,Carcinoma, Squamous Cell ,Humans ,Basal cell ,Female ,Photosensitivity Disorders ,business ,Diuretics ,medicine.drug - Published
- 2020
19. Erosive pustular dermatosis of the scalp following surgical procedures: a systematic review
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Rachel L. Giesey, Jeffrey F. Scott, Stephanie Saridakis, and Harib H. Ezaldein
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medicine.medical_specialty ,Actinic Damage ,business.industry ,medicine.medical_treatment ,Dermatology ,General Medicine ,Surgical procedures ,Local skin flap ,Erosive pustular dermatosis ,Secondary intention ,medicine.anatomical_structure ,Scalp ,medicine ,Skin grafting ,business - Abstract
Erosive pustular dermatosis of the scalp (EPDS) occurs in elderly individuals with significant actinic damage. EPDS also occurs in association with surgery; however, significant studies determining an association of EPDS with type of surgical closure is absent. This review examines whether the closure method following cutaneous surgery performed on the scalp is associated with development of EPDS. Databases were reviewed and studies describing EPDS after cutaneous surgery met inclusion criteria. Articles were excluded if EPDS developed after trauma or non-surgical procedures. Descriptive analyses were performed on the data. Thirteen case reports and 6 case series involving 32 patients met inclusion criteria. Fourteen articles (73.7%) stated that EPDS developed in the same location as, or near to, the closure site. Thirteen patients (40.6%) developed EPDS following skin grafting. Three patients (9.4%) developed EPDS following secondary intention healing, two patients (6.3%) following repair by primary intention, and one patient (3.1%) following repair with a local skin flap. Thirteen cases (40.6%) did not specify closure type. This review revealed that surgical procedures performed on the scalp utilizing skin grafts for closure may be increasingly associated with the development of EPDS compared to other closure types.
- Published
- 2020
20. Low irradiance compared with conventional photodynamic therapy in the treatment of actinic keratoses
- Author
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Ina Bosselmann, Julika Dick, Alexander Enk, and Patrick Gholam
- Subjects
Male ,medicine.medical_specialty ,Actinic Damage ,medicine.medical_treatment ,Immunology ,Treatment outcome ,Pain ,Photodynamic therapy ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,polycyclic compounds ,medicine ,Humans ,Immunology and Allergy ,Radiology, Nuclear Medicine and imaging ,Aged ,Pain Measurement ,Retrospective Studies ,Aged, 80 and over ,Multiple actinic keratoses ,business.industry ,Retrospective cohort study ,General Medicine ,Actinic keratoses ,Middle Aged ,Cheek ,eye diseases ,Keratosis, Actinic ,medicine.anatomical_structure ,Photochemotherapy ,Forehead ,Female ,business ,therapeutics ,030217 neurology & neurosurgery - Abstract
BACKGROUND Photodynamic therapy (PDT) is an effective therapy treating photodamaged areas with multiple actinic keratoses (AK). Still pain during therapy is one of the most challenging obstacles for patients. This retrospective study compares pain and efficacy intra-individual in patients using conventional PDT (c-PDT) compared to a low irradiance PDT protocol (li-PDT) with a reduced irradiance to 25% of c-PDT. METHODS Thirty-one patients were enrolled into this retrospective analysis treated with li-PDT and c-PDT on comparable fields of actinic damage on the forehead or the cheek. Pain was scored by the patients using a VAS. Moreover, number and time to therapy interruptions were documented. For effectiveness number and grade of AK were counted before and 4 weeks after PDT. RESULTS Maintaining a total light dose of 37 J/cm2 , a decrease in irradiation in li-PDT patients resulted in significant less pain (VAS score 2.8 vs 7.6) and fewer therapy interruptions compared to treatment with c- PDT (P
- Published
- 2018
21. Generalised papular variant of elastolytic giant cell granuloma
- Author
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Catarina Araújo, Maria José Guimarães, Regina Caldas, and A. Rodrigues
- Subjects
Papular eruption ,medicine.medical_specialty ,Actinic Damage ,Giant Cell Granuloma ,Asymptomatic ,Griseofulvin ,Pathogenesis ,Diabetes Complications ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Granuloma Annulare ,0302 clinical medicine ,Granuloma, Giant Cell ,medicine ,Humans ,Obesity ,Aged ,Unusual Presentation of More Common Disease/Injury ,business.industry ,General Medicine ,medicine.disease ,Dermatology ,Response to treatment ,Actinic granuloma ,Treatment Outcome ,030220 oncology & carcinogenesis ,Etiology ,medicine.symptom ,business ,Hydroxychloroquine - Abstract
Elastolytic giant cell granuloma (EGCG), also known as actinic granuloma, is an uncommon granulomatous dermatosis usually characterised by asymptomatic annular plaques on sun-exposed skin. Its aetiology is not fully elucidated, but actinic damage has been considered the main causal factor. Atypical variants with lesions in a non-photodistributed pattern are rare and often related to a systemic disorder, suggesting a more complex pathogenesis and demanding for a screening work-up. Herein, we report a case of an adult obese, diabetic woman presenting with a generalised pruritic papular eruption, histologically revealing an elastolytic giant cell granuloma, with a good response to treatment. In this case, the dermatosis was probably associated with her metabolic comorbidities.
- Published
- 2019
22. Chemical Peel (Deep, Medium, Light)
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Sidney J. Starkman and Devinder S. Mangat
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Modern medicine ,integumentary system ,Actinic Damage ,business.industry ,Chemical peel ,Yield (finance) ,Patient Selection ,Pulp and paper industry ,Skin Aging ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Chemexfoliation ,Skin resurfacing ,Chemical peeling ,Medicine ,Humans ,Rejuvenation ,Surgery ,sense organs ,030223 otorhinolaryngology ,business - Abstract
With modern medicine increasing both the average life span and quality of life, there has been a greater demand for treatment of age-related skin changes. As many new options in skin resurfacing are developed annually, it is chemical peeling that has withstood the trials of time and scrutiny. The different variations of chemoexfoliation have been used for rhytids, actinic damage, lentigos, and dyschromias. This article describes the most recent knowledge about chemical peeling, and exposes previously accepted yet incorrect dogmas. Chemical peeling, when practiced with knowledge and good technique, can yield excellent results in skin rejuvenation.
- Published
- 2019
23. Growth rate of clinically diagnosed superficial basal cell carcinoma and changes in dermoscopic features over time
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Gemma L. Clayton, Amanda Oakley, Christina Wlodek, Adam Trickey, and Adrian Jonathan Sykes
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Male ,medicine.medical_specialty ,dermoscopic ,Skin Neoplasms ,Actinic Damage ,growth ,Dermoscopy ,Dermatology ,Superficial basal cell carcinoma ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,basal cell carcinoma ,medicine ,Humans ,Basal cell carcinoma ,Family history ,sBCC ,Aged ,Retrospective Studies ,skin cancer ,business.industry ,Melanoma ,Middle Aged ,medicine.disease ,Fitzpatrick Skin Phototype ,superficial ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Mixed effects ,Female ,dermoscopy ,Skin cancer ,business - Abstract
Background/ObjectivesBasal cell carcinoma (BCC) is the most commonly occurring skin cancer. BCCs have been found to generally grow slowly. Data are limited on how the dermoscopic characteristics of BCCs evolve. We set out to determine the growth rate of superficial BCCs (sBCC) and assess the change in dermoscopic features over time.MethodsA retrospective review was performed of clinically diagnosed sBCC. Images, demographic and dermoscopic data were collected by a melanographer. Mixed effects linear regression models were used to investigate sBCC growth and associations between size and dermoscopic/demographic variables. We tested differences in trends over time in dermoscopic features using non‐parametric trend tests.Results100 individual sBCC were evaluated in 70 patients (mean age 62; 59% male), 69% had Fitzpatrick skin phototype 1 or 2, and 81% had some degree of actinic damage. sBCC were present on the back in 58% and 22% of men and women, respectively. The median surface area was 41.9 mm2 with a growth rate of 0.81 mm2/month. Males had larger sBCC than females. There was no association between sBCC size and Fitzpatrick skin phototype, history of skin cancer or family history of melanoma. There is some evidence larger sBCC gain shiny white structures (P = 0.053) over time.ConclusionssBCC grow at a rate unlikely to adversely affect patient outcomes associated with long wait times. Our data suggest that dermoscopy can aid in appropriate treatment selection for sBCC.
- Published
- 2019
24. ‘Scalp coordinate system’: a new tool to accurately describe cutaneous lesions on the scalp: a pilot study
- Author
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Michael A. Henderson, William Alexander, Preeya Alexander, George Miller, and Angela Webb
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Novel technique ,medicine.medical_specialty ,Skin Neoplasms ,Actinic Damage ,Pilot Projects ,Dermatology ,Manikins ,Time cost ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,In patient ,Radiation oncologist ,Scalp ,integumentary system ,business.industry ,Reproducibility of Results ,General Medicine ,Surgical procedures ,medicine.anatomical_structure ,Education, Medical, Graduate ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Radiology ,business ,Healthcare system - Abstract
BACKGROUND Skin cancers are extremely common and the incidence increases with age. Care for patients with multiple or complicated skin cancers often require multidisciplinary input involving a general practitioner, dermatologist, plastic surgeon and/or radiation oncologist. Timely, efficient care of these patients relies on precise and effective communication between all parties. Until now, descriptions regarding the location of lesions on the scalp have been inaccurate, which can lead to error with the incorrect lesion being excised or biopsied. METHODS A novel technique for accurately and efficiently describing the location of lesions on the scalp, using a coordinate system, is described (the 'scalp coordinate system' (SCS)). This method was tested in a pilot study by clinicians typically involved in the care of patients with cutaneous malignancies. A mannequin scalp was used in the study. RESULTS The SCS significantly improved the accuracy in the ability to both describe and locate lesions on the scalp. This improved accuracy comes at a minor time cost. DISCUSSION The direct and indirect costs arising from poor communication between medical subspecialties (particularly relevant in surgical procedures) are immense. An effective tool used by all involved clinicians is long overdue particularly in patients with scalps with extensive actinic damage, scarring or innocuous biopsy sites. The SCS provides the opportunity to improve outcomes for both the patient and healthcare system.
- Published
- 2018
25. Erosive Pustular Dermatosis: A Manifestation of Immunosenescence A Report of 8 Cases
- Author
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Paradi Mirmirani and Thusanth Thuraisingam
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Epidermal barrier ,integumentary system ,Actinic Damage ,business.industry ,Dermatology ,Immunosenescence ,Scarring alopecia ,medicine.disease ,Erosive pustular dermatosis ,Pathogenesis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Male patient ,Scalp ,medicine ,Original Article ,business - Abstract
Erosive pustular dermatosis (EPD) is a rare condition of the scalp and legs that is marked by crusted erosions or superficial ulcerations that may result in scarring alopecia and chronic wounds. The condition predominantly affects elderly female as compared to male patients. Its pathogenesis remains poorly understood. The majority of the cases in the literature are from the United Kingdom and continental Europe. In this series, we present 8 North American patients with EPD of the scalp, one of whom also had involvement of the legs and another with the involvement of the face. All our patients were advanced in age and had a predisposition to chronic actinic damage, which are common characteristics of EPD previously reported in the literature. We hypothesize that immunosenescence leads to an aberrant immune response to wound healing and, along with other factors such as a loss of the normal epidermal barrier, ultraviolet damage, and hormonal factors, may contribute to the development of this condition.
- Published
- 2017
26. Reversing precancerous actinic damage by mixing wavelengths (1064 nm, 532 nm).
- Author
-
Demetriou, Constantinos
- Subjects
- *
ND-YAG lasers , *PRECANCEROUS conditions , *SKIN cancer , *MEDICAL lasers , *ACTINIC keratosis , *PHOTOCHEMOTHERAPY , *CANCER treatment , *THERAPEUTICS - Abstract
Background: Premalignancies resulting from photodamage, such as actinic keratosis and carcinoma in situ, can be treated with various modalities. Most of these treatments may reverse or treat these conditions although they often involve considerable skin irritation over a long period of time, are very uncomfortable for the patients or they need many office visits and sometimes are very expensive, such as photodynamic therapy (PDT). Objective: To study the effectiveness of a mixed session of Q-switched KTP 532 nm and Nd:YAG 1064 nm laser treatment on precancerous lesions resulting from solar damage. Methods: Ten patients with long-standing actinic damage/keratosis or carcinoma in situ were subjected to only one session of mixed Q-switched KTP 532 nm and Nd:YAG 1064 nm laser treatment. Lesions were evenly and repeatedly scanned with both wavelengths until light pain or purpura presented. Results: All patients responded extremely well within a period of 20 days, with just one session, with virtually no pain, minimum irritation, no down time at all and excellent cosmetic outcome. Conclusion: The use of a mixed Q-switched 532 nm and Nd:YAG 1064 nm laser session seems to be ideal for treating precancerous lesions resulting from photodamage since it can be a fast, painless and simple office procedure with no down time and minimum discomfort for the patient. This method proves to be much more selective than traditional intense pulse light (IPL) photorejuvenation. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
27. Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors
- Author
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Gandini, Sara, Sera, Francesco, Cattaruzza, Maria Sofia, Pasquini, Paolo, Zanetti, Roberto, Masini, Cinzia, Boyle, Peter, and Melchi, Carmelo Francesco
- Subjects
- *
NEUROENDOCRINE tumors , *CANCER risk factors , *GENOTYPE-environment interaction , *SKIN care - Abstract
Abstract: A systematic meta-analysis of observational studies of melanoma and family history, actinic damage and phenotypic factors was conducted as part of a comprehensive meta-analysis of all major risk factors for melanoma. Following a systematic literature search, relative risks were extracted from 60 studies published before September 2002. Fixed and random effects models were used to obtain pooled estimates for family history (RR=1.74, 1.41–2.14), skin type (I vs. IV: RR=2.09, 1.67–2.58), high density of freckles (RR=2.10, 1.80–2.45), skin colour (Fair vs. Dark: RR=2.06, 1.68–2.52), eye colour (Blue vs. Dark: RR=1.47, 1.28–1.69) and hair colour (Red vs. Dark: RR=3.64, 2.56–5.37), pre-malignant and skin cancer lesions (RR=4.28, 2.80–6.55) and actinic damage indicators (RR=2.02, 1.24–3.29). Sub-group analysis and meta-regression were carried out to explore sources of between-study variation and bias. Sensitivity analyses investigated reliability of results and publication bias. Latitude and adjustment for phenotype were two study characteristics that significantly influenced the estimates. [Copyright &y& Elsevier]
- Published
- 2005
- Full Text
- View/download PDF
28. Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres.
- Author
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Hunzelmann, N., Nischt, R., Brenneisen, P., Eickert, A., and Krieg, T.
- Subjects
- *
EXTRACELLULAR matrix proteins , *SKIN physiology , *ELASTIN - Abstract
Background Fibulin-2 is a 195-kDa protein belonging to a novel family of extracellular matrix proteins that might be involved in microfibril and elastic fibre organization. Objectives To determine the localization of fibulin-2 in relation to elastic fibres in normal skin and in solar elastosis characterized by increased elastotic material in the papillary dermis. Methods The expression and synthesis of fibulin-2 was investigated by means of in situ hybridization, immunohistochemistry and Western blot analysis in normal and photoaged skin. Results Immunohistochemistry and elastic tissue staining revealed that fibulin-2 deposition mainly colocalized with microfibrils and elastin fibres, with a marked staining of elastotic material in solar elastosis. Western blot analysis demonstrated that in photoaged skin fibulin-2 showed the same electrophoretic mobility as in sun-protected skin. However, in actinic elastosis the amount of fibulin-2 was significantly higher. In addition, smaller degradation products were detectable, presumably reflecting increased proteinase activity in photodamaged skin. Conclusions This study shows that deposition of fibulin-2 and elastin is highly co-ordinated, indicating that this protein plays an important role in elastic fibre and microfibril formation in normal and actinically damaged skin. [ABSTRACT FROM AUTHOR]
- Published
- 2001
- Full Text
- View/download PDF
29. Reversed actinic damage in two children with xeroderma pigmentosum treated with topical imiquimod
- Author
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Nicole Knöpfel, Antonio Torrelo, I Latour, Angela Hernández-Martín, Cécile Ged, and Alain Taieb
- Subjects
medicine.medical_specialty ,Xeroderma pigmentosum ,Actinic Damage ,business.industry ,Dermatology ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,medicine ,Carcinoma ,030212 general & internal medicine ,Topical imiquimod ,business - Published
- 2018
30. Erosive pustular dermatosis of the scalp in an adolescent with near-total hair regrowth: Case report and review of the literature
- Author
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James R. Treat, Christopher Teng, Adam I. Rubin, JiaDe Yu, and Jesse A. Taylor
- Subjects
medicine.medical_specialty ,Actinic Damage ,Adolescent ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,integumentary system ,Skin Diseases, Vesiculobullous ,business.industry ,Dysostosis ,Alopecia ,medicine.disease ,Erosive pustular dermatosis ,medicine.anatomical_structure ,Neutrophilic dermatosis ,Scalp Dermatoses ,030220 oncology & carcinogenesis ,Scalp ,Pediatrics, Perinatology and Child Health ,Chronic inflammatory response ,Female ,Presentation (obstetrics) ,business - Abstract
Erosive pustular dermatosis of the scalp (EPDS) is an uncommon chronic inflammatory response to scalp trauma that usually resolves with cicatricial alopecia. It most commonly affects elderly patients with a history of actinic damage. Herein, we describe a 16-year-old girl with acrofacial dysostosis type 1 presenting after surgery with crusting purulent scalp lesions, whose clinical presentation and histopathologic findings were consistent with EPDS. A review of the literature on EPDS in children is also detailed.
- Published
- 2019
31. Post‐traumatic erosive dermatosis of the scalp: A hypergranulated variant
- Author
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Francesco Savoia, Aurora Alessandrini, Annalisa Patrizi, Michela Tabanelli, Cosimo Misciali, Andrea Sechi, Bianca Maria Piraccini, Lidia Sacchelli, and Sechi Marco, Piraccini BM, Alessandrini A, Patrizi A, Tabanelli M, Sacchelli L, Misciali C, Savoia F.
- Subjects
Male ,medicine.medical_specialty ,Actinic Damage ,Administration, Topical ,Dermoscopy ,Dermatology ,Chronic inflammatory disease ,Betamethasone ,Scalp Dermatosis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Glucocorticoids ,scalp dermatosis ,Aged ,Aged, 80 and over ,Scalp ,Skin Diseases, Vesiculobullous ,integumentary system ,business.industry ,Erosive pustular dermatosis ,Anti-Bacterial Agents ,medicine.anatomical_structure ,Scalp Dermatoses ,Male patient ,030220 oncology & carcinogenesis ,business ,Fusidic Acid - Abstract
Erosive pustular dermatosis of the scalp is a slowly progressive chronic inflammatory disease that predominantly affects elderly male patients with marked actinic damage. The clinical evolution consists firstly of keratotic and erosive plaques surmounted by yellow-brown crusts and non-follicular pustules; later, the active crusting lesions regress in number and the scarring process causes diffuse cutaneous thinning and loss of hair follicles. However, manifestations may be atypical, leading to frequent misdiagnosis. We present a case series of post-traumatic erosive pustular dermatosis on the scalp of 4 elderly patients. The characterising feature was the presence of erosion consisting of abundant hypergranulation tissue, with an almost total lack of crusts and pustules. Dermoscopy showed a unique pattern of stretched and dilated linear, telangiectatic and polymorphous on-focus vessels, milky-red areas and white scarring areas. This clinical entity is rarely reported in the literature. The majority of reported cases were located on the legs.
- Published
- 2019
32. Actinic damage of Y/Mo multilayer Bragg optics in a tabletop extreme ultraviolet laser
- Author
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Davide Bleiner
- Subjects
Materials science ,Optics ,Actinic Damage ,law ,business.industry ,Extreme ultraviolet ,Laser ,business ,law.invention - Published
- 2019
33. Erosive Pustular Dermatosis of the Scalp: Why Do We Miss It?
- Author
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Vincenzo Piccolo, Andrea Ronchi, Giuseppe Argenziano, Teresa Russo, Roberto Alfano, Stephanie Bianco, Piccolo, Vincenzo, Russo, Teresa, Bianco, Stephanie, Ronchi, Andrea, Alfano, Roberto, and Argenziano, Giuseppe
- Subjects
Male ,medicine.medical_specialty ,Delayed Diagnosis ,Actinic Damage ,Dermoscopy ,Thricoscopy ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Squamous cell carcinoma ,Medicine ,Humans ,Basal cell carcinoma ,Basal cell ,Diagnostic Errors ,Aged ,Retrospective Studies ,Aged, 80 and over ,Suppuration ,Skin Diseases, Vesiculobullous ,business.industry ,Incidence (epidemiology) ,Actinic keratosis ,Erosive pustular dermatosis of the scalp ,Middle Aged ,medicine.disease ,Erosive pustular dermatosis ,medicine.anatomical_structure ,Scalp Dermatoses ,030220 oncology & carcinogenesis ,Scalp ,Misdiagnosi ,Female ,business - Abstract
Erosive pustular dermatosis of the scalp (EPDS) is an uncommon disease and primarily affects older men who have photo-damaged bald scalp, as was confirmed by our case series. EPDS is probably an overlooked disease, whose diagnosis is often missed because of a higher incidence of other cutaneous diseases affecting the same area and usually secondary to chronic actinic damage, such as actinic keratosis, basal cell carcinoma, and squamous cell carcinoma. For the first time, we report a case series of misdiagnosed EPDS with the aim of understanding why a diagnosis of EPDS was initially missed and try to give some tips to avoid future diagnostic delay.
- Published
- 2019
34. Erosive pustular dermatosis of the scalp - an Australian perspective: Insights to aid clinical practice
- Author
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David Wong, Rudy Yeh, and Margit Marisa Polcz
- Subjects
medicine.medical_specialty ,Actinic Damage ,Calcineurin Inhibitors ,Anti-Inflammatory Agents ,Dermoscopy ,Dermatology ,Betamethasone ,Tacrolimus ,Curettage ,Diagnosis, Differential ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,medicine ,Humans ,Glucocorticoids ,Skin Diseases, Vesiculobullous ,business.industry ,Incidence ,Australia ,Erosive pustular dermatosis ,body regions ,Clinical Practice ,medicine.anatomical_structure ,Scalp Dermatoses ,030220 oncology & carcinogenesis ,Scalp ,business ,Mometasone Furoate ,Algorithms - Abstract
Erosive pustular dermatosis of the scalp has particular relevance in Australia, due to its association with actinic damage. Despite its rarity, the recalcitrant nature of erosive pustular dermatosis of the scalp dictates a protracted recovery fraught with relapse and recurrence, posing inherent challenges to successful treatment and complete recovery. In Australia, erosive pustular dermatosis of the scalp is prevalent in the elderly, who are negatively affected due to the condition. We propose a management outline to aid clinical practice, to improve the quality of life in the elderly, whilst providing insight into the current understanding and treatment of erosive pustular dermatosis of the scalp.
- Published
- 2018
35. Field cancerization in the skin: Past errors repeated.
- Author
-
Morton, Sarah and Muir, James
- Published
- 2021
- Full Text
- View/download PDF
36. Clinical comparison of actinic changes preceding squamous cell carcinoma vs. intraepidermal carcinoma in renal transplant recipients
- Author
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H Soyer, Adèle C. Green, Peter O'Rourke, and Zainab Jiyad
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,Actinic Damage ,Dermatology ,digestive system ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,parasitic diseases ,medicine ,Humans ,Basal cell ,business.industry ,Actinic keratosis ,Intraepidermal carcinoma ,medicine.disease ,Kidney Transplantation ,digestive system diseases ,Keratosis, Actinic ,stomatognathic diseases ,Renal transplant ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Epidermis ,business ,tissues ,Carcinoma in Situ - Abstract
Summary Intraepidermal carcinoma (IEC) is a type of in situ squamous cell carcinoma (SCC), although progression of IEC is rare. We sought to investigate differences between the actinic skin changes preceding the development of both SCC and IEC. Photographs of 63 skin sites at which either SCC or IEC subsequently developed in 37 renal transplant recipients (RTRs) were examined for features of actinic change. We found that areas of skin with an actinic keratosis (AK) > 1 cm2 in size were four times more likely to develop SCC as opposed to IEC (OR = 4.42; 95% CI 1.25–15.60). Skin sites with ≥ 25% of the area affected by AK were again four times more likely to develop SCC than IEC. These results highlight the scale of visible actinic damage required for development of SCC compared with IEC, emphasizing the importance of treating areas of skin with marked visible actinic change to reduce SCC risk in RTRs.
- Published
- 2017
37. Linearized solar elastosis of the legs: A novel presentation and review of the literature
- Author
-
Christina Lam, Mary M. Barrett, Jonathan D. Ho, Judy Cheng, and Hye Jin Chung
- Subjects
Pathology ,medicine.medical_specialty ,Histology ,integumentary system ,Actinic Damage ,business.industry ,food and beverages ,Dermatology ,Elastic Tissue ,Pathology and Forensic Medicine ,Skin Aging ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,biological sciences ,Medicine ,Humans ,Female ,Presentation (obstetrics) ,Anatomic Location ,business ,Ultraviolet radiation ,Aged - Abstract
There exists a spectrum of solar elastotic variants based on the clinical and histopathologic findings. We present here a peculiar case of solar elastosis that is unusual in its anatomic location, relative lack of background actinic damage, and pattern of linearization. Its presentation suggests that other factors in addition to ultraviolet radiation may play a role in the pathogenesis of solar elastosis.
- Published
- 2018
38. Aesthetics and Rejuvenation of the Temple
- Author
-
Jordan Rihani
- Subjects
Male ,Actinic Damage ,Esthetics ,Facial rejuvenation ,Cosmetic Techniques ,030230 surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Dermal Fillers ,Medicine ,Multimodal treatment ,Humans ,Rejuvenation ,Forehead ,Botulinum Toxins, Type A ,Hyaluronic Acid ,business.industry ,Middle Aged ,Skin Aging ,Aesthetics ,Rhytidoplasty ,Surgery ,Female ,business - Abstract
The temples are an often overlooked, but important element of facial rejuvenation. The anatomy of the temple should be understood prior to any intervention in this location. Multimodal treatment to re-establish youthful convexity, proper hairline position, and correct actinic damage is recommended for optimal results. Important anatomy, aesthetic goals, and methods of rejuvenation are reviewed in detail.
- Published
- 2018
39. Atypical fibroxanthoma arising on chronic burn scar: a rare case report and the review of the literature
- Author
-
Çalış, Elif, Keskin, Mustafa, Çakır, Aslı, Türkmen, İlknur, and Calis, E. Medipol Univ, Pathol, Istanbul, Turkey
- Subjects
Marjolin’s Ulcer ,Non Sun Damaged Skin ,Actinic Damage - Abstract
WOS: 000443414101354 Atypical Fibroxanthoma (AFX) is a rare cutaneous mesenchymal neoplasm, predominantly found on sundamaged skin of the head and neck in elderly patients. But uncommonly it can develop on a burn scar with or without actinic damage. Malignancy development is the major complication of severe burns and malignant transformations of those burn scars are accepted as Marjolin’s ulcers clinically. The most common malignancy in this setting is Squamous Cell Carcinoma (SCC), followed by Basal Cell Carcinoma (BCC) and Malignant Melanoma (MM). Mesenchymal tumors especially malign forms quite infrequently seen on scar tissue. Herein, we present a rare and unusual case of AFX arising on the non-sun-damaged area within a chronic burn scar of a young patient. Four cases of burn-related AFX reported in the literature are reviewed and the histopathological features anddifferential diagnosis are discussed.
- Published
- 2018
40. Erosive pustular dermatosis of the scalp and Kindler syndrome: a new association
- Author
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Astrid Lappi, Franco Rongioletti, M Lai, M.A. Brundu, Laura Atzori, Atzori, Laura, Lai, M, Lappi, A, Brundu, M. A, and Rongioletti, Franco
- Subjects
medicine.medical_specialty ,Pathology ,Actinic Damage ,Treatment outcome ,Dermatology ,Kindler syndrome ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Elderly people ,Sterile pustules ,Pityriasis ,integumentary system ,business.industry ,Atrophic skin ,Alopecia ,030206 dentistry ,medicine.disease ,Erosive pustular dermatosis ,Infectious Diseases ,medicine.anatomical_structure ,Scalp Dermatoses ,Scalp ,business - Abstract
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease that predominantly affects elderly people, with a chronic course and long-term management.(1) Sterile pustules, superficial erosions and crusted lesions on atrophic skin, resulting in cicatricial alopecia, characterize the typical clinical presentation. (1-3) Triggering factors include several drugs, actinic damage, local trauma, surgery, and physical or chemical procedures for actinic keratosis.(4-6) To the best of our knowledge, no previous association with Kindler syndrome was found in the literature.
- Published
- 2018
41. Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage
- Author
-
Manuel Pereiro-Ferreirós, Sabela Paradela, Aquilina Ramírez-Santos, Ignacio Suárez Conde, Carmen Paredes-Suárez, Isabel Rodríguez-Blanco, Romina Rodríguez-Lojo, Ángeles Flórez, Daniel González-Vilas, and Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Alcohol Drinking ,Actinic Damage ,lentigos ,Cross-sectional study ,MEDLINE ,Dermatology ,Risk Assessment ,Sex Factors ,Risk Factors ,Sex factors ,actinic keratosis ,lcsh:Dermatology ,Prevalence ,medicine ,actinic cheilitis ,Humans ,Aged ,Hardware_MEMORYSTRUCTURES ,clinical manifestations ,business.industry ,Actinic cheilitis ,Smoking ,Actinic keratosis ,General Medicine ,lcsh:RL1-803 ,Middle Aged ,Protective Factors ,Prognosis ,medicine.disease ,Lip ,Cross-Sectional Studies ,Cheilitis ,Job Description ,Multicenter study ,Spain ,Sunlight ,Female ,Risk assessment ,business - Abstract
Actinic cheilitis (AC) is a common condition that mainly involves the lower lip, which is associated with chronic exposure to ultraviolet (UV) radiation. AC is considered a precursor of malignancy (1), but the rate of progression from AC to invasive squamous cell carcinoma (SCC) has not yet been established. An epidemiological study previously described the prevalence of AC and its associated variables in the Galicia region (north-western Spain); the prevalence of AC in a population aged 45 years and over was 31.3%, and multivariate analysis showed that significant and independent risk factors for AC were age ≥60 years, Fitzpatrick skin phototypes I and II, working outdoors for more than 25 years, and a history of non-melanoma skin cancer (NMSC) (2). We report here a subanalysis of the clinical manifestations of AC and the associations of AC with other markers of actinic damage SI
- Published
- 2019
42. Infiltrated papules on the trunk and headaches: A case of actinic granuloma and a review of the literature
- Author
-
William D. Holmes, Sonal A. Parikh, Katalin Ferenczi, Jane M. Grant-Kels, Marti J. Rothe, and Syril Keena T. Que
- Subjects
Pathology ,medicine.medical_specialty ,Blindness ,Actinic Damage ,business.industry ,Annular elastolytic giant cell granuloma ,Dermatology ,macromolecular substances ,lcsh:RL1-803 ,medicine.disease ,Trunk ,Article ,Giant cell arteritis ,Actinic granuloma ,hemic and lymphatic diseases ,lcsh:Dermatology ,medicine ,Annular elastolytic giant-cell granuloma ,Arteritis ,Headaches ,medicine.symptom ,business ,Temporal arteritis - Abstract
Actinic granuloma is a rare granulomatous reaction that is more commonly seen in females and thought to occur as an autoimmune response to actinic damage of elastic tissue. We discuss a case of a patient with actinic granuloma presenting with concomitant temporal arteritis. Our case and review of the literature emphasize the association between actinic granuloma and temporal arteritis, a serious inflammatory condition that could lead to blindness if misdiagnosed. Keywords: Actinic granuloma, Annular elastolytic giant cell granuloma, Temporal arteritis, Giant cell arteritis
- Published
- 2015
- Full Text
- View/download PDF
43. Chronic actinic damage of facial skin
- Author
-
Cemal Bilaç, Mustafa Turhan Şahin, and Serap Öztürkcan
- Subjects
Keratinocytes ,Male ,Aging ,medicine.medical_specialty ,Skin Neoplasms ,Actinic Damage ,Carcinogenesis ,Ultraviolet Rays ,Sun protection ,Photoaging ,Human skin ,Dermatology ,Skin Aging ,medicine ,Humans ,Photosensitivity Disorders ,integumentary system ,business.industry ,Actinic keratosis ,Prognosis ,medicine.disease ,Hyperpigmentation ,Facial skin ,Chronic Disease ,Melanocytes ,Female ,medicine.symptom ,business ,Facial Dermatoses - Abstract
Chronic actinic damage of the skin manifests itself as extrinsic skin aging (photoaging) and photocarcinogenesis. During the last decade, substantial progress has been made in understanding cellular and molecular mechanisms of photoaging. DNA photodamage and ultraviolet-generated reactive oxygen species are the initial events that lead to most of the typical histologic and clinical manifestations of chronic photodamage of the skin. Chronic actinic damage affects all layers of the skin. Keratinocytes, melanocytes, fibroblasts, and endothelial cells are altered by ultraviolet radiation and can result in numerous changes in human skin, particularly the skin of fair-skinned individuals. These changes include actinic keratosis, thickening and wrinkling, elastosis, telengiectasia, solar comedones, diffuse or mottled hyperpigmentation, and skin cancers. There are many options in the treatment of changes caused by chronic actinic damage. The most effective measure of prevention of the photoaging and photocarcinogenesis is sun protection.
- Published
- 2014
44. Relationship between skin color and solar elastosis in aged Asian skin: A colorimetric-pathologic correlation
- Author
-
Young Chul Kye, Ga Na Oh, In Hyuk Kwon, Hyo Hyun Ahn, Dai Hyun Kim, and Soo Hong Seo
- Subjects
Male ,medicine.medical_specialty ,Histology ,Actinic Damage ,Biopsy ,Skin Pigmentation ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Pathologic correlation ,Asian People ,Patient age ,Republic of Korea ,Medicine ,Cheek skin ,Humans ,Instrumentation ,Aged ,Skin ,Aged, 80 and over ,integumentary system ,business.industry ,Middle Aged ,Dermatology ,Skin Aging ,Facial skin ,Medical Laboratory Technology ,Color changes ,030220 oncology & carcinogenesis ,Skin color ,Colorimetry ,Female ,Anatomy ,business ,Grading scale - Abstract
Aged skin is reported to be associated with unattractive skin color changes and solar elastosis. However, comparative studies have not documented the possible correlation between the two factors. This study investigated the plausible relationship between the facial skin color of elderly Asians and solar elastosis. A total of 22 skin specimens were collected from 22 Korean patients who underwent cheek skin biopsies. Skin color was quantitatively measured using colorimetric photography techniques to produce CIE L*a*b* values; the degree of solar elastosis was quantifiably assessed using a histologic grading scale. These values were used to investigate a correlation between the CIE L*a*b* coordinates and solar elastosis grade. The solar elastosis grade increased according to patient age (r = 0.67, p = .0006). However, the extent of solar elastosis was not statistically correlated with the CIE L*a*b* values, including L*, a*, and b* (r = 0.02, p = .95; r = 0.15, p = 0.50; r = -0.07, p = 0.76, respectively). The results showed that the solar elastosis grade increased, according to patient age, because of cumulative actinic damage. However, colorimetric skin color data did not correlate with the degree of solar elastosis. Therefore, cutaneous color changes and solar elastosis are separate, age-related phenomena. Physicians should be aware of the possible histologic changes in actinically damaged facial skin, regardless of the skin color.
- Published
- 2016
45. Erosive pustular dermatosis of the scalp and thigh associated with skin graft recipient and donor sites
- Author
-
Blandine Roche-Kubler, Anne Sophie Dupond, François Aubin, and Christine Monnin
- Subjects
Pathology ,medicine.medical_specialty ,integumentary system ,Actinic Damage ,business.industry ,Unknown aetiology ,Atrophic skin ,Inflammatory skin disease ,Dermatology ,Thigh ,medicine.disease ,Erosive pustular dermatosis ,body regions ,medicine.anatomical_structure ,Scalp ,Medicine ,business ,Pyoderma gangrenosum - Abstract
Erosive pustular dermatosis (EPD) is a rare inflammatory skin disease of unknown aetiology, characterized by multiple chronic, amicrobial pustules and crusted erosions. Typically, EPD occurs on legs with venous insufficiency [1] or atrophic skin caused by actinic damage on the scalp [2]. To our knowledge, only two cases of EPD simultaneously involving both the scalp and the leg have been reported in the literature [3, 4]. We report a new case of bipolar EPD remarkably involving both skin graft recipient [...]
- Published
- 2015
46. The double hatchet flap as a potential alternative closure technique for scalp defects
- Author
-
Markus Meissner, Roland Kaufmann, and Katharina Schultheis
- Subjects
medicine.medical_specialty ,Scalp ,Actinic Damage ,Wound Closure Techniques ,Computer science ,Dermatologic Surgical Procedures ,Skin Transplantation ,Dermatology ,Plastic Surgery Procedures ,Surgical Flaps ,Hatchet flap ,Surgery ,Wound Closure Technique ,Increased risk ,medicine.anatomical_structure ,medicine ,Humans ,Flap necrosis ,Skin elasticity - Abstract
There is a vast number of potential wound closure techniques in dermatosurgery. Taking various factors into account, such as anatomic site, defect size and depth, skin elasticity as well as other aspects (for example creases and hairline), surgeons are often required to tailor individual closure procedures, in order to achieve optimal results. Due to poor elasticity and frequent actinic damage, closure of scalp defects has proven to be particularly difficult and thus poses a challenge in ever -yday clinical practice.The double hatchet procedure – characterized by an advancement rotation component involving two opposite hatchet flaps – first described by Emmet in 1977 represents a simple and readily feasible plastic reconstruction technique for such defects [1]. It is particularly useful in the frontal and temporal region and marked by easy mobilization due to its relatively narrow base. However, this latter feature also entails a slightly increased risk for flap necrosis.
- Published
- 2015
47. O′Brien actinic granuloma: A case report and brief review of literature
- Author
-
Inês Coutinho, Leonor Ramos, Maria Manuel Brites, and Óscar Tellechea
- Subjects
Pathology ,medicine.medical_specialty ,Actinic Damage ,Annular elastolytic giant cell granuloma ,Case Report ,Dermatology ,Acitretin ,Lesion ,O′Brien actinic granuloma ,necrobiosis lipoidica presenting on the face and scalp ,Miescher granuloma of the face ,lcsh:Dermatology ,Medicine ,business.industry ,Disease progression ,Annular Lesion ,elastophagocytosis ,lcsh:RL1-803 ,medicine.disease ,Actinic granuloma ,O’Brien actinic granuloma ,Histopathology ,Annular elastolytic giant-cell granuloma ,medicine.symptom ,business ,medicine.drug - Abstract
O’Brien first described the actinic granuloma in 1975, as an infrequent granulomatous disorder occurring in sun-exposed skin, with a slow but often self-limited course. Ever since its initial description, the actinic physiopathogenic hypothesis has been debated by many authors. We report a 60-year-old female rural worker that presented with a 14 × 7 cm annular lesion with erythematous elevated borders and an atrophic center on the right calf. The lesion was evolving for 2 years, and histopathology confirmed actinic granuloma. She started acitretin with halting of disease progression after 6 months of therapy. Our case can also be associated to actinic damage, despite its unusual location, therefore highlighting the role of solar elastosis in the development of O’Brien actinic granuloma.
- Published
- 2015
48. Skin and antioxidants
- Author
-
Raja Dahmane, Aleksandar Godic, and Borut Poljšak
- Subjects
Skin protection ,medicine.medical_specialty ,Repair processes ,integumentary system ,Actinic Damage ,business.industry ,Photoaging ,Administration, Oral ,Physiology ,Sun damage ,Dermatology ,Administration, Cutaneous ,medicine.disease ,Antioxidants ,Diet ,Skin Aging ,Melanin ,Dietary Supplements ,medicine ,Humans ,Surgery ,Sun exposure ,business - Abstract
It is estimated that total sun exposure occurs non-intentionally in three quarters of our lifetimes. Our skin is exposed to majority of UV radiation during outdoor activities, e.g. walking, practicing sports, running, hiking, etc. and not when we are intentionally exposed to the sun on the beach. We rarely use sunscreens during those activities, or at least not as much and as regular as we should and are commonly prone to acute and chronic sun damage of the skin. The only protection of our skin is endogenous (synthesis of melanin and enzymatic antioxidants) and exogenous (antioxidants, which we consume from the food, like vitamins A, C, E, etc.). UV-induced photoaging of the skin becomes clinically evident with age, when endogenous antioxidative mechanisms and repair processes are not effective any more and actinic damage to the skin prevails. At this point it would be reasonable to ingest additional antioxidants and/or to apply them on the skin in topical preparations. We review endogenous and exogenous skin protection with antioxidants.
- Published
- 2013
49. Sunscreens, Skin Cancer, and Your Patient
- Author
-
Dana P. Wolfe and Terence M. Davidson
- Subjects
Premature aging ,medicine.medical_specialty ,integumentary system ,Actinic Damage ,business.industry ,Dermabrasion ,medicine.medical_treatment ,Treatment method ,Cancer ,Physical Therapy, Sports Therapy and Rehabilitation ,030229 sport sciences ,medicine.disease ,Dermatology ,03 medical and health sciences ,0302 clinical medicine ,Increased risk ,medicine ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Sunburn ,Skin cancer ,business - Abstract
In brief: Skin cancer is on the increase, at least partly because of the widespread pursuit of suntans. UV light causes not only tanning but also sunburn, an increased risk of skin cancer, and premature aging of the skin. Sunscreens are available that block short-wavelength UV light and thereby reduce these problems while allowing tanning. The principal types of sunscreens are listed and their properties discussed. Also described are the three types of skin tumors-basal cell, squamous cell, and malignant melanoma-along with cure rates and treatment methods. Surgical and medical techniques, chiefly chemical peeling and dermabrasion, can counteract to some degree the premature aging of skin from chronic actinic damage.
- Published
- 2016
50. Histopathological study of perilesional skin in patients diagnosed with nonmelanoma skin cancer
- Author
-
Athanassios Kyrgidis, Giuseppe Argenziano, Giulio Gualdi, Aimilios Lallas, Paola Monari, Silvia Crotti, Zoe Apalla, Fabio Facchetti, Piergiacomo Calzavara-Pinton, Apalla, Z, Calzavara Pinton, P, Lallas, A, Argenziano, Giuseppe, Kyrgidis, A, Crotti, S, Facchetti, F, Monari, P, and Gualdi, G.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Skin Neoplasms ,Adolescent ,Actinic Damage ,Carcinogenesis ,Ultraviolet Rays ,Bowen's Disease ,Dermatology ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Epidemiology ,medicine ,Humans ,In patient ,Basal cell ,Basal cell carcinoma ,Prospective Studies ,skin and connective tissue diseases ,Prospective cohort study ,Aged ,Skin ,Aged, 80 and over ,integumentary system ,business.industry ,Middle Aged ,medicine.disease ,Carcinoma, Basal Cell ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Female ,Histopathology ,Skin cancer ,business - Abstract
Summary Background Epidemiological and clinical data suggest that actinic damage to the skin is an important predictor of skin carcinogenesis. Aim To investigate the association of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) with sun-damage alterations seen by histopathology. Method In the current prospective study, perilesional skin of SCC or BCC lesions was evaluated for presence of alterations associated with chronic photodamage. Presence of scarring, perineural/perivascular invasion, haemorrhage/haemorrhagic crust, ulceration/erosion and margin involvement were also assessed. Result Of 6038 included lesions, 4523 (74.9%) were BCCs and 1515 (25.1%) were SCCs. Presence of actinic damage was five times more frequent in SCC than in BCC (OR = 5.29, 95% CI 4.44–6.00, P
- Published
- 2016
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