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Chronic actinic damage of facial skin
- Source :
- Clinics in Dermatology. 32:752-762
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Chronic actinic damage of the skin manifests itself as extrinsic skin aging (photoaging) and photocarcinogenesis. During the last decade, substantial progress has been made in understanding cellular and molecular mechanisms of photoaging. DNA photodamage and ultraviolet-generated reactive oxygen species are the initial events that lead to most of the typical histologic and clinical manifestations of chronic photodamage of the skin. Chronic actinic damage affects all layers of the skin. Keratinocytes, melanocytes, fibroblasts, and endothelial cells are altered by ultraviolet radiation and can result in numerous changes in human skin, particularly the skin of fair-skinned individuals. These changes include actinic keratosis, thickening and wrinkling, elastosis, telengiectasia, solar comedones, diffuse or mottled hyperpigmentation, and skin cancers. There are many options in the treatment of changes caused by chronic actinic damage. The most effective measure of prevention of the photoaging and photocarcinogenesis is sun protection.
- Subjects :
- Keratinocytes
Male
Aging
medicine.medical_specialty
Skin Neoplasms
Actinic Damage
Carcinogenesis
Ultraviolet Rays
Sun protection
Photoaging
Human skin
Dermatology
Skin Aging
medicine
Humans
Photosensitivity Disorders
integumentary system
business.industry
Actinic keratosis
Prognosis
medicine.disease
Hyperpigmentation
Facial skin
Chronic Disease
Melanocytes
Female
medicine.symptom
business
Facial Dermatoses
Subjects
Details
- ISSN :
- 0738081X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Clinics in Dermatology
- Accession number :
- edsair.doi.dedup.....149b7ea7cd58c67a2014ebe461fd445f