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Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)
- Source :
- Journal of the South African Veterinary Association, Vol 92, Iss 0, Pp e1-e6 (2021), Journal of the South African Veterinary Association
- Publication Year :
- 2021
- Publisher :
- AOSIS, 2021.
-
Abstract
- Cutaneous squamous cell carcinoma (SCC) is a slow growing but locally invasive neoplasm, most commonly caused by prolonged exposure to ultraviolet (UV) radiation. Whilst SCC accounts for 15% of skin tumours in domesticated cats, cutaneous SCC in non-domesticated felids (apart from captive snow leopards) appears to be uncommon, with only three reports in the literature to date. In this report, a captive African lion (Panthera leo) presented with two ulcerative lesions on the nasal planum. Histopathology of the lesions revealed epidermal keratinocyte dysplasia and neoplastic basal- and supra-basal epithelial cells with dyskeratosis and evidence of basement membrane breaching and dermal invasion, consistent with a diagnosis of SCC. There was also evidence of laminar fibrosis and inflammation of the subjacent dermis suggesting that the SCC most likely resulted from UV-induced neoplastic transformation of the epidermal squamous epithelium following actinic keratosis. The lion was treated with hypofractionated radiation therapy and remained in remission until his death (euthanised 17 months later because of age-related chronic renal failure). This is the first report of cutaneous SCC in a lion with evidence of actinic damage and resolution after radiation therapy.
- Subjects :
- Lions
Male
medicine.medical_specialty
Pathology
skin
Hypofractionated Radiation Therapy
Skin Neoplasms
040301 veterinary sciences
medicine.medical_treatment
Veterinary medicine
Nose Neoplasms
Case Report
radiation therapy
030308 mycology & parasitology
0403 veterinary science
03 medical and health sciences
laminar fibrosis
SF600-1100
medicine
Animals
cancer
Neoplastic transformation
actinic damage
0303 health sciences
lion
General Veterinary
business.industry
Actinic keratosis
Cancer
04 agricultural and veterinary sciences
General Medicine
medicine.disease
Dyskeratosis
uv
Radiation therapy
stomatognathic diseases
Dysplasia
Carcinoma, Squamous Cell
Histopathology
Radiation Dose Hypofractionation
business
Subjects
Details
- Language :
- English
- ISSN :
- 22249435 and 10199128
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Journal of the South African Veterinary Association
- Accession number :
- edsair.doi.dedup.....89cf4a94c47fb26bcb37c236ce2d8b99