1. New sesquiterpenoids from the stems of Datura metel L.
- Author
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Liu, Yan, Guan, Wei, Lu, Zhen-kun, Guo, Rui, Xia, Yong-Gang, Lv, Shao-Wa, Yang, Bing-You, and Kuang, Hai-Xue
- Subjects
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CELL lines , *CHROMATOGRAPHIC analysis , *HIGH performance liquid chromatography , *MASS spectrometry , *MEDICINAL plants , *CHINESE medicine , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *RESEARCH funding , *PLANT stems , *TERPENES , *PLANT extracts - Abstract
Four new sesquiterpenoids (1 – 4) and two known ones (5 – 6) were isolated and identified from the stems of Datura metel L. The structures of the isolated compounds were established by 1D and 2D NMR spectra, as well as HR-ESI-MS. Additionally, the compounds 1 – 3 possessed the similar novel skelecton and compounds 5 – 6 were isolated from the Datura genus for the first time. The hypothetical biogenetic pathway was teased and provided. Meanwhile, the antiproliferative activities were evaluated on the two human cancer cells of HepG2 and Hela, respectively. Unlabelled Image [ABSTRACT FROM AUTHOR]
- Published
- 2019
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