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Two triterpenoid glycosides from the roots of Camellia oleifera and their cytotoxic activity.
- Source :
- Journal of Asian Natural Products Research; Aug2015, Vol. 17 Issue 8, p800-807, 8p
- Publication Year :
- 2015
-
Abstract
- Two new triterpenoid saponins, oleiferoside N and oleiferoside O, were isolated from the EtOH extract from the roots ofCamellia oleiferaC. Abel. Their structures were elucidated as 16α-acetoxy-21β,22α-O-diangeloyloxy-23,28-dihydroxyolean-12-ene 3β-O-β-d-xylopyranosyl-(1 → 3)-α-l-arabinopyranosyl-(1 → 3)-β-d-glucuronopyranoside (1), 16α-acetoxy-21β-O-angeloyloxy-23,28-dihydroxy-22α-O-(2-methylbutanoyloxy)olean-12-ene 3β-O-β-d-xylopyranosyl-(1 → 3)-α-l-arabinopyranosyl-(1 → 3)-β-d-glucuronopyranoside (2), on the basis of spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR) and acid hydrolysis. Both were characterized to be oleanane-type saponins with sugar moieties linked to C-3 of the aglycone. Cytotoxic activities of two saponins were evaluated against four human tumor cell lines (A549, B16, BEL-7402, and MCF-7) by using the MTTin vitroassay. Compounds1and2showed moderate cytotoxic activities toward the tested cell lines. [ABSTRACT FROM PUBLISHER]
- Subjects :
- ANIMAL experimentation
ANTINEOPLASTIC agents
BIOLOGICAL assay
CELL culture
CELL lines
CHROMATOGRAPHIC analysis
GLYCOSIDES
INFRARED spectroscopy
MASS spectrometry
MICE
NUCLEAR magnetic resonance spectroscopy
RESEARCH funding
PLANT roots
TERPENES
TOXICITY testing
DESCRIPTIVE statistics
IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 17
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 108840780
- Full Text :
- https://doi.org/10.1080/10286020.2015.1004630