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17 results on '"Rana, Zaker"'

5. WNT Pathway Mutations in Metachronous Oligometastatic Castration-Sensitive Prostate Cancer

Author

Sutera, Philip, Deek, Matthew P., Van der Eecken, Kim, Shetty, Amol C., Chang, Jin Hee, Hodges, Theresa, Song, Yang, Verbeke, Sofie, Van Dorpe, Jo, Fonteyne, Valérie, De Laere, Bram, Mishra, Mark, Rana, Zaker, Molitoris, Jason, Ferris, Matthew, Ross, Ashley, Schaeffer, Edward, Roberts, Nicholas, Song, Daniel Y., DeWeese, Theodore, Pienta, Kenneth J., Antonarakis, Emmanuel S., Ost, Piet, and Tran, Phuoc T.

Published
2023
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6. Proton Pencil Beam Scanning Facilitates the Safe Treatment of Extended Radiation Targets for Hodgkin Lymphoma: A Report from the Proton Collaborative Group Registry.

Author

Ebadi, Maryam, Pankuch, Mark, Boyer, Sean, Chang, John, Stevens, Craig, Hall, Matthew D., Hasan, Shaakir, Bates, James E., Flampouri, Stella, Kole, Adam J., Mohindra, Pranshu, Rossi, Carl, Sanghvi, Parag, McGee, Lisa, Rana, Zaker, and Tseng, Yolanda D.

Subjects
PROTON therapy, DOSE-response relationship (Radiation), PATIENT safety, REPORTING of diseases, HEART, LUNGS, HODGKIN'S disease, BREAST
Abstract

Simple Summary: Using the Proton Therapy Collaborative group registry, we describe the impact of pencil beam scanning (PBS) proton beam therapy (PBT) for Hodgkin lymphoma patients who require radiation to both mediastinal and axillary targets. We performed dosimetric comparisons between delivered PBS plans and photons with butterfly volumetric arc therapy (BVMAT). Compared to BVMAT, PBS had greater target coverage, better conformity, and lower dose heterogeneity while achieving a lower dose to the lungs and heart. Nearly half of the BVMAT plans exceeded the lung V5 constraint (>55%). PBS was well tolerated without any pneumonitis or grade 3+ acute toxicity. We show here that patients requiring both mediastinal and axillary treatment may be another subgroup of lymphoma patients who may benefit from PBT. Because proton beam therapy (PBT) can lower the dose of radiation to the heart, lungs, and breast, it is an established radiation modality for patients with Hodgkin lymphoma (HL). Pencil beam scanning (PBS) PBT facilitates the treatment of more extensive targets. This may be especially of value for lymphoma patients who require RT to both mediastinal and axillary targets, defined here as extended target RT (ETRT), given the target distribution and need to minimize the lung, heart, and breast dose. Using the Proton Collaborative Group registry, we identified patients with HL treated with PBT to both their mediastinum and axilla, for which DICOM-RT was available. All patients were treated with PBS. To evaluate the dosimetric impact of PBS, we compared delivered PBS plans with VMAT butterfly photon plans optimized to have the same target volume coverage, when feasible. Between 2016 and 2021, twelve patients (median 26 years) received PBS ETRT (median 30.6 Gy (RBE)). Despite the large superior/inferior (SI, median 22.2 cm) and left/right (LR, median 22.8 cm) extent of the ETRT targets, all patients were treated with one isocenter except for two patients (both with SI and LR > 30 cm). Most commonly, anterior beams, with or without posterior beams, were used. Compared to photons, PBS had greater target coverage, better conformity, and lower dose heterogeneity while achieving lower doses to the lungs and heart, but not to the breast. No acute grade 3+ toxicities were reported, including pneumonitis. Proton ETRT in this small cohort was safely delivered with PBS and was associated with an improved sparing of the heart and lungs compared to VMAT. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Identification of a Predictive Genomic Biomarker for Prostate-directed Therapy in Synchronous Low-volume Metastatic Castration-sensitive Prostate Cancer

Author

Sutera, Philip, primary, Shetty, Amol C., additional, Song, Yang, additional, Hodges, Theresa, additional, Hoang, Tung, additional, Rana, Zaker, additional, Pienta, Kenneth, additional, Feng, Felix, additional, Song, Daniel Y., additional, DeWeese, Theodore, additional, Gillessen, Silke, additional, Sweeney, Christopher, additional, James, Nicholas, additional, Attard, Gerhardt, additional, Deek, Matthew, additional, and Tran, Phuoc T., additional

Published
2023
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9. Clinical and Genomic Differences Between Advanced Molecular Imaging-detected and Conventional Imaging-detected Metachronous Oligometastatic Castration-sensitive Prostate Cancer

Author

Sutera, Philip, primary, Song, Yang, additional, Van der Eecken, Kim, additional, Shetty, Amol C., additional, English, Keara, additional, Hodges, Theresa, additional, Chang, Jinhee, additional, Fonteyne, Valérie, additional, Rana, Zaker, additional, Ren, Lei, additional, Mendes, Adrianna A., additional, Lumen, Nicolaas, additional, Delrue, Louke, additional, Verbeke, Sofie, additional, De Man, Kathia, additional, Song, Daniel Y., additional, Pienta, Kenneth, additional, Feng, Felix Y., additional, Joniau, Steven, additional, Lotan, Tamara, additional, Lane, Barton, additional, Kiess, Ana, additional, Rowe, Steven, additional, Pomper, Martin, additional, DeWeese, Theodore, additional, Deek, Matthew, additional, Sweeney, Christopher, additional, Ost, Piet, additional, and Tran, Phuoc T., additional

Published
2023
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10. Prognostic impact of circulating tumor cells in oligometastatic hormone-sensitive prostate cancer following metastasis-directed therapy.

Author

Bazyar, Soha, primary, Sutera, Philip, additional, Phillips, Ryan, additional, Deek, Mathew Pierre, additional, Radwan, Noura, additional, Marshall, Catherine Handy, additional, Mishra, Mark V., additional, Rana, Zaker Hamid, additional, Molitoris, Jason K., additional, Kwok, Young, additional, Gupta, Santosh, additional, Tubbs, Alisa, additional, Wenstrup, Rick, additional, DeWeese, Theodore L., additional, Song, Daniel Y., additional, Feng, Felix Y, additional, Pienta, Kenneth J., additional, Antonarakis, Emmanuel S., additional, Kiess, Ana Ponce, additional, and Tran, Phuoc T., additional

Published
2023
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11. Genomic determinants of patterns of failure in metachronous oligometastatic castration-sensitive prostate cancer.

Author

Sutera, Philip, primary, Van der Eecken, Kim, additional, Shetty, Amol, additional, Song, Yang, additional, Hodges, Theresa, additional, Verbeke, Sofie, additional, Van Dorpe, Jo, additional, Fonteyne, Valerie, additional, De Laere, Bram, additional, Mishra, Mark V., additional, Rana, Zaker Hamid, additional, Molitoris, Jason K., additional, Ferris, Matthew J., additional, Roberts, Nicholas J, additional, Song, Daniel Y., additional, DeWeese, Theodore L., additional, Pienta, Kenneth J., additional, Deek, Matthew, additional, Ost, Piet, additional, and Tran, Phuoc T., additional

Published
2023
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12. Phase 2 randomized total eradication of metastatic lesions following definitive radiation to the prostate in de novo oligometastatic prostate cancer (TERPs) trial.

Author

Rana, Zaker Hamid, primary, Helie, Nicole, additional, Eggleston, Caitlin, additional, Baker, Kaysee, additional, Molitoris, Jason K., additional, Ferris, Matthew J., additional, Patel, Akshar, additional, Kwok, Young, additional, McAvoy, Sarah, additional, Kunaprayoon, Dan, additional, Hong, Jack J., additional, Deek, Matthew, additional, Sutera, Philip, additional, Deek, Rebecca A, additional, Bentzen, Soren, additional, Siddiqui, Minhaj, additional, Mannuel, Heather Dorothy, additional, Hussain, Arif, additional, Tran, Phuoc T., additional, and Mishra, Mark V., additional

Published
2023
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14. Long-Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials

Author

Deek, Matthew P., primary, Van der Eecken, Kim, additional, Sutera, Philip, additional, Deek, Rebecca A., additional, Fonteyne, Valérie, additional, Mendes, Adrianna A., additional, Decaestecker, Karel, additional, Kiess, Ana Ponce, additional, Lumen, Nicolaas, additional, Phillips, Ryan, additional, De Bruycker, Aurélie, additional, Mishra, Mark, additional, Rana, Zaker, additional, Molitoris, Jason, additional, Lambert, Bieke, additional, Delrue, Louke, additional, Wang, Hailun, additional, Lowe, Kathryn, additional, Verbeke, Sofie, additional, Van Dorpe, Jo, additional, Bultijnck, Renée, additional, Villeirs, Geert, additional, De Man, Kathia, additional, Ameye, Filip, additional, Song, Daniel Y., additional, DeWeese, Theodore, additional, Paller, Channing J., additional, Feng, Felix Y., additional, Wyatt, Alexander, additional, Pienta, Kenneth J., additional, Diehn, Maximillian, additional, Bentzen, Soren M., additional, Joniau, Steven, additional, Vanhaverbeke, Friedl, additional, De Meerleer, Gert, additional, Antonarakis, Emmanuel S., additional, Lotan, Tamara L., additional, Berlin, Alejandro, additional, Siva, Shankar, additional, Ost, Piet, additional, and Tran, Phuoc T., additional

Published
2022
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15. Genomic biomarkers to guide precision radiotherapy in prostate cancer

Author

Sutera, Philip, primary, Deek, Matthew P., additional, Van der Eecken, Kim, additional, Wyatt, Alexander W., additional, Kishan, Amar U., additional, Molitoris, Jason K., additional, Ferris, Matthew J., additional, Siddiqui, M. Minhaj, additional, Rana, Zaker, additional, Mishra, Mark V., additional, Kwok, Young, additional, Davicioni, Elai, additional, Spratt, Daniel E., additional, Ost, Piet, additional, Feng, Felix Y., additional, and Tran, Phuoc T., additional

Published
2022
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16. Genomic Determinants Associated with Modes of Progression and Patterns of Failure in Metachronous Oligometastatic Castration-sensitive Prostate Cancer

Author

Sutera, Philip, Song, Yang, Shetty, Amol C., English, Keara, Van der Eecken, Kim, Guler, Ozan Cem, Wang, Jarey, Cao, Yufeng, Bazyar, Soha, Verbeke, Sofie, Van Dorpe, Jo, Fonteyne, Valérie, De Laere, Bram, Mishra, Mark, Rana, Zaker, Molitoris, Jason, Ferris, Matthew, Kiess, Ana, Song, Daniel Y., DeWeese, Theodore, Pienta, Kenneth J., Barbieri, Christopher, Marchionni, Luigi, Ren, Lei, Sawant, Amit, Simone, Nicole, Berlin, Alejandro, Onal, Cem, Tran, Phuoc T., Ost, Piet, and Deek, Matthew P.

Abstract

For patients with metachronous oligometastatic castration-sensitive prostate cancer, tumor genomics may play a role in the mode of progression and pattern of failure after initial therapy for metastatic disease. Specifically, patients with TP53and RB1mutations have a higher likelihood of progression, and TP53, SPOP, and WNT pathway mutations may have a role in metastatic organotropism directing the likelihood of bone and visceral disease progression.

Published
2024
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17. Prognostic Significance of Immune Cell Infiltration in Muscle-invasive Bladder Cancer Treated with Definitive Chemoradiation: A Secondary Analysis of RTOG 0524 and RTOG 0712

Author

Rana, Zaker, Kamran, Sophia C., Shetty, Amol C., Sutera, Philip, Song, Yang, Bazyar, Soha, Solanki, Abhishek A., Simko, Jeffry P., Pollack, Alan, McConkey, David, Kates, Max, Siddiqui, M. Minhaj, Hiken, Jeffrey, Earls, Jon, Messina, David, Mouw, Kent W., Miyamoto, David, Shipley, William U., Michaelson, M. Dror, Zietman, Anthony, Coen, John J., Dahl, Douglas M., Jani, Ashesh B., Souhami, Luis, Chang, Brian K., Lee, R. Jeffrey, Pham, Huong, Marshall, David T., Shen, Xinglei, Pugh, Stephanie L., Feng, Felix Y., Efstathiou, Jason A., Tran, Phuoc T., and Deek, Matthew P.

Abstract

A novel transcriptional profiling platform revealed that gene expression consistent with high immune-cell infiltration and of specific genes associated with T-cell infiltration or IFNγ signaling was correlated with better survival following chemoradiation for muscle-invasive bladder cancer.

Published
2024
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