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Prognostic Significance of Immune Cell Infiltration in Muscle-invasive Bladder Cancer Treated with Definitive Chemoradiation: A Secondary Analysis of RTOG 0524 and RTOG 0712

Authors :
Rana, Zaker
Kamran, Sophia C.
Shetty, Amol C.
Sutera, Philip
Song, Yang
Bazyar, Soha
Solanki, Abhishek A.
Simko, Jeffry P.
Pollack, Alan
McConkey, David
Kates, Max
Siddiqui, M. Minhaj
Hiken, Jeffrey
Earls, Jon
Messina, David
Mouw, Kent W.
Miyamoto, David
Shipley, William U.
Michaelson, M. Dror
Zietman, Anthony
Coen, John J.
Dahl, Douglas M.
Jani, Ashesh B.
Souhami, Luis
Chang, Brian K.
Lee, R. Jeffrey
Pham, Huong
Marshall, David T.
Shen, Xinglei
Pugh, Stephanie L.
Feng, Felix Y.
Efstathiou, Jason A.
Tran, Phuoc T.
Deek, Matthew P.
Source :
European Urology Oncology; October 2024, Vol. 7 Issue: 5 p986-989, 4p
Publication Year :
2024

Abstract

A novel transcriptional profiling platform revealed that gene expression consistent with high immune-cell infiltration and of specific genes associated with T-cell infiltration or IFNγ signaling was correlated with better survival following chemoradiation for muscle-invasive bladder cancer.

Details

Language :
English
ISSN :
25889311
Volume :
7
Issue :
5
Database :
Supplemental Index
Journal :
European Urology Oncology
Publication Type :
Periodical
Accession number :
ejs66051089
Full Text :
https://doi.org/10.1016/j.euo.2024.03.015