Search

Your search keyword '"Cristofori, Fernanda"' showing total 34 results
Start Over Author "Cristofori, Fernanda" Publication Year Range Last 3 years
34 results on '"Cristofori, Fernanda"'

2. Novel Bacteroides Vulgatus strain protects against gluten-induced break of human celiac gut epithelial homeostasis: a pre-clinical proof-of-concept study

Author

Tran, Tina, Senger, Stefania, Baldassarre, Mariella, Brosnan, Rachel A., Cristofori, Fernanda, Crocco, Marco, De Santis, Stefania, Elli, Luca, Faherty, Christina S., Francavilla, Ruggero, Goodchild-Michelman, Isabella, Kenyon, Victoria A., Leonard, Maureen M., Lima, Rosiane S., Malerba, Federica, Montuori, Monica, Morelli, Annalisa, Norsa, Lorenzo, Passaro, Tiziana, Piemontese, Pasqua, Reed, James C., Sansotta, Naire, Valitutti, Francesco, Zomorrodi, Ali R., and Fasano, Alessio

Published
2024
Full Text
View/download PDF

3. List of contributors

Author

Aimo, Cristina, primary, Aronico, Nicola, additional, Auricchio, Renata, additional, Barone, Michele, additional, Biagi, Federico, additional, Bianchi, Paola Ilaria, additional, Bibbò, Stefano, additional, Broglio, Giacomo, additional, Caio, Giacomo, additional, Calabrese, Emma, additional, Cammarota, Giovanni, additional, Caproni, Marzia, additional, Carroccio, Antonio, additional, Castellaneta, Stefania, additional, Catassi, Carlo, additional, Catassi, Giulia, additional, Ciacci, Carolina, additional, Ciccocioppo, Rachele, additional, Copparoni, Roberto, additional, Corazza, Gino Roberto, additional, Corrà, Alberto, additional, Cristofori, Fernanda, additional, Dargenio, Vanessa Nadia, additional, De Giorgio, Roberto, additional, De Lisi, Giuseppe, additional, De Micco, Ida, additional, Di Sabatino, Antonio, additional, Di Stasio, Luigia, additional, Di Stefano, Michele, additional, Discepolo, Valentina, additional, Fasano, Alessio, additional, Francavilla, Ruggiero, additional, Gasbarrini, Antonio, additional, Gasbarrini, Giovanni, additional, Gatti, Simona, additional, Gianfrani, Carmen, additional, Giuliano, Alessandra, additional, Greco, Luigi, additional, Guandalini, Stefano, additional, Ianiro, Gianluca, additional, Lenti, Marco Vincenzo, additional, Lionetti, Elena, additional, Lucioni, Marco, additional, Maimaris, Stiliano, additional, Mamone, Gianfranco, additional, Mandile, Roberta, additional, Mansueto, Pasquale, additional, Marafini, Irene, additional, Mariotti, Elena Biancamaria, additional, Mengoli, Caterina, additional, Monteleone, Giovanni, additional, Monteleone, Ivan, additional, Neuhold, Susanna, additional, Novellino, Luisa, additional, Pilo, Caterina, additional, Plutino, Giuseppe, additional, Sansotta, Naire, additional, Santacroce, Giovanni, additional, Schiepatti, Annalisa, additional, Seidita, Aurelio, additional, Silano, Marco, additional, Troncone, Edoardo, additional, Troncone, Riccardo, additional, Vanoli, Alessandro, additional, Vitale, Serena, additional, Volta, Umberto, additional, Zanini, Annalisa, additional, and Zingone, Fabiana, additional

Published
2024
Full Text
View/download PDF

8. Capsule endoscopy in children with inflammatory bowel disease: A survey of the Italian society of pediatric gastroenterology, hepatology and nutrition (SIGENP)

Author

Bramuzzo, Matteo, primary, Renzo, Sara, additional, Labriola, Flavio, additional, De Angelis, Paola, additional, Aloi, Marina, additional, Alvisi, Patrizia, additional, Arrigo, Serena, additional, Caimmi, Silvia, additional, Caldore, Mariano, additional, Cananzi, Mara, additional, Cardile, Sabrina, additional, Cenni, Sabrina, additional, Comito, Donatella, additional, Cozzali, Rita, additional, Cristofori, Fernanda, additional, Saccomani, Marco Deganello, additional, Dell'Omo, Valeria, additional, Destro, Francesca, additional, Nardo, Giovanni Di, additional, Stefano, Marina Di, additional, Dipasquale, Valeria, additional, Faraci, Simona, additional, Felici, Enrico, additional, Fernicola, Paola, additional, Fuoti, Maurizio, additional, Gaiani, Federica, additional, Gatti, Simona, additional, Graziano, Francesco, additional, Illiceto, Maria Teresa, additional, Isoldi, Sara, additional, Mainetti, Martina, additional, Maino, Marta, additional, Marseglia, Antonio, additional, Martelossi, Stefano, additional, Motta, Matteo, additional, Norsa, Lorenzo, additional, Pacenza, Caterina, additional, Paci, Monica, additional, Pavanello, Paolo Maria, additional, Pizzol, Antonio, additional, Provera, Silvia, additional, Oliva, Salvatore, additional, Romano, Claudio, additional, and Sansotta, Naire, additional

Published
2024
Full Text
View/download PDF

10. Diagnostic Delay of Celiac Disease in Childhood

Author

Bianchi, Paola Ilaria, primary, Lenti, Marco Vincenzo, additional, Petrucci, Clarissa, additional, Gambini, Giulia, additional, Aronico, Nicola, additional, Varallo, Matteo, additional, Rossi, Carlo Maria, additional, Pozzi, Elena, additional, Groppali, Elena, additional, Siccardo, Francesca, additional, Franchino, Giulia, additional, Zuccotti, Gian Vincenzo, additional, Di Leo, Grazia, additional, Zanchi, Chiara, additional, Cristofori, Fernanda, additional, Francavilla, Ruggiero, additional, Aloi, Marina, additional, Gagliostro, Giulia, additional, Montuori, Monica, additional, Romaggioli, Sara, additional, Strisciuglio, Caterina, additional, Crocco, Marco, additional, Zampatti, Noemi, additional, Calvi, Angela, additional, Auricchio, Renata, additional, De Giacomo, Costantino, additional, Caimmi, Silvia Maria Elena, additional, Carraro, Carolina, additional, Staiano, Annamaria, additional, Cenni, Sabrina, additional, Congia, Mauro, additional, Schirru, Enrico, additional, Ferretti, Francesca, additional, Ciacci, Carolina, additional, Vecchione, Nicoletta, additional, Latorre, Mario Andrea, additional, Resuli, Semela, additional, Moltisanti, Giusy Cinzia, additional, Abruzzese, Giulia Maria, additional, Quadrelli, Andrea, additional, Saglio, Simone, additional, Canu, Pietro, additional, Ruggeri, Damiano, additional, De Silvestri, Annalisa, additional, Klersy, Catherine, additional, Marseglia, Gian Luigi, additional, Corazza, Gino Roberto, additional, and Di Sabatino, Antonio, additional

Published
2024
Full Text
View/download PDF

12. Capsule endoscopy in children with inflammatory bowel disease: A survey of the Italian society of pediatric gastroenterology, hepatology and nutrition (SIGENP)

Author

Aloi, Marina, Alvisi, Patrizia, Arrigo, Serena, Caimmi, Silvia, Caldore, Mariano, Cananzi, Mara, Cardile, Sabrina, Cenni, Sabrina, Comito, Donatella, Cozzali, Rita, Cristofori, Fernanda, Saccomani, Marco Deganello, Dell'Omo, Valeria, Destro, Francesca, Nardo, Giovanni Di, Stefano, Marina Di, Dipasquale, Valeria, Faraci, Simona, Felici, Enrico, Fernicola, Paola, Fuoti, Maurizio, Gaiani, Federica, Gatti, Simona, Graziano, Francesco, Illiceto, Maria Teresa, Isoldi, Sara, Mainetti, Martina, Maino, Marta, Marseglia, Antonio, Martelossi, Stefano, Motta, Matteo, Norsa, Lorenzo, Pacenza, Caterina, Paci, Monica, Pavanello, Paolo Maria, Pizzol, Antonio, Provera, Silvia, Oliva, Salvatore, Romano, Claudio, Sansotta, Naire, Bramuzzo, Matteo, Renzo, Sara, Labriola, Flavio, and De Angelis, Paola

Published
2024
Full Text
View/download PDF

13. Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial

Author

Mazzone, Luigi, Dooling, Sean W., Volpe, Elisabetta, Uljarević, Mirko, Waters, Jillian L., Sabatini, Andrea, Arturi, Lucrezia, Abate, Roberta, Riccioni, Assia, Siracusano, Martina, Pereira, Marcela, Engstrand, Lars, Cristofori, Fernanda, Adduce, Domenico, Francavilla, Ruggiero, Costa-Mattioli, Mauro, and Hardan, Antonio Y.

Published
2024
Full Text
View/download PDF

15. Prevalence and detection rate of celiac disease in Italy: Results of a SIGENP multicenter screening in school-age children

Author

Lionetti, Elena, primary, Pjetraj, Dorina, additional, Gatti, Simona, additional, Catassi, Giulia, additional, Bellantoni, Antonella, additional, Boffardi, Massimo, additional, Cananzi, Mara, additional, Cinquetti, Mauro, additional, Francavilla, Ruggiero, additional, Malamisura, Basilio, additional, Montuori, Monica, additional, Zuccotti, Gianvincenzo, additional, Cristofori, Fernanda, additional, Gaio, Paola, additional, Passaro, Tiziana, additional, Penagini, Francesca, additional, Testa, Alessandra, additional, Trovato, Chiara Maria, additional, and Catassi, Carlo, additional

Published
2023
Full Text
View/download PDF

16. Probiotics and gastrointestinal diseases

Author

DARGENIO, Vanessa N., primary, CASTELLANETA, Stefania, additional, PANICO, Serena, additional, PAPAGNI, Maria E., additional, DARGENIO, Costantino, additional, SCHETTINI, Federico, additional, FRANCAVILLA, Ruggiero, additional, and CRISTOFORI, Fernanda, additional

Published
2023
Full Text
View/download PDF

18. Italian children seem to be spared from the mysterious severe acute hepatitis outbreak: A report by SIGENP Acute Hepatitis Group

Author

Di Dato, Fabiola, primary, Di Giorgio, Angelo, additional, Mandato, Claudia, additional, Maggiore, Giuseppe, additional, Iorio, Raffaele, additional, Aloi, Marina, additional, Antonucci, Roberto, additional, Banzato, Claudia, additional, Buccella, Valentina, additional, Calvo, Pier Luigi, additional, Campanozzi, Angelo, additional, Cananzi, Mara, additional, Cherubini, Simonetta, additional, Cristofori, Fernanda, additional, D’Antiga, Lorenzo, additional, Saccomani, Marco Deganello, additional, De Giorgi, Anna, additional, Dell’Omo, Valeria, additional, Ferrari, Federica, additional, Francavilla, Ruggiero, additional, Fuoti, Maurizio Giuseppe, additional, Gaio, Paola, additional, Graziano, Francesco, additional, Indolfi, Giuseppe, additional, Inferrera, Ramona, additional, Madeo, Annalisa, additional, Mesini, Alessio, additional, Moramarco, Fulvio, additional, Motta, Valentina, additional, Parma, Barbara, additional, Pinon, Michele, additional, Provera, Silvia, additional, Ranucci, Giusy, additional, Tulone, Anna, additional, Valentini, Piero, additional, Veraldi, Silvio, additional, and Villirillo, Antonietta, additional

Published
2022
Full Text
View/download PDF

19. Case report: Late-onset hypertrophic pyloric stenosis in a 3-year-old boy: It is never too late

Author

Iacoviello, Onofrio, Verriello, Giuseppe, Castellaneta, Stefania, Palladino, Stefano, Wong, Michela, Mattioli, Girolamo, Giordano, Paola, Francavilla, Ruggiero, and Cristofori, Fernanda

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Hypertrophic Pyloric Stenosis (HPS) represents a relatively rare occurrence beyond infancy. Here, we present the case of a barely 3-year-old boy diagnosed with late-onset HPS and successfully treated with extra-mucosal pyloromyotomy. We review the literature, challenging the principle that more aggressive surgical approaches should be preferred over less invasive ones.

Published
2022

20. Nutritional Assessment of Baby Food Available in Italy

Author

Antignani, Angelo, primary, Francavilla, Ruggiero, additional, Vania, Andrea, additional, Leonardi, Lucia, additional, Di Mauro, Cristina, additional, Tezza, Giovanna, additional, Cristofori, Fernanda, additional, Dargenio, Vanessa, additional, Scotese, Immacolata, additional, Palma, Filomena, additional, and Caroli, Margherita, additional

Published
2022
Full Text
View/download PDF

23. Gut Immunobiosis and Biomodulators.

Author

Miniello, Vito Leonardo, Miniello, Andrea, Ficele, Laura, Skublewska-D'Elia, Aleksandra, Dargenio, Vanessa Nadia, Cristofori, Fernanda, and Francavilla, Ruggiero

Abstract

The human gastrointestinal (GI) tract hosts complex and dynamic populations of microorganisms (gut microbiota) in advantageous symbiosis with the host organism through sophisticated molecular cross-talk. The balance and diversification within microbial communities (eubiosis) are crucial for the immune and metabolic homeostasis of the host, as well as for inhibiting pathogen penetration. In contrast, compositional dysregulation of the microbiota (dysbiosis) is blamed for the determinism of numerous diseases. Although further advances in the so-called 'omics' disciplines are needed, dietary manipulation of the gut microbial ecosystem through biomodulators (prebiotics, probiotics, symbionts, and postbiotics) represents an intriguing target to stabilize and/or restore eubiosis. Recently, new approaches have been developed for the production of infant formulas supplemented with prebiotics (human milk oligosaccharides [HMOs], galacto-oligosaccharides [GOS], fructo-oligosaccharides [FOS]), probiotics, and postbiotics to obtain formulas that are nutritionally and biologically equivalent to human milk (closer to the reference). [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

24. Italian children seem to be spared from the mysterious severe acute hepatitis outbreak: A report by SIGENP Acute Hepatitis Group

Author

Aloi, Marina, Antonucci, Roberto, Banzato, Claudia, Buccella, Valentina, Calvo, Pier Luigi, Campanozzi, Angelo, Cananzi, Mara, Cherubini, Simonetta, Cristofori, Fernanda, D’Antiga, Lorenzo, Saccomani, Marco Deganello, De Giorgi, Anna, Dell’Omo, Valeria, Ferrari, Federica, Francavilla, Ruggiero, Fuoti, Maurizio Giuseppe, Gaio, Paola, Graziano, Francesco, Indolfi, Giuseppe, Inferrera, Ramona, Madeo, Annalisa, Mesini, Alessio, Moramarco, Fulvio, Motta, Valentina, Parma, Barbara, Pinon, Michele, Provera, Silvia, Ranucci, Giusy, Tulone, Anna, Valentini, Piero, Veraldi, Silvio, Villirillo, Antonietta, Di Dato, Fabiola, Di Giorgio, Angelo, Mandato, Claudia, Maggiore, Giuseppe, and Iorio, Raffaele

Published
2022
Full Text
View/download PDF

25. Risk of obesity during a gluten-free diet in pediatric and adult patients with celiac disease: a systematic review with meta-analysis.

Author

Barone, Michele, Iannone, Andrea, Cristofori, Fernanda, Dargenio, Vanessa Nadia, Indrio, Flavia, Verduci, Elvira, Leo, Alfredo Di, and Francavilla, Ruggiero

Subjects
CELIAC disease diagnosis, RISK of childhood obesity, ONLINE information services, EXPERIMENTAL design, META-analysis, CONFIDENCE intervals, BODY weight, CHILDHOOD obesity, SYSTEMATIC reviews, AGE distribution, CELIAC disease, LEANNESS, DESCRIPTIVE statistics, DISEASE prevalence, BODY mass index, MEDLINE, STATISTICAL models, DATA analysis software, GLUTEN-free diet, CHILDREN, ADULTS, ADOLESCENCE
Abstract

Context Obesity is a significant risk factor for many pathological conditions. Whether a gluten-free diet (GFD) is a risk factor for overweight or obesity remains controversial. Objective The primary aim of this study was to assess the prevalence of body mass index (BMI) categories at disease presentation and the variation in BMI category from underweight/normal to overweight/obese and vice versa during a GFD. Data Sources PubMed, Scopus, and Web of Science databases were searched through February 2021 for retrospective, cross-sectional, and prospective studies reporting BMI categories at disease diagnosis and during a GFD. Data Extraction Data were extracted by 2 reviewers independently. Disagreements were resolved by consensus; a third reviewer was consulted, if necessary. Risk of bias was assessed with the Cochrane ROBINS-I tool. Data Analysis Subgroup analysis based on age (pediatric/adult patients), study design (prospective, cross-sectional, retrospective), and duration of GFD was performed.. Forty-five studies were selected (7959 patients with celiac disease and 20 524 healthy controls). The mean BMI of celiac patients at presentation was significantly lower than that of controls (P  < 0.001). During a GFD, the mean BMI increased significantly (mean difference = 1.14 kg/m2 [95%CI, 0.68–1.60 kg/m2]; I2  = 82.8%; P  < 0.001), but only 9% of patients (95%CI, 7%–12%; I2  = 80.0%) changed from the underweight/normal BMI category to the overweight/obese category, while 20% (95%CI, 11%–29%; I2  = 85.8%) moved into a lower BMI category. Conclusion Most celiac patients had a normal BMI at presentation, although the mean BMI was significantly lower than that of controls. A GFD does not increase the risk of becoming overweight/obese, especially in children. The quality of several studies was suboptimal, with moderate or high overall risk of bias and heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study

Author

Cristofori, Fernanda, primary, D’Abramo, Fulvio Salvatore, additional, Rutigliano, Vincenzo, additional, Dargenio, Vanessa Nadia, additional, Castellaneta, Stefania, additional, Piscitelli, Domenico, additional, De Benedittis, Davide, additional, Indrio, Flavia, additional, Raguseo, Lidia Celeste, additional, Barone, Michele, additional, and Francavilla, Ruggiero, additional

Published
2021
Full Text
View/download PDF

29. Retrospective Study on Breastfeeding Practices by SARS-COV-2 Positive Mothers in a High Risk Area for Coronavirus Infection.

Author

Indrio, Flavia, Mantovani, Massimo Pettoello, Salatto, Alessia, Rinaldi, Matteo, Dargenio, Vanessa Nadia, Cristofori, Fernanda, Marchese, Flavia, Bianchi, Francesco Paolo, Nappi, Luigi, and Maffei, Gianfranco

Subjects
MATERNAL health services, COVID-19, PSYCHOLOGY of mothers, RETROSPECTIVE studies, MOTHER-infant relationship, BREASTFEEDING, HAND washing, VERTICAL transmission (Communicable diseases)
Abstract

Background: During the pandemic of SARS-Cov-2, among other clinical and public health issues, a major concern raised by SARS-CoV-2 is the possibility of transmission of the infection from mother to child in the perinatal period. This has placed a question mark on the safety of breastfeeding, with ambiguity on the joint management of SARS-CoV-2 positive or suspected mothers and their children. It was aimed to evaluate breastfeeding rates for newborns of asymptomatic SARS-CoV-2 positive mothers who were temporarily separated from their babies at birth, compared to those who were not separated. Results: Babies who were not isolated from their mothers at delivery were significantly more likely to be breastfed and were at no higher risk of infection with SARS-CoV-2. Conclusion: Following the World Health Organization (WHO) recommendations and strict hand and mask hygiene measures, breastfeeding practices can be established and maintained through rooming-in, thus promoting the mother-child bond without compromising the safety of the newborn. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

32. Italian children seem to be spared from the mysterious severe acute hepatitis outbreak: A report by SIGENP Acute Hepatitis Group

Author

Fabiola Di Dato, Angelo Di Giorgio, Claudia Mandato, Giuseppe Maggiore, Raffaele Iorio, Marina Aloi, Roberto Antonucci, Claudia Banzato, Valentina Buccella, Pier Luigi Calvo, Angelo Campanozzi, Mara Cananzi, Simonetta Cherubini, Fernanda Cristofori, Lorenzo D’Antiga, Marco Deganello Saccomani, Anna De Giorgi, Valeria Dell’Omo, Federica Ferrari, Ruggiero Francavilla, Maurizio Giuseppe Fuoti, Paola Gaio, Francesco Graziano, Giuseppe Indolfi, Ramona Inferrera, Annalisa Madeo, Alessio Mesini, Fulvio Moramarco, Valentina Motta, Barbara Parma, Michele Pinon, Silvia Provera, Giusy Ranucci, Anna Tulone, Piero Valentini, Silvio Veraldi, Antonietta Villirillo, DI DATO, Fabiola, Di Giorgio, Angelo, Mandato, Claudia, Maggiore, Giuseppe, Iorio, Raffaele, Aloi, Marina, Antonucci, Roberto, Banzato, Claudia, Buccella, Valentina, Luigi Calvo, Pier, Campanozzi, Angelo, Cananzi, Mara, Cherubini, Simonetta, Cristofori, Fernanda, D’Antiga, Lorenzo, Deganello Saccomani, Marco, De Giorgi, Anna, Dell’Omo, Valeria, Ferrari, Federica, Francavilla, Ruggiero, Giuseppe Fuoti, Maurizio, Gaio, Paola, Graziano, Francesco, Indolfi, Giuseppe, Inferrera, Ramona, Madeo, Annalisa, Mesini, Alessio, Moramarco, Fulvio, Motta, Valentina, Parma, Barbara, Pinon, Michele, Provera, Silvia, Ranucci, Giusy, Tulone, Anna, Valentini, Piero, Veraldi, Silvio, and Villirillo, Antonietta

Subjects
Hepatology, liver transplantation, adenoviru, adenovirus, acute liver failure, Liver Failure, Acute, hepatiti, Disease Outbreaks, Hepatitis, Italy, children, Acute Disease, Humans, hepatitis, Child
Published
2022

33. Self-Reported Nonceliac Gluten Sensitivity in Italian Young Adults: A Cross-Sectional Study. A Dietary Fad?

Author

Brindicci VF, Franceschini S, Gnasso I, Alcini P, Tassi EA, Santarelli L, Cristofori F, Dargenio VN, Castellaneta S, and Francavilla R

Abstract

Introduction: In different countries, the exact prevalence of people that refer symptoms after gluten ingestion is increasing and the unavailability of reliable laboratory tests to diagnose the condition known as nonceliac gluten sensitivity (NCGS) has opened the door to the spread of survey-based studies to hypothesize a prevalence of this condition with highly discordant results. We aim to describe the attitude toward gluten consumption in a large population of young adults in Italy., Methods: A questionnaire-based cross-sectional study was conducted in 13 Italian cities to investigate the dietary attitudes of more than 9,400 people distributed throughout the country about gluten consumption. Only those referring to gluten-related symptoms with a frequency equal to "always" or "most of the time" were considered self-reported NCGS (SR-NCGS) patients., Results: Five thousand two hundred thirty-four of 9,432 eligible participants (55.5%) fully completed the questionnaire. Excluding those with previous gastrointestinal diagnoses of celiac disease and wheat allergy, we have finally analyzed 4,987 questionnaires. Four hundred eighty-seven participants indicated gluten-related symptoms always or most of the time (SR-NCGS subjects), while 121 already had a medical diagnosis of NCGS. The minimum prevalence figure of SR-NCGS is 6.4% (95% confidence interval 6.0-6.9), with a higher prevalence in women (79.9%). The most frequent gluten-related symptoms were bloating, abdominal pain, and tiredness., Discussion: The high prevalence of people reporting symptoms after gluten ingestion requires that the diagnosis of NCGS should be ascertained with a double-blind controlled study to limit the number of people who improperly approach a gluten-free diet., (Copyright © 2024 by The American College of Gastroenterology.)

Published
2024
Full Text
View/download PDF

34. Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.

Author

Valitutti F, Leonard MM, Kenyon V, Montuori M, Piemontese P, Francavilla R, Malamisura B, Norsa L, Calvi A, Lionetti ME, Baldassarre M, Trovato CM, Perrone M, Passaro T, Sansotta N, Crocco M, Morelli A, Raguseo LC, Malerba F, Elli L, Cristofori F, Catassi C, and Fasano A

Subjects
Child, Humans, Prospective Studies, Gliadin, Immunoglobulin A, Autoantibodies, Immunoglobulin G, Biomarkers, Transglutaminases, Celiac Disease
Abstract

Introduction: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk., Methods: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity)., Results: Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion., Discussion: Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk., (Copyright © 2023 by The American College of Gastroenterology.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results