Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease.

Authors :: Valitutti F
Leonard MM
Kenyon V
Montuori M
Piemontese P
Francavilla R
Malamisura B
Norsa L
Calvi A
Lionetti ME
Baldassarre M
Trovato CM
Perrone M
Passaro T
Sansotta N
Crocco M
Morelli A
Raguseo LC
Malerba F
Elli L
Cristofori F
Catassi C
Fasano A
Source :: The American journal of gastroenterology [Am J Gastroenterol] 2023 Mar 01; Vol. 118 (3), pp. 574-577. Date of Electronic Publication: 2023 Jan 20.
Publication Year :: 2023
Abstract: Introduction: The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.<br />Methods: A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).<br />Results: Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.<br />Discussion: Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.<br /> (Copyright © 2023 by The American College of Gastroenterology.)

Subjects :: Child
Humans
Prospective Studies
Gliadin
Immunoglobulin A
Autoantibodies
Immunoglobulin G
Biomarkers
Transglutaminases
Celiac Disease

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