36 results on '"Yücel Karakurt"'
Search Results
2. Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography
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Erel İçel, Hayati Yılmaz, Turgay Uçak, Nurdan Gamze Taşlı, Adem Uğurlu, and Yücel Karakurt
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retina ,optic coherence tomography ,vessel density ,foveal avascular zone ,nidek rs-3000 advance ,Medicine ,Ophthalmology ,RE1-994 - Abstract
Objectives:To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL).Materials and Methods:A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study. Refraction and biometry measurements were performed. Retinal nerve fiber layer thickness (RNFLT), central macular volume, and central macular thickness (CMT) were measured by optical coherence tomography (OCT) after dilatation. Using the OCTA device, foveal avascular zone (FAZ) area, vascular density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, and the VD of the radial peripapillary capillary plexus (RPCP) of the optic disc were recorded.Results:The mean age of the study group was 11.27±3 years, the mean AL was 23.39±1.18 mm and the mean SE was -1.31±1.61 diopters. The mean FAZ area was 0.3±0.09 mm2, the mean SCP-VD was 43.88±3.4%, the mean DCP-VD was 39.6±3.55%, and the mean RPCP-VD was 52.47±3.42%. When the relationship between the OCTA measurements and the SE and AL values were analyzed, there was no statistical significance (p>0.05). When age and OCTA measurements were compared, only DCP-VD values were found to significantly decrease with increasing age (p=0.015). There was no significant difference in OCTA measurements based on gender (p>0.05). Similarly, no statistical age-based differences were observed in RNFLT, CMV and CMT values (p>0.05).Conclusion:With its short procedure time and no dye requirement, OCTA can be safely used in the evaluation of the optic disc and macular perfusion in children. Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.
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- 2020
- Full Text
- View/download PDF
3. The findings of corneal specular microscopy in patients with type-2 diabetes mellitus
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Nurdan Gamze Taşlı, Erel Icel, Yücel Karakurt, Turgay Ucak, Adem Ugurlu, Hayati Yilmaz, and Emin Murat Akbas
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Specular microscopy ,Corneal endothelial cells ,Diabetes mellitus ,Microalbuminuria ,Ophthalmology ,RE1-994 - Abstract
Abstract Background We aimed to compare the morphological characteristics of corneal endothelial cells in type 2 diabetic patients and age-matched healthy subjects by specular microscopy. We also aimed to determine the association of corneal morphological features with the general characteristics and laboratory data of diabetic patients, including disease duration, haemoglobin A1c (HbA1c) levels and urine albumin creatinine ratio. Methods A total of 195 diabetic patients and 100 healthy controls were enrolled in the study. All participants underwent a complete ophthalmological examination. Corneal endothelial measurements were performed using a noncontact specular microscopy. Laboratory data including serum fasting glucose, haemoglobin A1c levels, creatinine levels, and the urinary albumin-to-creatinine ratio were recorded. Diabetic patients were further subdivided into 3 groups according to the presence and stage of diabetic retinopathy. Specular microscopy findings and central corneal thickness of all patients were compared. Results The ECD and hexagonal cell ratio were significantly lower, while the average cell size, CV%, and central corneal thickness were determined to be significantly higher in diabetic patients than in healthy controls (p = 0.001). With the presence and advancement of diabetic retinopathy, the ECD and hexagonal cell ratio decreased, while the average cell size, CV%, and central corneal thickness increased. When correlation analysis was performed between corneal morphological features and laboratory data of diabetic patients, ECD showed a significant negative correlation with diabetes duration (p = 0.028). HbA1c levels, urinary albumin-creatinine ratio (p = 0.041), average cell size and CV showed a positive correlation with these parameters. Conclusion In conclusion, keratopathy is an important complication of type 2 diabetes. With an increase in the stage of diabetic retinopathy, alterations in corneal findings also increased. In that respect, we can suggest that keratopathy should be evaluated more cautiously in diabetic patients.
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- 2020
- Full Text
- View/download PDF
4. Assessment of Anterior Segment Parameters and Specular Microscopy Findings in Patients with COPD
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Nurdan Gamze Taşlı, Hasan Ölmez, Adem Uğurlu, Turgay Uçak, Erel İçel, Yücel Karakurt, and Hayati Yılmaz
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specular microscopy ,chronic obstructive pulmonary disease ,corneal endothelial cell. ,Medicine (General) ,R5-920 - Abstract
Objective: The aim of the present study was to assess the anterior segment parameters of patients with chronic obstructive pulmonary disease (COPD) by corneal specular microscopy and biometry and to compare the results with healthy controls. Materials and Methods: Our prospective study consisted of 122 eyes of 61 patients with COPD and 110 eyes of 55 patients without any systemic diseases. A comprehensive medical history was obtained, and corrected visual acuity, bio microscopic and fundus examination, intraocular pressure (IOP) measurement with applanation tonometry, and non-contact specular microscopy were performed in all participants. Results: The endothelial cell density was lower in the COPD group than in the control group (p
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- 2020
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5. Anizometropik Ambliyopi Olgularında Retina Sinir Lifi Tabakası, Maküla Kalınlığı ve Gangliyon Hücre Kompleksinin Değerlendirilmesi
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Nurdan Gamze Taşlı, Turgay Uçak, Erdinç Bozkurt, Erel İçel, Yücel Karakurt, Sümeyye Burcu Ağcayazı, and Mahmut Atum
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ambliyopi ,retina sinir lifi tabakası ,gangliyon hücre kompleksi ,optik koherens tomografi ,Medicine - Abstract
Amaç: Anizometropiye bağlı tek taraflı ambliyopisi bulunan olguların retina sinir lifi tabakası (RSLT), maküla kalınlığı (MK) ve gangliyon hücre kompleksinin (GHK) optik koherens tomografi (OKT) cihazı ile değerlendirilip, sonuçların sağlam göz ve kontrol grubuyla karşılaştırılması. Gereç ve Yöntemler: Çalışmaya tek gözde anizometropik ambliyopi tespit edilen 89 hastanın 89 ambliyop gözü, kontrol grubu olarakta hasta grubunun 89 sağlam gözü ve 31 sağlıklı kişinin 62 gözü çalışmaya dahil edildi. Tüm olguların detaylı oftalmolojik muayenesinin ardından OKT cihazı ile RSLT, MK ve GHK değerleri ölçülerek istatistiksel olarak karşılaştırıldı, p lt;0,05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya dahil edilen katılımcıların yaş ortalamaları ambliyopi hasta grubunda 13.19±6.28 yıl, kontrol grubunda ise 13.5±6.5 yıl idi. MK analizlerine bakıldığında gruplar arasında anlamlı farklılık tespit edilmedi (p gt;0,05). Olguların ortalama RSLT değerleri arasında gruplar istatistiksel olarak anlamlı farklılık saptanamamışken; superior ve inferior kadran kalınlığı ambliyop gözlerde kontrol grubuna göre anlamlı olarak yüksek bulundu (sırasıyla; p=0.045, p=0.026). GHK değerlendirmesinde üst kadran kontrol grubunda hasta grubuna göre anlamlı olarak daha inceydi (p=0,026). Sonuç: MK değerinde ambliyopi olguları ile kontrol grubu arasında anlamlı fark bulunmazken, RSLT’de üst ve alt kadran ile GHK üst kadran kalınlıkları hasta grubunda kontrol grubuna göre istatiksel olarak anlamlı yüksek bulunmuştur.
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- 2019
- Full Text
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6. Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study
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Nurdan Gamze Taşlı, Ferda Keskin Çimen, Yücel Karakurt, Turgay Uçak, Renad Mammadov, Bahadır Süleyman, Nezahat Kurt, and Halis Süleyman
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785 ,methanol ,optic neuropathy ,rutin ,astrocyte ,rat ,Ophthalmology ,RE1-994 - Abstract
AIM: To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ethanol. METHODS: Totally 30 rats were divided into 5 groups, with 6 rats in each group as follows: healthy controls (C), methotrexate (MTX), methotrexate+methanol (MTM), methotrexate+methanol+ethanol (MTME) and methotrexate+ methanol+Rutin (MTMR). In all rabbits except those of the control group, MTX, diluted in sterile serum physiologic, 0.3 mg/kg per oral was applied for 7d by the aid of a tube. After this procedure to the rats of MTM, MTME and MTMR groups, 20% methanol with a dose of 3 g/kg per oral was given by the aid of a tube. In MTME group, 4h after the application of methanol, 20% ethanol was applied by the same way with a dose of 0.5 g/kg. On the other hand, in MTMR group 4h after the application of methanol, Rutin, which was dissolved in distilled water, was applied by the same way with a dose of 50 mg/kg. RESULTS: There were statistically significant differences in tissue 8- hydroxy-2 deoxyguanine (8-OHdG), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO). glutathione peroxidase (tGSH) and superoxide dismutase (SOD) levels between groups (P
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- 2018
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7. Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A rat model study
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Halis Suleyman, Ferda Keskin Cimen, Erel Icel, Turgay Ucak, Nurdan Gamze Tasli, Adem Ugurlu, Yücel Karakurt, and Sumeyye Burcu Agcayazi
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Male ,Inflammation ,Pharmacology ,Resveratrol ,Toxicology ,medicine.disease_cause ,Neuroprotection ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Animals ,Humans ,Medicine ,Cisplatin ,business.industry ,Optic Nerve ,General Medicine ,Malondialdehyde ,Rats ,Disease Models, Animal ,Oxidative Stress ,Neuroprotective Agents ,chemistry ,Optic Nerve Injuries ,Toxicity ,030221 ophthalmology & optometry ,Optic nerve ,medicine.symptom ,business ,Oxidative stress ,medicine.drug - Abstract
Aim To investigate the effects of resveratrol on oxidative stress and inflammation parameters and histological alterations in cisplatin-induced optic nerve damage in a mouse model. Material and method Thirty-six albino Wistar male rats were divided into three groups as control, 5 mg/kg cisplatin-administered (Cis) and 5 mg/kg cisplatin + 25 mg/kg resveratrol-administered (Cis + Res) animals. At the end of the experimental period, the rats were sacrificed with high-dose (50 mg/kg) thiopental sodium, and their optic nerves were dissected. Malondialdehyde (MDA), total glutathione (tGSH), total oxidant status (TOS), total antioxidant status (TAS), tumour necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-KB) levels, and histopathological findings were assessed using the optic nerve tissues. Results In the Cis + Res group, the MDA, TOS, OSI, TNF-a and NFK-B levels were significantly lower and the tGSH and TAS levels were significantly higher compared with the Cis group (P = 0.001). In histological evaluations, there were dilated and congested blood vessels, destruction, oedema, degeneration, haemorrhage, and proliferating capillaries indicating the presence of inflammation and damage only in the Cis-administered group. However, in the Cis + Res group, the histological findings were very similar to the healthy controls. Conclusion Resveratrol is a promising neuroprotective agent for cisplatin-induced optic nerve toxicity with its anti-oxidant and anti-inflammatory effects. Further investigations are needed to evaluate the possible therapeutic effects on other optic nerve toxicities.
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- 2021
8. Evaluation of the Optic Disc and Macula in Healthy Children Using Optical Coherence Tomography Angiography
- Author
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Hayati Yilmaz, Yücel Karakurt, Adem Ugurlu, Nurdan Gamze Tasli, Erel Icel, and Turgay Ucak
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Male ,medicine.medical_specialty ,Adolescent ,genetic structures ,Fundus Oculi ,Optic Disk ,Visual Acuity ,Nerve fiber layer ,lcsh:Medicine ,foveal avascular zone ,Nidek RS-3000 Advance ,Retina ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,lcsh:Ophthalmology ,Optical coherence tomography ,Reference Values ,vessel density ,Statistical significance ,Ophthalmology ,medicine ,Humans ,Macula Lutea ,Prospective Studies ,Fluorescein Angiography ,Child ,Prospective cohort study ,Dioptre ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Retinal ,eye diseases ,medicine.anatomical_structure ,chemistry ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,Female ,Original Article ,optic coherence tomography ,sense organs ,business ,Perfusion ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,Optic disc - Abstract
Objectives To perform the measurements of the optic disc and macula in healthy children using optical coherence tomography angiography (OCTA) in order to determine the normative data values and compare these by age, gender, spherical equivalent (SE), and axial length (AL). Materials and methods A total of 146 eyes belonging to 146 healthy children (74 girls, 72 boys) aged 6 to 16 years were included in this prospective study. Refraction and biometry measurements were performed. Retinal nerve fiber layer thickness (RNFLT), central macular volume, and central macular thickness (CMT) were measured by optical coherence tomography (OCT) after dilatation. Using the OCTA device, foveal avascular zone (FAZ) area, vascular density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, and the VD of the radial peripapillary capillary plexus (RPCP) of the optic disc were recorded. Results The mean age of the study group was 11.27±3 years, the mean AL was 23.39±1.18 mm and the mean SE was -1.31±1.61 diopters. The mean FAZ area was 0.3±0.09 mm2, the mean SCP-VD was 43.88±3.4%, the mean DCP-VD was 39.6±3.55%, and the mean RPCP-VD was 52.47±3.42%. When the relationship between the OCTA measurements and the SE and AL values were analyzed, there was no statistical significance (p>0.05). When age and OCTA measurements were compared, only DCP-VD values were found to significantly decrease with increasing age (p=0.015). There was no significant difference in OCTA measurements based on gender (p>0.05). Similarly, no statistical age-based differences were observed in RNFLT, CMV and CMT values (p>0.05). Conclusion With its short procedure time and no dye requirement, OCTA can be safely used in the evaluation of the optic disc and macular perfusion in children. Determination of normative values in children will be useful in detecting pathologic changes in tissue in patients with retinal diseases.
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- 2020
9. Alterations in optical coherence tomography angiography findings in patients with high myopia
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Gamze Tasli, Adem Ugurlu, Yücel Karakurt, Erel Icel, Hayati Yilmaz, Erdinç Bozkurt, and Turgay Ucak
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medicine.medical_specialty ,genetic structures ,Nerve fiber layer ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Optical coherence tomography ,Ophthalmology ,Myopia ,medicine ,Humans ,Macula Lutea ,In patient ,Prospective Studies ,Prospective cohort study ,Retina ,medicine.diagnostic_test ,business.industry ,Angiography ,Retinal ,Diabetic retinopathy ,medicine.disease ,eye diseases ,Ganglion ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,sense organs ,business ,Tomography, Optical Coherence ,030217 neurology & neurosurgery - Abstract
PURPOSE: The aim of this study was to determine the macular changes using optical coherence tomography (OCT) and OCT-angiography (OCT-A) in eyes with high myopia. Determining the alterations in vascular structures can provide a clearer understanding of the pathophysiological mechanisms of this disease and help define new treatment options and preventive measures. MATERIALS AND METHODS: Ninety-two patients with high myopia (axial length ≥ 26 mm) and 70 control cases without any known systemic or ocular diseases were enrolled in this prospective study. One eye of each patient was included in the statistical analyses. RESULTS: Retinal nerve fiber layer (RNFL) thickness and Early Treatment Diabetic Retinopathy Study (ETDRS) macula map values were lower in myopia compared with the controls. Both superior and inferior ganglion cell complex (GCC) thicknesses were significantly thinner in the high myopia compared with the controls (p
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- 2020
10. Thiol–Disulfide Homeostasis and Serum Ischemia Modified Albumin Levels in Patients with Primary Open–Angle Glaucoma
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Turgay Ucak, Ozcan Erel, Nurdan Gamze Tasli, Erel Icel, Yücel Karakurt, Cuma Mertoglu, and Gamze Gok
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Male ,Retinal Ganglion Cells ,medicine.medical_specialty ,Antioxidant ,genetic structures ,Open angle glaucoma ,medicine.medical_treatment ,Visual Acuity ,Glaucoma ,Serum Albumin, Human ,medicine.disease_cause ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Nerve Fibers ,0302 clinical medicine ,Internal medicine ,medicine ,Homeostasis ,Humans ,Disulfides ,Prospective Studies ,Sulfhydryl Compounds ,Prospective cohort study ,Intraocular Pressure ,Aged ,chemistry.chemical_classification ,business.industry ,Albumin ,Middle Aged ,medicine.disease ,eye diseases ,Sensory Systems ,Oxidative Stress ,Ophthalmology ,Endocrinology ,chemistry ,Case-Control Studies ,030221 ophthalmology & optometry ,Thiol ,Female ,sense organs ,business ,Biomarkers ,Glaucoma, Open-Angle ,030217 neurology & neurosurgery ,Oxidative stress - Abstract
Aim: Glaucoma is an optic neuropathy causing progressive impairment of visual functions. We aimed to assess the alterations in thiol-disulfide homeostasis and serum ischemia modified albumin (IMA) levels, which are the determinants of antioxidant status, in patients with primary open-angle glaucoma (POAG). Material and Method: A total of 140 eyes from 70 patients with POAG and 174 eyes of 87 healthy, control cases were included in the study. All study participants underwent a complete ophthalmic evaluation. Alterations in serum thiol-disulfide homeostasis and IMA levels were measured in all participants. Results: IMA levels were significantly higher in glaucoma group (p:0.001). Native thiol, Total thiol and Native/Total thiol ratio were significantly decreased while Disulfide, Disulfide/Native thiol, and Disulfide/Total thiol ratios were significantly higher in glaucoma group (p:0.001). There was no significant difference regarding central corneal thickness (CCT), iridocorneal angle, albumin, IMA and adjusted IMA levels in patients with different stages of glaucoma. In correlation analysis, there was a negative correlation between Native thiol, Total thiol and Native/Total thiol ratio and disease period, number of daily drops required and stage of the disease in glaucoma patients. There was also a positive correlation between Disulfide, Disulfide/Native thiol and Disulfide/Total thiol levels and the disease activity. Conclusion: In patients with POAG, thiol-disulfide homeostasis is disturbed in the favor of pro-oxidant molecules and IMA levels are increased, indicating the presence of augmented oxidative stress. In that aspect, systemic and local anti-oxidant treatments may be new targets in glaucoma treatment. Larger, prospective studies about the role of anti-oxidants in prevention and treatment of POAG are warranted.
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- 2019
11. Ocular Problems Following Lightning Strike Injury: A Case Report
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Sumeyye Burcu Agcayazi, Turgay Ucak, Yücel Karakurt, Erel Icel, Adem Türk, and Nurdan Gamze Tasli
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Lightning strike ,business.industry ,Forensic engineering ,Medicine ,business - Published
- 2019
12. The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: an experimental study
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Erel Icel, Ferda Keskin Cimen, Yücel Karakurt, Nezahat Kurt, Turgay Ucak, Gamze Tasli, and Halis Suleyman
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Male ,0301 basic medicine ,medicine.medical_specialty ,Lutein ,Tuberculosis ,First line ,Interleukin-1beta ,Eye ,Toxicology ,Optic neuropathy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Malondialdehyde ,Ophthalmology ,Optic Nerve Diseases ,Isoniazid ,medicine ,Animals ,Rats, Wistar ,Adverse effect ,Ethambutol ,Tumor Necrosis Factor-alpha ,business.industry ,General Medicine ,bacterial infections and mycoses ,medicine.disease ,Glutathione ,eye diseases ,030104 developmental biology ,chemistry ,030221 ophthalmology & optometry ,ON - Optic nerve ,business ,medicine.drug - Abstract
Ethambutol and isoniazid are two major effective first line agents in tuberculosis treatment having some visual adverse effects. We aimed to determine the protective effects of lutein on oxidative optic neuropathy induced by ethambutol and isoniazid in an experimental model.Totally 24 albino Wistar male rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group), 50 mg/kg ethambutol +50 mg/kg isoniazid administered group (EI), 0.5 mg/kg lutein +50 mg/kg ethambutol +50 mg/kg isoniazid administered group (LEI-05) and only Lutein (0.5 mg/kg) (LUT group) administered group. From the blood samples and tissues obtained from the rats, Malondialdehyde (MDA), total glutathione (GSH), interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) levels were studied. Histopathological evaluations were performed at the end of the study.Serum and tissue IL-1β, TNF-α and MDA levels were the highest in EI group which were significantly lower in lutein administered group. On the other hand, serum and tissue total GSH levels were the lowest in EI group which were significantly higher in Lutein administered group. In histopathological evaluations, there were significant differences between EI group and all other three groups with edema and hemorrhage in connective tissue covering optic nerve, dilated and congested capillary, decrease in astrocytes and oligodendrocytes.Isoniazid and ethambutol induced toxic optic neuropathy although not common, may have some potential devastating effects on vision. Lutein is determined as an effective agent in prevention of isoniazid and ethambutol induced toxic optic neuropathy.
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- 2018
13. The findings of corneal specular microscopy in patients with type-2 diabetes mellitus
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Turgay Ucak, Hayati Yilmaz, Emin Murat Akbas, Nurdan Gamze Tasli, Adem Ugurlu, Yücel Karakurt, and Erel Icel
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Blood Glucose ,Male ,medicine.medical_specialty ,genetic structures ,Urinary system ,Cell Count ,Serum Albumin, Human ,Type 2 diabetes ,Corneal Diseases ,03 medical and health sciences ,chemistry.chemical_compound ,Diabetes mellitus ,0302 clinical medicine ,lcsh:Ophthalmology ,Ophthalmology ,medicine ,Humans ,Prospective Studies ,Aged ,Cell Size ,Glycated Hemoglobin ,Microscopy ,Creatinine ,Diabetic Retinopathy ,business.industry ,Endothelium, Corneal ,Type 2 Diabetes Mellitus ,Corneal endothelial cells ,General Medicine ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,Diabetes Mellitus, Type 2 ,chemistry ,lcsh:RE1-994 ,Specular microscopy ,030220 oncology & carcinogenesis ,030221 ophthalmology & optometry ,Female ,Microalbuminuria ,sense organs ,Complication ,business ,Research Article - Abstract
Background We aimed to compare the morphological characteristics of corneal endothelial cells in type 2 diabetic patients and age-matched healthy subjects by specular microscopy. We also aimed to determine the association of corneal morphological features with the general characteristics and laboratory data of diabetic patients, including disease duration, haemoglobin A1c (HbA1c) levels and urine albumin creatinine ratio. Methods A total of 195 diabetic patients and 100 healthy controls were enrolled in the study. All participants underwent a complete ophthalmological examination. Corneal endothelial measurements were performed using a noncontact specular microscopy. Laboratory data including serum fasting glucose, haemoglobin A1c levels, creatinine levels, and the urinary albumin-to-creatinine ratio were recorded. Diabetic patients were further subdivided into 3 groups according to the presence and stage of diabetic retinopathy. Specular microscopy findings and central corneal thickness of all patients were compared. Results The ECD and hexagonal cell ratio were significantly lower, while the average cell size, CV%, and central corneal thickness were determined to be significantly higher in diabetic patients than in healthy controls (p = 0.001). With the presence and advancement of diabetic retinopathy, the ECD and hexagonal cell ratio decreased, while the average cell size, CV%, and central corneal thickness increased. When correlation analysis was performed between corneal morphological features and laboratory data of diabetic patients, ECD showed a significant negative correlation with diabetes duration (p = 0.028). HbA1c levels, urinary albumin-creatinine ratio (p = 0.041), average cell size and CV showed a positive correlation with these parameters. Conclusion In conclusion, keratopathy is an important complication of type 2 diabetes. With an increase in the stage of diabetic retinopathy, alterations in corneal findings also increased. In that respect, we can suggest that keratopathy should be evaluated more cautiously in diabetic patients.
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- 2020
14. The effects of rutin on cisplatin induced oxidative retinal and optic nerve injury: an experimental study
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Turgay Ucak, Ferda Keskin Cimen, Yücel Karakurt, Nurdan Gamze Tasli, Aslı Özbek Bilgin, Halis Suleyman, and Nezahat Kurt
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Male ,0301 basic medicine ,genetic structures ,Rutin ,Antineoplastic Agents ,Oxidative phosphorylation ,Pharmacology ,Toxicology ,Antioxidants ,Retina ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Optic nerve injury ,Male rats ,medicine ,Animals ,Humans ,Rats, Wistar ,Cisplatin ,business.industry ,Optic Nerve ,Retinal ,General Medicine ,eye diseases ,Rats ,Disease Models, Animal ,Oxidative Stress ,030104 developmental biology ,chemistry ,030221 ophthalmology & optometry ,Lipid Peroxidation ,business ,Biomarkers ,medicine.drug - Abstract
To determine the role of rutin in prevention of cisplatin induced retinal and optic nerve injury in an experimental study.Totally 18 albino Wistar male rats were assigned into three groups, as follows: healthy controls (HC group), only cisplatin administered group for 14 days (CIS group), and rutin + cisplatin administered group for 14 days (RC group). Blood samples were obtained from animals just before the scarification. Serum malondialdehyde (MDA), myeloperoxidase (MPO), total glutathione (tGSH), superoxide dismutase (SOD), interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (TNF-α) levels were investigated. The eyes were enucleated for histopathological evaluations of retina and optic nerve.MDA, MPO, IL-1β and TNF-α levels were statistically significantly higher (p 0.001) in CIS group compared with other two groups while tGSH and SOD levels were statistically significantly lower (p 0.001). Regarding these parameters, in CIS group MDA, MPO, IL1β and TNF-α levels were statistically significantly increased with cisplatin administration and giving rutin concomitantly with cisplatin prevented this increase. On the other hand, tGSH and SOD levels were statistically significantly decreased with cisplatin administration and giving rutin concomitantly with cisplatin prevented this decrease. In qualitative analyses of histopathological findings of retina and optic nerve; the results of RC group were similar with the results of healthy controls; but there was statistically significant differences between CIS group and other two groups (p 0.001).Concomitant rutin administration may prevent the detrimental effects of cisplatin on lipid peroxidation, oxidative stress and inflammation markers and may also avert the histopathological damage on retina and optic nerve. Further studies are warranted to determine the effects of cisplatin and rutin on eye.
- Published
- 2018
15. Are The Neutrophil-to-lymphocyte, Platelet-to-lymphocyte And Monocyte-to-lymphocyte Ratios Predictive Factors For The Retinopathy Of Prematurity?
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Adem Uğurlu, Erel İçel, Nurdan Gamze Taşlı, Hayati Yılmaz, Turgay Uçak, and Yücel Karakurt
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Purpose: In this study, we aimed to evaluate the possible relationship between the neutrophil-to-lymphocyte, monocyte-to-lymphocyte and platelet-to-lymphocyte ratio and retinopathy of prematurity (ROP). Method: The data of 348 patients who applied to Erzincan University Ophthalmology Unit for screening the retinopathy of prematurity were analyzed retrospectively. One hundred sixty seven patients who were collected CBC samples within the first 72 hours after delivery and who met the inclusion criteria were included in the study. Infants with a gestational age of ≤35 week were screened for ROP. Pateints were divided into two groups. Group 1 was involved the patients with the diagnosis of ROP and group 2 was involved the normal patients (no ROP). The levels of NLR, PLR and MLR were determined in two groups. Results: Fifty nine patients who were detected ROP are in group 1 and 108 patients who were not seen ROP are in group 2 in the study. The mean gestational age at birth of the patients was 30,4 ± 2,1 [26-34] weeks in group 1 and 33,7 ± 1,7 [27-35] weeks in group 2.( P =0.004) The mean gestational weigth at birth was 1927,2 ± 158,4 [1690-2300] gram in group 1 and 2169,1 ± 283,1 [1750-3100] gram in group 2. ( P
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- 2019
16. Normative Data Assessment of Vessel Density and Foveal Avascular Zone Metrics Using AngioScan Software
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Nurdan Gamze Tasli, Hayati Yilmaz, Erel Icel, Adem Ugurlu, Turgay Ucak, Yücel Karakurt, and Sumeyye Burcu Elpeze
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Adult ,Male ,medicine.medical_specialty ,Fovea Centralis ,Computer science ,Fundus Oculi ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Software ,Vessel density ,Ophthalmology ,medicine ,Humans ,Prospective Studies ,Fluorescein Angiography ,business.industry ,Healthy subjects ,Retinal Vessels ,Optical coherence tomography angiography ,Foveal avascular zone ,Middle Aged ,Sensory Systems ,Capillaries ,Normative database ,Cross-Sectional Studies ,030221 ophthalmology & optometry ,Normative ,Female ,business ,Microvascular Density ,030217 neurology & neurosurgery ,Tomography, Optical Coherence - Abstract
Purpose: To establish a normative database for macular and peripapillary vessel densities (VD) and foveal avascular zone (FAZ) metrics in healthy subjects with the new version of AngioScan software...
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- 2019
17. Serum SCUBE-1 levels in patients with diabetic retinopathy
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Cuma Mertoglu, Yücel Karakurt, Aykut Icel, Nurdan Gamze Tasli, Erel Icel, Murat Gunay, and Turgay Ucak
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Adult ,Male ,medicine.medical_specialty ,Gastroenterology ,chemistry.chemical_compound ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Platelet ,In patient ,Prospective Studies ,Diabetic Retinopathy ,business.industry ,Calcium-Binding Proteins ,A protein ,Diabetic retinopathy ,Middle Aged ,Malondialdehyde ,medicine.disease ,Ophthalmology ,chemistry ,Case-Control Studies ,Correlation analysis ,Female ,Hemoglobin ,business ,Biomarkers ,Follow-Up Studies - Abstract
Signal peptide-CUB-Epidermal growth factor-like domain-containing protein 1 (SCUBE-1) is a protein expressed on the cell surface of endothelial cells and platelets. We aimed to determine the alterations in SCUBE-1 levels in patients at different stages of diabetic retinopathy (DR). Participants were grouped into 4 regarding the presence and stage of diabetic retinopathy as follows: control group (n 32), patients without DR (n 39), patients with background DR (n 42) and patients with proliferative DR (n 55). Age, gender, duration of diabetes, fasting blood glucose levels, serum hemoglobin A1c (HbA1c), SCUBE-1 and malondialdehyde (MDA) levels of the patients were recorded. Central macular thickness and central macular volume were recorded and compared between groups. Totally 136 patients with diabetes mellitus and 32 control cases were included in the study. There is a significant increase in SCUBE-1 and MDA levels with an advance in DR. In correlation analysis, there was only a significant correlation present between serum SCUBE-1 and MDA levels (p 0.001) but not with other parameters. For the first time in literature, we determined a significant increase in SCUBE-1 levels in patients with DR. Moreover, with an advance in DR, SCUBE-1 levels were also increasing.
- Published
- 2019
18. The Relation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio with High Axial Myopia
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Erel Icel, Hayati Yilmaz, Nurdan Gamze Tasli, Yücel Karakurt, Adem Türk, and Turgay Ucak
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Adult ,Blood Platelets ,Male ,Adolescent ,Neutrophils ,Lymphocyte ,Inflammation ,Refraction, Ocular ,03 medical and health sciences ,Leukocyte Count ,Young Adult ,0302 clinical medicine ,medicine ,Immunology and Allergy ,Humans ,Platelet ,Lymphocytes ,Prospective Studies ,Neutrophil to lymphocyte ratio ,Axial myopia ,Aged ,030203 arthritis & rheumatology ,business.industry ,Platelet Count ,fungi ,Middle Aged ,body regions ,Ophthalmology ,medicine.anatomical_structure ,Immunology ,Myopia, Degenerative ,030221 ophthalmology & optometry ,Disease Progression ,Female ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Purpose: To investigate the relation between high axial myopia and neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) values.Methods: Seventy-nine cases were enrolled, 50 m...
- Published
- 2019
19. Anizometropik Ambliyopi Olgularında Retina Sinir Lifi Tabakası, Maküla Kalınlığı ve Gangliyon Hücre Kompleksinin Değerlendirilmesi
- Author
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Yücel Karakurt, Mahmut Atum, Erdinç Bozkurt, Erel Icel, Sümeyye Burcu Ağcayazi, Nurdan Gamze Tasli, and Turgay Ucak
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Ambliyopi,retina sinir lifi tabakası,gangliyon hücre kompleksi,optik koherens tomografi ,business.industry ,Health Care Sciences and Services ,Ophthalmology ,medicine ,030212 general & internal medicine ,General Medicine ,030204 cardiovascular system & hematology ,Sağlık Bilimleri ve Hizmetleri ,business - Abstract
Amaç: Anizometropiyebağlı tek taraflı ambliyopisi bulunan olguların retina sinir lifitabakası (RSLT), maküla kalınlığı (MK) ve gangliyon hücre kompleksinin (GHK)optik koherens tomografi (OKT) cihazı ile değerlendirilip, sonuçların sağlamgöz ve kontrol grubuyla karşılaştırılması. Gereç ve Yöntemler: Çalışmaya tek gözde anizometropik ambliyopi tespit edilen 89 hastanın 89ambliyop gözü, kontrol grubu olarakta hasta grubunun 89 sağlam gözü ve 31sağlıklı kişinin 62 gözü çalışmaya dahil edildi. Tümolguların detaylı oftalmolojik muayenesinin ardından OKT cihazı ile RSLT, MK veGHK değerleri ölçülerek istatistiksel olarak karşılaştırıldı, p0,05).Olguların ortalama RSLT değerleri arasında gruplar istatistiksel olarak anlamlıfarklılık saptanamamışken; superior ve inferior kadran kalınlığı ambliyopgözlerde kontrol grubuna göre anlamlı olarak yüksek bulundu (sırasıyla;p=0.045, p=0.026). GHK değerlendirmesinde üst kadran kontrol grubunda hastagrubuna göre anlamlı olarak daha inceydi (p=0,026). Sonuç: MK değerinde ambliyopi olguları ile kontrol grubu arasında anlamlı farkbulunmazken, RSLT’de üst ve alt kadranile GHK üst kadran kalınlıkları hasta grubunda kontrol grubuna göre istatikselolarak anlamlı yüksek bulunmuştur.
- Published
- 2019
20. Prevalence and Load of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Patients With Chronic Blepharitis in the Province of Erzincan, Turkey
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Yücel Karakurt, Erhan Zeytun, and EBYÜ, Sağlık Hizmetleri Meslek Yüksekokulu
- Subjects
Adult ,Male ,medicine.medical_specialty ,business.product_category ,Turkey ,030231 tropical medicine ,Physical examination ,Parasite Load ,03 medical and health sciences ,0302 clinical medicine ,Demodex brevis ,parasitic diseases ,medicine ,Animals ,Humans ,Acari ,Blepharitis ,Aged ,Eyelashes ,General Veterinary ,biology ,medicine.diagnostic_test ,Middle Aged ,medicine.disease ,biology.organism_classification ,Dermatology ,Demodex folliculorum ,Acari, blepharitis, ocular symptom, eyelash, epidemiology ,Infectious Diseases ,Insect Science ,Case-Control Studies ,Chronic Disease ,Itching ,Parasitology ,Female ,medicine.symptom ,Eyelash ,business ,Demodex - Abstract
Chronic blepharitis is an ocular disease frequently encountered by ophthalmologists. Demodex mites can play a role in the pathogenesis of blepharitis along with bacterial agents, especially in treatment-resistant cases or recurrent cases after treatment. This study was performed to determine the prevalence and load of Demodex folliculorum (Simon) and Demodex brevis Akbulutova in chronic blepharitis patients and to assess the relationship between the prevalence and load of Demodex species and ocular symptoms. The study included 365 patients diagnosed with chronic blepharitis in clinical examination, and 175 controls without any chronic or ocular disease. In the study, two eyelashes were sampled from the lower and upper lids of the right and left eyes (a total of eight samples) of the participants. Eyelash samples were examined under a light microscope, and Demodex species were identified and counted. Demodex were detected in 79.2% (95% CI: 75–83%) of patients and 31.4% (95% CI: 24–38%) of controls in this study. D. folliculorum alone (mean: 4.96; min: 1; max: 17; P < 0.001) was detected in 72.3% of patients, in 0.7% D. brevis alone (mean: 1.00, P > 0.05), and in 27% both D. folliculorum and D. brevis (mean: 21.65; min: 2; max: 79; P < 0.001). In Demodex positive controls, only D. folliculorum (mean: 2.38; min: 1; max: 6) was detected while there was no D. brevis. Nevertheless, mean ocular symptom scores were significantly higher in Demodex positive patients than in Demodex negative patients (P < 0.001). Itching, foreign body sensation, and redness were the most common complaints in Demodex positive patients. As a result, Demodex mites were high in numbers in patients with chronic blepharitis in Erzincan. There was a positive correlation between Demodex mites and chronic blepharitis and ocular symptoms. It may be helpful to consider these findings in clinical assessment of blepharitis patients.
- Published
- 2019
21. The Effects of Intravitreal Ranibizumab, Aflibercept or Dexamethasone Implant Injections on Intraocular Pressure Changes
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Turgay Ucak, Burcu Agcayazi, Hayati Yilmaz, Yücel Karakurt, Gamze Tasli, and Erel Icel
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Male ,Vascular Endothelial Growth Factor A ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Recombinant Fusion Proteins ,Visual Acuity ,Angiogenesis Inhibitors ,Antibodies, Monoclonal, Humanized ,Dexamethasone ,03 medical and health sciences ,Macular Degeneration ,0302 clinical medicine ,Clinical Research ,Ophthalmology ,Ranibizumab ,Medicine ,Humans ,030212 general & internal medicine ,Intraocular Pressure ,Aflibercept ,Aged ,Retrospective Studies ,Aged, 80 and over ,Postoperative Care ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,Axial Length, Eye ,Receptors, Vascular Endothelial Growth Factor ,Correlation analysis ,Intravitreal Injections ,030221 ophthalmology & optometry ,Female ,Implant ,Intravitreal ranibizumab ,business ,medicine.drug - Abstract
BACKGROUND The aim of this study was to compare the alterations in intraocular pressure (IOP) values during the early postoperative period after intravitreal ranibizumab, aflibercept, or dexamethasone implant injections. MATERIAL AND METHODS In this retrospective study, a total of 188 patients were grouped into 3 groups: the ranibizumab group, the aflibercept group, and the dexamethasone group. Ocular axial length (AXL) and anterior chamber depth (ACD) were measured in the pre-injection period. IOP was measured just before the injection at 1 minute,10 minutes, 1 hour, 1 day, and 1 month after injection. RESULTS There was a transient peak in the ranibizumab group and the aflibercept group at 1 minute that started to decrease at 10 minutes and IOP values returned to preoperative values at approximately 1 hour. Similar alterations were also determined for the dexamethasone group with a lesser increase noted. In the correlation analysis, only alterations in IOP levels at 1 minute were negatively correlated with preoperative AXL values. There was not any correlation between preoperative AXL or ACD values and IOP alterations at any other time points. CONCLUSIONS There was a sudden, transient increase in IOP values after intravitreal ranibizumab or aflibercept injections; which return to normal values in a short time without requirement of any medical treatments. This transient peak was determined to be negatively correlated with the preoperative AXL.
- Published
- 2018
22. The effects of thiamine pyrophosphate on ethanol induced optic nerve damage
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Yücel Karakurt, Gamze Tasli, Ibrahim Ahiskali, Ferda Keskin Cimen, Turgay Ucak, Nezahat Kurt, Halis Suleyman, and Erel Icel
- Subjects
Male ,medicine.medical_specialty ,Interleukin 1 beta ,Tumor necrosis factor ,Interleukin-1beta ,medicine.disease_cause ,Protective Agents ,030226 pharmacology & pharmacy ,Optic neuropathy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,lcsh:RA1190-1270 ,Edema ,Internal medicine ,Malondialdehyde ,medicine ,Animals ,Pharmacology (medical) ,Rats, Wistar ,lcsh:Toxicology. Poisons ,Pharmacology ,Ethanol ,Tumor Necrosis Factor-alpha ,lcsh:RM1-950 ,Optic Nerve ,Glutathione ,medicine.disease ,Rats ,Endocrinology ,lcsh:Therapeutics. Pharmacology ,chemistry ,Oxidative stress ,Optic Nerve Injuries ,Optic nerve ,medicine.symptom ,Thiamine Pyrophosphate ,Thiamine pyrophosphate ,Research Article - Abstract
Background We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. Methods The rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group), only ethanol administered group (EtOH group), ethanol + thiamine pyrophosphate (20 mg/kg) administered group (TEt-20 group), and only thiamine pyrophosphate (20 mg/kg) (TPG group) administered group. To the rats in TEt-20 and TPG groups, 20 mg/kg thiamine pyrophosphate was administered via intraperitoneal route. To the rats in HC and EtOH groups, the same volume (0.5 ml) of distilled water as solvent was applied in the same manner. To the rats in TEt-20 and EtOH groups, one hour after application of thiamine pyrophosphate or distilled water, 32% ethanol with a dose of 5 g/kg was administered via oral gavage. This procedure was repeated once a day for 6 weeks. From the blood samples and tissues obtained from the rats, Malondialdehyde (MDA), reduced glutathione (GSH), interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) levels were studied. Histopathological evaluations were performed to the optic nerve tissue. Results Serum and tissue IL-1β, TNF-α and MDA levels were the highest in EtOH group which were significantly lower in thiamine pyrophosphate administered group (TEt-20 group) (p: 0.001). Serum and tissue reduced GSH levels were the lowest in EtOH group which were also significantly higher in TEt-20 group (p:0.001). In histopathological evaluations, in EtOH group there was obvious destruction and edema with hemorrhage and dilated blood vessels which were not present in any other groups. Conclusions There was an apparent destruction in ethanol administered group in histopathological analyses with an augmented level of oxidative stress markers and all those alterations were prevented with concomitant thiamine pyrophosphate administration. These protective effects of thiamine pyrophosphate are extremely important in chronic ethanol consumption. Clinical studies are warranted to define the exact role of thiamine pyrophosphate in prevention of ethanol induced optic neuropathy.
- Published
- 2018
23. Optical coherence tomography angiography findings of a handheld laser-induced maculopathy: a case report
- Author
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Yücel Karakurt, Hayati Yilmaz, Nurdan Gamze Tasli, Turgay Ucak, and Erel Icel
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Ophthalmology ,business.industry ,law ,Medicine ,Maculopathy ,Optical coherence tomography angiography ,business ,Nuclear medicine ,medicine.disease ,Laser ,law.invention - Published
- 2020
24. The effects of lycopene on alloxan induced diabetic optic neuropathy
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Halis Suleyman, Burcu Elpeze, Turgay Ucak, Yücel Karakurt, Aykut Icel, Ferda Keskin Cimen, and Erel Icel
- Subjects
Male ,medicine.medical_specialty ,Inflammatory response ,Anti-Inflammatory Agents ,Toxicology ,medicine.disease_cause ,Antioxidants ,Retina ,Diabetes Mellitus, Experimental ,Optic neuropathy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Lycopene ,Diabetic Neuropathies ,Diabetes mellitus ,Alloxan ,Internal medicine ,Malondialdehyde ,Optic Nerve Diseases ,medicine ,Animals ,Rats, Wistar ,Experimental model ,business.industry ,Tumor Necrosis Factor-alpha ,NF-kappa B ,General Medicine ,medicine.disease ,Glutathione ,Endocrinology ,chemistry ,030221 ophthalmology & optometry ,Optic nerve ,business ,Oxidative stress - Abstract
To determine the effects of lycopene treatment in prevention of diabetes associated inflammatory response and oxidative stress in an experimental model. With this aim we investigated the levels of oxidative stress markers including Malondialdehyde (MDA), and total oxidative status (TOS)together with inflammatory markers including nuclear factor- kappa B (NFKB) and tumor necrosis factor α (TNF-α) and antioxidants including total glutathione (TGSH), total oxidative status (TOS) and total anti-oxidative status (TAS) levels on eye tissue.Totally 18 albino Wistar male rats (250-280 grams) assigned into three groups, with six rats in each group as follows: healthy group (HG), control group (CG), and lycopene group (LG). The diabetes was induced with alloxan administration in rats of CG and LG. Lycopene (4 mg/kg) was administered to the rats in LG once a day for 3 months. At the end of this period, the animals were sacrificed and their eyes were enucleated for histopathological evaluations. From the tissues, MDA, GSH, TOS, TAS, TNF-α and NF-κB levels were analyzed.MDA, TOS, OSI, NFKB and TNF-α levels were significantly higher, while TGSH and TAS levels were significantly lower in CG compared with HG (p 0.001). On the other hand in LG; MDA, TOS, OSI, NFKB and TNF-α levels were significantly lower, while TGSH and TAS levels were significantly higher compared with CG (p 0.001). Regarding histopathological findings, although there was severe damage on optic nerve of rats in CG; there was only a slight damage in lycopene administered group.For the first time in literature we determined that, lycopene was significantly effective in prevention of augmented inflammation and oxidative stress on eye tissue associated with diabetes, as well as the tissue damage on optic nerve. However, studies investigating the long-term clinical effects of lycopene on diabetic individuals are warranted.
- Published
- 2018
25. Effects of Pycnogenol on cisplatin-induced optic nerve injury: an experimental study
- Author
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Halis Suleyman, Yücel Karakurt, Erel Icel, Ferda Keskin Cimen, Turgay Ucak, Hayati Yilmaz, and Burcu Agcayazi
- Subjects
0301 basic medicine ,Male ,Pathology ,medicine.medical_specialty ,genetic structures ,Inflammation ,Antineoplastic Agents ,Toxicology ,medicine.disease_cause ,Antioxidants ,Lipid peroxidation ,03 medical and health sciences ,chemistry.chemical_compound ,Optic nerve injury ,medicine ,Animals ,Rats, Wistar ,Cisplatin ,Flavonoids ,business.industry ,Plant Extracts ,Tumor Necrosis Factor-alpha ,Optic Nerve ,General Medicine ,Malondialdehyde ,eye diseases ,Rats ,Oxidative Stress ,030104 developmental biology ,chemistry ,Optic Nerve Injuries ,Optic nerve ,Tumor necrosis factor alpha ,Lipid Peroxidation ,medicine.symptom ,business ,Oxidative stress ,medicine.drug - Abstract
To determine the effects of Pycnogenol on cisplatin-induced optic nerve damage.Totally 18 albino Wistar male rats were assigned into three groups, with six rats in each group as follows: healthy controls (HC group), only cisplatin (2.5 mg/kg) administered group (CIS group) and Pycnogenol (40 mg/kg) + cisplatin (2.5 mg/kg) administered group (PYC group). We analyzed the levels of malondialdehyde (MDA) as a marker of lipid peroxidation and oxidative stress, total glutathione (tGSH) as a marker of antioxidant status, nuclear factor-kappa B (NF-κB) and tumor necrosis factor alpha (TNF-α) as inflammatory markers, total oxidative status (TOS) and total antioxidant status (TAS) on eye tissue together with histopathological evaluation of optic nerve in an experimental model.In CIS group MDA, TOS, TNF-α and NF-κB levels were statistically significantly higher (p 0.001) than HC group while tGSH and TAS levels were significantly lower (p 0.001). On the other hand, in PYC group MDA, TOS, TNF-α and NF-κB levels were statistically significantly lower (p 0.001) than CIS group while tGSH and TAS levels were significantly higher (p 0.001).Pycnogenol pretreatment was highly effective in preventing augmentation of cisplatin-induced oxidative stress and inflammation in eye tissue.
- Published
- 2018
26. The effects of lutein on cisplatin-induced retinal injury: an experimental study
- Author
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Sare Sipal, NurdanGamze Tasli, Turgay Ucak, Ibrahim Ahiskali, Halis Suleyman, Yücel Karakurt, and Nezahat Kurt
- Subjects
0301 basic medicine ,Retinal degeneration ,Male ,Retinal Ganglion Cells ,Lutein ,Pathology ,medicine.medical_specialty ,macromolecular substances ,Retinal Pigment Epithelium ,Toxicology ,medicine.disease_cause ,Antioxidants ,Retina ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Atrophy ,Retinal Diseases ,medicine ,Animals ,Rats, Wistar ,Carotenoid ,chemistry.chemical_classification ,Retinal pigment epithelium ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Retinal Degeneration ,Retinal Detachment ,food and beverages ,Retinal detachment ,General Medicine ,medicine.disease ,Rats ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,Cytokines ,Cisplatin ,business ,Oxidative stress ,Photoreceptor Cells, Vertebrate - Abstract
Lutein is one of the most common carotenoids defined in human plasma as having potent anti-oxidant effects. We aimed to determine the biochemical and histopathological effects of lutein on cisplatin-induced oxidative retinal injury in rats.Twenty-four rats were equally divided into four groups as healthy controls (HC group), only cisplatin (5 mg/kg) administered group (CIS group), Lutein (0.5 mg/kg) + cisplatin (5 mg/kg) administered group (LC group), and only Lutein (0.5 mg/kg) (LUT group) administered group. From the blood samples obtained, serum malondialdehyde (MDA), total glutathione (tGSH), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) levels were investigated. In histopathological analyses, the total retinal thickness, retinal pigment epithelium (RPE), photoreceptor layer (PL), outer nuclear layer (ONL), outer plexiform layer (OPL), inner nuclear layer (INL), inner plexiform layer (IPL), and ganglion cell layer (GCL) were evaluated.MDA, IL-1β, and TNF-a levels were statistically significantly higher (p 0.001) in CIS group compared with other three groups while tGSH levels were statistically significantly lower (p 0.001). In subgroup analyses, there was no any statistically significant difference regarding all four parameters analyzed between HC, LC, and LUT groups. In histopathological analyses, cisplatin-induced retinal damage included atrophy and disorganization on outer segment, degeneration and detachment of RPE and PL from choroid, degeneration and edema of INL and IPL, total degeneration of GCL; while cisplatin-induced retinal damage was determined to be significantly prevented with 0.5 mg lutein treatment on histopathological evaluations.Lutein co-administration was highly effective in prevention of cisplatin-induced retinal damage due to the anti-oxidant and anti-inflammatory effects of lutein.
- Published
- 2018
27. Evaluation of the Efficacy of Tea Tree Oil On the Density of Demodex Mites (Acari: Demodicidae) and Ocular Symptoms In Patients With Demodectic Blepharitis
- Author
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Erhan Zeytun, Yücel Karakurt, and EBYÜ, Sağlık Hizmetleri Meslek Yüksekokulu
- Subjects
Male ,medicine.medical_specialty ,Mite Infestations ,business.product_category ,03 medical and health sciences ,Random Allocation ,0302 clinical medicine ,Tea Tree Oil ,parasitic diseases ,medicine ,Animals ,Humans ,Acari ,In patient ,030212 general & internal medicine ,Eye Infections, Parasitic ,Ecology, Evolution, Behavior and Systematics ,Retrospective Studies ,Blepharitis ,Eyelashes ,Mites ,biology ,Tea tree oil ,Eye infection ,Middle Aged ,biology.organism_classification ,Dermatology ,Shampoo ,humanities ,030221 ophthalmology & optometry ,Anti-Infective Agents, Local ,Parasitology ,Demodicidae ,Female ,Eyelash ,business ,Demodex ,medicine.drug - Abstract
The objective of this study was to examine the efficacy of 7.5% tea tree oil (TTO) eyelash shampoo on the density of Demodex (Acari: Demodicidae) and ocular symptoms in patients with demodectic blepharitis. A total of 135 patients diagnosed with demodectic blepharitis, following clinical inspection and parasitological examinations, were included in the study. Patients were treated with eyelash shampoo, with or without TTO. Full Demodex reduction was attained in 36% of the patients who used eyelash shampoo with TTO, and the average Demodex count was reduced from 6.33/eyelash to zero (P , 0.001). In contrast, the average Demodex count in patients who did not achieve full reduction (64%) was reduced from 12.46/eyelash to 4.15/eyelash (P , 0.001). Full reduction was observed in 11.7% of patients who used TTO-free eyelash shampoo, and average Demodex count reduced from 2.00/eyelash to zero (P ¼ 0.017). The average Demodex count was reduced from 11.98/eyelash to 7.91/eyelash in patients (88.3%) who did not achieve full reduction (P ¼ 0.024). Additionally, ocular symptom scores (which are generated based on subjective experiences of itching, burning, the feeling of a foreign body in the eye, eye redness, and cylindrical dandruff) were reduced significantly (P , 0.001) in patients who used the eyelash shampoo with TTO. The symptom scores remained almost the same in patients who used TTO-free eyelash shampoo (P . 0.05). In conclusion, it was determined that eyelash shampoo with TTO is 3 times more effective at achieving full Demodex reduction, significantly reducing the Demodex count, and relieving ocular symptoms in patients where full reduction cannot be attained, without adverse side effects.
- Published
- 2018
28. Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study
- Author
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Turgay Ucak, Renad Mammadov, Nurdan Gamze Tasli, Nezahat Kurt, Ferda Keskin Cimen, Bahadir Suleyman, Yücel Karakurt, and Halis Suleyman
- Subjects
0301 basic medicine ,Pharmacology ,medicine.disease_cause ,Optic neuropathy ,03 medical and health sciences ,Rutin ,chemistry.chemical_compound ,0302 clinical medicine ,astrocyte ,lcsh:Ophthalmology ,Edema ,Medicine ,rat ,methanol ,chemistry.chemical_classification ,biology ,business.industry ,Glutathione peroxidase ,rutin ,medicine.disease ,Malondialdehyde ,optic neuropathy ,Ophthalmology ,030104 developmental biology ,Basic Research ,chemistry ,lcsh:RE1-994 ,Myeloperoxidase ,030221 ophthalmology & optometry ,biology.protein ,Methotrexate ,medicine.symptom ,business ,Oxidative stress ,medicine.drug - Abstract
AIM: To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ethanol. METHODS: Totally 30 rats were divided into 5 groups, with 6 rats in each group as follows: healthy controls (C), methotrexate (MTX), methotrexate+methanol (MTM), methotrexate+methanol+ethanol (MTME) and methotrexate+ methanol+Rutin (MTMR). In all rabbits except those of the control group, MTX, diluted in sterile serum physiologic, 0.3 mg/kg per oral was applied for 7d by the aid of a tube. After this procedure to the rats of MTM, MTME and MTMR groups, 20% methanol with a dose of 3 g/kg per oral was given by the aid of a tube. In MTME group, 4h after the application of methanol, 20% ethanol was applied by the same way with a dose of 0.5 g/kg. On the other hand, in MTMR group 4h after the application of methanol, Rutin, which was dissolved in distilled water, was applied by the same way with a dose of 50 mg/kg. RESULTS: There were statistically significant differences in tissue 8- hydroxy-2 deoxyguanine (8-OHdG), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO). glutathione peroxidase (tGSH) and superoxide dismutase (SOD) levels between groups (P
- Published
- 2017
29. Comparison of anterior segment parameters and corneal endothelial changes in patients with pseudoexfoliative glaucoma and pseudoexfoliation syndrome
- Author
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Erel Icel, Nurdan Gamze Tasli, Yücel Karakurt, Mahmut Atum, and Turgay Ucak
- Subjects
Intraocular pressure ,Corneal endothelium ,medicine.medical_specialty ,genetic structures ,business.industry ,Significant difference ,Anova test ,Healthy subjects ,Pseudoexfoliation syndrome ,General Medicine ,medicine.disease ,eye diseases ,Ophthalmology ,Pseudoexfoliative glaucoma ,medicine ,In patient ,sense organs ,business - Abstract
Aim: The aim of this study is to evaluate the changes in anterior chamber morphology and corneal endothelium in patients with pseudoexfoliation syndrome (PEX) and pseudoexfoliative glaucoma (PEXG) and to determine the differences according to the control group. Material and Methods: 61 eyes of 61 PEX patients, 56 eyes of 56 PEXG patients and 46 eyes of 46 healthy subjects were included in the study. Measurement of intraocular pressure (IOP) was taken and axial length (AL), K1, K2, central corneal thickness (CCT), white-to-white distance (WTW), anterior chamber depth (ACD), pupil diameter (PD) by optical biometry and endothelial cell density (ECD), polimegatism (CV), pleomorphism (HEX) and average cell area (AVG) by specular microscope were taken of all the patients. Evaluation among the groups were made by ANOVA test, and p 0.05). There were no statistically significant differences among the groups in terms of IOP, AL, K1, K2, WTW, ACD (p> 0.05). Pupil diameter values were lower in the PEX group. CCT and endothelial cell counts were found to be higher in the control group compared to the other groups, while no significant difference was found between PEX and PEXG groups. AVG results were found to be significantly higher in the PEXG group than in the control group (p
- Published
- 2019
30. Comparison of the clinical efficacy and safety of deep sclerectomy with mitomycin-c and trabeculectomy surgeries
- Author
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Yücel Karakurt, Hüseyin Acar, Senem Salar Gomceli, Cem Mesci, and Hasan Hasbi Erbil
- Subjects
medicine.medical_specialty ,Intraocular pressure ,business.industry ,medicine.medical_treatment ,Significant difference ,Mitomycin C ,Glaucoma ,General Medicine ,medicine.disease ,Deep sclerectomy ,eye diseases ,Surgery ,medicine ,Trabeculectomy ,Clinical efficacy ,business ,Complication - Abstract
Aim: Comparison of clinical efficacy and safety of trabeculectomy and deep sclerectomy with mitomycin-C (MMC) surgeries. Material and Methods: 58 eyes of 58 patients with glaucoma who underwent trabeculectomy or deep sclerectomy with MMC were evaluated retrospectively. The success criterion was regarded as follows; patients having intraocular pressure (IOP) less than 21 mmHg was regarded as complete success; patients with IOP less than 21 mmHg with medication was regarded as partial success; and patients with IOP higher than 21 mmHg with medication was regarded as un-success. Results: There was no statistically significant difference in IOP lowering effects between the two surgeries. Considering the success of the groups; complete success was achieved in 32 patients (91.4%) and partial success in 3 patients (8.6%) in the trabeculectomy group. Complete success was achieved in 20 patients (86.9%) and partial success in 3 patients (13.1%) in the deep sclerectomy with MMC group. In the deep sclerectomy with MMC group, hypotonia was detected in 2 patients (8.7%). In the trabeculectomy group, 5 patients (14.3%) had hypotonia, 2 patients (5.7%) had shallow anterior chamber and 1 patient (2.85%) had choroidal detachment. Conclusion: When IOP lowering effects of deep sclerectomy with MMC and trabeculectomy operations were compared, it was found that there was no statistically significant difference between the two techniques. When complication rates were compared, less complication was found in deep sclerectomy operations. It can be concluded that deep sclerectomy is safer than trabeculectomy and as effective as it is.
- Published
- 2019
31. Anterior segment parameters and corneal specular microscopy findings in rheumatoid arthritis
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Yücel Karakurt, Nurdan Gamze Tasli, Turgay Ucak, Erel Icel, Sumeyye Burcu Agcayazi, Nurdagul Aktas, and Hayati Yilmaz
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medicine.medical_specialty ,business.industry ,Ophthalmology ,Rheumatoid arthritis ,medicine ,General Medicine ,medicine.disease ,business ,Corneal specular microscopy - Published
- 2019
32. The Findings of Corneal Specular Microscopy in Patients with Keratoconus
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Yusuf Kemal Arslan, Nurdan Gamze Tasli, Yücel Karakurt, Adem Ugurlu, Sumeyye Burcu Agcayazi, Turgay Ucak, and Erel Icel
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medicine.medical_specialty ,Keratoconus ,Materials science ,Ophthalmology ,SPECULAR MICROSCOPY ,medicine ,In patient ,General Medicine ,medicine.disease ,Corneal specular microscopy - Published
- 2019
33. Evaluation of the effect of chronic smoking habit on corneal endothelial cells, central corneal thickness and dry eye tests
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Yücel Karakurt, Nurdan Gamze Tasli, Erel Icel, Sumeyye Burcu Agcayazi, Adem Ugurlu, Mukadder Sunar, and Turgay Ucak
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Corneal endothelium ,medicine.medical_specialty ,business.industry ,Smoking habit ,Ophthalmology ,SPECULAR MICROSCOPY ,Medicine ,General Medicine ,business - Published
- 2019
34. Evaluation of the Corneal Layers in Meibomian-Gland-Dysfunction-Related Dry Eye by In Vivo Slit-Scanning Confocal Microscopy
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Ilknur Akyol Salman, Erkan Erdogan, Sedat Azizi, Turgay Ucak, Ibrahim Yaşar, and Yücel Karakurt
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0301 basic medicine ,Adult ,Male ,Pathology ,medicine.medical_specialty ,Stromal cell ,law.invention ,Cornea ,03 medical and health sciences ,Basal (phylogenetics) ,Young Adult ,0302 clinical medicine ,In vivo ,Confocal microscopy ,law ,medicine ,Humans ,Prospective Studies ,Aged ,Microscopy, Confocal ,business.industry ,Meibomian gland dysfunction ,Meibomian Glands ,General Medicine ,Middle Aged ,Slit ,eye diseases ,Epithelium ,Ophthalmology ,030104 developmental biology ,medicine.anatomical_structure ,030221 ophthalmology & optometry ,Dry Eye Syndromes ,Female ,sense organs ,business ,Follow-Up Studies - Abstract
In the current study it was aimed to evaluate the findings of cornea in Dry Eye related Meibomian Gland Dysfunction through in vivo confocal microscopy. 30 patients of Dry Eye related Meibomian Gland Dysfunction (DEMGD) and 30 healty individuals were included. 46 eyes of 30 DEMGD patients (group 1) and 46 eyes of 30 healthy individuals (group 2) were formed as control group and images were captured from the centre of the cornea. 26 of the patients (%86,6) in Group 1 were male, and four of them (%13,4) were female and 25 of healthy individuals (% 83,3) were male and 5 of them(%16,7) were female. The ages of the patients in Group 1 were between 23-67 (51,58±13,4 on average). The ages of the healthy individuals in Group 2 were between 23-67 (51,45±10,4 on average). Tear film break-up time and Schirmer 1 values were significantly lower in the MGDDE group than the control group (p
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- 2016
35. Effects of two different contact lenses on ocular physiological parameters and tear function tests
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Adem Ugurlu, Turgay Ucak, Yucel Karakurt, Nurdan Gamze Tasli, Erel Icel, and Hayati Yılmaz
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Silicone geis ,Contact lens ,Ocular physiological phenomena ,Tears ,Ophthalmology ,RE1-994 - Abstract
Abstract Objective: To investigate the effects of two types of contact lenses made of two different types of silicone hydrogel material on ocular physiological parameters and tear function tests. Methods: The contact lenses with the appropriate diopters were supplied to the volunteering patients. The patients were evaluated before wearing the contact lenses (visit0:V0), at the first month(visit1:V1) and at the thirth month(visit2:V2) following their wear. At all visits a detailed biomicroscopic examination was done, ocular physiological variables were collected, the tear function tests were performed and the tear meniscus area (TMA) was visualized and measured with anterior segment optical coherence tomography (AS-OCT). Results: The results of Schirmer 1 test were 12.07 ± 1.51 [9-16] mm for the right eyes (samfilcon A group) and 12.09 ± 1.5 [9-16] mm for the left eyes (senofilcon A group) at V0. (p=0.950) At V2, the mean Schirmer 1 test results were 11.92±1.34 [9-15] mm in the samfilcon A group and 12.2±1.41 [9-16] mm in the senofilcon A group (p=0.239). The mean TMA dimensions in the AS-OCT images were 338.42±47.1 [241-401] microns in the samfilcon A group and 338.42±47.1 [241-401]microns in the senofilcon A group at V0. (p>0.05). At V2, the mean TMA dimensions were 337.2±45.53 [241-402] microns in thesamfilcon A group and 340.31±48.22 [240-411] microns in the senofilcon A group (p=0.728). Conclusions: Our study has demonstrated that contact lenses containing samfilcon A and senofilcon A silicone hydrogel material do not cause meaningful ocular surface problems.
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- 2019
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36. The effects of thiamine pyrophosphate on ethanol induced optic nerve damage
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Turgay Ucak, Yucel Karakurt, Gamze Tasli, Ferda Keskin Cimen, Erel Icel, Nezahat Kurt, Ibrahim Ahiskali, and Halis Süleyman
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Ethanol ,Rats ,Thiamine pyrophosphate ,Oxidative stress ,Glutathione ,Malondialdehyde ,Therapeutics. Pharmacology ,RM1-950 ,Toxicology. Poisons ,RA1190-1270 - Abstract
Abstract Background We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. Methods The rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group), only ethanol administered group (EtOH group), ethanol + thiamine pyrophosphate (20 mg/kg) administered group (TEt-20 group), and only thiamine pyrophosphate (20 mg/kg) (TPG group) administered group. To the rats in TEt-20 and TPG groups, 20 mg/kg thiamine pyrophosphate was administered via intraperitoneal route. To the rats in HC and EtOH groups, the same volume (0.5 ml) of distilled water as solvent was applied in the same manner. To the rats in TEt-20 and EtOH groups, one hour after application of thiamine pyrophosphate or distilled water, 32% ethanol with a dose of 5 g/kg was administered via oral gavage. This procedure was repeated once a day for 6 weeks. From the blood samples and tissues obtained from the rats, Malondialdehyde (MDA), reduced glutathione (GSH), interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) levels were studied. Histopathological evaluations were performed to the optic nerve tissue. Results Serum and tissue IL-1β, TNF-α and MDA levels were the highest in EtOH group which were significantly lower in thiamine pyrophosphate administered group (TEt-20 group) (p: 0.001). Serum and tissue reduced GSH levels were the lowest in EtOH group which were also significantly higher in TEt-20 group (p:0.001). In histopathological evaluations, in EtOH group there was obvious destruction and edema with hemorrhage and dilated blood vessels which were not present in any other groups. Conclusions There was an apparent destruction in ethanol administered group in histopathological analyses with an augmented level of oxidative stress markers and all those alterations were prevented with concomitant thiamine pyrophosphate administration. These protective effects of thiamine pyrophosphate are extremely important in chronic ethanol consumption. Clinical studies are warranted to define the exact role of thiamine pyrophosphate in prevention of ethanol induced optic neuropathy.
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- 2019
- Full Text
- View/download PDF
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