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The findings of corneal specular microscopy in patients with type-2 diabetes mellitus
- Source :
- BMC Ophthalmology, BMC Ophthalmology, Vol 20, Iss 1, Pp 1-7 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background We aimed to compare the morphological characteristics of corneal endothelial cells in type 2 diabetic patients and age-matched healthy subjects by specular microscopy. We also aimed to determine the association of corneal morphological features with the general characteristics and laboratory data of diabetic patients, including disease duration, haemoglobin A1c (HbA1c) levels and urine albumin creatinine ratio. Methods A total of 195 diabetic patients and 100 healthy controls were enrolled in the study. All participants underwent a complete ophthalmological examination. Corneal endothelial measurements were performed using a noncontact specular microscopy. Laboratory data including serum fasting glucose, haemoglobin A1c levels, creatinine levels, and the urinary albumin-to-creatinine ratio were recorded. Diabetic patients were further subdivided into 3 groups according to the presence and stage of diabetic retinopathy. Specular microscopy findings and central corneal thickness of all patients were compared. Results The ECD and hexagonal cell ratio were significantly lower, while the average cell size, CV%, and central corneal thickness were determined to be significantly higher in diabetic patients than in healthy controls (p = 0.001). With the presence and advancement of diabetic retinopathy, the ECD and hexagonal cell ratio decreased, while the average cell size, CV%, and central corneal thickness increased. When correlation analysis was performed between corneal morphological features and laboratory data of diabetic patients, ECD showed a significant negative correlation with diabetes duration (p = 0.028). HbA1c levels, urinary albumin-creatinine ratio (p = 0.041), average cell size and CV showed a positive correlation with these parameters. Conclusion In conclusion, keratopathy is an important complication of type 2 diabetes. With an increase in the stage of diabetic retinopathy, alterations in corneal findings also increased. In that respect, we can suggest that keratopathy should be evaluated more cautiously in diabetic patients.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
genetic structures
Urinary system
Cell Count
Serum Albumin, Human
Type 2 diabetes
Corneal Diseases
03 medical and health sciences
chemistry.chemical_compound
Diabetes mellitus
0302 clinical medicine
lcsh:Ophthalmology
Ophthalmology
medicine
Humans
Prospective Studies
Aged
Cell Size
Glycated Hemoglobin
Microscopy
Creatinine
Diabetic Retinopathy
business.industry
Endothelium, Corneal
Type 2 Diabetes Mellitus
Corneal endothelial cells
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
Diabetes Mellitus, Type 2
chemistry
lcsh:RE1-994
Specular microscopy
030220 oncology & carcinogenesis
030221 ophthalmology & optometry
Female
Microalbuminuria
sense organs
Complication
business
Research Article
Subjects
Details
- ISSN :
- 14712415
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Ophthalmology
- Accession number :
- edsair.doi.dedup.....e724c87e3b528b293dbcd81820b3d2a7