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The effects of lycopene on alloxan induced diabetic optic neuropathy
- Source :
- Cutaneous and ocular toxicology. 38(1)
- Publication Year :
- 2018
-
Abstract
- To determine the effects of lycopene treatment in prevention of diabetes associated inflammatory response and oxidative stress in an experimental model. With this aim we investigated the levels of oxidative stress markers including Malondialdehyde (MDA), and total oxidative status (TOS)together with inflammatory markers including nuclear factor- kappa B (NFKB) and tumor necrosis factor α (TNF-α) and antioxidants including total glutathione (TGSH), total oxidative status (TOS) and total anti-oxidative status (TAS) levels on eye tissue.Totally 18 albino Wistar male rats (250-280 grams) assigned into three groups, with six rats in each group as follows: healthy group (HG), control group (CG), and lycopene group (LG). The diabetes was induced with alloxan administration in rats of CG and LG. Lycopene (4 mg/kg) was administered to the rats in LG once a day for 3 months. At the end of this period, the animals were sacrificed and their eyes were enucleated for histopathological evaluations. From the tissues, MDA, GSH, TOS, TAS, TNF-α and NF-κB levels were analyzed.MDA, TOS, OSI, NFKB and TNF-α levels were significantly higher, while TGSH and TAS levels were significantly lower in CG compared with HG (p 0.001). On the other hand in LG; MDA, TOS, OSI, NFKB and TNF-α levels were significantly lower, while TGSH and TAS levels were significantly higher compared with CG (p 0.001). Regarding histopathological findings, although there was severe damage on optic nerve of rats in CG; there was only a slight damage in lycopene administered group.For the first time in literature we determined that, lycopene was significantly effective in prevention of augmented inflammation and oxidative stress on eye tissue associated with diabetes, as well as the tissue damage on optic nerve. However, studies investigating the long-term clinical effects of lycopene on diabetic individuals are warranted.
- Subjects :
- Male
medicine.medical_specialty
Inflammatory response
Anti-Inflammatory Agents
Toxicology
medicine.disease_cause
Antioxidants
Retina
Diabetes Mellitus, Experimental
Optic neuropathy
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Lycopene
Diabetic Neuropathies
Diabetes mellitus
Alloxan
Internal medicine
Malondialdehyde
Optic Nerve Diseases
medicine
Animals
Rats, Wistar
Experimental model
business.industry
Tumor Necrosis Factor-alpha
NF-kappa B
General Medicine
medicine.disease
Glutathione
Endocrinology
chemistry
030221 ophthalmology & optometry
Optic nerve
business
Oxidative stress
Subjects
Details
- ISSN :
- 15569535
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cutaneous and ocular toxicology
- Accession number :
- edsair.doi.dedup.....9931456168c370760399a2ee87301508