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Your search keyword '"Sikaris, Ken A."' showing total 129 results
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129 results on '"Sikaris, Ken A."'

2. Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1

Author

Chang, Christina C, Naranbhai, Vivek, Stern, Jared, Roche, Michael, Dantanarayana, Ashanti, Ke, Ruian, Tennakoon, Surekha, Solomon, Ajantha, Hoh, Rebecca, Hartogensis, Wendy, Hecht, Frederick M, Sikaris, Ken, Price, David J, Elliott, Julian H, Deeks, Steven G, Churchill, Melissa, Cameron, Paul U, Hengartner, Nicolas, Perelson, Alan S, and Lewin, Sharon R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Infectious Diseases, Sexually Transmitted Infections, Genetics, Neurosciences, HIV/AIDS, ARNTL Transcription Factors, Anti-Retroviral Agents, Blood Cells, Cells, Cultured, Female, Gene Expression Profiling, HIV, HIV Infections, Host-Pathogen Interactions, Humans, Male, Middle Aged, RNA, Viral, Real-Time Polymerase Chain Reaction, Transcription, Genetic, brain-and-muscle-ARNT-like-1, circadian rhythm, HIV latency, HIV transcription, stress, unspliced RNA, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology, Biomedical and clinical sciences, Health sciences
Abstract

Objective(s)To determine whether variation in cell-associated unspliced (CA-US) HIV RNA in HIV-infected individuals on antiretroviral therapy (ART) has a circadian basis.MethodsProspective observational study of HIV-infected individuals on ART. Blood was collected on three occasions and CA-US HIV RNA and mRNA of the circadian-locomotor-output-cycles-kaput (CLOCK)-associated genes quantified by real time PCR. CLOCK-associated proteins were over-expressed in a cell line stably transfected with an HIV long-terminal repeat (LTR) luciferase reporter.ResultsUsing a mixed effects model, there was a significant increase in log-CA-US RNA at the third visit compared with the first visit (effect size of 0.619 with standard error (SE) of 0.098, P

Published
2018

3. 8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19–22 July 2015, Vancouver, Canada

Author

Pate, Kelly Metcalf, Pohlmeyer, Chris, Walker‐Sperling, Victoria, Foote, Jeremy, Najarro, Kevin, Cryer, Catherine, Salgado, Maria, Gama, Lucio, Engle, Elizabeth, Shirk, Erin, Queen, Suzanne, Chioma, Stanley, Vermillion, Meghan, Bullock, Brandon, Li, Ming, Lyons, Claire, Adams, Robert, Zink, Chris, Clements, Janice, Mankowski, Joseph, Blankson, Joel, Micci, Luca, Ryan, Emily, Fromentin, Rémi, Benne, Clarisse, Chomont, Nicolas, Lifson, Jeffrey, Paiardini, Mirko, Lee, Sulggi, Fromentin, Remi, Silicano, Robert, Silicano, Janet, Richman, Douglas, O'Doherty, Una, Palmer, Sarah, Burbelo, Peter, Deeks, Steven, Ghneim, Khader, Ahlers, Jeff, Fourati, Slim, Shive, Carey, Cameron, Mark, Mukerjee, Pranab, Ghannoum, Mahmoud, Rodriguez, Benigno, Lederman, Michael, Sekaly, Rafick, Frange, Pierre, Faye, Albert, Avettand‐Fenoel, Veronique, Bellaton, Erainna, Deschamps, Diane, Angin, Mathieu, Caillat‐Zucman, Sophie, Peytavin, Gilles, Le Chenadec, Jerome, Warszawski, Josiane, Rouzioux, Christine, Saez‐Cirion, Asier, Cohort, ANRS Epf‐Co10 Pediatric, Chang, Christina, Cameron, Paul, Elliott, Julian, Perelson, Alan, Roche, Michael, Dantanarayana, Ashanti, Solomon, Ajantha, Naranbhai, Vivek, Tenakoon, Surekha, Hoh, Rebecca, McMahon, James, Sikaris, Ken, Hartogensis, Wendy, Bacchetti, Peter, Hecht, Frederick, Deeks, Steve, Lewin, Sharon, Byrareddy, Siddappa, Arthos, James, Cicala, Claudia, Reimann, Keith, Parslow, Tristram, Santangelo, Philip, Villinger, Francois, Fauci, Anthony, Ansari, Aftab, George, Michael, Weiser, Barbara, Burger, Harold, Lewy, Tyler, Anastos, Kathryn, Asmuth, David, Somsouk, Ma, Hunt, Peter, Min, Zhong, Miller, Christopher, and Li, Xiao Dong

Subjects
Mental Health, Digestive Diseases, Infectious Diseases, Pediatric AIDS, Bioengineering, Prevention, Clinical Research, Genetics, Health Services, Pediatric, Behavioral and Social Science, HIV/AIDS, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Reproductive health and childbirth, Good Health and Well Being, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Published
2015

4. 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).

Author

Pate, Kelly Metcalf, Pohlmeyer, Chris, Walker-Sperling, Victoria, Foote, Jeremy, Najarro, Kevin, Cryer, Catherine, Salgado, Maria, Gama, Lucio, Engle, Elizabeth, Shirk, Erin, Queen, Suzanne, Chioma, Stanley, Vermillion, Meghan, Bullock, Brandon, Li, Ming, Lyons, Claire, Adams, Robert, Zink, Chris, Clements, Janice, Mankowski, Joseph, Blankson, Joel, Micci, Luca, Ryan, Emily, Fromentin, Rémi, Benne, Clarisse, Chomont, Nicolas, Lifson, Jeffrey, Paiardini, Mirko, Lee, Sulggi, Fromentin, Remi, Silicano, Robert, Silicano, Janet, Richman, Douglas, O'Doherty, Una, Palmer, Sarah, Burbelo, Peter, Deeks, Steven, Ghneim, Khader, Ahlers, Jeff, Fourati, Slim, Shive, Carey, Cameron, Mark, Mukerjee, Pranab, Ghannoum, Mahmoud, Rodriguez, Benigno, Lederman, Michael, Sekaly, Rafick, Frange, Pierre, Faye, Albert, Avettand-Fenoel, Veronique, Bellaton, Erainna, Deschamps, Diane, Angin, Mathieu, Caillat-Zucman, Sophie, Peytavin, Gilles, Le Chenadec, Jerome, Warszawski, Josiane, Rouzioux, Christine, Saez-Cirion, Asier, Chang, Christina, Cameron, Paul, Elliott, Julian, Perelson, Alan, Roche, Michael, Dantanarayana, Ashanti, Solomon, Ajantha, Naranbhai, Vivek, Tenakoon, Surekha, Hoh, Rebecca, McMahon, James, Sikaris, Ken, Hartogensis, Wendy, Bacchetti, Peter, Hecht, Frederick, Deeks, Steve, Lewin, Sharon, Byrareddy, Siddappa, Arthos, James, Cicala, Claudia, Reimann, Keith, Parslow, Tristram, Santangelo, Philip, Villinger, Francois, Fauci, Anthony, Ansari, Aftab, George, Michael, Weiser, Barbara, Burger, Harold, Lewy, Tyler, Anastos, Kathryn, Asmuth, David, Somsouk, Ma, Hunt, Peter, Min, Zhong, Miller, Christopher, Li, Xiao Dong, and Hinkle, John

Subjects
Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Published
2015

13. Definitions and major prerequisites of direct and indirect approaches for estimating reference limits.

Author

Haeckel, Rainer, Adeli, Khosrow, Jones, Graham, Sikaris, Ken, and Wosniok, Werner

Subjects
DEFINITIONS, BIG data, CONFOUNDING variables, QUALITY assurance
Abstract

Reference intervals are established either by direct or indirect approaches. Whereas the definition of direct is well established, the definition of indirect is still a matter of debate. In this paper, a general definition that covers all indirect models presently in use is proposed. With the upcoming popularity of indirect models, it has become evident that further partitioning strategies are required to minimize the risk of patients' false classifications. With indirect methods, such partitions are much easier to execute than with direct methods. The authors believe that the future of reference interval estimation belongs to indirect models with big data pools either from one laboratory or combined from several regional centres (if necessary). Independent of the approach applied, the quality assurance of the pre-analytical and analytical phase, considering biological variables and other confounding factors, is essential. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Indirect methods for reference interval determination - Review and recommendations

Author

Jones, Graham R. D., Haeckel, Rainer, Loh, Tze Ping, Sikaris, Ken, Streichert, Thomas, Katayev, Alex, Barth, Julian H, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Özarda, Yeşim, and AAL-8873-2021

Subjects
Paper, Decision limits, Cost, Medical information, Project, Review, Patient care, Reference values, Clinical chemistry, Bhattacharya, Clinical Chemistry, Thyrotropin, Chemical Species, Humans, Priority journal, Risk assessment, Individual biological variations, Hospitalized population, Statistical approach, Indirect methods, Reference intervals, Methodology, Standard, Global multicenter, Statistical analysis, Determining reference limit, Publication, Reference standards, Pathology testing, Derivation, Comparative study, Medical laboratory technology, Reference value, Chemistry, clinical, Human
Abstract

Reference intervals are a vital part of the information supplied by clinical laboratories to support interpretation of numerical pathology results such as are produced in clinical chemistry and hematology laboratories. The traditional method for establishing reference intervals, known as the direct approach, is based on collecting samples from members of a preselected reference population, making the measurements and then determining the intervals. An alternative approach is to perform analysis of results generated as part of routine pathology testing and using appropriate statistical techniques to determine reference intervals. This is known as the indirect approach. This paper from a working group of the International Federation of Clinical Chemistry (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) aims to summarize current thinking on indirect approaches to reference intervals. The indirect approach has some major potential advantages compared with direct methods. The processes are faster, cheaper and do not involve patient inconvenience, discomfort or the risks associated with generating new patient health information. Indirect methods also use the same preanalytical and analytical techniques used for patient management and can provide very large numbers for assessment. Limitations to the indirect methods include possible effects of diseased subpopulations on the derived interval. The IFCC C-RIDL aims to encourage the use of indirect methods to establish and verify reference intervals, to promote publication of such intervals with clear explanation of the process used and also to support the development of improved statistical techniques for these studies.

Published
2019

23. Distinguishing reference intervals and clinical decision limits – A review by the IFCC committee on reference intervals and decision limits

Author

Sikaris, Ken Andrew, Streichert, Thomas, Macri, Joseph, Uludağ Üniversitesi/Tıp Fakültesi/Tıbbı Biyokimya Anabilim Dalı., İlçöl, Yeşim Özarda, and AAL-8873-2021

Subjects
Laboratory test, Standards, Clinical decision limits, Review, Reference values, Laboratory, Health care organization, Joint consensus statement, Laboratory technique, Organization and management, Clinical Chemistry, Thyrotropin, Chemical Species, Humans, High-density-lipoprotein, C-RIDL, Priority journal, Prediatric peference intervals, Reference intervals, Analytical performance, Lipid, European atherosclerosis society, Clinical laboratories, Prostate-specific antigen, Global multicenter, Glucose, Hemoglobin A1c, Clinical laboratory techniques, 99th percentile, Medical laboratory technology, Laboratories, Approved recommendation1987, Clinical decision making, Reference value, Clinical decision limit, Human
Abstract

Reference Intervals (RIs) and clinical decision limits (CDLs) are a vital part of the information supplied by laboratories to support the interpretation of numerical clinical pathology results. RIs describe the typical distribution of results seen in a healthy reference population while CDLs are associated with a significantly higher risk of adverse clinical outcomes or are diagnostic for the presence of a specific disease. However, as the two concepts are sometimes confused, there is a need to clarify the differences between these terms and to ensure they are easily distinguished, especially because CDLs have a clinical association with specific diseases and risks, thereby implying that effective clinical interventions are available. It is important to note that, because population-based RIs are derived from the range of values expected in a typical community population, laboratory results that fall outside a RI do not necessarily indicate a disease but rather that additional medical follow-up and/or treatment may be warranted. In contrast, CDLs are associated with a risk of specific adverse outcomes, and are commonly used to interpret laboratory test results, including lipid parameters, glucose, hemoglobin A1c (HbA1c), and tumor markers, to determine risk of disease, to diagnose or to treat. In recent years, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) has focused primarily on RIs and has performed multicenter studies to obtain common RIs. However, the broader responsibility of the Committee, from its name, includes decision limits. C-RIDL now aims to emphasize the importance of the correct use of both RIs and CDLs and to encourage laboratories to specify the appropriate information to clinicians as needed. This review discusses RIs and CDLs in detail, describes the similarities and the differences between these two important tools in laboratory medicine, and clearly explains the processes used to define them. C-RIDL encourages the involvement of laboratory professionals in the establishment of both RIs and CDLs.

Published
2018

27. Reporting and ideal testosterone levels in men undergoing androgen deprivation for prostate cancer—time for a rethink?

Author

Cabarkapa, Sonja, Perera, Marlon, Sikaris, Ken, O’Brien, Jonathan S., Bolton, Damien M., and Lawrentschuk, Nathan

Abstract

This study aims to review current laboratory reporting strategies across Australia and New Zealand with a view to propose a more useful template for reporting serum testosterone in the context of prostate cancer.

Published
2024
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42. Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease

Author

Ooi, Geraldine J., primary, Burton, Paul R., additional, Doyle, Lisa, additional, Wentworth, John M., additional, Bhathal, Prithi S., additional, Sikaris, Ken, additional, Cowley, Michael A., additional, Roberts, Stuart K., additional, Kemp, William, additional, Earnest, Arul, additional, O’Brien, Paul E., additional, and Brown, Wendy A., additional

Published
2016
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43. Harmonising Adult and Paediatric Reference Intervals in Australia and New Zealand: An Evidence-Based Approach for Establishing a First Panel of Chemistry Analytes

Author

Tate, Jillian R, Sikaris, Ken A, Jones, Graham RD, Yen, Tina, Koerbin, Gus, Ryan, Julie, Reed, Maxine, Gill, Janice, Koumantakis, George, Hickman, Peter, and Graham, Peter

Subjects
Special Report
Abstract

Scientific evidence supports the use of common reference intervals (RIs) for many general chemistry analytes, in particular those with sound calibration and traceability in place. Already the Nordic countries and United Kingdom have largely achieved harmonised RIs. Following a series of workshops organised by the Australasian Association of Clinical Biochemists (AACB) between 2012 and 2014 at which an evidence-based approach for determination of common intervals was developed, pathology organisations in Australia and New Zealand have reached a scientific consensus on what adult and paediatric intervals we should use across Australasia. The aim of this report is to describe the processes that the AACB and the Royal College of Pathologists of Australasia have taken towards recommending the implementation of a first panel of common RIs for use in Australasia.

Published
2014

44. An update report on the harmonization of adult reference intervals in Australasia.

Author

Koerbin, Gus, Sikaris, Ken, Jones, Graham R.D., Flatman, Robert, and Tate, Jillian R.

Subjects
*BIOCHEMISTS, *CLINICAL chemistry, *CALIBRATION, *METROLOGY, *ALBUMINS, *BLOOD gases
Abstract

The Australasian Association of Clinical Biochemists (AACB) has over the past 5 years been actively working to achieve harmonized reference intervals (RIs) for common clinical chemistry analytes using an evidence-based checklist approach where there is sound calibration and metrological traceability. It has now recommended harmonized RIs for 18 common clinical chemistry analytes which are performed in most routine laboratories and these have been endorsed by the Royal College of Pathologists of Australasia (RCPA). In 2017 another group of analytes including urea, albumin and arterial blood gas parameters were considered and suggested harmonized RIs proposed. This report provides an update of those harmonization efforts. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Indirect methods for reference interval determination – review and recommendations.

Author

Jones, Graham R.D., Haeckel, Rainer, Loh, Tze Ping, Sikaris, Ken, Streichert, Thomas, Katayev, Alex, Barth, Julian H., and Ozarda, Yesim

Subjects
PATHOLOGICAL laboratories, CLINICAL pathology, CLINICAL chemistry, HEMATOLOGY, STATISTICS
Abstract

Reference intervals are a vital part of the information supplied by clinical laboratories to support interpretation of numerical pathology results such as are produced in clinical chemistry and hematology laboratories. The traditional method for establishing reference intervals, known as the direct approach, is based on collecting samples from members of a preselected reference population, making the measurements and then determining the intervals. An alternative approach is to perform analysis of results generated as part of routine pathology testing and using appropriate statistical techniques to determine reference intervals. This is known as the indirect approach. This paper from a working group of the International Federation of Clinical Chemistry (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) aims to summarize current thinking on indirect approaches to reference intervals. The indirect approach has some major potential advantages compared with direct methods. The processes are faster, cheaper and do not involve patient inconvenience, discomfort or the risks associated with generating new patient health information. Indirect methods also use the same preanalytical and analytical techniques used for patient management and can provide very large numbers for assessment. Limitations to the indirect methods include possible effects of diseased subpopulations on the derived interval. The IFCC C-RIDL aims to encourage the use of indirect methods to establish and verify reference intervals, to promote publication of such intervals with clear explanation of the process used and also to support the development of improved statistical techniques for these studies. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
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