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Definitions and major prerequisites of direct and indirect approaches for estimating reference limits.
- Source :
- Clinical Chemistry & Laboratory Medicine; 2023, Vol. 61 Issue 3, p402-406, 5p
- Publication Year :
- 2023
-
Abstract
- Reference intervals are established either by direct or indirect approaches. Whereas the definition of direct is well established, the definition of indirect is still a matter of debate. In this paper, a general definition that covers all indirect models presently in use is proposed. With the upcoming popularity of indirect models, it has become evident that further partitioning strategies are required to minimize the risk of patients' false classifications. With indirect methods, such partitions are much easier to execute than with direct methods. The authors believe that the future of reference interval estimation belongs to indirect models with big data pools either from one laboratory or combined from several regional centres (if necessary). Independent of the approach applied, the quality assurance of the pre-analytical and analytical phase, considering biological variables and other confounding factors, is essential. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEFINITIONS
BIG data
CONFOUNDING variables
QUALITY assurance
Subjects
Details
- Language :
- English
- ISSN :
- 14346621
- Volume :
- 61
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical Chemistry & Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 161530007
- Full Text :
- https://doi.org/10.1515/cclm-2022-1061