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Indirect methods for reference interval determination - Review and recommendations
- Publication Year :
- 2019
- Publisher :
- Walter de Gruyter, 2019.
-
Abstract
- Reference intervals are a vital part of the information supplied by clinical laboratories to support interpretation of numerical pathology results such as are produced in clinical chemistry and hematology laboratories. The traditional method for establishing reference intervals, known as the direct approach, is based on collecting samples from members of a preselected reference population, making the measurements and then determining the intervals. An alternative approach is to perform analysis of results generated as part of routine pathology testing and using appropriate statistical techniques to determine reference intervals. This is known as the indirect approach. This paper from a working group of the International Federation of Clinical Chemistry (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) aims to summarize current thinking on indirect approaches to reference intervals. The indirect approach has some major potential advantages compared with direct methods. The processes are faster, cheaper and do not involve patient inconvenience, discomfort or the risks associated with generating new patient health information. Indirect methods also use the same preanalytical and analytical techniques used for patient management and can provide very large numbers for assessment. Limitations to the indirect methods include possible effects of diseased subpopulations on the derived interval. The IFCC C-RIDL aims to encourage the use of indirect methods to establish and verify reference intervals, to promote publication of such intervals with clear explanation of the process used and also to support the development of improved statistical techniques for these studies.
- Subjects :
- Paper
Decision limits
Cost
Medical information
Project
Review
Patient care
Reference values
Clinical chemistry
Bhattacharya
Clinical Chemistry
Thyrotropin
Chemical Species
Humans
Priority journal
Risk assessment
Individual biological variations
Hospitalized population
Statistical approach
Indirect methods
Reference intervals
Methodology
Standard
Global multicenter
Statistical analysis
Determining reference limit
Publication
Reference standards
Pathology testing
Derivation
Comparative study
Medical laboratory technology
Reference value
Chemistry, clinical
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.od......9458..2023a492d7b1db05a380e67c63a8e93b