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OBJECTIVE: To determine if Pyk2-deficiency increases midpalatal suture bone mass and preserves sutural integrity after maxillary expansion. SETTING AND SAMPLE: Thirty-six male Pyk2 knockout (KO) and control (WT) mice at 6-weeks of age. MATERIALS AND METHODS: Mice received nickel-titanium spring expanders delivering 0g (no intervention control), 10g or 20g force for 14 days. High-resolution micro-CT was used to determine bone volume/tissue volume (BV/TV), sutural width and intermolar width. Effects on osteoclasts, chondrocytes and suture morphology were determined by histomorphometry. RESULTS: Pyk2-KO controls (0g) had 7% higher BV/TV compared with WT controls. Expanded Pyk2-KO maxillae also exhibited 12% (10g) and 18% (20g) higher BV/TV than WT mice. Although bone loss following expansion occurred in both genotypes, BV/TV was decreased to a greater extent in WT maxillae (−10% at 10g; −22% at 20g) compared with Pyk2-KO maxillae (−11% only at 20g) (p

Objectives To investigate the susceptibility of partially desalivated rats to erosive tooth wear (ETW); the anti-erosive effect of a calcium-supplemented beverage; and the quantification of ETW by microcomputed tomography (micro-CT). Methods The study population consisted of thirty-eight rats, divided into partially desalivated (n = 19) and normal salivary flow (n = 19). They were randomly allocated into three subgroups (n = 6-7): A-diet soda, B-diet soda + calcium, C-water (control). Solutions were provided ad libitum for 28 days, and the rats were euthanized afterwards. Each left hemi-mandible was scanned using micro-CT for enamel volume (three molars) calculation. Visual analysis of photographs of the lingual surface of first molars was performed independently by three blinded examiners. Data were statistically analysed (α = .05). Results Micro-CT revealed no significant differences between partially desalivated or normal groups. Rats consuming A had more enamel loss than those consuming B or C, which did not differ from each other. For visual analysis, desalivation did not affect ETW. Rats consuming C showed the lowest ETW, followed by B and then A, for both partially desalivated and normal rats. Spearman correlation between the two ETW quantification methods was -.65. Conclusions Partial desalivation did not increase ETW. Ca-containing beverage prevented ETW. Micro-CT quantified ETW, although it was not as sensitive as visual analysis.

In semiconductor substrate fabrication process, copper traces are electroplated on prepreg material to play an important role of communicating signals between functional ICs. In recent years, larger size and high I/O number packages such as HFCBGA, 2.5D and 3D IC were developed, finer copper line width and space (L/S) trace substrate design become more and more important. However, the copper trace broken risk under several thermal manufacturing processes and reliability testing also increasing. A temperature cycling test (TCT) is one of the key experimental testing items for package reliability performance evaluation. The accumulated thermal stress will lead to trace broken risk during test, then the discontinue signal cause function failure. For specific application such as Automotive (ATV), function fail is lethal. Thus, consider risk assessment in the primary structure design stage is essential.In this work, a three-dimensional finite element model is used to evaluate structure design and material selection. In generally, the bilinear casting bulk model was used to evaluate copper trace lifetime performance under thermal cycling test condition. However, this bilinear constitutive model is difficult to simulate long-term creep behavior. Therefore, a new experimental technique was developed to measure the copper trace material properties. The mechanical tensile strength of the thin copper foil was tested with a micro-tester to examine the tensile stress–strain relationship. The copper foil is fabricated to be 18 micron thickness which similar to substrate copper trace thickness. Four kinds of tensile speed (1x100 ~ 1x10-3 mm/minute) at four temperature environments (25rC ~ 150°C) were applied and Stress-Strain (S-S) curves were measured by micro force test system. The tensile result of electroplated copper film shows lower Young’s modulus and higher tensile strength than casting bulk copper.The test vehicle of 11.8 x 11.4 mm2 BGA package which has substrate copper trace crack issue after TCT 1000 cycles (-65°C ~ 150°C) was chosen. Besides, the creep behavior of the copper was taken into account in the simulation model to verify the numerical model and copper’s constitutive model. The copper trace broken risk from the simulation was verified against the experimental data. Additional critical data, such as creep strain energy density (CSED) of the copper trace in the organic substrate and the maximum CSED level location in the substrate layer can be predicted. From the result, reduce the package thermal stress can bring lower CSED on trace, and in this study changed the lower Young’s modulus substrate material to control the thermal stress. The experimental and numerical methods presented here can be used as useful performance evaluation tools to support the choice of suitable package geometry and bill of material (BOM) selection.

Purpose Recent case reports suggest that amnion-chorion membranes (ACM) and dense polytetrafluoroethylene membranes (dPTFE) can be left exposed during ridge preservation. The aim of this study was to compare the effectiveness of these membranes in ridge preservation, particularly when they are intentionally left exposed. Materials and methods A split-mouth, single-blind, randomized trial design was used to compare treatments with the two membranes in 22 nonmolar sites on the same arch. Ridge dimensions were recorded clinically and with cone beam computed tomography prior to and 3 months after ridge preservation. Postoperative discomfort was recorded with Visual Analog Scale (VAS) forms. Mixed‑model analysis of variance was used to test significance. Results Clinical and radiographic ridge dimensions were not significantly different between the two treatments. ACM sites had significantly more osteoid and higher bone volume density but significantly less graft particles and bone surface density compared with dPTFE. Mineralized bone area and soft tissue area were not significantly different between the two treatments. ACM sites had significantly lower postoperative VAS scores compared with dPTFE. Conclusion Intentionally exposed ACM is equally effective in ridge preservation compared with dPTFE. Additionally, ACM use may aid in reducing postoperative VAS scores, and potentially result in better quality of bone available for implant placement, as evidenced by improved histomorphometric measures.

Drop test for solder joint reliability is critical for all area arrays and perimeter-leaded surface mount semiconductor devices typically used in handheld electronic products. Joint Electron Device Engineering Council, JEDEC, published a new test standard, JESD22-B111A, to be the revision of the JESD22-B111 for board level drop test in November, 2016. The major differences between JESD22-B111 and JESD22-B111A are PCB size (132×77mm2 to 77×77mm2), PCB layers (8 layers to 10 layers), sample size (15 components/PCB with package size ≦ 15×15 mm2 to 4 components/PCB with package size ≦ 17×17 mm2) and total number of test components (120 components to 48 components). JESD22-B111A also adds the specifications of PCB pad and solder mask opening size for 0.4mm component pitch and 5 lb-in torque value. The component placement on the square board that defined in JESD22-B111A is symmetric so that all of them shall have same stress level during drop test, it is different from the component placement on the rectangular board that defined in JESD22-B111 which results several stress level during drop test. In this paper, board level drop test and simulation followed JESD22-B111 and JESD22-B111A are executed. The simulation result shows conditions follow JESD22-B111A has both smaller normal stress and plastic strain than conditions follow JESD22-B111; drop test experiment result shows JESD22-B111A has longer characteristic life, too. The study of package surface mount placement orientation for rectangular package under JESD22-B111A condition is also executed by simulation, due to it is not defined in the new revised standard. The simulation result shows circumferential oriented component placement has larger plastic strain and radial oriented component placement has larger normal stress, it means the former ease to have solder fracturing failure mode and the latter ease to have intermetallic compound layers fracturing failure mode.

Global measurements of upper tropospheric/lower-stratospheric water vapor and ice particle size distribution in clouds are critically needed to reduce uncertainties in global weather and climate models. To address this need, the conically scanning Tropospheric Water and Cloud ICE (TWICE) millimeter and submillimeter radiometer instrument is being developed. A low-noise, power-efficient command and data handling (C&DH) subsystem has been designed to control TWICE data acquisition and other subsystems. The C&DH prototype board meets functional, noise and size, weight and power (SWaP) requirements for deployment in a 6U-class satellite. Considering the limited power resources available on such platforms, a highly-efficient power regulation board has been designed to minimize power losses and reduce system noise. Furthermore, all of the components have been tested for radiation tolerance in low-Earth orbit.

Objective: BoneCeramic can regenerate bone in alveolar defects, but it remains unknown whether it is feasible to move a tooth through BoneCeramic grafting sites. The objective of this study was to investigate three-dimensional real-time bone responses and micromechanical properties in the grafting sites during orthodontic tooth movement. Methods: Sixty 5-week-old rats were randomly assigned into three groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss), and no graft, respectively, after the extraction of the left maxillary first molar. After 4 weeks, the maxillary left second molar was moved into the extraction for 28 days. Dynamic bone microstructures and root resorption were evaluated using in vivo micro-computed tomography and histology. Stress distribution of tooth roots and biomechanical properties of corresponding bone tissue were examined by finite element methods and nanoindentation. Mixed-model analysis of variance was performed to compare the difference among time points with Bonferroni post hoc tests at the significance level of P < .05. Results: The BoneCeramic group had the least amount of tooth movement and root resorption volume and craters, highest bone volume fraction, trabecular number, mean trabecular thickness, microhardness, and elastic modulus, followed by Bio-Oss and the control group. The highest stress accumulated in the cervical region of the mesial roots. Conclusion: BoneCeramic has better osteoconductive potential and biomechanical properties and induces less root resorption compared with Bio-Oss grafting and naturally recovered extraction site.

Global measurements of cloud ice particle size, total ice water content and water vapor content in the upper troposphere are critically needed to improve knowledge of the role of ice clouds in Earth's climate, precipitation and cloud processes. Such observations will enable improvement in cloud and moisture simulations in global climate models as well as precipitation forecasts on a global basis. Measurements at a range of frequencies in the millimeter- and submillimeter-wave frequency range provide sensitivity to ice particle size distribution in the range of tens to hundreds of micrometers. To perform this measurement on a global basis, a new millimeter- and submillimeter-wave instrument is currently under development with suitable mass, power and volume to be deployed on 6U-Class nanosatellites. To achieve miniaturized receivers in this frequency range, InP MMIC technology has been scaled to 25-nm gate length transistors, enabling demonstration of low-noise amplifiers with sufficient gain at frequencies up to 1 THz. This technology is being applied to develop direct-detection submillimeter-wave receivers at 240 GHz, 310 GHz and 670 GHz. InP MMIC technology has also enabled multipliers for local oscillators and subharmonic mixers for temperature and humidity sounding channels near atmospheric absorption lines at 118.75, 183.31 and 380.20 GHz.

Objective: To investigate three-dimensional microarchitecture and micromechanical properties of alveolar bone in the BoneCeramic grafting sites during orthodontic tooth movement. Materials and Methods: Sixty 5-week-old rats were randomly assigned into three groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss), and no graft, respectively, after the extraction of the left maxillary first molar. After 4 weeks, the maxillary left second molar was moved into the extraction site for 28 days. Dynamic bone microstructures were evaluated using in vivo micro–computed tomography. Micromechanical properties and stress distribution of corresponding tissue were examined by nanoindentation and finite element methods. Mixed-model analysis of variance was performed to compare the difference among time points with Bonferroni post hoc tests at the significance level of P < .05. Results: The BoneCeramic group had the least amount of tooth movement and the highest bone volume fraction, tr...

Background/Objectives: This study investigated the biomechanical properties and bone-implant intersurface response of machined and laser surface-treated stainless steel (SS) mini-screw implants (MSIs). Material and Methods: Forty-eight 1.3mm in diameter and 6mm long SS MSIs were divided into two groups. The control (machined surface) group received no surface treatment; the laser-treated group received Nd-YAG laser surface treatment. Half in each group was used for examining surface roughness (Sa and Sq), surface texture, and facture resistance. The remaining MSIs were placed in the maxilla of six skeletally mature male beagle dogs in a randomized split-mouth design. A pair with the same surface treatment was placed on the same side and immediately loaded with 200g nickel–titanium coil springs for 8 weeks. After killing, the bone-implant contact (BIC) for each MSI was calculated using micro computed tomography. Analysis of variance model and two-sample t test were used for statistical analysis with a significance level of P

Improving routability during both global and detailed routing stage has become a critical problem in modern VLSI design. In this work, we propose a placement framework that offers a complete coverage solution in considering both global and detailed routing congestion. A placement migration strategy is proposed, which improves detailed routing congestion while preserving the placement integrity that is optimized for global routability. Using the benchmarks released from ISPD2014 Contest, practical design rules in advanced node design are considered in our placement framework. Evaluation on routability of our placement framework is conducted using commercial router provided by the 2014 ISPD Contest organizers. Experimental results show that the proposed methodologies can effectively improve placement solutions for both global and detailed router.

Introduction BoneCeramic (Straumann, Basel, Switzerland) can regenerate bone in alveolar defects after tooth extraction, but it is unknown whether it is feasible to move a tooth through BoneCeramic grafting sites. The objective of this study was to investigate 3-dimensional real-time root resorption and bone responses in grafted sites during orthodontic tooth movement. Methods Sixty 5-week-old rats were randomly assigned to 3 groups to receive BoneCeramic, natural bovine cancellous bone particles (Bio-Oss; Geistlich Pharma, Wolhusen, Switzerland), or no graft, after the extraction of the maxillary left first molar. After 4 weeks, the maxillary left second molar was moved into the extraction site for 28 days. Dynamic bone microstructures and root resorption were evaluated using in-vivo microcomputed tomography. Stress distribution and corresponding tissue responses were examined by the finite element method and histology. Mixed model analysis of variance was performed to compare the differences among time points with Bonferroni post-hoc tests at the significance level of P Results The BoneCeramic group had the least amount of tooth movement and root resorption volumes and craters, and the highest bone volume fraction, trabecular number, and mean trabecular thickness, followed by the Bio-Oss and the control groups. The highest stress accumulated in the cervical region of the mesial roots. Conclusions BoneCeramic has better osteoconductive potential and induces less root resorption compared with Bio-Oss grafting and naturally recovered extraction sites.