33 results on '"Bewig, Burkhard"'
Search Results
2. Utilization and determinants of use of non-pharmacological interventions in COPD: Results of the COSYCONET cohort
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Lutter, Johanna I., Lukas, Marco, Schwarzkopf, Larissa, Jörres, Rudolf A., Studnicka, Michael, Kahnert, Kathrin, Karrasch, Stefan, Bewig, Burkhard, Vogelmeier, Claus F., and Holle, Rolf
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- 2020
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3. Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis
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Renner, Sabine, Knoop, Christiane, Malfroot, Anne, Dupont, Lieven, Desager, Kristine, De Baets, Frans, Bosheva, Miroslava, Nedkova, Vania, Galabov, Ivan, Galeva, Ivanka, Freitag, Andreas, Morrison, Nancy, Wilcox, Pearce, Pressler, Tanja, Martinet, Yves, Chiron, Raphael, Fajac, Isabelle, Dominique, Stephan, Reix, Philippe, Prevotat, Anne, Sermet, Isabelle, Durieu, Isabelle, Fischer, Rainald, Huber, Rudolf, Staab, Doris, Mellies, Uwe, Sextro, Wolfgang, Welte, Tobias, Wilkens, Heinrike, Sommerwerk, Urte, Bewig, Burkhard, Inglezos, Ilias, Doudounakis, Stavros-Eleftherios, Bede, Olga, Gönczi, Ferenc, Újhelyi, Rita, McKone, Edward, McNally, Paul, Lucidi, Vincenzina, Cipolli, Marco, La Rosa, Mario, Minicucci, Laura, Padoan, Rita, Pisi, Giovanna, Gagliardini, Rolando, Colombo, Carla, Bronsveld, Inez, Sapiejka, Ewa, Mazurek, Henryk, Sands, Dorota, Górnicka, Grażyna, Stelmach, Iwona, Batura-Gabryel, Halina, Rachel, Marta, Minic, Predrag, Orosova, Jaroslava, Takac, Branko, Feketova, Anna, Martinez, Carmen, Hernandez, Gloria Garcia, Villa-Asensi, Jose Ramon, Gartner, Silvia, Sole, Amparo, Lindblad, Anders, Ledson, Martin, Bilton, Diana, Whitehouse, Joanna, Smyth, Alan, Ketchell, Ian, Lee, Timothy, MacGregor, Gordon, Pressler, Tacjana, Clancy, John Paul, Solé, Amparo, Quittner, Alexandra L., Liu, Keith, McGinnis, John P., II, Eagle, Gina, Gupta, Renu, and Konstan, Michael W.
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- 2020
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4. CAT score single item analysis in patients with COPD: Results from COSYCONET
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Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Ficker, Joachim H., Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Katus Hugo, A., Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Randerath Winfried, J., Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Speth, Kornelia, Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Berger, Patricia, Schottel, Diana, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Hübner, Gudrun, Marietta von Siemens, Sarah, Alter, Peter, Lutter, Johanna I., Kauczor, Hans-Ulrich, Jobst, Bertram, Bals, Robert, Trudzinski, Franziska C., Söhler, Sandra, Behr, Jürgen, Watz, Henrik, Waschki, Benjamin, Bewig, Burkhard, Jones, Paul W., Welte, Tobias, Vogelmeier, Claus F., Jörres, Rudolf A., and Kahnert, Kathrin
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- 2019
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5. Die Cytomegalievirus-Pneumonie
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Balke, Lorenz and Bewig, Burkhard
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- 2019
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6. Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013
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Tappe, Dennis, Schlottau, Kore, Cadar, Daniel, Hoffmann, Bernd, Balke, Lorenz, Bewig, Burkhard, Hoffmann, Donata, Eisermann, Philip, Fickenscher, Helmut, Krumbholz, Andi, Laufs, Helmut, Huhndorf, Monika, Rosenthal, Maria, Schulz-Schaeffer, Walter, Ismer, Gabriele, Hotop, Sven-Kevin, Bronstrup, Mark, Ott, Anthonina, Schmidt-Chanasit, Jonas, and Beer, Martin
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Zoos -- Analysis ,Autoimmunity -- Analysis ,Immunohistochemistry -- Analysis ,Phylogeny -- Analysis ,Antibodies -- Analysis ,Antigenic determinants -- Analysis ,Encephalitis -- Analysis ,Health - Abstract
Limbic encephalitis, a term coined in 1960 as a clinical/ anatomic description (1), is a rare regional inflammation of the brain involving mainly the limbic system but also other anatomic [...]
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- 2018
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7. Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment
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Kahnert, Kathrin, Andreas, Stefan, Kellerer, Christina, Lutter, Johanna I., Lucke, Tanja, Yildirim, Önder, Lehmann, Mareike, Seissler, Jochen, Behr, Jürgen, Frankenberger, Marion, Bals, Robert, Watz, Henrik, Welte, Tobias, Trudzinski, Franziska C., Vogelmeier, Claus F., Alter, Peter, Jörres, Rudolf A., Bahmer, Thomas, Bewig, Burkhard, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Grohé, Christian, Held, Matthias, Henke, Markus, Herth, Felix, Kirsten, Anne-Marie, Koczulla, Rembert, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Herzmann, Christian, Pfeifer, Michael, Randerath, Winfried J., Seeger, Werner, Studnicka, Michael, Taube, Christian, Timmermann, Hartmut, Schmeck, Bernd, Vogelmeier, Claus, and Wirtz, Hubert
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Male ,Epidemiology ,Science ,Vital Capacity ,Medizin ,Article ,Body Mass Index ,Cohort Studies ,Pulmonary Disease, Chronic Obstructive ,Sex Factors ,Forced Expiratory Volume ,Diabetes Mellitus ,Humans ,Hypoglycemic Agents ,Lung ,Aged ,Multidisciplinary ,Smoking ,Age Factors ,Middle Aged ,respiratory system ,Metformin ,respiratory tract diseases ,Pulmonary Emphysema ,Pulmonary Diffusing Capacity ,Medicine ,Female ,Drug therapy - Abstract
We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects of metformin. Patients of GOLD grades 1–4 of the COSYCONET cohort with follow-up data of up to 4.5 y were included. The annual decline in lung function (FEV1, FVC) and CO diffusing capacity (KCO, TLCO) in %predicted at baseline was evaluated for associations with age, sex, BMI, pack-years, smoking status, baseline lung function, exacerbation risk, respiratory symptoms, cardiac disease, as well as metformin-containing therapy compared to patients without diabetes and metformin. Among 2741 patients, 1541 (mean age 64.4 y, 601 female) fulfilled the inclusion criteria. In the group with metformin treatment vs. non-diabetes the mean annual decline in KCO and TLCO was significantly lower (0.2 vs 2.3, 0.8 vs. 2.8%predicted, respectively; p 1 and FVC. These results were confirmed using multiple regression and propensity score analyses. Our findings demonstrate an association between the annual decline of lung diffusing capacity and the intake of metformin in patients with COPD consistent with the hypothesis of anti-aging effects of metformin as reflected in a surrogate marker of emphysema.
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- 2022
8. Combination of National Quality Assurance Data Collection With a Standard Operating Procedure in Community-Acquired Pneumonia: A Win-Win Strategy?
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Schulte, Falko C., Bewig, Burkhard, Petzina, Rainer, Graf, Demian, Balke, Lorenz, Wehkamp, Ulrike, Jahnke, Iris, and Wehkamp, Kai
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- 2019
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9. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort
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von Siemens, Sarah Marietta, Perneczky, Robert, Waschki, Benjamin, Lutter, Johanna I, Welte, Tobias, Jörres, Rudolf A, Kahnert, Kathrin, group, COSYCONET study, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Vogelmeier, Claus F, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Jany, Berthold, Henke, Markus, Herth, Felix, Höffken, Gerd, Katus, Hugo A, Kirsten, Anne-Marie, Watz, Henrik, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Lange, Christoph, Kauffmann-Guerrero, Diego, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J, Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J Christian, Vogelmeier, Claus, Alter, Peter, Wagner, Ulrich, Wirtz, Hubert, Trudzinski, Franziska C, and Söhler, Sandra
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Male ,medicine.medical_specialty ,epidemiology [Cognitive Dysfunction] ,psychology [Pulmonary Disease, Chronic Obstructive] ,Medizin ,Comorbidity ,Cohort Studies ,03 medical and health sciences ,FEV1/FVC ratio ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Cognition ,epidemiology [Pulmonary Disease, Chronic Obstructive] ,Surveys and Questionnaires ,medicine ,Dementia ,Humans ,COPD ,Cognitive Dysfunction ,ddc:610 ,Cognitive skill ,Path analysis (statistics) ,Aged ,lcsh:RC705-779 ,business.industry ,Research ,physiology [Cognition] ,diagnosis [Pulmonary Disease, Chronic Obstructive] ,lcsh:Diseases of the respiratory system ,Middle Aged ,medicine.disease ,Mental Status and Dementia Tests ,humanities ,Cross-Sectional Studies ,Cognitive impairment ,diagnosis [Cognitive Dysfunction] ,030228 respiratory system ,Cohort ,Physical therapy ,Female ,psychology [Cognitive Dysfunction] ,business ,030217 neurology & neurosurgery ,Cognitive load - Abstract
Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1–4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George‘s respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.
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- 2022
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10. Acute Kidney Injury in Patients with Severe ARDS Requiring Extracorporeal Membrane Oxygenation: Incidence, Prognostic Impact and Risk Factors
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Pilarczyk, Kevin, primary, Huenges, Katharina, additional, Bewig, Burkhard, additional, Balke, Lorenz, additional, Cremer, Jochen, additional, Haneya, Assad, additional, and Panholzer, Bernd, additional
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- 2022
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11. Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET
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Trudzinski, F.C., Jörres, R.A., Alter, P., Kahnert, K., Waschki, B., Herr, C., Kellerer, C., Omlor, A., Vogelmeier, C.F., Fähndrich, S., Watz, H., Welte, T., Jany, B., Söhler, S., Biertz, F., Herth, F., Kauczor, H.-U., Bals, R., Andreas, Stefan, Behr, Jürgen, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Henke, Markus, Höffken, Gerd, Katus, Hugo A., Kirsten, Anne-Marie, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Lange, Christoph, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J., Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J. Christian, Wagner, and Wirtz, Hubert
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Adult ,Male ,medicine.medical_specialty ,Exacerbation ,Medizin ,lcsh:Medicine ,Severity of Illness Index ,Gastroenterology ,Article ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,Medical research ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Signs and symptoms ,lcsh:Science ,Survival rate ,Aged ,Oxygen saturation (medicine) ,Aged, 80 and over ,Inflammation ,COPD ,Oxygenated Hemoglobin ,Multidisciplinary ,Proportional hazards model ,business.industry ,Hazard ratio ,lcsh:R ,Middle Aged ,Prognosis ,medicine.disease ,Comorbidity ,Survival Rate ,Risk factors ,030228 respiratory system ,Oxyhemoglobins ,Female ,lcsh:Q ,Blood Gas Analysis ,business ,Biomarkers - Abstract
We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1–4) of the baseline dataset of the COSYCONET COPD cohort were used. The associations with dyspnea, exacerbation history, BODE-Index (cut-off ≤2) and all-cause mortality over 3 years of follow-up were determined by logistic and Cox regression analyses, with sex, age, BMI and pack years as covariates. Predictive values were evaluated by ROC curves. Capillary blood gases included SaO2, PaO2, PaCO2, pH, BE and the concentration of OxyHem [haemoglobin (Hb) x fractional SaO2, g/dL] as a simple-to-measure correlate of oxygen content. Inflammatory markers were WBC, CRP, IL-6 and -8, TNF-alpha and fibrinogen, and comorbidities comprised a broad panel including cardiac and metabolic disorders. Among BG, OxyHem was associated with dyspnoea, exacerbation history, BODE-Index and mortality. Among inflammatory markers and comorbidities, only WBC and heart failure were consistently related to all outcomes. ROC analyses indicated that OxyHem provided information of a magnitude comparable to that of WBC, with optimal cut-off values of 12.5 g/dL and 8000/µL, respectively. Regarding mortality, OxyHem also carried independent, additional information, showing a hazard ratio of 2.77 (95% CI: 1.85–4.15, p 8000/µL was 2.33 (95% CI: 1.60–3.39, p 2. It thus appears well suited for clinical use with minimal equipment, especially for GPs.
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- 2020
12. IL23R on myeloid cells is involved in murine pulmonary granuloma formation
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Schreiber, Tina, primary, Falk-Paulsen, Maren, additional, Kuiper, Jan, additional, Aden, Konrad, additional, Noth, Rainer, additional, Gisch, Nicolas, additional, Schreiber, Stefan, additional, Rosenstiel, Philip, additional, and Bewig, Burkhard, additional
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- 2021
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13. Severe Adult Respiratory Distress Syndrome from Goodpasture Syndrome. Survival Using Extracorporeal Membrane Oxygenation
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Balke, Lorenz, Both, Marcus, Arlt, Alexander, Rosenberg, Mark, and Bewig, Burkhard
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- 2015
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14. Sex-specific associations of comorbidome and pulmorbidome with mortality in chronic obstructive pulmonary disease: results from COSYCONET.
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Trudzinski, Franziska C., Jörres, Rudolf A., Alter, Peter, Walter, Julia, Watz, Henrik, Koch, Andrea, John, Matthias, Lommatzsch, Marek, Vogelmeier, Claus F., Kauczor, Hans-Ulrich, Welte, Tobias, Behr, Jürgen, Tufman, Amanda, Bals, Robert, Herth, Felix J. F., Kahnert, Kathrin, The COSYCONET Study Group, Andreas, Stefan, Bewig, Burkhard, and Buhl, Roland
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COMORBIDITY ,CHRONIC obstructive pulmonary disease ,MENTAL illness ,ASTHMATICS ,CORONARY artery disease - Abstract
In patients with COPD, it has not been comprehensively assessed whether the predictive value of comorbidities for mortality differs between men and women. We therefore aimed to examine sex differences of COPD comorbidities in regard with prognosis by classifying comorbidities into a comorbidome related to extrapulmonary disorders and a pulmorbidome, referring to pulmonary disorders. The study population comprised 1044 women and 1531 men with the diagnosis of COPD from COSYCONET, among them 2175 of GOLD grades 1–4 and 400 at risk. Associations of comorbidities with mortality were studied using Cox regression analysis for men and women separately. During the follow-up (median 3.7 years) 59 women and 159 men died. In men, obesity, hypertension, coronary artery disease, liver cirrhosis, osteoporosis, kidney disease, anaemia and increased heart rate (HR) predict mortality, in women heart failure, hyperuricemia, mental disorders, kidney disease and increased HR (p < 0.05 each). Regarding the pulmorbidome, significant predictors in men were impairment in diffusion capacity and hyperinflation, in women asthma and hyperinflation. Similar results were obtained when repeating the analyses in GOLD 1–4 patients only. Gender differences should be considered in COPD risk assessment for a tailored approach towards the treatment of COPD. Clinical Trial Registration: ClinicalTrials.gov NCT01245933. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Medikamentöse Therapie des hyperkapnischen respiratorischen Versagens im Notfall
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Bewig, Burkhard, primary and Balke, Lorenz, additional
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- 2021
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16. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET
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Kirsten Anne-Marie, Anne Wirz, Erich Traugott, Ficker Joachim H, Bertram J. Jobst, Vivien Janke, Stubbe Beate, Johanna I. Lutter, Barbara Ziss, Franziska C. Trudzinski, Patricia Berger, Henrik Watz, Gogol Manfred, Thomas Bahmer, Beate Polte, Kronsbein Juliane, Campus Kiel, Lange Christoph, Martina Seibert, Rudolf A. Jörres, Pfeifer Michael, Timmermann Hartmut, Grohé Christian, Tobias Welte, Studnicka Michael, Petra Hundack-Winter, Jana Graf, Jürgen Behr, Diana Schottel, Buhl Roland, Virchow J. Christian, Bewig Burkhard, Ruhrlandklinik gGmbH. Essen, Wirtz Hubert, Rosalie Untsch, Birte Struck, Peter Alter, Kathrin Kahnert, Gudrun Hübner, Vogelmeier Claus, Sabine Michalewski, Kropf-Sanchen Cornelia, Kenn Klaus, Pontus Mertsch, Sonja Rohweder, Hauck Rainer, Andreas Stefan, Ilona Kietzmann, Zabel Peter, Michaela Schrade-Illmann, Höffken Gerd, Julia Tobias, Frank Biertz, Seeger Werner, Manuel Klöser, Kahnert Kathrin, Teschler Helmut, Anita Reichel, Gina Spangel, Ulrike Rieber, Randerath Winfried J, Julia Teng, Tanja Lucke, Herth Felix, Jeanette Pieper, Lenka Krabbe, Taube Christian, Jürgen Biederer, Wagner Ulrich, Doris Lehnert, Claus Vogelmeier, Katrin Schwedler, Henke Markus, Jany Berthold, Katus Hugo A, Bals Robert, Zaklina Hinz, Cornelia Böckmann, Ellen Burmann, Margret Gleiniger, Behr Jürgen, Britta Markworth, Ewert Ralf, Gertraud Weiß, Katrin Wons, Barbara Arikan, Watz Henrik, Beate Schaufler, Lena Sterk, Robert Bals, Hans-Ulrich Kauczor, Koczulla Rembert, Held Matthias, and Welte Tobias
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Copd patients ,Medizin ,Comorbidity ,Severity of Illness Index ,Pulmonary Disease, Chronic Obstructive ,Medicine ,Humans ,In patient ,Lung ,Aged ,Aged, 80 and over ,COPD ,Bronchiectasis ,business.industry ,Phlegm ,Middle Aged ,medicine.disease ,Radiological weapon ,Clinical diagnosis ,Cohort ,Female ,Radiography, Thoracic ,Radiology ,medicine.symptom ,business ,Tomography, X-Ray Computed - Abstract
Bronchiectasis (BE) might be frequently present in COPD but masked by COPD symptoms. We studied the relationship of clinical signs of bronchiectasis to the presence and extent of its radiological signs in patients of different COPD severity. Visit 4 data (GOLD grades 1-4) of the COSYCONET cohort was used. Chest CT scans were evaluated for bronchiectasis in 6 lobes using a 3-point scale (0: absence, 1: ≤50%, 2: >50% BE-involvement for each lobe). 1176 patients were included (61%male, age 67.3y), among them 38 (3.2%) with reported physicians' diagnosis of bronchiectasis and 76 (6.5%) with alpha1-antitrypsin deficiency (AA1D). CT scans were obtained in 429 patients. Within this group, any signs of bronchiectasis were found in 46.6% of patients, whereby ≤50% BE occurred in 18.6% in ≤2 lobes, in 10.0% in 3-4 lobes, in 15.9% in 5-6 lobes; >50% bronchiectasis in at least 1 lobe was observed in 2.1%. Scores ≥4 correlated with an elevated ratio FRC/RV. The clinical diagnosis of bronchiectasis correlated with phlegm and cough and with radiological scores of at least 3, optimally ≥5. In COPD patients, clinical diagnosis and radiological signs of BE showed only weak correlations. Correlations became significant with increasing BE-severity implying radiological alterations in several lobes. This indicates the importance of reporting both presence and extent of bronchiectasis on CT. Further research is warranted to refine the criteria for CT scoring of bronchiectasis and to determine the relevance of radiologically but not clinically detectible bronchiectasis and their possible implications for therapy in COPD patients.
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- 2020
17. CAT score single item analysis in patients with COPD: results from COSYCONET
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J. Randerath Winfried, Pfeifer Michael, Kenn Klaus, Joachim H. Ficker, Gogol Manfred, Grohé Christian, Höffken Gerd, Zaklina Hinz, Julia Tobias, Henke Markus, Teschler Helmut, Welte Tobias, Benjamin Waschki, Buhl Roland, Paul W. Jones, Kirsten Anne-Marie, A. Katus Hugo, Taube Christian, Bewig Burkhard, Beate Polte, Kronsbein Juliane, Stubbe Beate, Bals Robert, Johanna I. Lutter, Sarah Marietta von Siemens, Lange Christoph, Vogelmeier Claus, Ellen Burmann, Wirtz Hubert, Kathrin Kahnert, Erich Traugott, Behr Jürgen, Birte Struck, Vivien Janke, Lenka Krabbe, Timmermann Hartmut, Wagner Ulrich, Anita Reichel, Sabine Michalewski, Gudrun Hübner, Seeger Werner, Doris Lehnert, Jany Berthold, Kropf-Sanchen Cornelia, Sandra Söhler, Jeanette Pieper, Ulrike Rieber, Peter Alter, Herth Felix, Zabel Peter, Andreas Stefan, Koczulla Rembert, Held Matthias, Tobias Welte, Franziska C. Trudzinski, Patricia Berger, Kahnert Kathrin, Jana Graf, Jürgen Behr, Rosalie Untsch, Rudolf A. Jörres, Kornelia Speth, Britta Markworth, Ewert Ralf, Gertraud Weiß, Hans-Ulrich Kauczor, Claus Vogelmeier, Katrin Schwedler, Katrin Wons, Bertram J. Jobst, Barbara Arikan, Margret Gleiniger, Henrik Watz, Watz Henrik, Studnicka Michael, Beate Schaufler, Diana Schottel, Sonja Rohweder, Robert Bals, Ilona Kietzmann, Virchow J. Christian, Burkhard Bewig, Hauck Rainer, and Michaela Schrade-Illmann
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Pulmonary and Respiratory Medicine ,Percentile ,medicine.medical_specialty ,Medizin ,Diagnostic Techniques, Respiratory System ,Single item ,CAT score ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Internal medicine ,medicine ,COPD ,In patient ,030212 general & internal medicine ,Lung function ,Emphysema ,business.industry ,Regression analysis ,Cat Score ,Copd ,medicine.disease ,Exploratory factor analysis ,respiratory tract diseases ,030228 respiratory system ,Cohort ,business - Abstract
The COPD Assessment Test (CAT) is in widespread use for the evaluation of patients with chronic obstructive pulmonary disease (COPD). We assessed whether the CAT items carry additional information beyond the sum score regarding COPD characteristics including emphysema. Patients of GOLD grades 1 to 4 from the COPD cohort COSYCONET (German COPD and Systemic Consequences - Comorbidities Network) with complete CAT data were included (n = 2270), of whom 493 had chest CT evaluated for the presence of emphysema. Comorbidities and lung function were assessed following standardised procedures. Cross-sectional data analysis was based on multiple regression analysis of the single CAT items against a panel of comorbidities, lung function, or CT characteristics (qualitative score, 15th percentile of mean lung density), with age, BMI and gender as covariates. This was supported by exploratory factor analysis. Regarding the relationship to comorbidities and emphysema, there were marked differences between CAT items, especially items 1 and 2 versus 3 to 8. This grouping was basically confirmed by factor analysis. Items 4 and 5, and to a lower degree 1, 2 and 6, appeared to be informative regarding the presence of emphysema, whereas the total score was not or less informative. Regarding comorbidities, similar findings as for the total CAT score were obtained for the modified Medical Research Council scale (mMRC) which was also informative regarding emphysema. Our findings suggest that the usefulness of the CAT can be increased if evaluated on the basis of single items which may be indicating the presence of comorbidities and emphysema.
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- 2020
18. Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis
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Bilton, Diana, primary, Pressler, Tacjana, additional, Fajac, Isabelle, additional, Clancy, John Paul, additional, Sands, Dorota, additional, Minic, Predrag, additional, Cipolli, Marco, additional, Galeva, Ivanka, additional, Solé, Amparo, additional, Quittner, Alexandra L., additional, Liu, Keith, additional, McGinnis, John P., additional, Eagle, Gina, additional, Gupta, Renu, additional, Konstan, Michael W., additional, Renner, Sabine, additional, Knoop, Christiane, additional, Malfroot, Anne, additional, Dupont, Lieven, additional, Desager, Kristine, additional, De Baets, Frans, additional, Bosheva, Miroslava, additional, Nedkova, Vania, additional, Galabov, Ivan, additional, Freitag, Andreas, additional, Morrison, Nancy, additional, Wilcox, Pearce, additional, Pressler, Tanja, additional, Martinet, Yves, additional, Chiron, Raphael, additional, Dominique, Stephan, additional, Reix, Philippe, additional, Prevotat, Anne, additional, Sermet, Isabelle, additional, Durieu, Isabelle, additional, Fischer, Rainald, additional, Huber, Rudolf, additional, Staab, Doris, additional, Mellies, Uwe, additional, Sextro, Wolfgang, additional, Welte, Tobias, additional, Wilkens, Heinrike, additional, Sommerwerk, Urte, additional, Bewig, Burkhard, additional, Inglezos, Ilias, additional, Doudounakis, Stavros-Eleftherios, additional, Bede, Olga, additional, Gönczi, Ferenc, additional, Újhelyi, Rita, additional, McKone, Edward, additional, McNally, Paul, additional, Lucidi, Vincenzina, additional, La Rosa, Mario, additional, Minicucci, Laura, additional, Padoan, Rita, additional, Pisi, Giovanna, additional, Gagliardini, Rolando, additional, Colombo, Carla, additional, Bronsveld, Inez, additional, Sapiejka, Ewa, additional, Mazurek, Henryk, additional, Górnicka, Grażyna, additional, Stelmach, Iwona, additional, Batura-Gabryel, Halina, additional, Rachel, Marta, additional, Orosova, Jaroslava, additional, Takac, Branko, additional, Feketova, Anna, additional, Martinez, Carmen, additional, Hernandez, Gloria Garcia, additional, Villa-Asensi, Jose Ramon, additional, Gartner, Silvia, additional, Sole, Amparo, additional, Lindblad, Anders, additional, Ledson, Martin, additional, Bilton, Diana, additional, Whitehouse, Joanna, additional, Smyth, Alan, additional, Ketchell, Ian, additional, Lee, Timothy, additional, and MacGregor, Gordon, additional
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- 2020
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19. CAT score single item analysis in patients with COPD: Results from COSYCONET
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Marietta von Siemens, Sarah, primary, Alter, Peter, additional, Lutter, Johanna I., additional, Kauczor, Hans-Ulrich, additional, Jobst, Bertram, additional, Bals, Robert, additional, Trudzinski, Franziska C., additional, Söhler, Sandra, additional, Behr, Jürgen, additional, Watz, Henrik, additional, Waschki, Benjamin, additional, Bewig, Burkhard, additional, Jones, Paul W., additional, Welte, Tobias, additional, Vogelmeier, Claus F., additional, Jörres, Rudolf A., additional, Kahnert, Kathrin, additional, Stefan, Andreas, additional, Robert, Bals, additional, Jürgen, Behr, additional, Kathrin, Kahnert, additional, Burkhard, Bewig, additional, Roland, Buhl, additional, Ralf, Ewert, additional, Beate, Stubbe, additional, Ficker, Joachim H., additional, Manfred, Gogol, additional, Christian, Grohé, additional, Rainer, Hauck, additional, Matthias, Held, additional, Berthold, Jany, additional, Markus, Henke, additional, Felix, Herth, additional, Gerd, Höffken, additional, Katus Hugo, A., additional, Anne-Marie, Kirsten, additional, Henrik, Watz, additional, Rembert, Koczulla, additional, Klaus, Kenn, additional, Juliane, Kronsbein, additional, Cornelia, Kropf-Sanchen, additional, Christoph, Lange, additional, Peter, Zabel, additional, Michael, Pfeifer, additional, Randerath Winfried, J., additional, Werner, Seeger, additional, Michael, Studnicka, additional, Christian, Taube, additional, Helmut, Teschler, additional, Hartmut, Timmermann, additional, Christian, Virchow J., additional, Claus, Vogelmeier, additional, Ulrich, Wagner, additional, Tobias, Welte, additional, Hubert, Wirtz, additional, Lehnert, Doris, additional, Struck, Birte, additional, Krabbe, Lenka, additional, Arikan, Barbara, additional, Tobias, Julia, additional, Speth, Kornelia, additional, Pieper, Jeanette, additional, Gleiniger, Margret, additional, Markworth, Britta, additional, Hinz, Zaklina, additional, Burmann, Ellen, additional, Wons, Katrin, additional, Rieber, Ulrike, additional, Schaufler, Beate, additional, Schwedler, Katrin, additional, Michalewski, Sabine, additional, Rohweder, Sonja, additional, Berger, Patricia, additional, Schottel, Diana, additional, Janke, Vivien, additional, Untsch, Rosalie, additional, Graf, Jana, additional, Reichel, Anita, additional, Weiß, Gertraud, additional, Traugott, Erich, additional, Kietzmann, Ilona, additional, Schrade-Illmann, Michaela, additional, Polte, Beate, additional, and Hübner, Gudrun, additional
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- 2019
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20. Combined effects of lung function, blood gases and kidney function on the exacerbation risk in stable COPD: Results from the COSYCONET cohort
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F.C. Trudzinski, K. Kahnert, C.F. Vogelmeier, P. Alter, F. Seiler, S. Fähndrich, H. Watz, T. Welte, T. Speer, S. Zewinger, F. Biertz, H.-U. Kauczor, R.A. Jörres, R. Bals, Andreas Stefan, Bals Robert, Behr Jürgen, Kahnert Kathrin, Bewig Burkhard, Buhl Roland, Ewert Ralf, Stubbe Beate, Ficker Joachim H, Gogol Manfred, Grohé Christian, Hauck Rainer, Held Matthias, Jany Berthold, Henke Markus, Herth Felix, Höffken Gerd, Katus Hugo A, Kirsten Anne-Marie, Watz Henrik, Koczulla Rembert, Kenn Klaus, Kronsbein Juliane, Kropf-Sanchen Cornelia, Lange Christoph, Zabel Peter, Pfeifer Michael, Randerath Winfried J, null eeger Werner, Studnicka Michael, Taube Christian, Teschler Helmut, Timmermann Hartmut, Virchow J. Christian, Vogelmeier Claus, Wagner Ulrich, Welte Tobias, and Wirtz Hubert
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Exacerbation ,Partial Pressure ,Medizin ,Renal function ,Comorbidity ,Acid-Base Imbalance ,Kidney Function Tests ,Risk Assessment ,Cohort Studies ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,DLCO ,Diffusing capacity ,Internal medicine ,Forced Expiratory Volume ,medicine ,Humans ,Respiratory function ,030212 general & internal medicine ,Aged ,COPD ,Carbon Monoxide ,business.industry ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Respiratory Function Tests ,Cross-Sectional Studies ,030228 respiratory system ,Cohort ,Cardiology ,Disease Progression ,Pulmonary Diffusing Capacity ,Female ,Blood Gas Analysis ,Risk assessment ,business ,Glomerular Filtration Rate - Abstract
Rationale Alterations of acid-base metabolism are an important outcome predictor in acute exacerbations of COPD, whereas sufficient metabolic compensation and adequate renal function are associated with decreased mortality. In stable COPD there is, however, only limited information on the combined role of acid-base balance, blood gases, renal and respiratory function on exacerbation risk grading. Methods We used baseline data of the COPD cohort COSYCONET, applying linear and logistic regression analyses, the results of which were implemented into a comprehensive structural equation model. As most informative parameters it comprised the estimated glomerular filtration rate (eGFR), lung function defined via forced expiratory volume in 1 s (FEV1), intrathoracic gas volume (ITGV) and (diffusing capacity for carbon monoxide (DLCO), moreover arterial oxygen content (CaO2), partial pressure of oxygen (PaCO2), base exess (BE) and exacerbation risk according to GOLD criteria. All measures were adjusted for age, gender, body-mass index, the current smoking status and pack years. Results 1506 patients with stable COPD (GOLD grade 1–4; mean age 64.5 ± 8.1 y; mean FEV1 54 ± 18 %predicted, mean eGFR 82.3 ± 16.9 mL/min/1.73 m2) were included. BE was linked to eGFR, lung function and PaCO2 and played a role as indirect predictor of exacerbation risk via these measures; moreover, eGFR was directly linked to exacerbation risk. These associations remained significant after taking into account medication (diuretics, oral and inhaled corticosteroids), whereby corticosteroids had effects on exacerbation risk and lung function, diuretics on eGFR, BE and lung function. Conclusion Even in stable COPD acid-base metabolism plays a key integrative role in COPD risk assessment despite rather small deviations from normality. It partially mediates the effects of impairments in kidney function, which are also directly linked to exacerbation risk.
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- 2019
21. Pseudomonas aeruginosa populations in the cystic fibrosis lung lose susceptibility to newly applied β-lactams within 3 days
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Tueffers, Leif, primary, Barbosa, Camilo, additional, Bobis, Ingrid, additional, Schubert, Sabine, additional, Höppner, Marc, additional, Rühlemann, Malte, additional, Franke, Andre, additional, Rosenstiel, Philip, additional, Friedrichs, Anette, additional, Krenz-Weinreich, Annegret, additional, Fickenscher, Helmut, additional, Bewig, Burkhard, additional, Schreiber, Stefan, additional, and Schulenburg, Hinrich, additional
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- 2019
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22. Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort.
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Lutter, Johanna I., Jörres, Rudolf A., Kahnert, Kathrin, Schwarzkopf, Larissa, Studnicka, Michael, Karrasch, Stefan, Schulz, Holger, Vogelmeier, Claus F., Holle, Rolf, for the COSYCONET Study Group, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Gogol, Manfred, and Grohé, Christian
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OBSTRUCTIVE lung diseases ,QUALITY of life ,VISUAL analog scale - Abstract
Background: Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is limited information about the development of patient-reported health-related quality of life (HRQL) over the full range of the natural history of COPD. We examined the longitudinal association between change in FEV1 and change in disease-specific and generic HRQL.Methods: We analysed data of 1734 patients with COPD participating in the COSYCONET cohort with up to 3 years of follow-up. Patients completed the Saint George's Respiratory Questionnaire (SGRQ) and the EQ-5D Visual Analog Scale (EQ VAS). Change score models were used to investigate the relationship between HRQL and FEV1 and to calculate mean changes in HRQL per FEV1 change categories [decrease (≤ - 100 ml), no change, increase (≥ 100 ml)] after 3 years. Applying hierarchical linear models (HLM), we estimated the cross-sectional between-subject difference and the longitudinal within-subject change of HRQL as related to a FEV1 difference or change.Results: We observed a statistically significant deterioration in SGRQ (total score + 1.3 units) after 3 years, which was completely driven by the activity component (+ 4 units). No significant change was found for the generic EQ VAS. Over the same period, 58% of patients experienced a decrease in FEV1, 28% were recorded as no change in FEV1, and 13% experienced an increase. The relationship between HRQL and FEV1 was found to be approximately linear with decrease in FEV1 being statistically significantly associated with a deterioration in SGRQ (+ 3.20 units). Increase in FEV1 was associated with improvements in SGRQ (- 3.81 units). The associations between change in FEV1 and the EQ VAS were similar. Results of the HLMs were consistent and highly statistically significant, indicating cross-sectional and longitudinal associations. The largest estimates were found for the association between FEV1 and the SGRQ activity domain.Conclusions: Difference and change in FEV1 over time correlate with difference and change in disease-specific and generic HRQL. We conclude, that deterioration of HRQL should induce timely re-examination of physical status and lung function and possibly reassessment of therapeutic regimes.Trial Registration: NCT01245933. Date of registration: 18 November 2010. [ABSTRACT FROM AUTHOR]- Published
- 2020
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23. Scintigraphy Leading to the Misdiagnosis of Chronic Thromboembolic Disease in a Patient With Pulmonary Veno-Occlusive Disease
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Balke, Lorenz, primary, Both, Marcus, additional, Winkler, Christine, additional, Schreiber, Tina, additional, Röcken, Christoph, additional, Koch, Karoline, additional, and Bewig, Burkhard, additional
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- 2016
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24. Lung Transplantation in a Multidrug-Resistant Gram-Negative Acinetobacter Baumannii–Colonized Patient: A Case Report
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Reinecke, Alexander, primary, Bewig, Burkhard, primary, Haneya, Assad, primary, Cremer, Jochen, primary, and Huenges, Katharina, additional
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- 2015
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25. Parenting stress in mothers with cystic fibrosis
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Ullrich, Gerald, primary, Bobis, Ingrid, additional, and Bewig, Burkhard, additional
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- 2015
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26. Parenting stress in mothers with cystic fibrosis.
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Ullrich, Gerald, Bobis, Ingrid, and Bewig, Burkhard
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PSYCHOLOGICAL adaptation ,CHI-squared test ,CYSTIC fibrosis ,PSYCHOLOGY of mothers ,PARENT-child relationships ,PARENTING ,PROBABILITY theory ,QUESTIONNAIRES ,RESEARCH funding ,PSYCHOLOGICAL stress ,T-test (Statistics) ,SOCIAL support ,BODY mass index ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Aim: To assess the parenting experience of mothers with cystic fibrosis (CF) and to compare with normative data.Methods: Cross-sectional study with a validated generic parental stress questionnaire (PSQ). This PSQ differentiates four components of parental stress: main factor “parental stress”, compounding factor “role restrictions”, protective factors “support from spouse”, and “social support”. Cut-off scores categorise results as “normal”, “borderline” or “concerning”. Sample: Seventy-three women were informed by their local CF centre. Of these, 36 enrolled and had a first-born child aged 1–12 years (consistent with reference values of the PSQ). Of these, 31 (86%) returned the PSQ. Mean age of mothers was 32.6 years ± 6.9 years, mean age of first-born child was 5.2 years ± 3.4 years. Most of the mothers had one biological child, five women had two children and one had three children.Results: Parental stress scores were normally distributed, the same applies for contributing factors and for the two protective factors. Favourable scores were twice as frequent as concerning scores. Mothers of younger children scored slightly better than mothers of school-aged children.Conclusion: In line with the only comparable study, mothers with CF seem to be a remarkably resilient group who mostly cope well with parental stress even in the face of a progressive, chronic disease requiring time-consuming treatment.Implications for RehabilitationToday, motherhood is increasingly becoming an option in fertile women with cystic fibrosis.The additional burden of parenting seems to be rewarded by fulfilling essential personal goals.CF clinics should routinely address a possible wish for a child and to discuss it, openly. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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27. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort.
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von Siemens, Sarah Marietta, Perneczky, Robert, Vogelmeier, Claus F., Behr, Jürgen, Kauffmann-Guerrero, Diego, Alter, Peter, Trudzinski, Franziska C., Bals, Robert, Grohé, Christian, Söhler, Sandra, Waschki, Benjamin, Lutter, Johanna I., Welte, Tobias, Jörres, Rudolf A., Kahnert, Kathrin, the COSYCONET study group, Andreas, Stefan, Bewig, Burkhard, Buhl, Roland, and Ewert, Ralf
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COGNITIVE ability ,COGNITION disorders ,PATH analysis (Statistics) ,MONTREAL Cognitive Assessment ,OXYGEN in the blood ,CHARACTERISTIC functions ,BLOOD lactate - Abstract
Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1-4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George's respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were < 9 points in 1.6% of patients and < 13 points in 12% when using the original evaluation algorithm distinguishing between < 60 or > =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment. [ABSTRACT FROM AUTHOR]
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- 2019
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28. Lung Transplantation in a Multidrug-Resistant Gram-Negative Acinetobacter Baumannii–Colonized Patient: A Case Report
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Huenges, Katharina, Reinecke, Alexander, Bewig, Burkhard, Haneya, Assad, and Cremer, Jochen
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- 2016
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29. Schlafbezogenes Gedächtnis bei Patienten mit Schlafapnoe-Syndrom und gesunden Kontrollen
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Kaselow, Lars, Priv.-Doz. Dr. Paul Christian Baier, Prof. Dr. Burkhard Bewig, Baier, Paul Christian, and Bewig, Burkhard
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doctoral thesis ,Abschlussarbeit ,Medizinische Fakultät ,OSAS ,Gedächtnis, Schlaf, OSAS ,ddc:610 ,Gedächtnis ,ddc:6XX ,Faculty of Medicine ,Schlaf - Abstract
Obwohl der Einfluss des Schlafes auf das Gedächtnis zunehmend Gegenstand der Forschung ist, wurde die Auswirkung der Schlafstörung auf die Gedächtnisleistung von Patienten mit Schlaferkrankungen nur selten untersucht. Studien, welche kognitive Dysfunktionen bei Patienten mit obstruktiven Schlafapnoe-Syndrom feststellten, betrachteten vor allem die Lernprozesse während der Wachphasen des Tages. Wir erforschten neben der abendlichen Enkodierung auch die schlafabhängige Gedächtniskonsolidierung in den Domänen räumliches, deklaratives und prozedurales Gedächtnis über Nacht. Ziel unserer Studie war die Evaluation, ob Patienten mit einem obstruktiven Schlafapnoe-Syndrom gegebenenfalls schlafvermittelt eine schlechtere Gedächtnisleistung im Vergleich zu gesunden Versuchspersonen aufweisen. Wir verglichen 26 Patienten im Alter von 52,2 ± 9,1 Jahren mit 18 gesunden Kontrollpersonen im Alter von 47,7 ± 8,4 Jahren. In einer abendlichen sowie morgendlichen Lernphase wurden räumliche (Virtual Water Maze), deklarative (Wortliste) und prozedurale (Spiegelzeichnen) Aufgaben erlernt. Außerdem wurden die Konzentration und die Leistung des Arbeitsgedächtnisses (Zahlennachsprechen) erfasst. Insgesamt sprechen unsere Ergebnisse gegen die Hypothese, dass Patienten mit Schlafapnoe-Syndrom in der Enkodierung oder der schlafbezogenen Konsolidierung Defizite im räumlichen Gedächtnis aufweisen, zumindest in einer künstlichen Realität. Beeinträchtigungen des deklarativen und prozeduralen schlafabhängigen Lernens waren hingegen nachweisbar und standen mit der Schwere des Schlafapnoe-Syndroms und teilweise mit den Hypoxien in Verbindung. Zukünftige Studien müssen weitere Faktoren mit Wirkung auf die Gedächtnisbildung berücksichtigen, um ein weitergehendes Verständnis des schlafabhängigen Gedächtnisses bei Patienten mit Schlafapnoe zu erhalten.
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- 2019
30. A comparison of the i-gel® and the PRO-Breathe® laryngeal mask during pressure support ventilation in children
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Geßner, Michael, Prof. Dr. Thomas Ledowski, Prof. Dr. Burkhard Bewig, Ledowski, Thomas, and Bewig, Burkhard
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doctoral thesis ,Abschlussarbeit ,i-gel, Larynxmaske, Kinderanästhesie, Atemwegshilfe ,Medizinische Fakultät ,i-gel ,ddc:610 ,ddc:6XX ,Larynxmaske ,Kinderanästhesie ,Atemwegshilfe ,Faculty of Medicine - Abstract
Die effektive Beatmung und Atemwegssicherung bei Kindern ist aufgrund der von Erwachsenen abweichenden Anatomie und Physiologie von großer Bedeutung. Diese randomisierte Studie vergleicht die klassische Larynxmaske und die i-gel®-Atemwegshilfe unter standardisierter druckunterstützter Beatmung bei 200 Kindern (0-16 J., 5-60 kg) in Bezug auf Dichtigkeit, Platzierungsversuche sowie peri- und postoperative Komplikationen.
- Published
- 2019
31. Einfluss von schwer verlaufenden RSV- Infektionen der unteren Atemwege vor dem 3. Lebensjahr auf Häufigkeit von respiratorischen Symptomen und Lungenfunktion im Schulalter
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Karp, Lydia, Ankermann, Tobias, and Bewig, Burkhard
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doctoral thesis ,Abschlussarbeit ,Medizinische Fakultät ,RSV, Atemwegsinfektionen, Asthma ,Atemwegsinfektionen ,RSV ,ddc:610 ,ddc:6XX ,Faculty of Medicine ,Asthma - Abstract
In prospektiven Studien konnte gezeigt werden, dass schwere respiratory syncytial virus- Infektionen (RSV- Infektionen) der unteren Atemwege im Säuglings- und Kleinkindalter mit der Entwicklung rezidivierender Atemwegserkrankungen und einer chronischen Lungenerkrankung in Verbindung stehen. In der vorliegenden Fall-Kontroll-Studie sollte untersucht werden, ob eine schwere RSV- Infektion der unteren Atemwege bei Kindern, im Vergleich zu Kindern mit einer schweren viralen Atemwegsinfektion durch andere Erreger- unabhängig von einer Vorselektion nach atopischer Prädisposition- vermehrt zu respiratorischen Symptomen und einem Asthma bronchiale führt. 25 Kinder, die im Zeitraum von 2000 bis 2009 stationär in der Klinik für Kinder- und Jugendmedizin I im Universitätsklinikum Schleswig Holstein, Campus Kiel und im Städtischen Krankenhaus Kiel mit der Diagnose einer unteren Atemwegsinfektion in Behandlung waren, wurden im Schulalter nachuntersucht. Im Nasopharyngealsekret konnten bei diesen Kindern nur RS-Viren nachgewiesen werden. Verglichen wurden die Kinder mit 26 Kindern einer Kontrollgruppe, bei denen andere Erreger im Nasopharyngealsekret gefunden wurden, bzw. es keinen Nachweis von Nukleinsäuren gab. 64% der Kinder in der Fallgruppe entwickelten weitere Majorinfekte der Atemwege, insbesondere Pneumonien und Bronchitiden, im Vergleich zu 44% in der Kontrollgruppe. In der Fallgruppe dauern Infekte der Atemwege bei 29,2% der Kinder mindestens 2 Wochen, in der Kontrollgruppe dauern Infekte der Atemwege bei 52% der Kinder mindestens 2 Wochen. Pseudokrupp entwickelten 8% der Kinder der Fallgruppe und 42,3% aller Kinder der Kontrollgruppe.Bei der Untersuchung der Lungenfunktion wies die Fallgruppe signifikant niedrigere Werte der Vitalkapazität in % (p=0,032) und des exspiratorischen Spitzenflusses bei 25% der Vitalkapazität in % auf (p=0,035) im Vergleich zur Kontrollgruppe.
- Published
- 2018
32. Inzidenz einer klinischen und serologischen Lupus-like Disease unter TNF-alpha-Inhibitor-Therapie
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Winkelmann, Simon Julius, Oltmann Schröder, Johann, and Bewig, Burkhard
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doctoral thesis ,Lupus-like disease ,Abschlussarbeit ,rheumatoide Arthritis ,Medizinische Fakultät ,Morbus Crohn ,ddc:610 ,Infliximab, Lupus-like disease, rheumatoide Arthritis, Morbus Crohn ,ddc:6XX ,Infliximab ,Faculty of Medicine - Abstract
Weltweit wurden bisher etwa 4 000 000 TNFα-Inhibitor-Therapien verschrieben. In über 1500 Fällen wurde von einer sog. lupus-like disease unter dieser Therapie berichtet. Mehrere Fallstudien fassten diese Ereignisse zwar zusammen, aber eine genaue Inzidenz dieses Phänomens hatte bisher nicht eindeutig festgestellt werden können. Daher untersuchten wir 223 Patienten unserer Klinik, die wegen chronisch-entzündlicher Erkrankungen mit TNFα-Inhibitoren behandelt wurden, auf das Auftreten einer Lupus-like disease. Wir analysierten prospektiv über zwei Jahre die Entwicklung klinischer Symptome und Messwerte aus Serumblutproben auf dsDNA-Antikörper und ANAs und konnten im Verlauf der Studie einen deutlichen Anstieg aufzeigen. Der Messwert für dsDNS-Antikörper, der zu Studienbeginn bei allen Patienten negativ war, zeigte nach zwei Jahren ein Überschreiten der Grenze von 20 U/ml bei 16 von 49 Patienten, also bei 32,7% der bis zu diesem Zeitpunkt analysierten Proben (p=0,0002). Die Mittelwerte stiegen von 5,6 auf 18,5 U/ml nach 104 Wochen (p < 0,0001). Die ANA-Titer stiegen ebenfalls im Median von 1:80 auf 1:320. Ein ANA-Nachweis gelang bei 9,8% der Kohorte zu Studienbeginn und bei 37,5% zum Ende der Beobachtungen (p=0,001). In fünf Fällen (2,2%) wurde der primäre Endpunkt der Studie erreicht. Es entwickelte sich eine klinische lupus-like disease mit ausgeprägten klinischen Beschwerden in Form von Arthritiden der Hände. Diese befielen ausschließlich Patientinnen mit chronisch-entzündlichen Darmerkrankungen unter Infliximab oder Adalimumab. Unter der Therapie mit beiden genannten Präparaten entwickelten sich auch die rein serologischen Auffälligkeiten am häufigsten (Infliximab 46,1%; Adalimumab 15,6%). Die Daten zeigen das hohe Potential der Therapie mit TNFα-Inhibitoren, eine systematische Induktion von sowohl serologischen als auch klinischen Autoimmunphänomenen auszulösen. Die von uns ermittelte Inzidenz von 2,2% ist darüber hinaus höher, als die Anzahl publizierter Fälle in Zusammenschau mit der Anzahl der weltweiten Verordnungen dieser Medikamente erwarten ließ.
- Published
- 2017
33. Einfluss von Alter und Geschlecht auf die Beziehung zwischen Herzfrequenzvariabilität, hämodynamischen Parametern und subjektiver Quantifizierung akuten postoperativen Schmerzes
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Stein, Jessica, Ledowski, Thomas, and Bewig, Burkhard
- Subjects
Herzfrequenzvariabilität (HRV) ,doctoral thesis ,Surgical Stress Index (SSI) ,Abschlussarbeit ,Medizinische Fakultät ,Schmerz, Herzfrequenzvariabilität (HRV), Surgical Stress Index (SSI) ,ddc:610 ,Schmerz ,ddc:6XX ,Faculty of Medicine - Abstract
Skin Conductance und Surgical Stress Index sind Methoden, die versuchen Schmerz zu objektivieren. Sie basieren auf der Messung der sympathovagalen Balance, die durch Alter und Geschlecht beeinflusst wird. Beide Faktoren werden jedoch weder in die Berechnung der Skin Conductance noch in die des Surgical Stress Index mit einbezogen. Ziel dieser Studie war es daher die Korrelation von Alter und Geschlecht auf die autonome kardiale Kontrolle, hämodynamische Parameter sowie deren Beziehung zu Stadien akuten postoperativen Schmerzes zu untersuchen. Dafür wurden 220 Patienten postoperativ im Aufwachraum gebeten ihre Schmerzen auf einer Numerischen Rating Skala von 0-10 zu quantifizieren. Gleichzeitig wurden Parameter der Herzfrequenzvariabilität, systolischer Blutdruck, Herz- und Atemfrequenz gemessen. Beim Vergleich dieser Daten mit der Numerischen Rating Skala von 0-4 versus 5-10 wurden bei stärkeren Schmerzen höhere Werte für die LowFrequenzy/HighFrequency-Ratio und niedrigere für Ultra Short Entropy gemessen. Alle anderen Parameter stiegen zwar mit zunehmenden Schmerzen an, allerdings ohne statistische Signifikanz zu erreichen. Die Receiver-Operating-Kurvenanalyse für die LowFrequency/High Frequency-Ratio ergab keine ausreichende Sensitivität und Spezifität mittels einzelner Werte Rückschlüsse auf das Ausmaß akuten Schmerzes zu ziehen. Bei der Differenzierung zwischen den Geschlechtern wiesen männliche Probanden bei moderatem oder starkem Schmerz höhere Werte für systolischen Blutdruck und LowFrequency/High-Frequency-Ratio auf. Bei der Betrachtung einzelner Werte in Bezug auf das Alter zeigte sich eine negative Korrelation mit dem Blutdruck, der Herzfrequenz und allen Parametern der Herzfrequenzvariabilität, ausgenommen der LowFrequency/High-Frequency-Ratio. Schlussfolgernd lässt sich daher sagen: Akuter Schmerz moduliert die sympatho-vagale Balance. Die Genauigkeit hierauf basierender Methoden könnte durch die Beachtung von Alter und Geschlecht eines Patienten potentiell verbessert werden.
- Published
- 2016
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