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The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort
- Source :
- Respiratory Research, Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019), Respiratory research 20(1), 257 (2019). doi:10.1186/s12931-019-1217-5
- Publication Year :
- 2022
- Publisher :
- Universität des Saarlandes, 2022.
-
Abstract
- Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1–4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George‘s respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.
- Subjects :
- Male
medicine.medical_specialty
epidemiology [Cognitive Dysfunction]
psychology [Pulmonary Disease, Chronic Obstructive]
Medizin
Comorbidity
Cohort Studies
03 medical and health sciences
FEV1/FVC ratio
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Cognition
epidemiology [Pulmonary Disease, Chronic Obstructive]
Surveys and Questionnaires
medicine
Dementia
Humans
COPD
Cognitive Dysfunction
ddc:610
Cognitive skill
Path analysis (statistics)
Aged
lcsh:RC705-779
business.industry
Research
physiology [Cognition]
diagnosis [Pulmonary Disease, Chronic Obstructive]
lcsh:Diseases of the respiratory system
Middle Aged
medicine.disease
Mental Status and Dementia Tests
humanities
Cross-Sectional Studies
Cognitive impairment
diagnosis [Cognitive Dysfunction]
030228 respiratory system
Cohort
Physical therapy
Female
psychology [Cognitive Dysfunction]
business
030217 neurology & neurosurgery
Cognitive load
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Respiratory Research, Respiratory Research, Vol 20, Iss 1, Pp 1-13 (2019), Respiratory research 20(1), 257 (2019). doi:10.1186/s12931-019-1217-5
- Accession number :
- edsair.doi.dedup.....ca382345838a2a0dcc2586b2fceb23e3
- Full Text :
- https://doi.org/10.22028/d291-36799