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The genus Phyllosticta has been reported worldwide and contains many pathogenic and endophytic species isolated from a wide range of plant hosts. A multipoint phylogeny based on gene coding combinatorial data sets for the internal transcribed spacer (ITS), large subunit of ribosomal RNA (LSU rDNA), translation elongation factor 1α (TEF1α), actin (ACT), and glycerol-3-phosphate dehydrogenase (GPDH), combined with morphological characteristics, was performed. We describe three new species, P. fujianensis sp. nov., P. saprophytica sp. nov., and P. turpiniae sp. nov., and annotate and discusse their similarities and differences in morphological relationships and phylogenetic phases with closely related species. [ABSTRACT FROM AUTHOR]

Purpose: Urologic chronic pelvic pain syndrome has attracted a lot of attention in the new century, and an increasing number of relevant studies have been published. Therefore, we performed a bibliometric analysis of these publications, hoping to show the current research hotspots and future research trends. Methods: The articles on were selected from the Web of Science Core Collection. Countries, authors, references and keywords in the field were visualized and analyzed using CiteSpace and VOSViewer software. Results: A total of 1014 articles on urologic chronic pelvic pain syndrome were identified, with "chronic pelvic pain syndrome" being the most common keyword, with a strong association with "interstitial cystitis" and "chronic prostatitis". The hotspot of urologic chronic pelvic pain syndrome research has gradually shifted from chronic prostatitis / urologic chronic pelvic pain syndrome to cystitis/bladder pain syndrome over the past few years. Future research tends to focus on urologic chronic pelvic pain syndrome etiology, including oxidative stress and inflammation. Conclusion: Research on urologic chronic pelvic pain syndrome is steadily growing. The United States has made the most prominent contribution in this area, and the share of China's contribution is expected to grow further. The etiology of urologic chronic pelvic pain syndrome, including inflammation and oxidative stress, have been the focus of current research and developmental trends in the future research. [ABSTRACT FROM AUTHOR]

The marine environment is the material basis for the survival and development of fishery resources, and changes in the marine environment affect the fishery economy. Therefore, against the background of sustainability and environmental uncertainty, it is important to investigate the development of the marine environment and the marine fishery economy to improve the quality of both. Taking the panel data for 11 coastal cities in China from 2011 to 2020, we use several methods, including the entropy method, a coupling harmonious degree model, and a Tobit model, to measure the marine-environment quality and marine-fishery-economy quality, their coordination, and the factors affecting that coordination. We find that (1) the marine-environment quality and marine-fishery economy quality show a significant upward trend over time, but they are spatially unbalanced, with obvious interprovincial differences. (2) Coordination between the marine-environment quality and marine-fishery-economy quality has risen steadily, but the level of coordination is still low, remaining at the primary level in most areas. (3) The important factors affecting coordination between the marine-environment quality and marine-fishery-economy quality include the strength of the marine fishery industry, scale of the marine fishery economy, production capacity of marine fisheries, marine-environment quality, and quality of the marine environment and its resources. In light of these findings, we should increase the coordination between the marine-environment quality and marine-fishery-economy quality by upgrading the marine fishery industry, modernizing marine fisheries, linking the environmental governance of marine and land areas, and strengthening the ecological construction of the marine environment. [ABSTRACT FROM AUTHOR]

Heart failure (HF) is an epidemic disease affecting a large population worldwide. Traditional Chinese medicine (TCM) is playing an increasingly important role in the clinical treatment of HF. According to the TCM theory, HF could be classified into Yang deficiency and Qi-yin deficiency; however, there are few objective and biological lines of evidence for differentiation of TCM HF syndromes to date. In this study, data-independent acquisition (DIA) mass spectrometry was applied to comparatively analyze the protein expression in serum samples obtained from 12 Yang deficiency patients, 12 Qi-yin deficiency patients, and 12 healthy volunteers. Compared to the healthy controls, a total of 121 differentially expressed proteins (DEPs) (77 upregulated and 44 downregulated proteins) were identified in Yang deficiency samples, while 59 DEPs (49 upregulated and 10 downregulated proteins) were detected in Qi-yin deficiency samples. Enrichment analyses of these DEPs based on the GO and KEGG databases revealed functional clusters associated with the immune system, signal transduction, and infectious disease. Several previously reported HF biomarker proteins were found to be the hub proteins in a protein-protein interaction network analysis. Three novel hub DEPs were identified as potential biomarkers for differentiation between different TCM syndromes of HF. The results provide biological insight into the differences of different TCM HF syndromes and an opportunity for specific biomarker identification for different TCM HF syndromes. [ABSTRACT FROM AUTHOR]

Background: Elderly people are susceptible to atrial fibrillation (AF) and ischemic stroke (IS); however, less information is known about the association between AF and the risk of cardiovascular disease (CVD) mortality in elderly population with IS. We aimed to investigate the features of AF among aged people with IS and to illustrate whether AF accounted for CVD mortality. Methods: At baseline, 790 patients with IS were enrolled from the general northeast Chinese elderly population (>60 years) between September 2017 to March 2019. The prevalence, awareness, and treatment of AF in each age group were analyzed, as well as major-related cardiovascular risk factors. The population was followed until July 31, 2021, and information on CVD death was obtained. Results: A total of 25 people had AF, and the prevalence of AF in the elderly population with IS was 3.2%. The AF prevalence grew along with age from 1% (60–64 years) to 4.3% (70–74 years) and 4.2% (≥75 years), which was higher in the urban residents than in the rural residents (5.7 vs. 2.2%, P = 0.014). The awareness and treatment rates of patients with AF were 80 and 8%. After a median follow-up period of 3.3 years, 58 subjects died due to CVD and 5 subjects were accompanied with AF (rate 70.6/1,000 person-years). Elderly IS patients with AF had a 3.65-fold increased risk of CVD death in the fully adjusted model when compared with non-AF participants. Conclusion: The AF prevalence increased with age among the elderly population with IS. Moreover, elderly patients with IS in northeast China with AF had a higher CVD mortality. Therefore, early screening and prompt management of AF in elderly population with IS in northeast China are required. [ABSTRACT FROM AUTHOR]

Rushan is a traditional dairy product consumed by the Bai people in the Yunnan Province of China, and its production still follows the traditional procedure of backslopping. However, how the microbial composition of raw materials and processing shape the microorganisms in rushan have not been systemically reported. In this study, high-throughput sequencing technique was applied to analyze the microbial compositions of raw milk, fresh rushan, curd whey, acid whey, and dry rushan at the phylum, family, genus, and Lactobacillus species levels. The results indicated that Lactobacillus , Lactococcus , and Streptococcus were dominant genera in rushan, whereas Lactobacillus kefiranofaciens and Lactobacillus helveticus were the 2 abundant species at the Lactobacillus species level. The network analysis indicated that raw milk mainly contributed to the microbial diversity of rushan, whereas acid whey made a great contribution to shaping the relative abundance of microbes in rushan and dramatically increased acid-producing genera, such as Lactobacillus and Acetobacter. The variation in microbial composition led to an increase in the relative abundance of pathways related to energy supply, acid production, fatty acid accumulation, cysteine, methionine, and lysine accumulation. The volatile profile of rushan was rich in esters and acids, and the high relative abundance of Lactobacillus might be associated with reduction of amino acid metabolism, degradation of unpleasant flavored xylene, and accumulation of decanoic, dodecanoic, and tetradecanoic acids in the products. The accumulation of medium long-chain fatty acids might result from the relative abundance of FabF , FabZ , and FabI , particularly from Lactobacillus amylolyticus and Lacticaseibacillus paracasei. [Display omitted] [ABSTRACT FROM AUTHOR]

Background: The epidemiology on the human papillomavirus (HPV) among females in Southern China is not well-established. Baseline data on the prevalence of HPV infection in China prior to mass prophylactic HPV vaccination would be useful. Thus, this study aims to determine the type-specific HPV prevalence and distribution among females from Southern China prior to mass HPV vaccination.Methods: A retrospective cross-sectional study employing 214,715 women attending ChenZhou NO.1 People's Hospital for cervical screening during 2012-2018 was conducted prior to widespread HPV vaccination. HPV genotype was detected using nucleic acid molecular diversion hybridization tests. The overall prevalence, age-specific prevalence, type distribution, and annual trend were analyzed.Results: The overall HPV prevalence was 18.71% (95% confidence interval [CI], 18.55-18.88%) among Southern China females. During 2012-2018, the prevalence of HPV infection showed a downward tendency, from 21.63% (95% CI, 21.07-22.20%) in 2012 to 18.75% (95% CI, 18.35-19.16%) in 2018. Age-specific HPV distribution displayed a peak at young women aged less than 21 years (33.11, 95% CI, 31.13-35.15%), 20.07% (95% CI, 19.70-20.44%) among women aged 21-30 years, 17.29% (95% CI, 17.01-17.57%) among women aged 31-40 years, 17.23% (95% CI, 16.95-17.51%) among women aged 41-50 years, 21.65% (95% CI, 21.11-22.20%) among women aged 51-60 years, and 25.95% (95% CI, 24.86-27.07%) among women aged over 60 years. Of the 21 subtypes identified, the top three prevalent high-risk HPV (HR-HPV) genotypes were HPV52 (5.12%; 95% CI, 21.11-22.20%), - 16 (2.96%; 95% CI, 2.89-3.03%), and - 58 (2.51%; 95% CI, 2.44-2.58%); the predominant low-risk HPV (LR-HPV) genotypes were HPV81 (1.86%; 95%CI, 1.80-1.92%) and - 6 (0.69%; 95% CI, 0.66-0.73%) respectively. Incidence of HR-HPV only, LR-HPV only and mixed LR- and HR-HPV were 15.17, 2.07 and 1.47% respectively. Besides, single HPV infection accounted for 77.30% of all positive cases in this study.Conclusions: This study highlights 1) a high prevalence of HPV infection among females with a decreasing tendency towards 2012-2018, especially for young women under the age of 21 prior to mass HPV vaccination; 2) HPV52, - 16 and - 58 were the predominant HPV genotypes, suggesting potential use of HPV vaccine covering these HPV genotypes in Southern China. [ABSTRACT FROM AUTHOR]

Background: About 83,000 COVID-19 patients were confirmed in China up to May 2020. Amid the well-documented threats to physical health, the effects of this public health crisis - and the varied efforts to contain its spread - have altered individuals' "normal" daily functioning. These impacts on social, psychological, and emotional well-being remain relatively unexplored - in particular, the ways in which Chinese men and women experience and respond to potential behavioral stressors. Our study investigated sex differences in psychological stress, emotional reactions, and behavioral responses to COVID-19 and related threats among Chinese residents.Methods: In late February (2020), an anonymous online questionnaire was disseminated via WeChat, a popular social media platform in China. The cross-sectional study utilized a non-probabilistic "snowball" or convenience sampling of residents from various provinces and regions of China. Basic demographic characteristics (e.g., age and gender) - along with residential living arrangements and conditions - were measured along with psychological stress and emotional responses to the COVID-19 pandemic.Results: Three thousand eighty-eight questionnaires were returned: 1749 females (56.6%) and 1339 males (43.4%). The mean stress level,as measured by a visual analog scale, was 3.4 (SD = 2.4) - but differed significantly by sex. Besides sex, factors positively associated with stress included: age (< 45 years), employment (unsteady income, unemployed), risk of infection (exposureto COVID-19, completed medical observation), difficulties encountered (diseases, work/study, financial, mental), and related behaviors (higher desire for COVID-19 knowledge, more time concerning on the COVID-19 outbreak). "Protective" factors included frequent contact with colleagues, calmness of mood comparing with the pre-pandemic, and psychological resilience. Males and females also differed significantly in adapting to current living/working, conditions, responding to run a fever, and needing psychological support services.Conclusions: The self-reported stress of Chinese residents related to the COVID-19 pandemic was significantly related to sex, age, employment, resilience and coping styles. Future responses to such public health threats may wish to provide sex- and/or age-appropriate supports for psychological health and emotional well-being to those at greatest risk of experiencing stress. [ABSTRACT FROM AUTHOR]

Previous research reported that fermented yak milk had a diverse microbial composition. For this study, raw yak milk, qula, and fermented yak milk samples were collected from the Aba Tibetan autonomous region of China. The genus and species microbial composition of these samples were analyzed by high-throughput sequencing of 16S rRNA and groEL gene amplicons, and the volatile profile of the samples was quantified by gas chromatography–mass spectrometry. The results indicated variation in abundance of microbiota at the genus level among the fermented yak milk samples, with Lactobacillus as the most abundant genus in the majority of samples, ranging from 41.6 to 98.3%. The volatile profile of the samples varied among those collected from different villages. Correlations between bacterial composition and volatile compounds of the samples were also observed. Lactobacillus displayed a significant correlation with volatile compounds such as benzaldehyde, 2,3-pentanedione, ethanol, and ethyl acetate, whereas the samples with relatively high abundance of Streptococcus and Lactococcus displayed relatively low contents of volatile compounds. [ABSTRACT FROM AUTHOR]

Purpose: Women in many countries are breaking through the gender barrier and are working in positions where they have a major impact on the buying and selling activities in business-to-business relationships. A number of studies have investigated the role gender plays in driving perceptions of sales representatives in the USA, however, little research has been undertaken on this important topic in China, one of the largest and most influential countries. Consequently, the purpose of this study is to examine whether the gender of both the buyer and seller, affects perceptions of expertise, trust and loyalty in business relationships. Design/methodology/approach: A survey instrument was developed, tested and used on individuals with purchasing responsibility in China. Confirmatory factor analysis was used in the pre-test and the final study data to develop and refine measurement instruments, assessing construct validity, identifying method effects and evaluating factor variance across groups. Independent t-tests were used to compare male and female buyers on their evaluation of sales reps. Findings: The results indicate that the gender of the sales person does not seem to be a consideration for male buyers in evaluating reps in any of the variables tested. However, female buyers consistently give less favorable evaluations to female sales people than male sales representatives. The possible implications of these findings are discussed. Research limitations/implications: First, this research uses a quantitative methodology in both the collection and analysis of the data. Thus, future studies may want to use a qualitative data set to gain a more in-depth understanding of the business-to-business relationships between men and women in the workplace. Also, as the study was concentrated on a relatively small number of business professionals from only one area in China, subsequently researchers should consider increasing the geographic domain where respondents are sampled, to help improve the generalizability of the results. Practical implications: The gender bias by female buyers found in this study has several important implications for businesses in China. Specifically, the suggests that female buyers may carry with them a "collective negative bias" against other women, in this case, female sales reps. The solution to this problem is not to avoid assigning female sales reps to female buyers, rather, it is to change the negative collective social-esteem identity preconceptions. Organizations can do this through training by making women aware of their own predisposition to unfairly evaluate women that they interact with in the workplace. Originality/value: It has been argued that gender plays a small role in perceptions of sales representatives in buyer-seller relationships. While this seems to be true in the USA, it has not (until now) been empirically tested in China. Somewhat surprisingly, the gender differences we did uncover are not from male buyers in their assessments, but from female buyers in their evaluation of women sales representatives. This result provides some interesting insight into Chinese business relationships and how some women in positions of power are more critical of other women within their sphere of influence. [ABSTRACT FROM AUTHOR]

Hong Kong is located at the southern margin of a Mesozoic igneous belt in Southeast China, where voluminous magmatism formed during the Early Jurassic to Early Cretaceous. The final phase of volcanism formed the rhyolitic High Island Formation, which shows geochemistry similar to A‐type granite. For example, these rocks have high content of SiO2 and alkali (e.g., high K2O + Na2O, with K2O/Na2O ratios greater than 1.0) and are characterized by weakly enrichment in high‐field‐strength elements (HFSEs) and rare‐earth elements (REEs) (except for Eu) and extreme depletion of Ba, Sr, P, Ti, and Eu, with high 10,000× Ga/Al ratios. Zircon U–Pb dating for three porphyroclastic rhyolite samples from the High Island Formation yielded weighted mean 206Pb/238U ages of 140.0 ± 0.8, 139.8 ± 0.7, and 139.1 ± 1.1 Ma. These zircons have εHf(t) values of −9.0 to +0.4, with two‐stage Hf model ages (TDM2) of 1,763–1,172 Ma, indicating a magma source that involved melting of predominantly Palaeoproterozoic to Mesoproterozoic continental crust with a minor juvenile mantle component. The ~140 Ma A‐type magmas in Hong Kong area were probably formed in response to rollback and/or break‐off of the Palaeo‐Pacific Plate. Previous studies indicate that the tectonic transformation from the Palaeo‐Tethys to Palaeo‐Pacific tectonic domain occurred at >165 Ma. Hong Kong underwent a repeated slab subduction and rollback process involving (a) Palaeo‐Pacific Plate subduction formed I‐type granites and continental margin arc volcanic rocks at 165–161 Ma; (b) slab rollback lead to the formation of A‐type granites at 161–159 Ma with minor magmatism formation during the rollback stage at ~159–148 Ma; (c) renewed slab subduction formed continental margin arc rocks at 148–141 Ma; and (d) renewed slab rollback resulted in the formation of A‐type volcanic rocks at 141–139 Ma (e.g., High Island Formation). [ABSTRACT FROM AUTHOR]

The complete mitogenome sequence of Ochotona coreana was determined using long PCR. The genome was 17,283 bp in length and contained 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, 1 origin of L strand replication, and 1 control region. The overall base composition of the heavy strand is A (31.5%), C (28.7%), T (26.2%), and G (13.6%). The base compositions present clearly the A–T skew, which is most obviously in the control region and protein-coding genes. Mitochondrial genome analyses based on MP, ML, NJ and Bayesian analyses yielded identical phylogenetic trees. This study verifies the evolutionary status of O. coreana in Ochotonidae at the molecular level. The mitochondrial genome would be a significant supplement for the O. coreana genetic background. The seven Ochotona species formed a monophyletic group with the high bootstrap value (100%) in all examinations. [ABSTRACT FROM AUTHOR]

The complete mitogenome sequence of Blarinella griselda was determined using long PCR. The genome was 16,947 bp in length and contained 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, 1 origin of L strand replication and 1 control region. The overall base composition of the heavy strand is A (33.1%), C (22.6%), T (31.6%) and G (12.7%). The base compositions present clearly the A–T skew, which is most obviously in the control region and protein-coding genes. Mitochondrial genome analyses based on MP, ML, NJ and Bayesian analyses yielded identical phylogenetic trees. This study verifies the evolutionary status of Blarinella griselda in Soricidae at the molecular level. The mitochondrial genome would be a significant supplement for the Blarinella griselda genetic background. The three Blarinella species formed a monophyletic group with the high bootstrap value (100%) in all examinations. [ABSTRACT FROM AUTHOR]

Total yield of rice in China has been greatly improved in recent decades. However, this yield improvement is excessively dependent on the input of nitrogen (N) fertilizer. In recent years, since the demand for rice quantity has basically been met, consumers pay more attention to rice quality, especially the eating quality. Increasing N application improves the yield of rice, but it changes the protein and amylose content in rice, generally reducing the eating quality. It is necessary to establish a more reasonable N management to balance yield and eating quality for rice sustainable development in China. In this study, we assessed the effectiveness of various N managements on rice yield and eating quality by meta-analysis. Under traditional N management, increasing the amount of total N and late-stage N applications weaken the yield increase and decrease the eating quality with the significant increase in protein and amylose content in rice. By reducing total N and late-stage N application input, eating quality and N use efficiency could be significantly improved. Further, conditional inference tree analysis indicated that adjusting the amount of late-stage N application was a major measure to improve traditional N fertilization, since it could increase agronomic N use efficiency in rice production and balance yield maintenance and eating quality improvement. Our supplementary experiment results further confirmed that adjusting N management could improve the rice yield and eating quality with less N input. Thus, we propose the following adjusting N management strategies for rice sustainable production in China: (1) Decreasing the traditional high N rate is absolutely necessary, although it will slightly decrease rice yield, but significantly improve rice eating quality and N use efficiency; (2) Reducing the amount of late-stage N application appropriately could improve the rice eating quality; (3) Improving agronomic N use efficiency is the key to balance rice yield and eating quality. Our results provide an important reference for the future N management in rice production for the purpose of achieving high yield and better eating quality. • Rice yield and quality under various N management were assessed using meta-analysis. • Amount and proportion of N application significantly affected rice yield and eating quality. • Improving agronomic N use efficiency is key to balance rice yield and eating quality. [ABSTRACT FROM AUTHOR]

The aim of this study was to elucidate the prevalence of blaCTX-M-27-producing Escherichia coli and transmission mechanisms of blaCTX-M-27 from swine farms in China. A total of 333 E. coli isolates were collected from two farms from 2013 to 2016. Thirty-two CTX-M-27-positive E. coli were obtained, and all were multidrug-resistant. Pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) profiles indicated a wide range of strain types that carried blaCTX-M-27, and the sequence type ST10 predominated. Conjugation, replicon typing, S1-PFGE and hybridization experiments confirmed that 28 out of 32 CTX-M-27 positive isolates carried blaCTX-M-27 genes on plasmids F18:A-:B10 (16) and F24:A-:B1 (12).The blaCTX-M-27 genes for 24 isolates were transmitted by plasmids with sizes ranging from 40 to 155 kb. A comparative analysis with blaCTX-M-27-plasmids indicated that the tra-trb region of F24:A-:B1 plasmids was destroyed by insertion of a complex region (eight isolates) and a novel structure containing blaCTX-M-27 in the F18:A-:B10 plasmids (12 isolates). The novel structure increased the stability of the blaCTX-M-27 gene in E. coli. This study indicated that the predominant vehicle for blaCTX-M-27 transmission has diversified over time and that control strategies to limit blaCTX-M-27 transmission in farm animals are necessary. [ABSTRACT FROM AUTHOR]

This paper presents a direct modelling approach to evaluate household travel energy consumption and CO 2 emissions based on the spatial form of neighborhoods and streets. It integrates one multinomial logit model and four double hurdle models to predict travel outcomes: vehicle ownership portfolio choice, car travel distance, bus travel distance, motorcycle travel distance and ebike travel distance. The energy consumption and CO 2 emissions are then estimated using these travel outcomes. A full application of the modelling approach is demonstrated through a pilot project in Jinan, China. A holdout validation is also performed to address the over-fitting problem of models calibrated from the training set data. Results show that the proposed approach is operational and appropriate for sketch planning applications to promote clean energy and low carbon city planning in urbanizing China. • A direct modelling approach to evaluate household travel energy consumption and CO 2 emissions is presented. • The approach assesses the impact of the spatial form of neighborhoods and streets. • A holdout validation is performed to address the over-fitting problem of calibrated models. [ABSTRACT FROM AUTHOR]

Along with the environmental protection policies becoming strict in China, the air pollution control devices (especially selective catalytic reduction (SCR)) are widely equipped in coal-fired power plants. The installation and run of these devices will inevitably affect mercury (Hg) species distribution in coal fired by-products such like fly ash (FA) and gypsum. In this work, a new on-line coupling system based on atomic fluorescence spectrometry (AFS) with a home-made chromatographic workstation was successfully developed to identify Hg species through thermal programmed desorption (TPD). The influences of matrix, furnace temperature, and carrier gas flow on analytical performance were investigated and the parameters were optimized. The FA and gypsum samples from coal-fired power plants equipped with SCR were collected and the mercury species were analyzed by the developed coupling system. HgCl 2 and HgO were the main species in FA, while Hg 2 Cl 2 and HgO were the main species in gypsum. All of Hg species in the studied FA and gypsum samples were released below 400 °C. A sequential extraction procedure was applied to further verify the operational Hg species including mobile and non-mobile fractions in FA and gypsum samples. This study demonstrated that AFS coupled with TPD procedure was an effective method to analyze Hg species in coal combustion by-products from power plants. [Display omitted] • A thermal desorption-atomic fluorescence spectrometry on-line coupling system was successfully developed to identify Hg species in coal-fired by-products. • Different mercury species were found in fly ash and gypsum from the plants equipped with selective catalytic reduction system. • Sequential extraction analysis verified the mobile and non-mobile mercury in fly ash and gypsum. [ABSTRACT FROM AUTHOR]

Objective: To investigate the association between the concentration of perchlorate in drinking water and the height and weight of children and adolescents in Sichuan Province., Methods: Perchlorate in the drinking water of 24 counties in Sichuan Province from 2021 to 2022 was detected and analyzed, 66 drinking water samples were collected, and the content of perchlorate in drinking water during the wet season and dry season was detected by ultra-high performance liquid chromatography in series. The linear mixed effect model was used to estimate the relationship between perchlorate in drinking water and the height and weight of 144,644 children and adolescents, and 33 pieces of local average wage data were used as confounding factors for quality control., Results: After controlling the age, gender, and local economic situation, we found that the concentration of perchlorate in drinking water increased by 10 μg/L is associated with a 1.0 cm decrease in height and a 1.6 kg decrease in weight in children and adolescents ( p  < 0.05)., Conclusion: The concentration of perchlorate in drinking water may be negatively correlated with the height and weight of children., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Guo, Zong, Yong, Jiang, Qin, Zhou, Ren, Gao, Kang, Huang, Chen and Zhang.)

This study investigates the quantity and quality variations of dissolved organic matter (DOM) leaching from the soil in groundwater irrigation area of the North China Plain, constrained by the concentration of Ca/Na. Soil samples with dominant humic-like (HLC) and protein-like (PLC) components were paired with parallel concentration gradients of Ca/Na extractants for equilibrium experiments. Fluorescence-PARAFAC, UV-visible spectroscopy, and multiple statistical analyses were combined for data analysis and interpretation. The results reveal that the primary DOM components remained dominant for specific soil sample, with a higher relative abundance of PLC (HLC) in Ca (Na) extract. HLC preferentially binds to soil phase in all extractions, while PLC is readily released into the solution. However, Ca inhibits HLC desorption and promotes PLC release more significantly than Na, as indicated by stronger ion/proton reaction (IPR) and electrostatic effect (ESE). The strongest IPR and ESE are seen in the HLC-dominated DOM extracted with Ca, suggesting a condition where Ca bridges to HLC and forms total dissolved organic carbon (DOC) that decreases. In contrast, Na extraction exhibits only a weaker ESE that is offset by soil-contained HLC and exchangeable Ca, resulting in subtle DOC decrease. The trends in leaching of HLC and PLC are self-dependent, and the level of variation in either component correlates with the increasing concentration of specific cations present. These findings underscore the crucial role of soil organic matter (SOM) composition and its interaction with leaching cations in soil management in large-scale groundwater irrigation areas, where SOM quality and groundwater chemistry vary., (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Background: Lung cancer is one of the most common malignant tumors in the world. It has become an increasingly important public health problem in China. In this study, we systematically assessed the lung cancer situation in China from 1990 to 2019 and provided an epidemiological knowledge base for the revision of health policies. The relevant data were extracted from the Global Burden of Disease (GBD) database., Methods: Based on GBD 2019 data, we evaluated the incidence, prevalence, and death rates of lung cancer in China and their change trends from 1990 to 2019, making comparisons by gender and age., Results: The age-standardized incidence and death rates (ASIR and ASDR, respectively) of lung cancer in China were higher than the average levels in Asia, Africa, Europe, and Oceania and also higher than those of neighboring Asian countries. Lung cancer rose from the seventh leading cause of death in 1990 to the fourth leading one in 2019, indicating that the disease burden of lung cancer is increasing. In 2019, the incidence, prevalence, and death rates of lung cancer were all higher in men than in women across all age groups. All three indices were lower in men and women <50 years old than in men and women >50 years. From 1990 to 2019, the ASIR, age-standardized prevalence rate (ASPR), and ASDR showed trends of increase ( P < .05), and the rise in the ASPR (average annual percentage change [AAPC] = 1.9) was greater than those in the ASIR (AAPC = 1) and ASDR (AAPC = .8)., Conclusions: From 1990 to 2019, the incidence, prevalence, and death rates of lung cancer continued to increase in China. To reduce this burden, prevention and management of known risk factors should be promoted through national policies.

Older adults often face more pronounced energy inequality in their daily lives, which is one of the reasons for their accumulation of stress or anxiety and may further aggravate their depression. Analyzing the relationship between energy poverty and the depression level of China's older adults will provide policy enlightenment for solving the problems of older adults' relative poverty, energy poverty, and mental poverty and thus promote happy and healthy aging. In this paper, using the data of China Health and Retirement Longitudinal Study in 2018, we used the entropy weighting method to objectively assign weights to 10 indicators reflecting the status of energy poverty and construct a multidimensional energy poverty index for older adults. First, we analyzed the relationship between multidimensional energy poverty and the depression levels of older adults using multiple linear regression model and quantile regression models. Next, we used instrumental variable linear regression model and instrumental variable quantile regression models for endogeneity tests. Then, we performed a robustness check by replacing the core explanatory variable. After that, we conducted heterogeneity analyses by residential area, type of residence, and solitary status. Finally, we analyzed the mediating role of life satisfaction using structural equation modeling. Multidimensional energy poverty has aggravated depression among older adults, and the effect is greater for older adults with higher depression levels. The effect of multidimensional energy poverty on depression is greater for older adults in western China, urban areas, and those who live alone. Multidimensional energy poverty has aggravated depression among older adults by reducing their life satisfaction., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Hou, Zhou and Jiang.)

This study aimed to evaluate the composition of the gastric microbiota in the gastric mucosa and gastric fluid of patients with chronic antral gastritis. Specifically, we sought to determine whether Helicobacter pylori (Hp) infection changes the bacterial community in the gastric mucosa or alters the microbiota in the gastric fluid. The bacterial community at another site in the stomach was also investigated. DNA was extracted from 160 samples collected from 40 patients with chronic antral gastritis (20 Hp-positive and 20 Hp-negative cases). Three tissue samples of the gastric mucosa (gastric angle, body, and antral mucosa) and one tube of gastric fluid were collected from every patient. A 16S rRNA amplification library was created, and high-throughput sequencing was performed. A profile of the community composition was obtained using bioinformatics methods, including cluster, taxonomy, and diversity analyses. Analysis of the gastric bacterial community revealed that the community compositions of the gastric mucosa and gastric fluid of patients without Hp are similar to but show differences from those of Hp-positive patients. The microbiota in Hp-positive patients exhibited reduced microbial diversity, and the gastric fluid of these patients contained a small proportion of Hp. The richness of Leptotrichia in mucosal samples was greater than that in gastric fluid samples from Hp-negative patients with chronic antral gastritis. Hp changes the growth of other microbiota in the mucosa and affects the microbiota in the gastric fluid of patients with chronic antral gastritis. In addition to Hp, the presence of other bacteria might be related to the development of chronic antral gastritis.

Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of hepatocellular carcinoma (HCC). We conducted a nested case-control study of 347 HCC cases and 691 matched controls within a prospective cohort of 18 244 Chinese men in Shanghai, China. The concentrations of 8-epi-prostaglandin F2α (8-epi-PGF2α), a biomarker of oxidative stress, and prostaglandin E2 (PGE2) metabolite (PGE-M), a biomarker of the inflammation mediator PGE2, were determined in baseline urine samples using validated mass spectrometry assays. 8-epi-PGF2α levels were significantly higher in HCC cases than control subjects (geometric means 0.92 versus 0.80 pmol/mg creatinine, P < 0.001). The relative risks of developing HCC for the highest relative to the lowest quartile of 8-epi-PGF2α were 2.55 (95% confidence interval = 1.62-4.01, Ptrend < 0.001). This positive 8-epi-PGF2α-HCC risk association was independent of smoking status, alcohol consumption and hepatitis B or liver cirrhosis and was present 10 years before the clinical manifestation of HCC. This study did not find any significant association between urinary PEG-M and HCC risk. This study provides direct evidence in support of the critical role of oxidative stress in the development of HCC regardless of its underlying causes., (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)