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Prediagnostic levels of urinary 8-epi-prostaglandin F2α and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma.
- Source :
-
Carcinogenesis [Carcinogenesis] 2019 Aug 22; Vol. 40 (8), pp. 989-997. - Publication Year :
- 2019
-
Abstract
- Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of hepatocellular carcinoma (HCC). We conducted a nested case-control study of 347 HCC cases and 691 matched controls within a prospective cohort of 18 244 Chinese men in Shanghai, China. The concentrations of 8-epi-prostaglandin F2α (8-epi-PGF2α), a biomarker of oxidative stress, and prostaglandin E2 (PGE2) metabolite (PGE-M), a biomarker of the inflammation mediator PGE2, were determined in baseline urine samples using validated mass spectrometry assays. 8-epi-PGF2α levels were significantly higher in HCC cases than control subjects (geometric means 0.92 versus 0.80 pmol/mg creatinine, P < 0.001). The relative risks of developing HCC for the highest relative to the lowest quartile of 8-epi-PGF2α were 2.55 (95% confidence interval = 1.62-4.01, Ptrend < 0.001). This positive 8-epi-PGF2α-HCC risk association was independent of smoking status, alcohol consumption and hepatitis B or liver cirrhosis and was present 10 years before the clinical manifestation of HCC. This study did not find any significant association between urinary PEG-M and HCC risk. This study provides direct evidence in support of the critical role of oxidative stress in the development of HCC regardless of its underlying causes.<br /> (© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Biomarkers, Tumor urine
Body Mass Index
Carcinoma, Hepatocellular epidemiology
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular pathology
Case-Control Studies
China epidemiology
Cohort Studies
Dinoprost urine
Female
Humans
Inflammation epidemiology
Inflammation genetics
Inflammation pathology
Inflammation urine
Liver Neoplasms epidemiology
Liver Neoplasms genetics
Liver Neoplasms pathology
Male
Middle Aged
Oxidative Stress genetics
Risk Factors
Carcinoma, Hepatocellular urine
Dinoprost analogs & derivatives
Dinoprostone urine
Liver Neoplasms urine
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2180
- Volume :
- 40
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 30615102
- Full Text :
- https://doi.org/10.1093/carcin/bgy180