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A recent systematic review conducted by researchers at the School of Medicine in Isfahan, Iran, explored the relationship between chitotriosidase (CHIT1) levels and amyotrophic lateral sclerosis (ALS). The review analyzed 14 studies and found that the level of CHIT1 in the cerebrospinal fluid of ALS patients was significantly higher than that of healthy control and disease control groups. The findings suggest a strong association between CHIT1 increase and ALS disorder. As the elderly population continues to grow, identifying effective diagnostic and treatment methods for ALS becomes increasingly important. [Extracted from the article]

A recent study conducted by researchers at Cairo University examined the role of biomarkers of inflammation and MRI techniques in the early detection of cystinosis-associated myopathy. Cystinosis is a lysosomal storage disorder that causes multi-organ dysfunction. The study evaluated 22 pediatric patients with nephropathic cystinosis and found that chitotriosidase activity was significantly elevated in these patients compared to controls with chronic kidney disease. However, there were no significant differences in muscle morphology between cystinosis patients and healthy controls on MRI scans. The researchers concluded that further studies are needed to determine the role of MRI in assessing cystinosis myopathy. [Extracted from the article]

The article highlights the initiation of a clinical trial, aimed at studying a novel form of histiocytosis associated with injecting drug use, focusing on its clinical features and diagnostic criteria. Topics discussed include the role of chitotriosidase activity in screening, the significance of tissue biopsies for diagnosis, and the investigation of polyvinylpyrrolidone accumulation in macrophages using advanced microscopy and mass spectrometry techniques.

A recent study conducted by researchers at the University of Belgrade explored the impact of serum chitotriosidase activity on tuberculosis (TB) treatment response. The study included 149 patients with confirmed TB disease and found that anti-TB treatment was associated with a significant decrease in serum chitotriosidase levels. The researchers concluded that serum chitotriosidase values can serve as strong biomarkers for starting anti-TB treatment and monitoring treatment response. Further studies are needed to explore other factors associated with chitotriosidase activity in TB patients. [Extracted from the article]

Researchers at Copenhagen University Hospital have conducted a retrospective study on the treatment outcomes of three siblings with Gaucher's Disease Type 3 (GD3). The study compared the use of hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT) in treating the disease. The results showed that HSCT led to better neurological outcomes and a normalization of chitotriosidase levels, suggesting that HSCT may be a more effective treatment option for GD3. The researchers recommend considering HSCT as a treatment option to limit disease progression and improve neurological outcomes. [Extracted from the article]

New research from the Children's Hospital of China Medical University explores the relationship between the GBA1 gene and osteoporosis in specific populations, as well as its role in the development of Gaucher disease. The study found that a variant in the GBA1 gene may increase the risk of bone disease. Additionally, elevated endoplasmic reticulum stress and inflammasome activation were associated with osteoporosis development, highlighting the importance of monitoring patients with Gaucher disease. The research suggests that initiating enzyme replacement therapy earlier in Gaucher disease may lead to greater improvements in bone density. [Extracted from the article]

A study conducted at the University Hospital Center Mother Teresa in Tirana, Albania, evaluated the long-term efficacy and safety of Taliglucerase alfa in children and adolescents with Type 1 Gaucher disease. Over a six-year period, 10 patients were monitored for various parameters, including hemoglobin concentration, platelet count, liver and spleen volume, bone mineral density, glucosylsphingosine level, chitotriosidase activity, and growth parameters. The study found that Taliglucerase alfa exhibited good efficacy and a safe profile in the treatment of children and adolescents with Type 1 Gaucher disease. [Extracted from the article]

A recent study conducted by researchers at the Department of Experimental Medicine in Rome, Italy, aimed to evaluate the association between chitotriosidase (CHIT) activity and arterial stiffness in individuals with type 2 diabetes (T2D) without cardiovascular complications. The study found that there was no significant difference in CHIT activity between individuals with high arterial stiffness and those with low arterial stiffness. However, the high arterial stiffness group did exhibit other risk factors for cardiovascular disease, such as older age, longer duration of diabetes, higher blood pressure, and higher blood glucose levels. This study provides new insights into the association between CHIT activity and cardiovascular disease in individuals with T2D. [Extracted from the article]

For more information on this research see: Can Serum Chitotriosidase Levels, Immune and Oxidative Stress Parameters Be Early Diagnostic Indicators in Patients With Silicosis? Keywords: Biomarkers; Chitotriosidase; Diagnostics and Screening; Enzymes and Coenzymes; Health and Medicine; Lung Diseases and Conditions; Lung Injury; Occupational Diseases and Conditions; Pneumoconiosis; Respiratory Tract Diseases and Conditions; Silicosis EN Biomarkers Chitotriosidase Diagnostics and Screening Enzymes and Coenzymes Health and Medicine Lung Diseases and Conditions Lung Injury Occupational Diseases and Conditions Pneumoconiosis Respiratory Tract Diseases and Conditions Silicosis 1184 1184 1 10/09/23 20231013 NES 231013 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators publish new report on silicosis. [Extracted from the article]

For more information on this research see: Evaluation of biochemical profile and oxidative damage to lipids and proteins in patients with lysosomal acid lipase deficiency. Biochemicals, Biochemistry, Carboxylic Ester Hydrolases, Chemicals, Chitotriosidase, Enzymes and Coenzymes, Lipase Keywords: Biochemicals; Biochemistry; Carboxylic Ester Hydrolases; Chemicals; Chitotriosidase; Enzymes and Coenzymes; Lipase EN Biochemicals Biochemistry Carboxylic Ester Hydrolases Chemicals Chitotriosidase Enzymes and Coenzymes Lipase 506 506 1 05/02/23 20230505 NES 230505 2023 MAY 5 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on carboxylic ester hydrolases. [Extracted from the article]

Keywords: Biomarkers; Biopterin; Cancer; Chitotriosidase; Diagnostics and Screening; Enzymes and Coenzymes; Gastric Cancer; Gastroenterology; Health and Medicine; Neopterin; Oncology; Surgery EN Biomarkers Biopterin Cancer Chitotriosidase Diagnostics and Screening Enzymes and Coenzymes Gastric Cancer Gastroenterology Health and Medicine Neopterin Oncology Surgery 1239 1239 1 04/24/23 20230427 NES 230427 2023 APR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- A new study on gastric cancer is now available. Biomarkers, Biopterin, Cancer, Chitotriosidase, Diagnostics and Screening, Enzymes and Coenzymes, Gastric Cancer, Gastroenterology, Health and Medicine, Neopterin, Oncology, Surgery. [Extracted from the article]

Gaucher disease (GD) is a recessively inherited disorder resulting in storage of glucosylceramide (GlcCer) in lysosomes of tissue macrophages. Keywords: Brain Diseases and Conditions; Chitotriosidase; Connective Tissue Cells; Drugs and Therapies; Enzyme Replacement Therapy; Enzymes and Coenzymes; Gaucher Disease; Gaucher's Disease; Glucocerebrosidase; Health and Medicine; Hematology; Immunology; Lipid Metabolism Disorders; Lysosomal Storage Diseases and Conditions; Macrophages; Metabolic Diseases and Conditions; Mononuclear Phagocyte System; Myeloid Cells; Nutritional and Metabolic Diseases and Conditions; Phagocytes; Sphingolipidoses EN Brain Diseases and Conditions Chitotriosidase Connective Tissue Cells Drugs and Therapies Enzyme Replacement Therapy Enzymes and Coenzymes Gaucher Disease Gaucher's Disease Glucocerebrosidase Health and Medicine Hematology Immunology Lipid Metabolism Disorders Lysosomal Storage Diseases and Conditions Macrophages Metabolic Diseases and Conditions Mononuclear Phagocyte System Myeloid Cells Nutritional and Metabolic Diseases and Conditions Phagocytes Sphingolipidoses 481 481 1 04/10/23 20230413 NES 230413 2023 APR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Current study results on Gaucher's disease have been published. Brain Diseases and Conditions, Chitotriosidase, Connective Tissue Cells, Drugs and Therapies, Enzyme Replacement Therapy, Enzymes and Coenzymes, Gaucher Disease, Gaucher's Disease, Glucocerebrosidase, Health and Medicine, Hematology, Immunology, Lipid Metabolism Disorders, Lysosomal Storage Diseases and Conditions, Macrophages, Metabolic Diseases and Conditions, Mononuclear Phagocyte System, Myeloid Cells, Nutritional and Metabolic Diseases and Conditions, Phagocytes, Sphingolipidoses. [Extracted from the article]

We aimed to investigate the effects of sphingomyelin phosphodiesterase 1 (SMPD1) gene variants on the clinical and laboratory findings in patients with beta-thalassemia major. Keywords: Istanbul; Turkey; Eurasia; Aminotransferase; Anemia; Beta Thalassemia; Chitotriosidase; Congenital Anemia; Enzymes and Coenzymes; Genetics; Health and Medicine; Hematologic Diseases and Conditions; Hematology; Hemic and Lymphatic Diseases and Conditions; Hemoglobinopathies; Hemolytic; Thalassemia EN Istanbul Turkey Eurasia Aminotransferase Anemia Beta Thalassemia Chitotriosidase Congenital Anemia Enzymes and Coenzymes Genetics Health and Medicine Hematologic Diseases and Conditions Hematology Hemic and Lymphatic Diseases and Conditions Hemoglobinopathies Hemolytic Thalassemia 501 501 1 03/27/23 20230330 NES 230330 2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators publish new report on Hematologic Diseases and Conditions - Beta Thalassemia. Conclusion These results imply that the clinical and laboratory findings and some features of disease progression in patients with beta-thalassemia major are similar to those of Niemann-Pick disease.". [Extracted from the article]

Biliary Tract Diseases and Conditions, Biomarkers, Biopterin, Chitotriosidase, Cholecystitis, Diagnostics and Screening, Digestive System Diseases and Conditions, Enzymes and Coenzymes, Gallbladder Diseases and Conditions, Gastroenterology, Health and Medicine, Neopterin Keywords: Biliary Tract Diseases and Conditions; Biomarkers; Biopterin; Chitotriosidase; Cholecystitis; Diagnostics and Screening; Digestive System Diseases and Conditions; Enzymes and Coenzymes; Gallbladder Diseases and Conditions; Gastroenterology; Health and Medicine; Neopterin EN Biliary Tract Diseases and Conditions Biomarkers Biopterin Chitotriosidase Cholecystitis Diagnostics and Screening Digestive System Diseases and Conditions Enzymes and Coenzymes Gallbladder Diseases and Conditions Gastroenterology Health and Medicine Neopterin 698 698 1 03/23/23 20230319 NES 230319 2023 MAR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Fresh data on cholecystitis are presented in a new report. [Extracted from the article]

Keywords: Biomedicine; Chitotriosidase; Enzymes and Coenzymes; Genetics; Health and Medicine EN Biomedicine Chitotriosidase Enzymes and Coenzymes Genetics Health and Medicine 2023 FEB 17 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in biomedicine. Biomedicine, Chitotriosidase, Enzymes and Coenzymes, Genetics, Health and Medicine. [Extracted from the article]