Search

A recent study conducted by researchers at the University of Pittsburgh explores the role of the Shu complex in promoting RAD51 activity, which is crucial for DNA repair and replication stress. The study found that the Shu complex, consisting of SWSAP1, SWS1, and SPIDR, binds to RAD51 and enhances its stability and ability to exchange strands. The researchers also discovered that the Shu complex enhances the diffusion of RPA on single-stranded DNA. Furthermore, the study identified cancer variants in SWSAP1 that affect the formation of the Shu complex, suggesting its potential as a therapeutic target for cancer treatment. [Extracted from the article]

A recent study conducted by researchers at Northeastern University in Boston, Massachusetts, has explored the use of gene regulation therapeutics for the treatment of skin-related diseases, specifically psoriasis. The study focused on a bottlebrush polymer-antisense oligonucleotide (ASO) conjugate called pacDNA, which targets the IL-17 receptor A (IL-17RA) involved in psoriasis pathogenesis. The researchers found that systemic administration of pacDNA effectively reduced IL-17RA gene expression in the skin and reversed the development of psoriasis in a mouse model. These findings suggest that pacDNA has potential as a nanoconstruct for systemic oligonucleotide delivery to the skin and for treating psoriasis and other skin-related disorders. The research was funded by the National Cancer Institute, National Institute of General Medical Sciences, and National Science Foundation. [Extracted from the article]

Researchers at Indiana University School of Medicine have identified a potential treatment for HER2+ breast cancer. The study focuses on the inhibition of HUNK, a protein associated with resistance to HER2-targeted agents. The researchers characterized a selective HUNK inhibitor and found that it effectively prevents the phosphorylation of a downstream substrate, Rubicon, which is involved in autophagy and tumorigenesis in HER2+ breast cancer. This research provides valuable insights into the development of new treatments for HER2+ breast cancer. [Extracted from the article]

A recent study conducted by researchers at the University of Chester in the United Kingdom explores the effects of endocrine-disrupting chemicals (EDCs) on calcium signaling pathways and cellular stress. EDCs, which have been a concern since the 1970s, have been found to have estrogenic or anti-estrogenic properties and can bind to hormone receptors. The study focuses on the impact of EDCs on calcium transporters, specifically the SERCA Ca2+ ATPases, which can lead to cytotoxicity and cell death. The research also suggests that the inhibition of these transporters can trigger the endoplasmic reticulum (ER) stress response. This study provides valuable insights into the potential harmful effects of EDCs on biological systems. [Extracted from the article]

A study conducted by researchers at the University of Buenos Aires in Argentina explores the structural complexity of pyomelanin in Pseudomonas bacteria. Pyomelanin is a pigment that is produced through alterations in tyrosine degradation. The researchers found strain-specific differences in the structural features of pyomelanin across different Pseudomonas strains, and these differences had distinct physiological effects. The study also found that the addition of pyomelanin increased the survival of Pseudomonas bacteria when exposed to UVC radiation. [Extracted from the article]

Researchers at Hunan University in Changsha, China have reported new data on a triple-action, smart-decomposition antimicrobial booster based-combination therapy against "ESKAPE" pathogens. The study focuses on the development of novel antimicrobial agents and effective anti-resistance combination therapies to combat the global antibiotic resistance crisis. The researchers have identified a dual-action oligoamidine booster that exhibits a triple-targeting mechanism, enhancing the eradication of antibiotic-resistant pathogens and suppressing the development of bacterial resistance. This research provides valuable insights and design principles for the development of new antimicrobial treatments. [Extracted from the article]

A recent study from Nanjing University of Science and Technology in China explores the use of DNA self-assembly technology to improve biochemical reactions. The researchers discuss the importance of enhancing the efficiency, rate, and controllability of biochemical reactions in various fields, such as biomedicine and chemical biology. They highlight the advantages of DNA self-assembly technology, including programmability and biocompatibility, and summarize recent advances in its applications for improving biochemical reaction performances. The study also addresses the challenges and future prospects of using DNA self-assembly technology in biochemical reaction regulation and improvement. [Extracted from the article]

A new study conducted at Harvard University in Cambridge, Massachusetts has explored the use of molecular glues and bifunctional compounds in the field of Life Sciences. These compounds induce proximity between proteins and can lead to novel functional outcomes. The research provides a framework for understanding and exploiting the similarities between these compounds and other biological processes. The study was supported by the NIH National Institute of General Medical Sciences and the NIH National Cancer Institute. For more information, the research article can be found in Cell Chemical Biology. [Extracted from the article]

A recent report from Shanghai Jiao Tong University discusses advancements in the delivery of therapeutic proteins and peptides for the treatment of central nervous system (CNS) diseases. The researchers highlight the challenges faced in clinical applications, such as low biomembrane permeability and the blood-brain barrier (BBB). They also present an overview of the current understanding of the BBB and the development of efficient approaches for delivering drugs to the CNS, particularly through the use of nanoparticles. The report concludes by discussing the limitations of current strategies and suggesting future research prospects. This research has been peer-reviewed and published in ACS Nano. [Extracted from the article]

A study conducted by researchers at Nankai University in Tianjin, China, has found that vitexicarpin, a compound extracted from the fruits of Vitex rotundifolia, has potential anticancer activity against colorectal cancer (CRC). The study investigated the impact of vitexicarpin on CRC through various experiments and found that it directly binds to inosine monophosphate dehydrogenase 2 (IMPDH2) and promotes c-Myc ubiquitination, leading to the inhibition of epithelial-mesenchymal transition (EMT). Vitexicarpin was also found to hinder the migration and invasion of CRC cells both in vitro and in vivo. These findings provide potential molecular targets for CRC treatment and shed light on new mechanisms for c-Myc regulation in tumors. [Extracted from the article]

Researchers at Monash University in Melbourne, Australia have made significant progress in the development of new antibiotics to combat life-threatening infections caused by Gram-negative 'superbugs'. With a lack of new antibiotics in development, the researchers focused on discovering new natural scaffolds with distinct mechanisms of action. They successfully developed a total chemical synthesis methodology for a unique cyclic lipodepsipeptide called laterocidine, which showed activity against multiple drug-resistant pathogens. Through structure-activity relationship studies, they identified important structural features that drive the antimicrobial activity of laterocidine and engineered a peptide that surpassed the efficacy of the original peptide. This engineered peptide demonstrated complete inhibition of the growth of a polymyxin-resistant strain of Pseudomonas aeruginosa. The research was supported by the National Health & Medical Research Council of Australia. [Extracted from the article]

A recent report from the University of Lille highlights the findings of the French Society of Medicinal Chemistry (SCT), which was founded in 1966. The SCT's mission is to promote knowledge in pharmaceutical research and development, focusing on areas such as drug candidates, chemical biology, pharmacokinetics, and toxicity. The society organizes an annual international congress and thematic days for young researchers, as well as webinars and a newsletter to share scientific achievements. These activities reflect the current changes in the field and aim to improve communication and inclusiveness. The research has been peer-reviewed and can be accessed through the journal ChemMedChem. [Extracted from the article]

The article introduces a new method using mass spectrometry imaging to create detailed maps of lipid distribution throughout developing vertebrate embryos. This method allows researchers to see how lipid location changes alongside embryo development, revealing new insights into how metabolism supports organ formation and patterning.

A study conducted by researchers at Nankai University in Tianjin, China, explores the use of organic afterglow luminescent probes (OALPs) in cancer theranostics. OALPs are characterized by their long-lasting luminescence after irradiation, making them useful in autofluorescence-free optical imaging. They offer enhanced imaging sensitivity, deeper tissue penetration, and clearer results compared to traditional optical imaging methods. The study outlines two design approaches for OALPs: coencapsulation and conjugation, and discusses their integration with therapy in the field of cancer theranostics. The researchers also highlight challenges in advancing the next generation of OALPs to broaden their applications. [Extracted from the article]

A report from the University of Washington discusses research on biosensors and their role in understanding drug resistance in cancer cells. The study focused on the adaptive effects of Ras-G12C inhibitors on Ras signaling at the single-cell level. The researchers used Ras biosensors to analyze the activity and signaling environment of Ras in cancer cells and found that certain cells underwent adaptive signaling and metabolic changes in response to the drugs. The study identified major vault protein as a mediator of Ras activation and highlighted the importance of single-cell analysis in understanding drug resistance. [Extracted from the article]

A recent report from East China Normal University discusses research findings on osteosarcomas, a rare malignant tumor that primarily affects children and adolescents. The study aimed to identify potential therapeutic targets for the treatment of osteosarcoma, as no efficient target has been validated in clinical practice. The researchers designed and synthesized photo-cross-linking probes based on a lead compound and identified DDX5 as a potential target protein using an activity-based protein profiling strategy. Further experiments supported the finding that the compound binds to DDX5 and induces its degradation, affecting cell proliferation and migration through the PI3K-AKT-mTOR signaling pathway. The research concludes that DDX5 is a potential therapeutic target for the treatment of osteosarcoma. [Extracted from the article]

Researchers at the Dana-Farber Cancer Institute in Boston, Massachusetts have made new findings in the field of Obesity, Fitness, and Wellness. They have discovered a mechanism called "template-assisted covalent modification" that underlies the activity of covalent molecular glues. These glues are small molecules that can stabilize neoprotein interfaces and have potential therapeutic applications. The researchers identified a series of molecular glue degraders that recruit a specific ligase to degrade target proteins. This research opens up new possibilities for proximity-driven pharmacology. [Extracted from the article]

A study conducted by researchers at Baylor University College of Medicine in Houston, Texas, explores the role of glutathione (GSH) in maintaining cellular redox homeostasis and regulating cellular processes. The study highlights the importance of understanding the subcellular compartmentalization of GSH and its implications for drug development, particularly in covalent drug design and antitumor strategies. The research emphasizes the need for innovative methodologies to advance our understanding of GSH dynamics and facilitate the development of precise therapeutic interventions. The study was supported by the National Institutes of Health and the Cancer Prevention & Research Institute of Texas. [Extracted from the article]

A recent report from Hunan Normal University in Changsha, China discusses the development of a new fluorescent probe that enables the ultrasensitive detection of biothiols in highly diluted plasma and high-fidelity imaging of dihydroartemisinin-induced ferroptosis. The researchers engineered a stable fluorescent probe that has a low background fluorescence and is able to accurately monitor biomarkers in biological systems. The probe demonstrated high sensitivity and selectivity towards biothiols, allowing for the detection of liver injury plasma and the imaging of fluctuations in biothiol levels in nonsmall-cell lung cancer. This research provides insights into enhancing the sensitivity and accuracy of fluorescent probes for the detection and imaging of biomarkers in disease development. [Extracted from the article]

A recent study conducted by researchers at the University of Jordan explores the potential anticancer activities of phosphodiesterase 5 inhibitors (PDE5i) in lung cancer. PDE5 is an enzyme that has been linked to cancer development, and PDE5 inhibitors like sildenafil (Viagra) and tadalafil (Cialis) are commonly used to treat erectile dysfunction and arterial hypertension. The study found that PDE5 inhibitors significantly inhibited the proliferation of lung cancer cells and showed anti-tumorigenic effects. The research suggests that PDE5 inhibition may suppress lung cancer cell growth by interacting with various cancer cell signaling pathways. [Extracted from the article]

The article focuses on a new molecular prognostic score for high-grade serous ovarian cancer (HGSOC). Topics include the development of a 20-gene signature-based mPS, its validation and superior predictive performance compared to traditional clinicopathological parameters, and its potential to guide targeted therapies by revealing key molecular pathways involved in HGSOC.

A recent study conducted by researchers at Hebei Medical University explores the connection between depression and Alzheimer's disease (AD). The study focuses on the serotonergic system, which is involved in both AD and depression. Using various techniques, the researchers found that the activity of serotonin neurons in the dorsal raphe nucleus decreased in AD mouse models. Activation of the neural circuit associated with these neurons improved depressive symptoms and cognitive impairments in the mice. These findings provide new insights into the relationship between depression and AD and offer potential targets for pharmaceutical prevention of AD. [Extracted from the article]

Researchers from Heinrich Heine University Dusseldorf and the University of Duisburg-Essen have identified and synthesized a group of molecules called callyaerins that can combat tuberculosis in a new way. Tuberculosis is a significant infectious disease that causes millions of deaths each year. The callyaerins act against the tuberculosis bacterium by targeting a non-essential membrane protein, disrupting its growth without affecting human cells. This discovery provides a new mechanism of action for developing novel antibiotics. [Extracted from the article]

Researchers from China Three Gorges University have published a report on the synthesis of carbohydrates with unsaturated glycosyl donors under mild conditions. Carbohydrates and their conjugates are important in life activities and drug development. The researchers have developed synthetic strategies with high stereoselectivity and milder conditions compared to previous works, achieving chemo-/regio- and stereoselective glycosylation via palladium catalysis at room temperature. The report introduces the research progress in constructing four types of glycosides: O-glycosides, C-glycosides, N-glycosides, and S-glycosides. This research has been peer-reviewed and provides valuable insights into the field of carbohydrate synthesis. [Extracted from the article]

A recent study conducted by researchers at Nanjing University Medical School in China explores the relationship between small molecules and physiological processes throughout the human lifespan. The study focuses on the importance of identifying small-molecule targets in pharmacological discovery and understanding the pharmacodynamics and toxicological mechanisms of small-molecule drugs. Chemical proteomics is highlighted as a valuable method for identifying unknown targets of compounds within complex biological matrices. The research aims to provide directions and strategies for the discovery of novel pharmaceuticals and the improvement of drug safety evaluation. [Extracted from the article]

A recent review from Tufts University discusses the use of lipid nanoparticles (LNPs) for the delivery of messenger RNA (mRNA) in nanomedicine. The review highlights the importance of LNPs in achieving selective, efficient, and safe mRNA delivery, and explores the four-step SCER cascade process involved in this delivery. The research emphasizes the roles of ionizable lipids and helper phospholipids in the process. The review aims to provide an updated overview of LNP-based mRNA delivery, addressing challenges and exploring future developments for clinical translation. The research was supported by the National Institutes of Health (NIH) and has been peer-reviewed. [Extracted from the article]

A report from Nankai University in Tianjin, China discusses the use of nanozymes in various applications. Nanozymes are nanomaterial structures that have customizable catalytic activity and are cost-effective to produce. The report focuses on recent advancements in nanozyme research, specifically in modulating electron transfer processes to enhance their catalytic activity and specificity. The review also explores the bioapplications of nanozymes, including antimicrobial treatments, cancer therapy, and biosensing. The research aims to provide valuable insights for the design and synthesis of nanozymes with improved performance. [Extracted from the article]

Researchers from Shandong University in Jinan, People's Republic of China, have conducted a study on anti-infectives. They have developed a bioinspired skeletal reconstruction approach that allows for the synthesis of platensilin, platensimycin, and platencin, which are potential inhibitors of beta-ketoacyl-acyl carrier protein synthase (FabF) in the bacterial and mammalian fatty acid synthesis system. These compounds show promise as drug leads for antibacterial and antidiabetic therapies. The researchers have also prepared analogs with different polycyclic scaffolds, and one of these analogs has demonstrated improved antibacterial activity against S. aureus compared to platensimycin. The study has been published in the Journal of the American Chemical Society. [Extracted from the article]

Researchers from the Siberian Branch of the Russian Academy of Sciences have conducted a study on xenografts, specifically focusing on the impact of soloxolone amides on glioblastoma cells. The researchers found that compound 7, soloxolone para-methylanilide, effectively inhibited the aggressive phenotype of glioblastoma cells, including the glial-mesenchymal transition induced by transforming growth factor-beta 1 (TGF-b1). Compound 7 also demonstrated a synergistic effect with temozolomide (TMZ), a chemotherapy drug, in reducing the invasiveness of glioblastoma cells and increasing their sensitivity to chemotherapy. In vivo studies on mice showed that compound 7, alone or in combination with TMZ, effectively suppressed the growth of U87 xenograft tumors. This research suggests that compound 7 has potential as a component of combination therapy for glioblastoma. [Extracted from the article]

A recent report from investigators at Princeton University in New Jersey explores the post-translational regulation of protein function in cellular processes. The researchers used proximity-triggered protein trans-splicing technology to synthesize target proteins from premade parts, allowing for the differentiation of cellular location and activity state. This approach was applied to a diverse set of proteins, including oncofusions breakpoint cluster region-Abelson (BCR-ABL) and DNAJ-PKAc, revealing distinct phases of signaling and identifying potential therapeutic targets for cancer cells. The research provides insights into cellular signaling and the molecular connections of oncofusion kinases. [Extracted from the article]

A study conducted by Xuzhou Medical University in China investigated the protective effect of karanjin, a natural flavonoid compound, against sepsis-induced acute lung injury (ALI) in mice. The researchers found that karanjin alleviated lung tissue lesions, edema, and oxidative stress in mice with ALI. It also inhibited inflammation and the activation of the TLR4 pathway. The study concluded that karanjin repressed sepsis-induced ALI in mice by suppressing the TLR4 pathway. [Extracted from the article]

A recent study conducted at Emory University in Atlanta, Georgia, has identified a potential target for treating immune-suppressive triple negative breast cancer (TNBC). The study focused on the OTUD4/CD73 proteolytic axis and its role in inhibiting tumor immune responses. Researchers discovered that inhibiting the proteolytic interaction between CD73 and OTUD4 with a newly developed inhibitor called ST80 led to the reinvigoration of cytotoxic CD8+ T cell activities and sensitized refractory tumors to anti-PD-L1 therapy. These findings offer a novel strategy for targeting the immunosuppressive OTUD4/CD73 proteolytic axis in the treatment of immune-suppressive breast cancers. [Extracted from the article]

A German research team has developed a method to study antigen processing and transport processes in real time using a "cage" that can be opened with light to release trapped antigens. The team used a peptide derived from an HIV antigen as their model and demonstrated the versatility of the method in tracing antigen transport in human cells. The researchers aim to use this light-activated system to gain a better understanding of the kinetics of various immunological processes in vivo. Robert Tampe and Ralph Wieneke, the leaders of the research team, are renowned for their work in membrane biology, cellular quality control, antigen processing, and recognition. [Extracted from the article]

A recent report from investigators at Northeastern University discusses the potential of indoloquinoline alkaloids as antimalarials. The researchers focused on the plant Cryptolepis sanguinolenta, which has long been used in Africa for malaria treatment. The plant contains indoloquinolines, such as cryptolepine, neocryptolepine, and isocryptolepine, which have shown antimalarial properties. The report explores the effects of these alkaloids in vitro and in vivo, their mechanisms of action, and structure-activity relationship studies. The researchers also found that the indoloquinolines have a synergistic effect when combined with other antimalarial drugs. [Extracted from the article]

A study conducted by the CSIR - Indian Institute of Chemical Biology in Kolkata, India, has examined the impact of differentially charged liposomes on dendritic cells (DCs), which are important antigen-presenting cells involved in the immune response. The study found that liposomes can induce the maturation of DCs and enhance the expression of certain molecules and cytokines. Cationic liposomes were found to be more efficient in uptake and processing by DCs compared to neutral and anionic liposomes. These findings suggest that cationic liposomes may be a preferred option for vaccine delivery vehicles, particularly for activating DCs. [Extracted from the article]

A recent study conducted by researchers at the Institute of Chemical Biology and Fundamental Medicine SB RAS in Novosibirsk, Russia, has found that a short 19 bp dsRNA with 3'-trinucleotide overhangs, known as immunostimulating RNA (isRNA), has strong antiproliferative action against cancer cells. The isRNA also demonstrated immunostimulatory activity through the activation of cytokines and Type-I IFN secretion, as well as anti-tumor and anti-metastatic effects in vivo. The study aimed to determine the effects of chemical modifications on the isRNA's ability to activate the innate immune system and inhibit tumor cell proliferation. The researchers identified specific chemical modifications that enhance the properties of isRNA, which could improve its pharmacokinetic and pharmacodynamic properties and increase its specificity for desired effects. [Extracted from the article]

A report from the Rajiv Gandhi Center for Biotechnology in Kerala, India discusses the development of synthetic alpha-helical pores for use in nanobiotechnology. The researchers focus on creating functional and stable transmembrane pores composed of short synthetic alpha-helical peptides. These pores can be easily modified and have potential applications in nanopore technology, chemical biology, and as components of nanodevices and therapeutic tools. The research highlights the advantages of assembling alpha-helical transmembrane pores, including their structural and functional versatility. [Extracted from the article]

Researchers at Shandong University in Qingdao, China have discovered a method for incorporating lithocholic acid (LCA) into peptide chains, creating a peptide-LCA hybrid macrocyclic peptide library. This library has the potential to produce stable peptide-LCA hybrid drugs with improved stability and resistance to proteases. The researchers identified two peptides, TP-2C-4L3 and EP-2C-4L5, that showed strong binding affinities to their targets, Trop2 and EphA2, respectively. This study highlights the benefits of LCA in peptides and opens up new possibilities for the de novo discovery of peptide-LCA hybrid drugs. [Extracted from the article]

A new report from the University of Florida provides fresh data on the biosynthesis of enediyne natural products, which are known for their potent cytotoxicities. The research reveals that the biosynthesis of the defining core of these natural products, the 1,5-diyne-3-ene moiety, involves a diiodotetrayne intermediate. This finding establishes a unified biosynthetic pathway for enediynes and has implications for chemistry, enzymology, and translational applications of these natural products. The research was supported by various organizations, including the U.S. Department of Health & Human Services and the German Research Foundation. [Extracted from the article]

According to a preprint abstract from biorxiv.org, researchers have been exploring the use of targeted protein degradation (TPD) using bivalent proteolysis targeting chimeras (PROTAC) technology to expand the druggable proteome. In a publication in Nature Chemical Biology, the authors introduced a trivalent PROTAC called SIM1, which showed a superior degradation profile compared to its parent molecule MZ1, specifically targeting bromo and extra terminal (BET) proteins. However, the claim that trivalent PROTACs eliminate the hook effect is not entirely accurate, as the presence or absence of a hook effect is influenced by various factors beyond PROTAC valency. This research has not yet undergone peer review. [Extracted from the article]

This article discusses a new method for studying the dynamics of morphogen production and its role in tissue patterning during development. The researchers used an optogenetic system to generate gradients of a morphogen called Shh, which mimicked the spatial arrangement of neural progenitors found in vertebrate neural tube development. They measured the clearance rates of the morphogen and investigated how the level and duration of exposure to the morphogen affected cell fate acquisition and maintenance. This optogenetic approach provides a framework for studying the interplay between biochemical cues, gradient formation, and transcriptional programs in developmental patterning. [Extracted from the article]

A patent application by inventor Minghong Hao describes a kinetic ensemble system for identifying target pockets and generating lead compounds. The system combines computational components, such as physics-based simulation and artificial intelligence, with experimental components, including biophysical and chemical biology processes. The invention aims to address the challenges of traditional drug discovery by utilizing AI and machine learning algorithms to analyze genetic, genomic, and proteomic data. The patent application is currently in the approval process. [Extracted from the article]

A recent report discusses research findings on breast cancer, focusing on the role of nitric oxide (NO) and reactive nitrogen species (RNS) in cancer progression. The study highlights the importance of understanding the spatial distribution of NO and RNS in deciphering their roles in biological processes. The researchers found that increased expression of NOS2, a gene involved in NO production, is associated with poor survival in breast cancer. Additionally, NOS2 can interact with the enzyme cyclooxygenase-2 (COX-2) to promote cancer progression. The study suggests that targeting NOS2 and COX-2 could be a potential strategy for developing therapies to prevent or treat aggressive breast cancer. [Extracted from the article]

MiNA Therapeutics Limited has submitted a patent application for TMEM173 saRNA compositions and methods of use. The patent application describes the use of synthetic isolated small activating RNAs (saRNAs) to up-regulate the expression of the TMEM173 gene, which is involved in immune signaling pathways. The saRNAs are designed to target specific sequences of the TMEM173 gene and can be used to modulate immune responses and potentially treat diseases such as cancer. The patent application provides details on the saRNA compositions, pharmaceutical compositions, and methods of administration. MiNA Therapeutics Limited, based in London, United Kingdom, is the assignee of the patent. [Extracted from the article]

A study conducted by the Institute of Chemical Biology and Fundamental Medicine in Novosibirsk, Russia, explored the effects of cell-free DNA (cfDNA) from tumor cells and fibroblasts on the progression of B16 melanoma. The researchers found that cfDNA from fibroblasts increased the viability, migration, and invasiveness of B16 cells, while cfDNA from melanoma cells had a negative effect, reducing viability and migration and leading to decreased tumor size and metastasis. The study suggests that fibroblast DNA in the tumor microenvironment may play a role in tumor progression and the formation of new tumor foci. Further research is needed to understand the mechanisms involved. [Extracted from the article]

A recent study from Rice University in Houston, Texas explores the use of proximity-induced chemistry as a strategy for improving protein-based medical treatments. This method allows for site-specific modification of proteins with therapeutic agents, enhancing their effectiveness without extensive engineering. By enabling the formation of irreversible covalent bonds between therapeutic proteins and their targets, proximity-induced chemistry addresses challenges such as low affinity and limited availability of small molecules. This research has the potential to reshape the field of protein drug preparation and advance the development of novel protein therapeutics. [Extracted from the article]