108 results on '"Tobe, Sheldon"'
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2. Renal denervation for uncontrolled hypertension
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Marcusohn, Erez, Tobe, Sheldon W., Dueck, Andrew, and Madan, Mina
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Medical colleges ,Antihypertensive drugs ,Hypertension ,Health - Abstract
In 2021, about 5.8 million people in Canada were living with hypertension. (1) Despite the availability of pharmacotherapy, hypertension is a leading cause of death and disability globally, and in [...]
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- 2023
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3. Ligne directrice C-CHANGE pour l'harmonisation des lignes directrices nationales de prevention et de prise en charge des maladies cardiovasculaires en contexte de soins primaires au Canada : mise a jour 2022
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Jain, Rahul, Stone, James A., Agarwal, Gina, Andrade, Jason G., Bacon, Simon L., Bajaj, Harpreet S., Baker, Brian, Cheng, Gemma, Dannenbaum, David, Gelfer, Mark, Habert, Jeffrey, Hickey, John, Keshavjee, Karim, Kitty, Darlene, Lindsay, Patrice, LAbbe, Mary R., Lau, David C.W., Macle, Laurent, McDonald, Michael, Nerenberg, Kara, Pearson, Glen J., Pham, Thuy, Poppe, Alexandre Y., Rabi, Doreen M., Sherifali, Diana, Selby, Peter, Smith, Eric, Stern, Sol, Thanassoulis, George, Terenzi, Kristin, Tu, Karen, Udell, Jacob, Virani, Sean A., Ward, Richard A., Warburton, Darren E.R., Wharton, Sean, Zymantas, Jennifer, Hua-Stewart, Diane, Liu, Peter P., and Tobe, Sheldon W.
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Anticoagulants (Medicine) ,Hypoglycemic agents ,Cardiovascular diseases -- Care and treatment -- Management -- Prevention -- Cases ,Type 2 diabetes ,Company legal issue ,Company business management ,Health - Abstract
L'objectif du projet C-CHANGE (Canadian Cardiovascular Harmonized National Guideline Endeavour), une initiative d'harmonisation des lignes directrices nationales de prevention et de prise en charge des maladies cardiovasculaires, est de faciliter [...]
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- 2023
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4. Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2022 update
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Jain, Rahul, Stone, James A., Agarwal, Gina, Andrade, Jason G., Bacon, Simon L., Bajaj, Harpreet S., Baker, Brian, Cheng, Gemma, Dannenbaum, David, Gelfer, Mark, Habert, Jeffrey, Hickey, John, Keshavjee, Karim, Kitty, Darlene, Lindsay, Patrice, L'Abbe, Mary R., Lau, David C.W., Macle, Laurent, McDonald, Michael, Nerenberg, Kara, Pearson, Glen J., Pham, Thuy, Poppe, Alexandre Y., Rabi, Doreen M., Sherifali, Diana, Selby, Peter, Smith, Eric, Stern, Sol, Thanassoulis, George, Terenzi, Kristin, Tu, Karen, Udell, Jacob, Virani, Sean A., Ward, Richard A., Warburton, Darren E.R., Wharton, Sean, Zymantas, Jennifer, Hua-Stewart, Diane, Liu, Peter P., and Tobe, Sheldon W.
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Practice guidelines (Medicine) -- Evaluation ,Primary health care -- Methods ,Cardiovascular diseases -- Prevention ,Health - Abstract
The goal of the Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) process is to give all Canadian health care providers easy access to a comprehensive and practical set of harmonized [...]
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- 2022
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5. Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial
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Garg, Amit X., Devereaux, P.J., Hill, Andrew, Sood, Manish, Aggarwal, Bharat, Dubois, Luc, Hiremath, Swapnil, Guzman, Randolph, Iyer, Vikram, James, Matthew, McArthur, Eric, Moist, Louise, Ouellet, George, Parikh, Chirag R., Schumann, Virginia, Sharan, Sumit, Thiessen-Philbrook, Heather, Tobe, Sheldon, Wald, Ron, Walsh, Michael, Weir, Matthew, and Pannu, Neesh
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Curcumin -- Health aspects ,Aneurysmectomy -- Methods -- Patient outcomes ,Abdominal aortic aneurysm -- Development and progression -- Care and treatment ,Health - Abstract
BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans. METHODS: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers and local research staff were unaware of the treatment assignment. The primary outcomes were median concentrations of 4 biomarkers indicating injury and inflammation (postoperative urine interleukin-18 and perioperative rise in serum creatinine, plasma W-terminal pro-B-type natriuretic peptide and plasma high-sensitivity C-reactive protein). RESULTS: Baseline characteristics were similar in the 2 groups (606 patients overall; median age 76 yr). More than 85% of patients in each group took more than 80% of their scheduled capsules. Neither curcumin nor placebo significantly affected any of the 4 biomarkers (p > 0.05 for all comparisons). Regarding the secondary outcomes, there was a higher risk of acute kidney injury with curcumin than with placebo (17% v. 10%, p = 0.01), but no between-group difference in the median length of hospital stay (5 v. 5 days, p > 0.9) or the risk of clinical events (9% v. 9%, p = 0.9). INTERPRETATION: Curcumin had no beneficial effects when used in elective abdominal aortic aneurysm repair. These findings emphasize the importance of testing turmeric and curcumin before espousing their health benefits, as is currently done in the popular media. Trial registration: ClinicalTrials.gov, no. NCT01225094., Many modern medicines come from plants. (1,2) Turmeric, a plant in the ginger family that is native to South Asia, has been used for centuries as a spice and traditional [...]
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- 2018
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6. Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update
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Tobe, Sheldon W., Stone, James A., Anderson, Todd, Bacon, Simon, Cheng, Alice Y.Y., Daskalopoulou, Stella S., Ezekowitz, Justin A., Gregoire, Jean C., Gubitz, Gord, Jain, Rahul, Keshavjee, Karim, Lindsay, Patty, L'Abbe, Mary, Lau, David C.W., Leiter, Lawrence A., O'Meara, Eileen, Pearson, Glen J., Rabi, Doreen M., Sherifali, Diana, Selby, Peter, Tu, Jack V., Wharton, Sean, Walker, Kimberly M., Hua-Stewart, Diane, and Liu, Peter P.
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Merck & Company Inc. -- Management ,Bayer AG -- Management ,Eli Lilly and Co. -- Management ,Sanofi S.A. -- Management ,Canadians ,Evidence-based medicine ,Hypertension ,Type 2 diabetes ,Diabetes therapy ,Pharmaceutical industry ,Blood glucose ,Company business management ,Health ,Canadian Cardiovascular Society -- Management ,University of Toronto -- Management - Abstract
The Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) is a nationally endorsed guideline process, targeting primary care health care practitioners. The C-CHANGE guideline is a composite of nine of Canada's [...]
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- 2018
- Full Text
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7. Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes
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Sarafidis, Pantelis, Agarwal, Rajiv, Pitt, Bertram, Wanner, Christoph, Filippatos, Gerasimos, Boletis, John, Tuttle, Katherine R., Ruilope, Luis M., Rossing, Peter, Toto, Robert, Anker, Stefan D., Liu, Zhi-Hong, Joseph, Amer, Ahlers, Christiane, Brinker, Meike, Lawatscheck, Robert, Bakris, George, Aizenberg, Diego, Bartolacci, Inés, Besada, Diego, Bittar, Julio, Chahin, Mariano, Elbert, Alicia, Gelersztein, Elizabeth, Liberman, Alberto, Maffei, Laura, Manghi, Federico Pérez, Sanabria, Hugo, Vallejos, Augusto, Viñes, Gloria, Wassermann, Alfredo, Abhayaratna, Walter, Acharya, Shamasunder, Ekinci, Elif, Lee, Darren, MacIsaac, Richard, Mah, Peak Mann, Nelson, Craig, Packham, David, Pape, Alexia, Roger, Simon, Stephenson, Hugo, Suranyi, Michael, Wittert, Gary, Vale, Elizabeth, Colman, Peter, Colquhoun, David, Ellis, Chris, Joshua, Kim, Pedagogos, Eugenia, Regal, Paul, Topliss, Duncan, Vandeleur, James, Verjans, Johan, Wittert, Gary, Wynne, Katie-Jane, Clodi, Martin, Ebenbichler, Christoph, Fliesser-Görzer, Evelyn, Hanusch, Ursula, Krebs, Michael, Lhotta, Karl, Ludvik, Bernhard, Mayer, Gert, Neudorfer, Peter, Paulweber, Bernhard, Prager, Rudolf, Preiß, Wolfgang, Prischl, Friedrich, Schernthaner, Gerit-Holger, Sourij, Harald, Wiesholzer, Martin, Drexel, Heinz, Oberbauer, Rainer, Schönherr, Hans-Robert, Doubel, Peter, Engelen, Wendy, Gillard, Pieter, Hougardy, Jean-Michel, Krzesinski, Jean-Marie, Maes, Bart, Speeckaert, Marijn, Stas, Koen, van Gaal, Luc, Vanbelleghem, Hilde, Duyck, Francis, Scheen, André, Antunes, Daniela, Botelho, Roberto, Brito, Claudia, Canani, Luis, Canziani, Maria Eugenia, Cerqueira, Maria, de Paula, Rogerio, Eliaschewitz, Freddy, Figueiredo, Carlos Eduardo, Forti, Adriana, Hissa, Miguel, Leite, Emerson Lima Maurilo, Noronha, Irene, Paolino, Bruno, Paschoalin, Nathalia, Paschoalin, Raphael, Filho, Roberto Pecoits, Pereira, Marcio, Portes, Evandro, Precoma, Dalton, Rea, Rosangela, Riella, Miguel, Salles, Joao Eduardo, Vasconcellos, Eduardo, Vencio, Sergio, Bacci, Marcelo, Maia, Lilia, Villacorta, Aline, Apostolova, Emiliya, Boshnyashka, Radostina, Farah, Ghassan, Georgiev, Dimitar, Gushterova, Valentina, Klyuchkova, Neli, Lucheva, Mariya, Manova, Petya, Minkova, Dotska, Nonchev, Boyan, Pichmanova, Mariyana, Prakova, Zhulieta, Rangelov, Rangel, Rashkov, Rosen, Stanchev, Pavel, Stoyanovska-Elencheva, Bilyana, Tagarev, Zhivko, Temelkova-Kurktschieva, Theodora, Vasileva, Svetla, Yoncheva-Mihaylova, Mariana, Marinchev, Angel, Miteva, Mariya, Barre, Paul, Carlson, Brian, Conway, James, Cournoyer, Serge, Dumas, Richard, Fikry, Sameh, Goluch, Richard, Hamet, Pavel, Hart, Randolph, Henein, Sam, Liutkus, Joanne, Madore, Francois, Martinho, Valdemar, Mazza, Giuseppe, McFarlane, Philip, Keefe, Dennis O′, Peterson, Sean, Schwartz, Daniel, Shu, Daniel, Steele, Andrew, Tellier, Guy, Tennankore, Karthik, Tobe, Sheldon, Tsoukas, George, Tytus, Richard, Vitou, Louise, Walsh, Michael, Weisnagel, Stanley, Wilderman, Igor, Yale, Jean-Francois, El Boreky, Fadia, Kelly, Alan, Leiter, Lawrence, Teitelbaum, Ivor, Cobos, Jorge, Godoy, Juan, González, Fernando, Lobos, Sergio, Palma, Juan Carlos, Prieto Dominguez, Juan Carlos, Reyes, Eliana, Romero, Carmen, Saavedra, Victor, Vega, Mario, Medina, Marcelo, Varleta, Paola, Bu, Ruifang, Cai, Hanqing, Chen, Nan, Chen, Qinkai, Chen, Dejun, Cheng, Jinluo, Dong, Youping, Dong, Junwu, Guan, Tianjun, Hao, Chuanming, Huang, Wen, Jiang, Fangfang, Lei, Minxiang, Li, Ling, Li, Zhonghe, Li, Xuemei, Li, Jingmei, Li, Yan, Liang, Xinling, Liang, Bo, Liu, Fang, Liu, Yinghong, Liu, Yuantao, Liu, Zhihong, Long, Gang, Lu, Guoyuan, Lu, Weiping, Lu, Yibing, Luo, Ping, Ma, Jianhua, Mo, Zhaohui, Niu, Jianying, Peng, Ai, Shen, Jiansong, Shen, Feixia, Shi, Bingyin, Su, Qing, Sun, Zhuxing, Tang, Shuifu, Tong, Nanwei, Wang, Hao, Wang, Xinjun, Wang, Guixia, Wang, Jianqin, Wang, Yangang, Wang, Li, Wei, Jiali, Wu, Tianfeng, Wu, Chaoqing, Xing, Changying, Xiong, Fei, Xu, Xudong, Xu, Ning, Yan, Tiekun, Yang, Jinkui, Yin, Aiping, Zeng, Longyi, Zhang, Hao, Zhang, Yanlin, Zhang, Ying, Zhao, Wenjing, Zhao, Zhiquan, Zheng, Hongguang, Zhong, Ling, Zhu, Dalong, Zhuang, Yongze, Du, Yuming, Fang, Yi, Guo, Weiying, Jiang, Sheng, Kuang, Jian, Li, Dongmei, Li, Hongmei, Li, Yinan, Li, Yuxiu, Liu, Jian, Liu, Yu, Miao, Heng, Peng, Wen, Wang, Lihua, Xu, Mingtong, Zhong, Liyong, Zhu, Jun, Arango, Clara, Barrera, Sandra, López, Nelly Beltrán, Benitez, Diego, Blanco, Guillermo, Cadena, Andrés, Coronel, Julian, Cure, Carlos, Durán, Carlos, González, Alexander, Guzmán, Gustavo, Hernández, Eric, Ibarra, Jaime, Jaramillo, Carlos, Jaramillo, Nicolás, Kattah, William, Molina, Dora, Sánchez, Gregorio, Terront, Mónica, Trujillo, Freddy, Urina, Miguel, Vargas, Ruben, Villegas, Iván, Yupanqui, Hernán, Arcos, Edgar, Aroca, Gustavo, Barreto, Germán, Bermudez, Andres, Botero, Rodrigo, Cárdenas, Tatiana, Figueroa, Wilmer, Jaramillo, Mónica, Liévano, Manuel, López, Mónica, Molina, Dora, Rosero, Ricardo, Trillos, Pedro, Alferi, Dino, Brada, Michal, Brezina, Jiri, Bucek, Petr, Edelsberger, Tomas, Gulakova, Drahomira, Zapletalova, Jitka Hasalova, Hola, Olga, Hornova, Lucie, Houdova, Jana, Hrmova, Helena, Karasek, David, Kopecka, Sarka, Kovar, Richard, Krcova, Eva, Kuchar, Jiri, Kutejova, Vlasta, Lubanda, Hana, Matyasek, Ivo, Mokrejsova, Magdalena, Okenka, Libor, Prazny, Martin, Pumprla, Jiri, Tomanek, Pavel, Andersen, Ulla, Andries, Alin, Bech, Jesper, Faber, Jens, Gislason, Gunnar, Hangaard, Jørgen, Pacyk, Grzegorz Jaroslaw, Juhl, Claus, Krarup, Thure, Lindhardt, Morten, Madsbad, Sten, Nielsen, Joan, Pedersen-Bjergaard, Ulrik, Poulsen, Per, Rasmussen, Ole, Rossing, Peter, Schousboe, Karoline, Gram, Jeppe, Lauridsen, Thomas, Pedersen, Erling, Thorsteinsson, Birger, Flöjt, Päivi, Honkasalo, Mikko, Honkasalo, Mikko, Humaloja, Kari, Kananen, Kristiina, Kantola, Ilkka, Koistinen, Arvo, Korsoff, Pirkko, Lahtela, Jorma, Nieminen, Sakari, Nieminen, Tuomo, Sadeharju, Karita, Strand, Jorma, Sulosaari, Sakari, Cariou, Bertrand, Chantrel, François, Clavel, Sylvaine, Combe, Christian, Fauvel, Jean-Pierre, Gallouj, Karim, Gouet, Didier, Guerci, Bruno, Guerrot, Dominique, Hourmant, Maryvonne, Klein, Alexandre, Mariat, Christophe, Marre, Michel, Mesbah, Rafik, Le Meur, Yannick, Monier, Arnaud, Moranne, Olivier, Roussel, Ronan, Serusclat, Pierre, Vendrely, Benoit, Verges, Bruno, Zaoui, Philippe, Axthelm, Christoph, Bergmann, Andreas, Birkenfeld, Andreas L., Braun, Hermann, Busch, Klaus, Contzen, Christel, Degenhardt, Stefan, Derwahl, Karl, Giebel, Thomas, Hagenow, Andreas, Haller, Hermann, Hasslacher, Christoph, Horacek, Thomas, Jungmair, Wolfgang, Kloos, Christof, Koch, Thorsten, Krüger, Thilo, Mühlfeld, Anja, Müller, Joachim, Pfützner, Andreas, Pistrosch, Frank, Rinke, Andrea, Rose, Ludger, Rump, Lars, Schettler, Volker, Schiefke, Ingolf, Schlichthaar, Heike, Schröppel, Bernd, Schöll, Norbert, Schubert, Kristin, Schürholz, Thomas, Sigal, Helena, Stemler, Lutz, Strack, Georg, Täschner, Heidrun, Toursarkissian, Nicole, Tschöpe, Diethelm, Ulmer, Achim, van der Giet, Markus, Wanner, Christoph, Winkelmann, Bernhard R., Boletis, Ioannis, Dimitriadis, George, Hatziagelaki, Erifili, Iatrou, Christos, Ioannidis, Ioannis, Kounadi, Theodora, Makriniotou, Ioanna, Papadopoulou, Dorothea, Papagianni, Aikaterini, Passadakis, Ploumis, Piaditis, George, Stefanidis, Ioannis, Ip, Tai Pang, Lee, Paul, Andrea Luk, On Yan, Ma, Ronald, Chow, Wing Sun, Wang, Angela, Yeung, Vincent, Bajcsi, Dora, Danos, Peter, Harcsa, Eleonora, Kalina, Akos, Kazup, Szilvia, Keltai, Katalin, Kirschner, Robert, Kiss, Julianna, Kovacs, Laszlo, Lamboy, Beata, Literati-Nagy, Botond, Mileder, Margit, Nagy, Laszlo, Noori, Ebrahim, Nyirati, Gabor, Petro, Gizella, Schneider, Karoly, Simon, Judit, Szocs, Albert, Vasas, Szilard, Wudi, Krisztina, Zilahi, Zsolt, Zsom, Marianna, Eustace, Joe, Holian, John, Reddan, Donal, Meara, Yvonne O′, Abramof Ness, Rosane, Adawi, Faiad, Armaly, Zaher, Atar, Shaul, Bashkin, Amir, Ben Chetrit, Sydney, Yanay, Noa Berar, Chernin, Gil, Darawsha, Mahmud, Efrati, Shai, Elias, Mazen, Farber, Evgeny, Glandt, Mariela, Grossman, Ehud, Halabi, Majdi, Harman-Boehm, Ilana, Khazim, Khaled, Liberty, Idit, Minuchin, Oscar, Mosenzon, Ofri, Nakhoul, Farid, Nimer, Assy, Schwartz, Doron, Wainstein, Julio, Yagil, Yoram, Zukermann, Robert, Avogaro, Angelo, Battaglia, Giovanni Giorgio, Bevilacqua, Maurizio Tiziano, Bonora, Enzo, Bossi, Carlo Antonio, Calabrò, Paolo, Cavalot, Franco Luigi, Cimino, Roberto, Cozzolino, Mario Gennaro, David, Salvatore, Emdin, Michele, Fiaccadori, Enrico, Fiorina, Paolo, Giorda, Carlo Bruno, Gregorini, Maria Cristina, La Manna, Gaetano, Maggi, Davide Carlo, Manti, Roberta, Meregalli, Giancarla, Pani, Antonello, Parvanova, Aneliy Ilieva, Perico, Norberto, Piatti, PierMarco, Pisani, Antonio, Pontiroli, Antonio Ettore, Ponzani, Paola, Santorelli, Gennaro, Santoro, Domenico, Scanziani, Renzo, Teatini, Ugo, Tonolo, Giancarlo, Trevisan, Roberto, Veronelli, Anna Maria, Viviani, Giorgio Luciano, Araki, Hideo, Bando, Yukihiro, Ebisui, Osamu, Fujita, Naruhiro, Fukasawa, Hirotaka, Furuya, Ryuichi, Hamamoto, Yoshiyuki, Hamasaki, Akihiro, Hasegawa, Kotaro, Hatazaki, Masahiro, Hayashi, Terumasa, Higashi, Takayuki, Hirohata, Yoshihide, Horinouchi, Shuji, Hoshi, Ayumu, Imoto, Hirofumi, Inagaki, Akemi, Inagaki, Masayuki, Inaguma, Daijo, Inoue, Toshihiko, Ishii, Masao, Ishiko, Tamayo, Isono, Motohide, Jinnouchi, Hideaki, Kanai, Hidetoshi, Kanda, Daisuke, Kanehara, Hideo, Kashima, Masayuki, Kataoka, Yuko, Katayama, Shigehiro, Kato, Kiyoe, Katsuki, Takeshi, Kawamitsu, Katsunori, Kawasaki, Satsuki, Kikuchi, Fumi, Kikuchi, Hidetoshi, Kishimoto, Rui, Kobayashi, Kunihisa, Koide, Junko, Komi, Rieko, Kubota, Miyuki, Kuriya, Genpei, Kurose, Takeshi, Kusano, Yoshiro, Hajime, Maeda, Matsubayashi, Sunao, Matsumoto, Kazunari, Matsumura, Naoya, Matsuo, Yasuto, Matsuoka, Naoki, Miyaoka, Hiroaki, Miyata, Satoshi, Morita, Takeshi, Murakami, Isao, Murao, Satoshi, Nakamura, Udai, Nakayama, Mikihiro, Nakazawa, Jun, Nohara, Sakae, Nomiyama, Takashi, Noritake, Masayuki, Oda, Yoshiaki, Ogiwara, Takayuki, Ohashi, Hiroshi, Okamoto, Hideki, Okino, Shinichi, Osonoi, Takeshi, Sasaki, Nobuhiro, Sayo, Yoshitaka, Sekigami, Taiji, Shibasaki, Taro, Shibata, Hirotaka, Shimoyama, Tatsushi, Shinoda, Junji, Sobajima, Hiroshi, Sugitatsu, Kazuya, Sugiura, Toshiyuki, Sugiyama, Toru, Suzuki, Daisuke, Suzuki, Hiroyuki, Suzuki, Masaaki, Takeda, Asami, Tanaka, Asami, Tanaka, Seiichi, Tsunematsu, Izumi, Ueda, Yasuo, Uekihara, Soichi, Ujihara, Makoto, Yajima, Ken, Yamada, Daishiro, Yamada, Masayo, Yamagata, Kazuo, Yamakawa, Ken, Yamakawa, Fumiko, Yamasaki, Yoshimitsu, Yambe, Yuko, Yanagida, Taihei, Yanai, Hidekatsu, Yanase, Toshihiko, Yasuda, Tetsuyuki, Kriauciuniene, Dovile, Lasiene, Jurate, Navickas, Antanas, Radzeviciene, Lina, Urbanaviciene, Egle, Urbonas, Gediminas, Velaviciene, Audrone, Abd Ghani, Rohana, Aziz, Nor Azizah, Lee, Li Yuan, Loh, Chek Loong, Ali, Norhaliza Mohd, Noor, Nurain Mohd, Fatnoon Nik Ahmad, Nik Nur, Ratnasingam, Jeyakantha, Halimi Bin Wan Hasan, Wan Hasnul, Izani Wan Mohamed, Wan Mohd, Khir, Rizmy Najme, Mohamad, Masni, Alexander Tan, Tong Boon, Avila Pardo, Sandro, Adrian, Miriam Bastidas, Wong, Alfredo Chew, Escobedo de la Peña, Jorge, Salmón, Guillermo Fanghänel, Gálvez, Guillermo González, Ochoa, Ramiro Gutiérrez, Santana, Saúl Irizar, Rovalo, Magdalena Madero, Machado, Gustavo Méndez, Ruiz, Luis Nevarez, Ibarra, Denisse Ramos, López, Gabriel Ramos, Reyna, Leobardo Sauque, Ortiz, Gustavo Solache, Ortiz, Rafael Valdez, Mesa, Juan Villagordoa, Salazar, Melchor Alpizar, Hernández, Pedro García, González, José, Soto, José Lazcano, Mendoza, Arturo Saldaña, Santana, Sergio Irizar, Vilchis, Elvira González, Bakker, R.C., Barendregt, J.N.M., Boonstra, A.H., Bos, Willem, Brouwer, C.B., Buren, M. van, Gansevoort, Ron, Kooy, Adriaan, Krekels, Marielle, Leendert, Ruud J.M. van, Lieverse, Louis A.G., Luik, P.T., Penne, E. Lars, Gregoor, Peter Smak, Vogt, Liffert, Born, Bert-Jan van den, Baker, John, Crawford, Veronica, Cutfield, Rick, Dunn, Peter, Krebs, Jeremy, Nirmalaraj, Kingsley, Scott, Russell, Smuts, Nine, Titchener, Janet, Eriksen, Erik, Finnes, Trine, Høivik, Hans, Karlsson, Thomas, Munk, Peter Scott, Radtke, Maria, Risberg, Knut, Rocke, Jan, Solnør, Leidulv, Stenehjem, Aud-Eldrid, Tafjord, Anne-Beathe, Asprusten, Emil, Hagemeier, Robert, Høye, Kjetil, Selsås, Hilde, Thorup, Frode, Wium, Cecilie, Pamugas, Glenda, Panelo, Araceli, Perez, Ronald, Tanque, Maribel, Tirador, Louie, Villa, Michael, Bautista, Albert, Catindig, Elizabeth, Manalo, Carlo, Mirasol, Roberto, Butrymowicz, Patrycja, Ciechanowski, Kazimierz, Cieslik, Grazyna, Franek, Edward, Gumprecht, Janusz, Hoffmann, Michal, Krzykowska, Jolanta, Kurnatowska, Ilona, Landa, Katarzyna, Madrzejewski, Adam, Madziarska, Katarzyna, Mazur, Stanislaw, Napora, Piotr, Nowicki, Michal, Ocicka-Kozakiewicz, Anna, Rewerska, Barbara, Rusicka, Teresa, Ruxer, Jan, Skokowska, Ewa, Stankiewicz, Andrzej, Stompor, Tomasz, Tiuryn-Petrulewicz, Agnieszka, Wasilewska, Katarzyna, Wierusz-Wysocka, Bogna, Wnetrzak-Michalska, Renata, Jedynasty, Krystyna, Anand, Izabela Sein, Almeida, Edgar, Ballesteros, Rosa, Barreto, Carlos, Beirao, Idalina, Birne, Rita, Esteves, Cesar, Guia, Jose, Heitor, Susana, Marques, Olinda, Melo, Pedro, Nolasco, Fernando, Pereira, Amalia, Roque, Cristina, Rosario, Francisco, Silva, Gil, Silva, Ana, Teixeira e Costa, Fernando, Lobos, Ana Vila, Alves, Ana Rita, Brandao, Ilidio, Carvalho, Rui, Coelho, Joao, Lourenco, Ana, Matos, Pedro, Rosario, Vanisa, Neves, Joao Sergio, Cortes-Maisonet, Gregorio, Roman-Miranda, Amaury, Brito-Peguero, Yudit, Colon-Vega, Gildred, Albota, Adrian, Bala, Cornelia, Barbonta, Hortensia, Caceaune, Elena, Catrinoui, Doina, Constantin, Ciprian, Dumitrescu, Adriana, Mindrescu, Nicoleta, Mistode, Cristina, Negrisanu, Gabriela, Onaca, Adriana, Paveliu, Silvia, Pintilei, Ella, Pop, Lavinia, Popa, Amorin, Popescu, Alexandrina, Radulian, Gabriela, Szilagyi, Iosif, Turcu, Liana, Vacaru, Georgeta, Vlad, Adrian, Filimon, Adriana, Veresiu, Ioan, Antsiferov, Mikhail, Arkhipov, Mikhail, Babkin, Andrey, Barbarash, Olga, Baranov, Vitaliy, Chernyavskaya, Elena, Demko, Arkadiy, Dreval, Alexander, Edin, Anton, Ermakova, Polina, Fadeev, Valentin, Galyavich, Albert, Gaysina, Leyla, Gordeev, Ivan, Ipatko, Irina, Kalashnikova, Marina, Khalimov, Yuriy, Klimontov, Vadim, Kobalava, Zhanna, Kosmacheva, Elena, Koziolova, Natalya, Sergey Levashov, Lyudmila Kvitkova, Libis, Roman, Marasaev, Vyacheslav, Malykh, Natalia, Martynenko, Vladimir, Malyutina, Sofya, Merai, Imad, Mkrtumyan, Ashot, Nechaeva, Galina, Petunina, Nina, Palyutin, Shamil, Pimenov, Leonid, Rechkova, Elena, Rodionova, Tatyana, Rymar, Oksana, Sardinov, Ruslan, Semenova, Olga, Sherenkov, Alexander, Solovev, Oleg, Smolyarchuk, Elena, Strongin, Leonid, Ukhanova, Olga, Verlan, Nadezhda, Vorokhobina, Natalya, Yakhontov, Davyd, Yakushin, Sergey, Zakharova, Elena, Zalevskaya, Alsu, Zanozina, Olga, Zhdanova, Elena, Zhukova, Larisa, Zykova, Tatyana, Argunova, Yulia, Nikolaev, Konstantin, Villevalde, Svetlana, Fang Sum, Chee, Suhail, Sufi Muhummad, San Tan, Ru, Vathsala, Anantharaman, Wong, Edmund, Bee, Yong Mong, Babikova, Jana, Buganova, Ingrid, Dzupina, Andrej, Ochodnicka, Zuzana, Sosovec, Dalibor, Spodniakova, Denisa, Minarik, Peter, Ahmed, Fayzal, Amod, Aslam, Bhana, Sindeep, Distiller, Larry, Jansen van Rensburg, Dirkie, Joshi, Mukesh, Joshi, Shaifali, Lakha, Deepak, Mitha, Essack, Podgorski, Gracjan, Ranjith, Naresh, Rayner, Brian, Rheeder, Paul, Sarvan, Mohamed, Seeber, Mary, Siebert, Heidi, Tayob, Mohammed, Trokis, Julien, Urbach, Dorothea, van Zyl, Louis, Jansen van Rensburg, Dirkie, Choi, Bum-Soon, Choi, Moon Gi, Chung, ChoonHee, Hwang, YouCheol, Kim, ChongHwa, Kim, InJoo, Kim, JaeHyeon, Kim, SinGon, Kim, SungGyun, Kim, Tae Hee, Lee, WooJe, Lee, ByungWan, Lee, Kang Wook, Oh, Kook-Hwan, Oh, Ji Eun, Oh, Yun Kyu, Oh, Dong-Jin, Park, Junbeom, Shin, Seok Joon, Sung, Su-Ah, Yu, Jae Myung, Chung, HyeSoo, Huh, Ji Hye, Kang, JunGoo, Kim, ChulSik, Kim, HyeSoon, Kim, NamHoon, Lim, Soo, Cho, Young Min, Park, Cheol Young, Agraz, Irene, Ampudia, Francisco Javier, Bouarich, Hanane, Calero, Francesca, Castro, Cristina, Guldris, Secundino Cigarrán, Garrit, Josep Cruzado, de Álvaro, Fernando, Galcerán, Josep, Albarrán, Olga González, Jaras, Julio Hernández, Ibernón, Meritxell, Deben, Francisco Martínez, Ma, Esteban, Dolores Martínez, Pascual Izuel, José María, Martins, Judith, Mediavilla, Juan, Michán, Alfredo, Santos, Julio Pascual, Poch, Esteban, Rusillo, Manuel Polaina, Juan, Carlos Sánchez, Olmo, Rafael Santamaría, Segura de la Morena, José Julián, Soto, Alfonso, Troya, Maribel, Castro, Fernando Cereto, Fernández, Pablo Gómez, Sánchez, Laura Fuentes, Moya, Mercedes González, Marrero, Domingo Hernández, Maroto, Gonzalo Piedrola, Redón, Josep, Seron, Daniel, Bruchfeld, Annette, Curiac, Dan, Eliasson, Ken, Frank, Malin, Guron, Gregor, Hellberg, Olof, Hellgren, Margareta, Larnefeldt, Hans, Lindholm, Carl-Johan, Löndahl, Magnus, Rein-Hedin, Erik, Soveri, Inga, Spaak, Jonas, Tengmark, Bengt-Olov, Lif-Tiberg, Cornelia, Månflod, Johan, Nguyen, Han, Ackermann, Daniel, Bilz, Stefan, Burnier, Michel, Forster, Christian, Kalbermatter, Stefan, Kistler, Andreas, Pechère-Bertschi, Antoinette, Schultes, Bernd, Laimer, Markus, Rudofsky, Gottfried, Strey, Christopher, Wuerzner, Gregoire, Chang, Chiz-Tzung, Hung, Cheng-Chieh, Jiang, Ju-Ying, Lee, Chien-Te, Lin, Shuei-Liong, Tarng, Der-Cherng, Tu, Shih-Te, Wu, Mai-Szu, Wu, Ming-Ju, Chuang, Lee-Ming, Deerochanawong, Chaicharn, Kitiyakara, Chagriya, Ophascharoensuk, Vuddhidej, Pongchaiyakul, Chatlert, Satirapoj, Bancha, Kosachunhanan, Natapong, Sritara, Piyamitr, Eren, Necmi, Gul, Ibrahim, Gulel, Okan, Kocyigit, Ismail, Kumbasar, Abdulbaki, Sahin, Idris, Sari, Ramazan, Sayin, Burak, Tavli, Talat, Ustundag, Sedat, Yenicerioglu, Yavuz, Badak, Ozer, Cayli, Murat, Oguz, Aytekin, Ozdogan, Oner, Sari, Ibrahim, Temizhan, Ahmet, Tigen, Mustafa, Turk, Ugur, Yilmaz, Huseyin, Yilmaz, Mehmet, Bondarets, Iryna, Botsyurko, Volodymyr, Chernikova, Viktoriia, Donets, Oleksandra, Fushtey, Ivan, Grachova, Mariia, Isayeva, Anna, Kogut, Dmytro, Komisarenko, Julia, Kravchun, Nonna, Malyar, Kateryna, Mankovsky, Borys, Martynyuk, Liliya, Maslyanko, Vitaliy, Myshanych, Halyna, Pererva, Larysa, Pertseva, Nataliia, Serhiyenko, Oleksandr, Smirnov, Ivan, Sokolova, Liubov, Stryzhak, Vasyl, Vlasenko, Maryna, Isayeva, Ganna, Larin, Oleksandr, AbouSaleh, Ahmad, Barratt, Jonathan, Dang, Cuong, Kahal, Hassan, Kirk, Adam, Kilvert, Anne, Kon, Sui Phi, McCafferty, Kieran, Patel, Dipesh, Rice, Sam, Vijayaraman, Arutchelvam, Wong, Yuk-ki, Gibson, Martin, Wahba, Mona, Zaidi, Reza, Bilous, Rudy, Johnson, Andrew, Kalathil, Dhanya, Kilvert, Anne, Kyriakidou, Christina, Mathew, Amit, Mukhtar, Rasha, Munsoor, Imrozia, Poterajlo, Anton, Swift, Pauline, Acosta, Idalia, Adams, Atoya, Adler, Sharon, Ajani, Dilawar, Ali, Slamat, Alicic, Radica, Al-Karadsheh, Amer, Alla, Sreedhara, Allison, D., Andrawis, Nabil, Arif, Ahmed, Awad, Ahmed, Azizad, Masoud, Bahrami, Michael, Bansal, Shweta, Barag, Steven, Barakzoy, Ahmad, Barney, Mark, Barzilay, Joshua, Bashir, Khalid, Bautista, Jose, Beddhu, Srinivasan, Belo, Diogo, Benjamin, Sabrina, Berenji, Ramin, Bhargava, Anuj, Birriel, Jose, Brietzke, Stephen, Brosius, Frank, Brusco, Osvaldo, Burgner, Anna, Busch, Robert, Canadas, Rafael, Caramori, Maria, Cardona, Jose, Case, Christopher, Cruz, Humberto, Dandillaya, Ramprasad, Dawoud, Dalia, Din, Zia, Dixon, Bradley, Doshi, Ankur, Drakakis, James, El Shahawy, Mahfouz, El-Meanawy, Ashraf, El-Shahawy, Mohammed, Evans, John, Fadda, George, Farooq, Umar, Fernando, Roland, Fink, Raymond, First, Brian, Fitz-Patrick, David, Flack, John, Fluck, Patrick, Fogelfeld, Leon, Fonseca, Vivian, Frias, Juan, Galphin, Claude, Garcia-Mayol, Luis, Goldstein, Gary, Gonzalez, Edgar, Gonzalez-Abreu, Francisco, Gore, Ashwini, Grant, David, Habwe, Violet, Hamilton, Maxine, Hammoud, Jamal, Handelsman, Stuart, Hartman, Israel, Heigerick, Glenn, Henry, Andrew, Hernandez, German, Hernandez-Cassis, Carlos, Herrera, Carlos, Hertel, Joachim, Huang, Wenyu, Iglesias, Rogelio, Iranmanesh, Ali, Jackson, Timothy, Jain, Mahendra, Jamerson, Kenneth, Johnson, Karen, Judd, Eric, Kaplan, Joshua, Kayali, Zeid, Khan, Bobby, Khan, Muhammad, Kharait, Sourabh, Kirkman, M. Sue, Kopyt, Nelson, Kotzker, Wayne, Kovesdy, Csaba, Kreit, Camil, Krishna, Arvind, Kronfli, Saeed, Lee, Keung, LeJeune, Derek, Lemus, Brenda, Leon-Forero, Carlos, Linfert, Douglas, Lora, Henry, Lurie, Alexander, Maddukuri, Geetha, Magno, Alexander, Maletz, Louis, Mandayam, Sreedhar, Markell, Mariana, Mayfield, Ronald, Mbogua, Caroline, McMullen, Dierdre, Meisner, Carl, Minton, Stephen, Mocherla, Bharat, Mohandas, Rajesh, Montero, Manuel, Moustafa, Moustafa, Nadkarni, Salil, Nakhle, Samer, Navarro, Jesus, Neyra, Nilda, Nica, Romanita, Nicol, Philip, Norwood, Paul, Numrungroad, Visal, Donovan, Richard O′, Odugbesan, A., Paoli-Bruno, Jorge, Parikh, Samir, Patel, Rakesh, Peixoto, Aldo, Pergola, Pablo, Perlman, Alan, Pettis, Karlton, Pisoni, Roberto, Ponduchi, Mirela, Posada, Jorge, Prabhakar, Sharma, Radhakrishnan, Jai, Rahman, Mahboob, Raina, Rupesh, Rastogi, Anjay, Reisin, Efrain, Rendell, Marc, Robertson, David, Rocco, Michael, Romeu, Hugo, Rosas, Sylvia, Rosenfeld, Jack, Ross, Dennis, Rothman, Jeffrey, Rudolph, Lance, Ruhullah, Yusuf, Ruoff, Gary, Ryu, Jeffrey, Sahani, Mandeep, Sam, Ramin, Samuels, Garfield, Sanchez, William, Santos, Vladimir, Satko, Scott, Saxena, Sanjeev, Scott, David, Seco, Gilberto, Seek, Melvin, Serota, Harvey, Shafi, Tariq, Shahid, Nauman, Shanik, Michael, Sharma, Santosh, Sinha, Arjun, Smelser, James, Smith, Mark, Soe, Kyaw, Solomon, Richard, Soroka, Eugene, Soufer, Joseph, Spinowitz, Bruce, Spry, Leslie, Suarez, Rosa, Subramanian, Bala, Szerlip, Harold, Tamirisa, Aparna, Thomson, Stephen, Tran, Tuan-Huy, Treger, Richard, Trullenque, Gretel, Turk, Thomas, Umpierrez, Guillermo, Urbach, Daniel, Valdes, Martin, Valika, Shujauddin, Vega, Damaris, Weissman, Peter, Whaley-Connell, Adam, Winston, Jonathan, Wise, Jonathan, Wynne, Alan, Zeig, Steven, Abdel-Rahman, Emaad, Abreu, Edel, Awad, Alaa, Bahri, Nader, Bertsch, John, Bleich, David, Bornfreund, Jonathan, Brar, Harjeet, Brian, Susan, Brinson, Cynthia, Bruschetta, Humberto, Carpio, Jose, Cohen, Steven, Cosby, John, Dhanireddy, Soni, Diaz, Jorge, Dunn, Fredrick, Eppanapally, Sabitha, Fayad, Joseph, Goel, Archana, Govindaraju, Kanakadurga, Halpern, Stephen, Jones, Audrey, Kaye, William, Knight, Herbert, Koch, Stanley, Kohli, Nandini, Lastra, Guido, Lerman, Sam, Loredo, Jorge, Lovre, Dragana, Mandviwala, Mustafa, Martin, Earl, Meyer, Jill, Murray, John, Oliver, David, Oparil, Suzanne, Penabad, Jesus, Pereira, Isabel, Popeil, Larry, Quesada, Gonzalo, Ramanathan, Kodangudi, Ramos-Gonez, Luis, Rastegar, Mandana, Rastogi, Padmashri, Rondon, Juan, Roy-Chaudhury, Prabir, Smith, David, Williamson, Don, Womack, Catherine, Yamout, Hala, Yuryev, Michael, Chu, Phuong, Van Hoang, Lam, Khanh, Tran, Phi Nga, Nguyen Thi, Son, Pham Nguyen, Tran, Lan Phuong, Le, Thuy Khuong, Nguyen, Boi Ngoc, Nguyen, Thao, Nui, Nguyen Minh, Nam, Tran Quang, and Tran, Kim Chi
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- 2023
- Full Text
- View/download PDF
8. Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE): 2014 update
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Tobe, Sheldon W., Stone, James A., Walker, Kimberly M., Anderson, Todd, Bhattacharyya, Onil, Cheng, Alice Y.Y., Gregoire, Jean, Gubitz, Gord, L'Abbe, Mary, Lau, David C.W., Leiter, Lawrence A., Oh, Paul, Padwal, Raj, Poirier, Luc, Selby, Peter, Tremblay, Mark, Ward, Richard A., Hua, Diane, and Liu, Peter P.
- Subjects
Practice guidelines (Medicine) -- Analysis ,Cardiovascular diseases -- Care and treatment -- Research ,Health - Abstract
In Canada, the multiple chronic conditions and cardiovascular risk factors of our aging population continue to challenge health care providers and burden health systems. Cardiovascular disease is a major contributor [...]
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- 2014
- Full Text
- View/download PDF
9. Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure
- Author
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Smeijer, J. David, Koomen, Jeroen, Kohan, Donald E., McMurray, John J.V., Bakris, George L., Correa-Rotter, Ricardo, Hou, Fan-Fan, Januzzi, James L., Kitzman, Dalane W., Kolansky, Daniel M., Makino, Hirofumi, Perkovic, Vlado, Tobe, Sheldon, Parving, Hans-Henrik, de Zeeuw, Dick, and Heerspink, Hiddo J.L.
- Abstract
The endothelin receptor antagonist atrasentan reduced the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) in the SONAR (Study of Diabetic Nephropathy with Atrasentan) trial, although with a numerically higher incidence of heart failure (HF) hospitalization.
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- 2022
- Full Text
- View/download PDF
10. Risks and benefits of intensive blood pressure lowering in patients with type 2 diabetes
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Rabi, Doreen M., Padwal, Raj, Tobe, Sheldon W., Gilbert, Richard E., Leiter, Lawrence A., Quinn, Robert R., and Khan, Nadia
- Subjects
Merck & Company Inc. ,Bristol-Myers Squibb Co. ,Novartis AG ,AstraZeneca PLC ,Sanofi S.A. ,Stroke (Disease) -- Complications and side effects -- Care and treatment ,Blood pressure ,Type 2 diabetes -- Complications and side effects -- Care and treatment ,Pharmaceutical industry ,Hypertension -- Complications and side effects -- Care and treatment ,Health ,Care and treatment ,Complications and side effects - Abstract
The debate about appropriate blood pressure targets for patients with hypertension and diabetes is of substantial public health importance because the global burden of diabetes and hypertension is large and [...]
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- 2013
- Full Text
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11. Harmonization of guidelines for the prevention and treatment of cardiovascular disease: the C-CHANGE initiative
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Tobe, Sheldon W., Stone, James A., Brouwers, Melissa, Bhattacharyya, Onil, Walker, Kimberly M., Dawes, Martin, Genest, Jr., Jacques, Grover, Steven, Gubitz, Gordon, Lau, David, Pipe, Andrew, Selby, Peter, Tremblay, Mark S., Warburton, Darren E.R., Ward, Richard, Woo, Vincent, Leiter, Lawrence A., and Liu, Peter P.
- Subjects
Merck & Company Inc. -- Management ,Pfizer Inc. -- Management ,Bristol-Myers Squibb Co. -- Management ,Cholesterol -- Health aspects ,Infection control -- Health aspects ,Cardiovascular diseases -- Care and treatment -- Health aspects ,Pharmaceutical industry -- Health aspects ,Company business management ,Health - Abstract
Cardiovascular disease is the most prevalent chronic medical condition in Canada, and evidence-based management of risk factors for cardiovascular disease can reduce morbidity and mortality. (1) However, there are more [...]
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- 2011
- Full Text
- View/download PDF
12. Guidelines for the management of chronic kidney disease
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Levin, Adeera, Hemmelgarn, Brenda, Culleton, Bruce, Tobe, Sheldon, McFarlane, Philip, Ruzicka, Marcel, Burns, Kevin, Manns, Braden, White, Colin, Madore, Francoise, Moist, Louise, Klarenbach, Scott, Barrett, Brendan, Foley, Robert, Jindal, Kailash, Senior, Peter, Pannu, Neesh, Shurraw, Sabin, Akbari, Ayub, Cohn, Adam, Reslerova, Martina, Deved, Vinay, Mendelssohn, David, Nesrallah, Gihad, Kappel, Joanne, and Tonelli, Marcello
- Subjects
Company business management ,Bristol-Myers Squibb Co. -- Management ,Merck & Company Inc. -- Management ,Novartis AG -- Management ,Roche Holding AG -- Management ,Kidney diseases -- Care and treatment ,Pharmaceutical industry ,Cholesterol ,Antilipemic agents - Abstract
New guidelines for the management of chronic kidney disease have been developed by the Canadian Society of Nephrology (Appendix 1 contains the fulltext guidelines; available at www.cmaj.ca/cgi/content/full/179/11/1154/DC1). These guidelines describe [...]
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- 2008
13. Effect of nurse-directed hypertension treatment among First Nations people with existing hypertension and diabetes mellitus: the Diabetes Risk Evaluation and Microalbuminuria (DREAM 3) randomized controlled trial
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Tobe, Sheldon W., Pylypchuk, George, Wentworth, Joan, Kiss, Alexander, Szalai, John Paul, Perkins, Nancy, Hartman, Susan, Ironstand, Laurie, and Hoppe, Jacqueline
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Canadian native peoples -- Diseases ,Canadian native peoples -- Care and treatment ,Diabetes -- Care and treatment ,Hypertension -- Care and treatment - Abstract
ABSTRACT Background: First Nations people with diabetes mellitus and hypertension are at greater risk of renal and cardiovascular complications than are non-native patients because of barriers to health care services. [...]
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- 2006
14. Applying the 2005 Canadian Hypertension Education Program recommendations: 5. Therapy for patients with hypertension and diabetes mellitus
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Tobe, Sheldon, McAlister, Finlay A., and Leiter, Lawrence
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Hypertension -- Drug therapy ,Hypertension -- Case studies ,Diabetes -- Drug therapy ,Diabetes -- Case studies ,Antihypertensive drugs -- Dosage and administration ,Hypoglycemic agents -- Dosage and administration - Abstract
The number of people with diabetes is expected to double within a decade. Most people with diabetes have or will develop hypertension, and observational and randomized trial evidence has proven [...]
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- 2005
15. The Effect of Atrasentan on Kidney and Heart Failure Outcomes by Baseline Albuminuria and Kidney Function
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Waijer, Simke W., Gansevoort, Ron T., Bakris, George L., Correa-Rotter, Ricardo, Hou, Fan-Fan, Kohan, Donald E., Kitzman, Dalane W., Makino, Hirofumi, McMurray, John J.V., Perkovic, Vlado, Tobe, Sheldon, Parving, Hans-Henrik, de Zeeuw, Dick, and Heerspink, Hiddo J.L.
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- 2021
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16. Bioavailability of oral curcumin
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Garg, Amit X., Moist, Louise, Pannu, Neesh, Tobe, Sheldon, Walsh, Michael, and Weir, Matthew
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Health - Abstract
In our research article, we conclude that the regimen of curcumin we tested exerted no beneficial pharmacodynamic effect on the outcomes we assessed in the setting of elective abdominal aortic [...]
- Published
- 2019
17. Pharmacokinetics of single and chronic dose zidovudine in two HIV positive patients undergoing continuous ambulatory peritoneal dialysis (CAPD)
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Gallicano, Keith D., Tobe, Sheldon, Sahai, Jan, McGilveray, Iain J., Cameron, D. William, Kriger, Frank, and Garber, Gary
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Continuous ambulatory peritoneal dialysis -- Physiological aspects ,HIV infection -- Complications ,Zidovudine -- Physiological aspects ,Pharmacokinetics -- Research ,Chronic kidney failure -- Care and treatment ,Health - Published
- 1992
18. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease
- Author
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Cheung, Alfred K., Chang, Tara I., Cushman, William C., Furth, Susan L., Hou, Fan Fan, Ix, Joachim H., Knoll, Gregory A., Muntner, Paul, Pecoits-Filho, Roberto, Sarnak, Mark J., Tobe, Sheldon W., Tomson, Charles R.V., and Mann, Johannes F.E.
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- 2021
- Full Text
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19. Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease
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Cheung, Alfred K., Chang, Tara I., Cushman, William C., Furth, Susan L., Hou, Fan Fan, Ix, Joachim H., Knoll, Gregory A., Muntner, Paul, Pecoits-Filho, Roberto, Sarnak, Mark J., Tobe, Sheldon W., Tomson, Charles R.V., Lytvyn, Lyubov, Craig, Jonathan C., Tunnicliffe, David J., Howell, Martin, Tonelli, Marcello, Cheung, Michael, Earley, Amy, and Mann, Johannes F.E.
- Abstract
The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease for patients not receiving dialysis represents an update to the KDIGO 2012 guideline on this topic. Development of this guideline update followed a rigorous process of evidence review and appraisal. Guideline recommendations are based on systematic reviews of relevant studies and appraisal of the quality of the evidence. The strength of recommendations is based on the “Grading of Recommendations Assessment, Development and Evaluation” (GRADE) approach. The scope includes topics covered in the original guideline, such as optimal blood pressure targets, lifestyle interventions, antihypertensive medications, and specific management in kidney transplant recipients and children. Some aspects of general and cardiovascular health, such as lipid and smoking management, are excluded. This guideline also introduces a chapter dedicated to proper blood pressure measurement since all large randomized trials targeting blood pressure with pivotal outcomes used standardized preparation and measurement protocols adhered to by patients and clinicians. Based on previous and new evidence, in particular the Systolic Blood Pressure Intervention Trial (SPRINT) results, we propose a systolic blood pressure target of less than 120 mm Hg using standardized office reading for most people with chronic kidney disease (CKD) not receiving dialysis, the exception being children and kidney transplant recipients. The goal of this guideline is to provide clinicians and patients a useful resource with actionable recommendations supplemented with practice points. The burden of the recommendations on patients and resources, public policy implications, and limitations of the evidence are taken into consideration. Lastly, knowledge gaps and recommendations for future research are provided.
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- 2021
- Full Text
- View/download PDF
20. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
- Author
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Heerspink, Hiddo J L, Parving, Hans-Henrik, Andress, Dennis L, Bakris, George, Correa-Rotter, Ricardo, Hou, Fan-Fan, Kitzman, Dalane W, Kohan, Donald, Makino, Hirofumi, McMurray, John J V, Melnick, Joel Z, Miller, Michael G, Pergola, Pablo E, Perkovic, Vlado, Tobe, Sheldon, Yi, Tingting, Wigderson, Melissa, de Zeeuw, Dick, Elbert, Alicia, Vallejos, Augusto, Alvarisqueta, Andres, Maffei, Laura, Juncos, Luis, de Arteaga, Javier, Greloni, Gustavo, Farias, Eduardo, Zucchini, Alfredo, Vogel, Daniel, Cusumano, Ana, Santos, Juan, Fraenkel, Margaret, Gallagher, Martin, Davis, Tim, Acharya, Shamasunder, Cooke, Duncan, Suranyi, Michael, Roger, Simon, Toussaint, Nigel, Pollock, Carol, Chan, Doris, Stranks, Stephen, MacIsaac, Richard, Endre, Zoltan, Schmidt, Alice, Prager, Rudolf, Mayer, Gert, Warling, Xavier, Jadoul, Michel, Hougardy, Jean, Vercammen, Chris, Van Vlem, Bruno, Gillard, Pieter, Costa e Forti, Adriana, Borges, Joao Lindolfo, Santos Canani, Luis, Eliaschewitz, Freddy, Leite, Silmara, Fraige Filho, Fadlo, Paschoalin, Raphael, Moura Neto, Jose Andrade, Deboni, Luciane, de Lourdes Noronha, Irene, Cercato, Cintia, Prompt, Carlos Alberto, Zanella, Maria, Rassi, Nelson, D'Avila, Domingos, Milagres, Rosangela, Felicio, Joao, Pecoits Filho, Roberto, Riella, Miguel Carlos, Salles, Joao, Keitel, Elizete, Draibe, Sergio, Amodeo, Celso, Youmbissi, Joseph, Roy, Louise, Cournoyer, Serge, Jolly, Shivinder, Pichette, Vincent, Nesrallah, Gihad, Bajaj, Harpreet Singh, Khandwala, Hasnain, Aronson, Ronnie, Goluch, Richard, Tam, Paul, Rabbat, Christian, Tobe, Sheldon, Bailey, Gordon, Chow, Stephen, Castillo, Alvaro, Danin Vargas, Alfredo, Gonzalez, Fernando, Munoz, Rodrigo, Gutierrez, Vicente, Godoy, Gonzalo, Zhao, Hongwen, Liu, Zhangsuo, Zhao, Minghui, Guo, Xiaohui, Su, Benli, Fu, Shuxia, Xu, Yan, Yang, Jinkui, Shi, Bingyin, Xiao, Guanqing, Shi, Wei, Hao, Chuanming, Xing, Changying, Hou, Fanfan, Luo, Qun, Li, Yuxiu, Ji, Linong, Zuo, Li, Wang, Song, Ni, Zhaohui, Ding, Guohua, Chen, Nan, Zhao, Jiajun, Jia, Weiping, Yu, Shengqiang, Weng, Jian, Xu, Gang, Fu, Ping, Sun, Shiren, Liu, Bicheng, Ding, Xiaoqiang, Rychlik, Ivan, Oplustilova, Alexandra, Bartaskova, Dagmar, Honova, Vaclava, Chmelickova, Hana, Petr, Martin, Bucek, Petr, Tesar, Vladimir, Zahumensky, Emil, Povlsen, Johan, Egstrup, Kenneth, Oczachowska-Kulik, Anna, Rossing, Peter, Lahtela, Jorma, Strand, Jorma, Kantola, Ilkka, Petit, Catherine, Combe, Christian, Zaoui, Philippe, Esnault, Vincent, Urena Torres, Pablo, Halimi, Jean-Michel, Dussol, Bertrand, Bieler, Tasso, Budde, Klemens, Dellanna, Frank, Segiet, Thomas, Kosch, Christine, Schmidt-Guertler, Hans, Schenkenberger, Isabelle, Vielhauer, Volker, Pistrosch, Frank, Alscher, Mark, Hasslacher, Christoph, Hugo, Christian, Muehlfeld, Anja, Wanner, Christoph, Passadakis, Ploumis, Apostolou, Theofanis, Tentolouris, Nikolaos, Stefanidis, Ioannis, Mavromatidis, Konstantinos, Liakopoulos, Vasilios, Goumenos, Dimitrios, Siamopoulos, Konstantinos, Yeung, Vincent, Ozaki, Risa, Fung, Samuel, Tan, Kathryn, Tang, Sydney, Lui, Sing Leung, Cheung, Siu Fai, Sreenan, Seamus, Eustace, Joseph, O'Shea, Donal, Lavin, Peter, Stack, Austin, Yagil, Yoram, Wainstein, Julio, Knobler, Hilla, Cohen, Josef, Kenis, Irina, Daoud, Deeb, Bar-Dayan, Yosefa, Frajewicki, Victor, Adawi, Faiad, Gesualdo, Loreto, Santoro, Domenico, Marino, Francesco, Galfre, Andrea, Brunati, Chiara, Ruggenenti, Piero, Rombola, Giuseppe, Pugliese, Giuseppe, Ravera, Maura, Malberti, Fabio, Pontoriero, Giuseppe, Rampino, Teresa, De Cosmo, Salvatore, Esposito, Ciro, Nappi, Felice, Abaterusso, Cataldo, Conte, Giuseppe, Panichi, Vincenzo, Lauro, Davide, Capasso, Giovambattista, Russo, Domenico, Anzai, Jiichi, Naka, Motoji, Ato, Keita, Tsujimoto, Tetsuro, Nimura, Toshinori, Nakashima, Eitaro, Takeda, Tetsuro, Fujii, Shinya, Kobayashi, Kunihisa, Iwaoka, Hideaki, Nagayama, Koji, Harada, Hiroyuki, Maeda, Hajime, Kishimoto, Rui, Iitsuka, Tadashi, Itabashi, Naoki, Furuya, Ryuichi, Maeda, Yoshitaka, Yamada, Daishiro, Sasaki, Nobuhiro, Sasaki, Hiromitsu, Ueda, Shinichiro, Kashihara, Naoki, Watanabe, Shuichi, Nakamura, Takehiro, Kanai, Hidetoshi, Makita, Yuichiro, Ono, Keiko, Iehara, Noriyuki, Goto, Daisuke, Kosuge, Keiichiro, Tsuchida, Kenichi, Sato, Toshiaki, Sekikawa, Takashi, Okamoto, Hideki, Tanaka, Tsuyoshi, Ikeda, Naoko, Tadika, Takenobu, Mukasa, Koji, Osonoi, Takeshi, Hirano, Fuminori, Nishimura, Motonobu, Yambe, Yuko, Tanaka, Yukio, Ujihara, Makoto, Sakai, Takashi, Imura, Mitsuo, Umayahara, Yutaka, Makino, Shinya, Nakazawa, Jun, Yamaguchi, Yukinari, Kashine, Susumu, Miyaoka, Hiroaki, Suzuki, Katsunori, Inoue, Toshihiko, Nagai, Sou, Sato, Nobuyuki, Yamamoto, Masahiro, Taya, Noriyasu, Fujita, Akira, Matsutani, Akira, Shibagaki, Yugo, Sato, Yuichi, Yamauchi, Akira, Tsutsui, Masahiro, Ishiko, Tamayo, Kaneko, Shizuka, Azuma, Nobuyuki, Matsuda, Hirofumi, Hashiguchi, Yasuhiro, Onishi, Yukiko, Tokui, Mikiya, Matsuhisa, Munehide, Kiyosue, Arihiro, Shinoda, Junji, Ishikawa, Kazuo, Ahmad, Ghazali, Vijayasingham, Shalini, Aziz, Nor Azizah, Hussein, Zanariah, Fung, Yin Khet, Hassan, Wan Hasnul Halimi Wan, Wong, Hin Seng, Goh, Bak Leong, Ali, Norhaliza Mohd, Merican, Nor Shaffinaz Yusuf Azmi, Vaithilingam, Indralingam, Nik Ahmad, Nik Nur Fatnoon, Adam, Noor, Sukor, Norlela, Vengadasalam, V Paranthaman P, Abdul Kadir, Khalid, Mohamed, Mafauzy, Renoirte Lopez, Karina, Leguizamo-Dimas, Aniceto, Chew Wong, Alfredo, Chevaile-Ramos, Jose, Gonzalez Gonzalez, Jose, Rico Hernandez, Raul, Nino-Cruz, Jose, Sauque Reyna, Leobardo, Gonzalez-Galvez, Guillermo, Madero Rovalo, Magdalena, Bochicchio-Ricardelli, Tomasso, Aldrete, Jorge, Carranza-Madrigal, Jaime, Vogt, Liffert, Smak Gregoor, Peter, Barendregt, JNM, Luik, Peter, Gansevoort, Ronald, Laverman, Gozewijn, Pilmore, Helen, Lunt, Helen, Baker, John, Miller, Steven, Rabindranath, Kannaiyan, Zapata-Rincon, Luis, Vargas-Gonzales, Rolando, Calderon Ticona, Jorge, Dextre Espinoza, Augusto, Burga Nunez, Jose, Zea-Nunez, Carlos Antonio, Herrada Orue, Benjamin, Medina-Santander, Boris, Delgado-Butron, Cesar, Farfan-Aspilcueta, Julio, Mazur, Stanislaw, Necki, Miroslaw, Wruk, Michal, Klodawska, Katarzyna, Popenda, Grazyna, Skokowska, Ewa, Arciszewska, Malgorzata, Wiecek, Andrzej, Ciechanowski, Kazimierz, Nowicki, Michal, Birne, Rita, Cabrita, Antonio, Ramos, Aura, Antunes Ferreira, Manuel Anibal, Matta Fontanet, Evelyn, Alcantara-Gonzalez, Altagracia Aurora, Comulada-Rivera, Angel, Galindo Ramos, Eugenia, Cangiano, Jose, Quesada-Suarez, Luis, Calderon Ortiz, Ricardo, Vazquez-Tanus, Jose, Burgos-Calderon, Rafael, Rosado, Carlos, Hancu, Nicolae, Pintilei, Ella, Mistodie, Cristina, Bako, Gabriel, Ionutiu, Lavinia, Petrica, Ligia, Timar, Romulus, Tuta, Liliana, Duma, Livia, Tutescu, Adriana, Ivanova, Svetlana, Essaian, Ashot, Zrazhevskiy, Konstantin, Tomilina, Natalia, Smolyarchuk, Elena, Kuzin, Anatoly, Lantseva, Olga, Karpova, Irina, Shamkhalova, Minara, Liberanskaya, Natalia, Yavdosyuk, Andrey, Shvarts, Yuri, Bardymova, Tatiana, Blagoveshchenskaya, Olga, Solovev, Oleg, Rechkova, Elena, Pikalova, Natalia, Pavlova, Maria, Kolmakova, Elena, Sayfutdinov, Rustam, Villevalde, Svetlana, Koziolova, Natalya, Martynenko, Vladimir, Marasaev, Vyacheslav, Maksudova, Adelya, Sigitova, Olga, Mordovin, Viktor, Klimontov, Vadim, Samoylova, Yulia, Karonova, Tatiana, Yeoh, Lee Ying, Teo, Boon Wee, Foo, Marjorie Wai Yin, Liew, Adrian, Tkac, Ivan, Oroszova, Aniko, Fekete, Jozef, Rosenberger, Jaroslav, Obetkova, Ida, Fulopova, Alla, Kolesarova, Eva, Raslova, Katarina, Smolko, Peter, Oksa, Adrian, Distiller, Larry, Trokis, Julien, Adams, Luthando, Makan, Hemant, Ramlachan, Padaruth, Mitha, Essack, Coetzee, Kathleen, Punt, Zelda, Bhorat, Qasim, Naiker, Puvenesvari, Ellis, Graham, Van Zyl, Louis, Lee, Kwan Woo, Kim, Min Seon, Yoo, Soon-Jib, Yoon, Kun Ho, Cho, Yong-Wook, Park, Tae-Sun, Kim, Sang Yong, Choi, Moon-Gi, Oh, Tae Keun, Lee, Kang-Wook, Shon, Ho Sang, Suh, Sung Hwan, Kim, Byung-Joon, Doo-Man, Kim, Yi, Joo Hark, Lee, Sang Ah, Cho, Ho Chan, Kim, Sin-Gon, Cha, Dae-Ryong, Seo, Ji A, Choi, Kyung Mook, Woo, Jeong-Taek, Ahn, Kyu Jeung, Lee, Jae Hyuk, Kim, In-Joo, Lee, Moon-Kyu, Jang, Hak Chul, Park, Kyong-Soo, Kim, Beom Seok, Mok, Ji Oh, Shin, Mijung, Yoon, Sun Ae, Nam-Goong, Il-Seong, Chung, Choon Hee, Yu, Tae Yang, Lee, Hyoung Woo, Soto Gonzalez, Alfonso, Almirall, Jaume, Egido, Jesus, Calero Gonzalez, Francesca, Fernandez Fresnedo, Gema, Valera Cortes, Ildefonso, Praga Terente, Manuel, Garcia Mendez, Isabel, Navarro Gonzalez, Juan, Herrero Calvo, Jose, Cigarran Guldris, Secundino, Prieto Velasco, Mario, Minguela Pesquera, Jose Ignacio, Galan, Antonio, Pascual, Julio, Marques Vidas, Maria, Martins Munoz, Judith, Rodriguez-Perez, Jose, Castro-Alonso, Cristina, Bonet Sol, Josep, Seron, Daniel, Fernandez Giraldez, Elvira, Arrieta Lezama, Javier, Montero, Nuria, Hernandez-Jaras, Julio, Santamaria Olmo, Rafael, Molas Coten, Jose Ramon, Hellberg, Olof, Fellstrom, Bengt, Bock, Andreas, Pei, Dee, Lin, Ching-Ling, Tien, Kai-Jen, Chen, Ching-Chu, Huang, Chien-Ning, Jiang, Ju-Ying, Wu, Du-An, Chu, Chih-Hsun, Tseng, Shih-Ting, Chen, Jung-Fu, Bau, Cho-Tsan, Sheu, Wayne, Wu, Mai-Szu, Sari, Ramazan, Sezer, Siren, Yildiz, Alaattin, Satman, Ilhan, Kalender, Betul, Mankovskyy, Borys, Fushtey, Ivan, Stanislavchuk, Mykola, Kolenyk, Mykola, Dudar, Iryna, Zolotaikina, Viktoriia, Abrahamovych, Orest, Kostynenko, Tetyana, Petrosyan, Olena, Kuskalo, Petro, Galushchak, Olga, Legun, Oleg, Topchii, Ivan, Martynyuk, Liliya, Stryzhak, Vasyl, Panina, Svitlana, Tkach, Sergii, Korpachev, Vadym, Maxwell, Peter, Gnudi, Luigi, Kon, Sui Phin, Tindall, Hilary, Kalra, Phillip, Mark, Patrick, Patel, Dipesh, El-Shahawy, Mohamed, Bai, Liqun, Nica, Romanita, Lien, Yeong-Hau, Menefee, Judson, Busch, Robert, Miller, Alan, Ahmed, Azazuddin, Arif, Ahmed, Lee, Joseph, Desai, Sachin, Bansal, Shweta, Bentsianov, Marie, Belledonne, Mario, Jere, Charles, Gaona, Raul, Greenwood, Gregory, Brusco, Osvaldo, Boiskin, Mark, Belo, Diogo, Minasian, Raffi, Atray, Naveen, Lawrence, Mary, Taliercio, John, Pergola, Pablo, Scott, David, Alvarez, German, Marder, Bradley, Powell, Thomas, Bakdash, Wa'el, Stoica, George, McFadden, Christopher, Rendell, Marc, Wise, Jonathan, Jones, Audrey, Jardula, Michael, Madu, Ivy-Joan, Varghese, Freemu, Tulloch, Brian, Ahmed, Ziauddin, Hames, Melanie, Nazeer, Imran, Shahid, Newman, John, Rekha, Montero, Manuel, Fitz-Patrick, David, Phillips, Lawrence, Guasch, Antonio, Christofides, Elena, Gundroo, Aijaz, Amin, Mohammad, Bowman-Stroud, Cynthia, Link, Michael, Mulloy, Laura, Nammour, Michael, Lalwani, Tarik, Hanson, Lenita, Whaley-Connell, Adam, Herman, Lee, Chatha, Rupi, Osama, Sayed, Liss, Kenneth, Kayali, Zeid, Bhargava, Anuj, Israel, Ezra, Peguero-Rivera, Alfredo, Fang, Michael, Slover, Judith, Barengolts, Elena, Flores, Jose, Muoneke, Rosemary, Savin, Virginia, Awua-Larbi, Stella, Levine, Andrew, Newman, George, Golestaneh, Laden, Bohm, Guillermo, Reisin, Efrain, Cruz, Lucita, Weiss, Robert, Zieve, Franklin, Horwitz, Edward, Chuang, Peale, Mersey, James, Manley, John, Graf, Ronald, Bedros, Fadi, Joshi, Sudhir, Frias, Juan, Assefi, Ali, O'Shaughnessy, Andrew, Brantley, Roman, Minga, Todd, Tietjen, David, Kantor, Samuel, Jamal, Aamir, Guadiz, Ramon, Hershon, Kenneth, Bressler, Peter, Kopyt, Nelson, Cathcart, Harold, Bloom, Scott, Reichel, Ronald, Nakhle, Samer, Dulude, Emily, Tarkan, Joshua, Baker, Penelope, Zeig, Steven, Moya Hechevarria, Jaynier, Ropero-Cartier, Armando, De la Calle, Gilda, Doshi, Ankur, Saba, Fadi, Sligh, Teresa, Shaw, Sylvia, Kumar, Jayant, Szerlip, Harold, Bayliss, George, Perlman, Alan, Sakhrani, Lakhi, Gouge, Steven, Argoud, Georges, Acosta, Idalia, Elder, John, Joshi, Sucharit, Sensenbrenner, John, Vicks, Steven, Mangoo-Karim, Roberto, Galphin, Claude, Leon-Forero, Carlos, Gilbert, John, Brown, Eric, Ijaz, Adeel, Butt, Salman, Markell, Mariana, Arauz-Pacheco, Carlos, Sloan, Lance, Alvarado, Odilon, Jabbour, Serge, Simon, Eric, Rastogi, Anjay, James, Sam, Bakris, George, Hall, Karen, Melish, John, Dixon, Brad, Adolphe, Allen, Kovesdy, Csaba, Beddhu, Srinivasan, Solomon, Richard, Fernando, Ronald, Levin, Ellis, Thakar, Charuhas, Robey, Brooks, Goldfarb, David, Fried, Linda, Maddukuri, Geetha, Thomson, Stephen, Annand, Andrew, Kronfli, Saeed, Kalirao, Paramjit, Schmidt, Rebecca, Dahl, Neera, Blumenthal, Samuel, Weinstein, Debra, Ostergaard, Ove, Weinstein, Talia, Ono, Yasuhiro, Yalcin, Murat, and Karim, Shahana
- Abstract
Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.
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- 2019
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21. Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children
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Rabi, Doreen M., McBrien, Kerry A., Sapir-Pichhadze, Ruth, Nakhla, Meranda, Ahmed, Sofia B., Dumanski, Sandra M., Butalia, Sonia, Leung, Alexander A., Harris, Kevin C., Cloutier, Lyne, Zarnke, Kelly B., Ruzicka, Marcel, Hiremath, Swapnil, Feldman, Ross D., Tobe, Sheldon W., Campbell, Tavis S., Bacon, Simon L., Nerenberg, Kara A., Dresser, George K., Fournier, Anne, Burgess, Ellen, Lindsay, Patrice, Rabkin, Simon W., Prebtani, Ally P.H., Grover, Steven, Honos, George, Alfonsi, Jeffrey E., Arcand, JoAnne, Audibert, François, Benoit, Geneviève, Bittman, Jesse, Bolli, Peter, Côté, Anne-Marie, Dionne, Janis, Don-Wauchope, Andrew, Edwards, Cedric, Firoz, Tabassum, Gabor, Jonathan Y., Gilbert, Richard E., Grégoire, Jean C., Gryn, Steven E., Gupta, Milan, Hannah-Shmouni, Fady, Hegele, Robert A., Herman, Robert J., Hill, Michael D., Howlett, Jonathan G., Hundemer, Gregory L., Jones, Charlotte, Kaczorowski, Janusz, Khan, Nadia A., Kuyper, Laura M., Lamarre-Cliche, Maxime, Lavoie, Kim L., Leiter, Lawrence A., Lewanczuk, Richard, Logan, Alexander G., Magee, Laura A., Mangat, Birinder K., McFarlane, Philip A., McLean, Donna, Michaud, Andre, Milot, Alain, Moe, Gordon W., Penner, S. Brian, Pipe, Andrew, Poppe, Alexandre Y., Rey, Evelyne, Roerecke, Michael, Schiffrin, Ernesto L., Selby, Peter, Sharma, Mike, Shoamanesh, Ashkan, Sivapalan, Praveena, Townsend, Raymond R., Tran, Karen, Trudeau, Luc, Tsuyuki, Ross T., Vallée, Michel, Woo, Vincent, Bell, Alan D., and Daskalopoulou, Stella S.
- Abstract
Hypertension Canada’s 2020 guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children provide comprehensive, evidence-based guidance for health care professionals and patients. Hypertension Canada develops the guidelines using rigourous methodology, carefully mitigating the risk of bias in our process. All draft recommendations undergo critical review by expert methodologists without conflict to ensure quality. Our guideline panel is diverse, including multiple health professional groups (nurses, pharmacy, academics, and physicians), and worked in concert with experts in primary care and implementation to ensure optimal usability. The 2020 guidelines include new guidance on the management of resistant hypertension and the management of hypertension in women planning pregnancy.
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- 2020
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22. Hypertension Canada’s 2020 Evidence Review and Guidelines for the Management of Resistant Hypertension
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Hiremath, Swapnil, Sapir-Pichhadze, Ruth, Nakhla, Meranda, Gabor, Jonathan Y., Khan, Nadia A., Kuyper, Laura M., Ruzicka, Marcel, Tobe, Sheldon W., Tran, Karen, Rabi, Doreen M., and Daskalopoulou, Stella S.
- Abstract
We present Hypertension Canada’s inaugural evidence-based recommendations for the diagnosis and management of resistant hypertension. Hypertension is present in 21% of the Canadian population, and among those with hypertension, resistant hypertension has an estimated prevalence from 10% to 30%. This subgroup of hypertensive individuals is important, because resistant hypertension portends a high cardiovascular risk. Because of its importance, Hypertension Canada formed a Guidelines Committee to conduct a review of the evidence and develop recommendations for the diagnosis and management of resistant hypertension. The Hypertension Canada Guidelines Committee recommends that patients with blood pressure above target, despite use of 3 or more blood pressure-lowering drugs at optimal doses, preferably including a diuretic, be identified as those with apparent resistant hypertension. Patients identified with apparent resistant hypertension should be assessed for white coat effect, nonadherence, and therapeutic inertia, investigated for secondary hypertension, and referred to a provider with expertise in hypertension. There is no randomized controlled trial evidence for better cardiovascular outcomes with any class of antihypertensive agent at this time, so recommendations for a preferred drug class cannot be made. Furthermore, we provide a summary of the current evidence concerning the role of device therapy in the management of resistant hypertension. We will continue updating the guidelines as additional high-quality evidence with relevance to daily practice becomes available.
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- 2020
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23. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial
- Author
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Gerstein, Hertzel C, Colhoun, Helen M, Dagenais, Gilles R, Diaz, Rafael, Lakshmanan, Mark, Pais, Prem, Probstfield, Jeffrey, Riesmeyer, Jeffrey S, Riddle, Matthew C, Rydén, Lars, Xavier, Denis, Atisso, Charles Messan, Dyal, Leanne, Hall, Stephanie, Rao-Melacini, Purnima, Wong, Gloria, Avezum, Alvaro, Basile, Jan, Chung, Namsik, Conget, Ignacio, Cushman, William C, Franek, Edward, Hancu, Nicolae, Hanefeld, Markolf, Holt, Shaun, Jansky, Petr, Keltai, Matyas, Lanas, Fernando, Leiter, Lawrence A, Lopez-Jaramillo, Patricio, Cardona Munoz, Ernesto German, Pirags, Valdis, Pogosova, Nana, Raubenheimer, Peter J, Shaw, Jonathan E, Sheu, Wayne H-H, Temelkova-Kurktschiev, Theodora, Abella, Mercedes, Alebuena, Andrea, Almagro, Sandra, Amoroso, Eduardo, Anadon, Paula, Andreu, Elizabeth, Aristimuño, Guillermo, Arzadun, Maria, Barbieri, Maria, Barcudi, Raul, Bartolacci, Ines, Bolobanich, Gabriel, Bordonava, Anselmo, Bustamante Labarta, Miguel, Bustos, Betina, Caccavo, Alberto, Camino, Alejandra, Cantero, Maria, Carignano, Maria, Cartasegna, Luis, Cipullo, Marcela, Commendatore, Víctor, Conosciuto, Victoria, Costamagna, Osvaldo, Crespo, Claudia, Cuello, Jose, Cuneo, Carlos, Cusimano, Sandra, Dean, Sofia, Dituro, Claudio, Dominguez, Andrea, Farah, Miguel, Fernandez, Alberto, Fernandez, Florencia, Ferrari, Adriana, Flammia, Patricia, Fuentealba, Jose, Gallardo, Karina Beatriz, Garcia, Celso, Garcia Duran, Ruben, Garrido, Marcelo, Gavicola, Rodolfo, Gerbaudo, Claudio, Gilli, Graciela, Giotto, Ana Paula, Godoy Bolzán, Pedro, Gomez Vilamajo, Oscar, Guerlloy, Fernando, Guridi, Cristian, Gutierrez Garrido, Narcisa, Hasbani, Eduardo, Hermida, Sonia, Hominal, Miguel, Hrabar, Adrian, Ingaramo, Adrián, Izzicupo, Alejandra, Krynski, Mario, Lagrutta, Mariana, Lanchiotti, Paulina, Langhe, Maria, Leonard, Veronica, Llanos, Javier, Lopez Santi, Ricardo, Lowenstein, Jorge, Luquez, Cecilia, Mackinnon, Ignacio, Mana, Melina, Manzur, Sara, Marino, Javier, Martella, Carolina, Martinez, Roger, Matias, Re, Matkovich, Javier, Meritano, Monica, Montaña, Oscar, Mulazzi, María, Ochoa, Juan, Paterlini, Gustavo, Pelagagge, María, Peralta Lopez, Maria Elena, Prado, Aldo, Pruyas, Lorena, Racca, Martín, Ricotti, Carola, Rodriguez, Carolina, Romero Vidomlansky, Mariano, Ronderos, Ricardo, Sadowski, Ana Laura, Sala, Jorgelina, Sánchez, Alejandro, Santoro, Andrea, Schiavi, Lilia, Sein, Mariano, Sernia, Virginia, Serra, Leonardo, Sicer, Maximiliano, Smith, Tomas, Soso, Leonardo, Sposetti, Georgina, Steinacher, Andrea, Stival, Jorge, Tedesco, Jorge, Tonin, Hugo, Tortolo, Mauro, Ulla, Maria, Vallejos, Julio, Vico, Marisa, Virgillito, Luciana, Visco, Virginia, Vogel, Daniel, Waisman, Florencia, Zaidman, César, Zucchiatti, Noemi, Badshah, Imran, Cohen, Neale, Colman, Peter, Colquhoun, David, Davis, Timothy, Fourlanos, Spiros, Fulcher, Greg, Hamlyn, Jane, Haywood, Cilla, Hocking, Samantha, Huchinson, Maeve, Jeffries, William, Kyl, Mervyn, Lo, Clement, Mah, PeakMann, Makepeace, Ashley, Marope, Dolly, Nanayakkar, Natalie, Nankervis, Alison, Palmer, Neil, Palolus, Barbara, Pillai, Satish, Price, Sarah, Price, Sarah, Proietto, Joseph, Reutens, Anne, Rodrigo, Natassia, Sheikh, Abdul, Smith, Greg, So, Michelle, Soldatos, Georgia, Stuckey, Bronwyn, Sumithran, Priya, Teede, Helena, Vora, Parind, Williams, Lyn, Abib, Eduardo, Adão Poço, Christiani, Alves, Érica Ferreira, Andreatta Bernardi Barea, Janaina, Avezum Oliveira, Livia, Castro, Denise Ludovico da Costa de, Correa da Cruz, Ivan, Costa, Midiã, Cruz, Ivan, Cunha, Sidney, Da Silva, Marco Antonio Vieira, de Carvalho Camara Bona, Renata, de Paula, Bruna, Eliaschewitz, Freddy, Fazolli, Guilherme, Ferreira Filho, Carlos Alberto, Fortes, Jose, França, Cesar, Franco, Denise Reis, Genestreti, Paulo Roberto, Giorgeto, Flavio, Gonçalves, Rodrigo Marques, Grossman, Michele Elka, Henrique Marcelino, Ana Claudia, Hernandes, Mauro, Horta, Ana, Jaeger, Cristiano, Kaneblai, Midia, Kauffman Rutenberg, Cecilia, Kerr Saraiva, Jose Francisco, Lemos, Maria Angelica, Maia, Lilia, Manenti, Euler Roberto, Marques, Mariana, Melissa Valerio, Cynthia, Moreira, Rodrigo, Mothé, Flávia, Mouco, Osana Maria, Moura, Philip, Moura Jorge, José Carlos, Nakashima, Carlos, Nakazone, Marcelo, Napoli, Thiago, Nunes, Cristiane, Nunes Salles, Joao Eduardo, Oliveira, Karla, Oliveira, Marcela, Pantano, Gracielly de Souza, Petri, Fabio, Piazza, Leonardo, Pires, Andreia Carla, Pizzato, Patricia, Prata, Sergio, Precoma, Dalton, Rech, Rafael, Reis, Gilmar, Reis, Heleno, Resende, Elisabete, Ribas Fortes, Jose, Rodovalho, Sylka, Rossi dos Santos, Fabio, Salles, Joao Eduardo, Sampaio, Célia Regina, Santos, Thiago, Santos dos Santos, Vanessa, Silva e Quadros, Tulio, Silveira, Daniel, Siqueira, Katia Nunes, Teireira, M, Uehara, Marcelo, Valerio, C, Vianna, Henrique, Vidotti, Maria Helena, Visconti, Guilherme de Lima, Zanella, Maria Teresa, Andreeva, Viktoriya, Borisov, Radoslav, Botushanov, Nikolay, Dimitrov, Georgi, Dimova, Kameliya, Dragoychev, Tsvetan, Grigorova, Valentina, Gushterova, Valentina, Ivanov, Ivaylo, Kocelova, Tatyana, Kurktschiev, Dimo, Miletieva, Milena, Nenkova-Gugusheva, Neli, Pancheva, Ralitsa, Pavlova, Maria, Raev, Dimitar, Spasova, Vesela, Stoikov, Anastas, Troev, Dimitar, Yanev, Todor, Yoncheva-Mihaylova, Mariana, Abitbol, Alexander, Ajala, Buki, Alguwaihes, Abdullh, Ardilouze, Jean-Luc, Aris-Jilwan, Nahla, Arnaout, Amel, Aronson, Ronnie, Aslam, Nadeem, Babin, Sandra, Bailargeon, Jean-Patrice, Bailey, Allan, Bajaj, Harpreet, Beauchesne, Christian, Beca, Sorin, Belanger, Andre, Bell, Alan, Bellabarba, Diego, Berard, Lori, Berenbaum, Brian, Bergeron, Vincent, Berlingieri, Joseph, Bernier, Frédéric, Bishara, Phoebe, Blank, David, Blumer, Ian, Brault, Suzanne, Breton, Donald, Carpentier, André, Cha, James, Chandra, Prakash, Chiasson, Jean-Louis, Conway, James R, Couture, Ghyslaine, Couture, Nathalie, Dagenais, Gilles, Datta, Dyotirmoy, D'Ignazio, Giuseppe, Dumas, Richard, Fay, Didier, Frechette, Andre, Frenette, Louise, Fung, Daisy, Gagnon, Nathalie, Galter, Meri, Garon, Jean, Gauthier, Jean Sebastien, Geadah, Christian, Gilbert, Jeremy, Girard, Ronald, Goldenberg, Ronald, Grossman, Loren David, Gupta, Nikhil, Halle, Jean-Pierre, Hivert, Marie-France, Houde, Ghislaine, Houlden, Robyn, Hramiak, Irene, Jablonski, Ted, Jain, Akshay Jain, Khandwala, Hasnain, Khosla, Munish, Lachance, C, Laflamme, Emilie, Langlois, Marie-France, Larivee, Luc, Liutkus, Joanne, Lochnan, Heather, Malik, Saleem, McDonald, Charlotte, Mehta, Pravinsagar, Mihailidis, John, Milot, Alain, Narula, Priya, Nault, Patrice, Nayar, Arun, Nisker, William, Ouellet, Gilles, Palardy, Jean, Patel, Minta, Paul, Terri, Pedersen, Sue, Perron, Patrice, Pesant, Marie-Hélène, Poirier, Paul, Poulin, Marie-Claude, Punthakee, Zubin, Rehman, Waheed, Ross, Stuart, Sagar, P, Saliba, Nouhad, Sandler, Sam, Schiffrin, Alicia, Schlosser, Robert, Seth-Sharma, Anila, Sherman, Mark, Sionit, David, Sivakumar, Tharsan, Soto, Juan, St-Amour, Eric, Steen, Oren, Sussman, Jack, Telner, Adam, Tobe, Sheldon, Twum-Barima, David-Yaw, Van Zanten, Audrey, VanRossum, Nicole, Vecchiarelli, Jonathan, Ward, Rick, Wessengel, John, Weisnagel, Stanley, Wilderman, Igor, Woo, Vincent, Yakubovich, Natalia, Yale, Jean-Francois, Yared, Zeina, Acevedo, Monica, Aguirre, Maria Loreto, Aizman, Andres, Barroso, Maria Soledad, Cobos, Leonardo, Danin Vargas, Alfredo, Descalzi, Barbara, Godoy, Gonzalo, Grumberg, Elio, Lahsen, Rodolfo, Larenas, Gladys, Ortiz, Eugenia, Paredes, Javier, Potthoff, Sergio, Retamal, Eva, Rojas, Luis, Salgado, Manuel, Santibanez, Claudio, Solis, Carmen, Stokins, Benjamin, Accini, Jose, Acebedo, Javier, Agudelo Baena, Lina Maria, Alarcon, Soraya, Angel, Juliana, Arcos, Edgar, Aroca Martinez, M, Atuesta, Leonor, Balaguera, Jose, Ballestas, Doris, Barrera, Sandra Isabel, Barrios Reyes, Rosmy, Bayona, Adolfo, Bermudez, Andres, Bernal, Diego Zarate, Blanquicett, Marco, Bravo, Victor, Bueno, Wendy, Burbano Delgado, Alvaro, Cadena, Alberto, Cadena, Andres, Caicedo, Sandra, Celemin, Carlos, Consuegra, Ricardo, Contreras Pimienta, Cristhian, Corredor, Kelly Johenis, Cure, Carlos, De La Hoz Rueda, Lizeth Dayana, Delgado, Erika, Diaz, Sarahy, Diego, Marta, Donado, Anabell, Encinales Sanabria, William, Escobar, Juliana, Escorcia, Gillian, Forero, Leonardo, Fuentes, Laura, Garcia, Maria, Garcia Lozada, Henry, Garcia Ortiz, Luis, Giraldo, Angela, Gomez Gonzalez, Laura, Granada, Javier, Gutierrez, Corina, Henao, Natalia, Hernandez, Edwin, Herrera Uejbe, Olga Maria, Higuera Cobos, Juan Diego, Ibarra Gómez, Jaime, Jaimes, Edwin Hernandez, Jaramillo, Monica, Jaramillo, Nicolas, Jaramillo Gomez, Carlos, Jaramillo Sanchez, Monica, Jarava Durán, Ivonne, Lopez Ceballos, Catalina, Madrid, Claudia, María Amastha, Elias, Mercado, Jennifer, Molina, Dora Ines, Molina Soto, Jessica, Montoya, Carlos, Morales, Alexander, Muñoz, Carolina, Orozco, Luis Alejandro, Osorio, Oscar, Palmera Sanchez, Jorge Mario, Peña, Adwar, Perez, Jose, Perez Agudelo, Juan, Pérez Amador, Germán, Pertuz, Carlos, Posada, Irina, Puerta, Carlos, Quintero, Adalberto, Quiroz, Diana, Rendon, Carmen, Reyes, Alberto, Reyes, Alvaro, Ripoll, Diana, Rivera, Carlos, Rocha, Maria, Rodriguez, Jose F, Rodriguez Villanueva, Kervis Asid, Rodriguez Zabala, Javier Emilio, Rojas, Sindy, Romero, Maria, Rosero, Ricardo, Rosillo Cardenas, Angelica Rocio, Rueda, Lina, Sanchez, Gregorio, Sanchez, Tatiana, Sotomayor Herazo, Arístides, Suarez, Monica, Torres, Mariana, Trujillo, Freddy, Urina, Miguel, Van Strahlen, Lazaro, Velandia, Carlos, Velasquez Guzman, Carolina, Velazquez, Elizabeth, Vidal Prada, Tatiana, Yepez Alvaran, Juan Pablo, Zarate, Diego, Andelova, Jana, Benesova, Radka, Buzova, Barbara, Cech, Vladimir, Chodova, Ida, Choura, Miroslav, Dufka, Antonin, Gamova, Andrea, Gorgol, Jakub, Hala, Tomas, Havlova, Hana, Hlavkova, Dagmar, Horanska, Petra, Ilcisin-Valova, Juliana, Jenickova, Petra, Jerabek, Ondrej, Kantorova, Ilona, Kolomaznikova, Katerina, Kopeckova, Iva, Kopeckova, Miroslava, Linhart, Karel, Linhart, Tomas, Malecha, Jan, Malicherova, Emilia, Neubauerova, Dana, Oznerova, Martina, Partys, Radan, Pederzoliova, Eva, Petrusova, Maria, Prymkova, Vera, Racicka, Eva, Reissova, Ida, Roderova, Eva, Stanek, Libor, Striova, Alena, Svarcova, Dana, Svoboda, Petr, Szeghy Malicharova, Emilia, Urge, Jan, Vesely, Ladislav, Wasserburger, Bedich, Wasserburgerova, Hilde, Zahumensky, Emil, Zamrazil, Vaclav, Alawi, Hasan, Anastasiadis, Ernestos, Axthelm, Elisabeth, Bieler, Tasso, Buhrig, Christina, Degtyareva, Elizaveta, Dellanna, Frank, Derwahl, Karl-Michael, Diessel, Stephan, Dogiami, Barbara, Dorn-Weitzel, Kirsten, Ernst, Monika, Faulmann, Grit, Fetscher, Baerbel, Forst, Thomas, Freyer-Lahres, Gabriele, Funke, Klaus, Ganz, Xenia, Gleixner, Christiane, Hanefeld, Christoph, Heinrichs, Sven, Helleberg, Stephanie, Henkel, Elena, Hetzel, Gerd Ruediger, Hoffmann, Caren, Jacob, Frohmut, Jacob, Stephan, John, Franziska, Jonczyk, Antonius, Kamke, Wolfram, Klein, Christiane, Kleinhardt, Martina, Kleophas, Werner, Kosch, Christine, Kreutzmann, Kristin, Kühn, Achim, Lee-Barkey, Young Hee, Lier, Alexander, Maatouk, Sarah, Minnich, Joachim, Mitry, Michael, Muessig, Ilona, Nicula, Diana, Niemann, Martina, Nothroff, Joerg, Ott, Petra, Pfuetzner, Andreas, Pfützner, Andreas, Pistrosch, Frank, Pohl, Wildgard, Prochazkova, Zdenka, Retkowska, Marlena, Rosin, Heiko, Sachsenheimer, Daniela, Samer, Holger, Sanuri, Mazin, Schaefer, Axel, Schaper, Frank, Schulze, Erik-Delf, Schulze, Marita, Schumann, Martina, Segiet, Thomas, Sowa, Veronika, Stahl, Hans-Detlev, Steinfeldt, Franziska, Teige, Madlen, Trieb, Bjoern, Tschoepe, Diethelm, Uebel, Peter, Warken, Bernd, Weigmann, Ingo, Weyland, Klaus, Wilhelm, Klara, Balo, Timea, Balsay, Miklos, Bende, Ilona, Bezzegh, Katalin, Birkus, Zita, Buday, Barbara, Csomai, Melinda, Deak, Laszlo, Dezso, Eniko, Faludi, Peter, Faluvegi, M, Fazekas, Ilona, Feher, Agota, Fejer, Csaba, Finta, Ervin, Fulcz, Agnes, Gaal, Zsolt, Gurzo, Mihaly, Hati, Krisztina, Herczeg, Gabriella, Jozsef, Ildiko, Juhasz, Marta, Keltai, Katalin, Koranyi, Laszlo, Kulcsar, Eniko, Kun, Krisztina, Laczko, Andrea, Literáti-Nagy, Botond, Mezo, Izabella, Mileder, Margit, Moricz, I, Nagy, Károly, Nagybaczoni, Bela, Nemeth, Csaba, Oze, Agnes, Pauer, Jozsef, Peterfai, Eva, Polocsanyi, Bela, Poor, Ferenc, Reiber, István, Salamon, Csaba, Sebestyen, Julia, Torok, Ildiko, Tuu, Marianna, Varga, Andrea, Vass, Viktor, Ahn, Chul Min, Ahn, Chulwoo, ByungWon, Park, Chang, Hyuk-Jae, Chang, Kiyuk, Choi, Eui-Young, Choi, Han Seok, Chung, Jin-Wook, Hong, Bum- Kee, Hong, Young Joon, Hyon, Min Su, Jeong, Myung Ho, Kang, Shinae, Kim, Byeong-Keuk, Kim, Ji-Hyun, Kim, Ju Han, Kim, Kee-Sik, Kim, Kee-Sik, Kim, Moo Hyun, Kim, Pum-Joon, Kim, Soon-Kil, Kim, Yong-Seok, Kim, Young Kwon, Koh, Yoon Seok, Kwon, Hyuck Moon, Lee, Byoung Kwon, Lee, Byung-Wan, Lee, Jin Bae, Lee, Myoung-Mook, Lim, Young-Mee, Min, Pil Ki, Park, Jong Sung, Park, Jongsuk, Park, Keun Ho, Park, Sungha, Pyun, Wook Bum, Rim, Se Joong, Ryu, Dong-Ryeol, Seo, Hong-Seog, Seung, Ki Bae, Shin, Dong-Ho, Sim, Doo Sun, Yoon, Young Won, Andersone, Ilze, Babicka, Kristine, Balcere, Inga, Barons, Roberts, Capkovska, Inguna, Geldnere, Kristine, Grigane, Inese, Jegere, Baiba, Lagzdina, Ilze, Mora, Lija, Pastare, Sigita, Ritenberga, Rota, Romanova, Janina, Saknite, Inta, Sidlovska, Natalja, Sokolova, Jelena, Steina, Sandra, Strizko, Iveta, Teterovska, Dace, Vizina, Brigita, Barsiene, Lina, Belozariene, Gintare, Daugintyte-Petrusiene, Laura, Drungiliene, Nijole, Garsviene, Nijole, Grigiene, Ala, Grizas, Vytautas, Jociene, Virginija, Kalvaitiene, Dalia, Kaupiene, Jugeta, Kavaliauskiene, Jurate, Kozloviene, Dalia, Lapteva, Ilona, Maneikiene, Birute, Marcinkeviciene, Jolanta, Markauskiene, Vaidilija, Meiluniene, Salomeja, Norkus, Almantas, Norviliene, Rita, Petrenko, Vladimiras, Radzeviciene, Ruta, Sakalyte, Gintare, Urbonas, Gediminas, Urbutiene, Skaiste, Vasiliauskas, Donatas, Velickiene, Dzilda, Aguilar, Carlos, Alcocer, Marco, Avalos-Ramirez, Juan Antonio, Banda-Elizondo, Ramiro, Bricio-Ramirez, Rubria, Cardenas Mejia, Karla, Cavazos, Francisco, Chapa, Jesus, Cienfuegos, Erika, De la Peña, Astrid, de la Peña Topete, Gilberto, De los Rios Ibarra, Manuel Odin, Elias, Daniel, Flores-Moreno, Claudia, Garcia Hernandez, Pedro, Gonzalez, Luis Gerardo, Guerra Moya, Rosa Linda, Guerra-Lopez, Arturo, Hernandez Baylon, Raymundo, Herrera Colorado, Carolina, Herrera-Marmolejo, Marisol, Islas-Palacios, Neri, Lopez, Esteban, Lopez, Fernando, Lopez Alvarado, Agustin, Luna Ceballos, Rosa Isela, Morales Villegas, Enrique, Moreno-Virgen, Gualberto, Parra Perez, Rosa Linda, Pascoe Gonzalez, Sara, Peralta-Cantu, Irving, Previn, Roopa, Ramirez, Rosa, Ramirez, Rubria, Ramos Zavala, Maria Guadalupe, Rodriguez, Monica, Salgado-Sedano, Rocio, Sanchez-Aguilar, Ana Claudia, Santa Rosa Franco, Edith, Sauque-Reyna, Leobardo, Suarez Otero, Rodrigo, Torres, Ivonne, Velarde-Harnandez, Enrique, Villagordoa, Juan, Villeda-Espinoza, Efrain, Vital-Lopez, Jorge, Zavala- Bello, Cristian Jair, Baker, John, Barrington-Ward, Elaine, Brownless, Thomas, Carroll, Richard, Carson, Simon, Choe, Michelle, Corin, Andrew, Corley, Brian, Cutfield, Richard, Dalaman, Neelam, Dixon, Paul, Drury, Paul, Dyson, Keith, Florkowski, Chris, Ford, Monica, Frengley, William, Helm, Colin, Katzen, Colin, Kerr, Jane, Khanolkar, Manish, Kim, David, Koops, Renata, Krebs, Jeremy, Leikis, Robert, Low, Kwan, Luckey, Alison, Luke, Richard, Macaulay, Susan, Marks, Rodney, McNamara, Catherine, Millar-Coote, Dean, Miller, Steven, Mottershead, Naomi, Reid, James, Robertson, Narcisa, Rosen, Ian, Rowe, David, Schmiedel, Ole, Scott, Russell, Sebastian, Jeffrey, Sheahan, Davitt, Stiebel, Victoria, Ternouth, Ian, Tofield, Chris, Venter, Dirk, Williams, Michael, Williams, Miles, Wu, Fiona, Young, Simon, Arciszewska, Malgorzata, Bochenek, Anna, Borkowski, Piotr, Borowy, Przemyslaw, Chrzanowski, Tomasz, Czerwinski, Edward, Dwojak, Marek, Grodzicka, Agnieszka, Janiec, Izabela, Jaruga, Joanna, Jazwinska-Tarnawska, Ewa Krystyna, Jedynasty, Krystyna, Juzwiak-Czapiewska, Danuta, Karczewicz-Janowska, Jadwiga, Konieczny, Jan, Konieczny, Marek, Korol, Marek, Kozina, Maciej, Krzyzagorska, Ewa, Kucharczyk-Petryka, Ewa, Laz, Roman, Majchrzak, Anna, Mrozowska, Zdzislawa, Mularczyk, Michal, Nowacka, Elzbieta, Peczynska, Jadwiga, Petryka, Robert, Pietrzak, Radoslaw, Pisarczyk-Wiza, Dorota, Rozanska, Aleksandra, Ruzga, Zofia, Rzeszotarska, Emilia, Sacha, Malgorzata, Sekulska, Marzenna, Sidorowicz-Bialynicka, Anna, Stasinska, Teresa, Strzelecka-Sosik, Agnieszka, Swierszcz, Teresa, Szymkowiak, Katarzyna Miroslawa, Turowska, Olga, Wisniewska, Krystyna, Wiza, Maciej, Wozniak, Iwona, Zelazowska, Katarzyna, Ziolkowska-Gawron, Bernadetta, Zytkiewicz-Jaruga, Danuta, Albota, Adrian, Alexandru, Carmina, Avram, Rodica, Bala, Cornelia, Barbonta, Diana, Barbu, Roxana, Braicu, Daniela, Calutiu, Nicoleta, Catrinoiu, Doina, Cerghizan, Anca, Ciorba, Alina, Craciun, Anca, Doros, Rodica, Duma, Livia, Dumitrache, Ancuta, Ferariu, Ioana, Ferician Moza, Anca, Ghergan, Alexandrina, Ghise, Gheorghe, Graur, Mariana, Gribovschi, Mihaela, Mihai, Bogdan, Mihalache, Laura, Mihalcea, Madalina, Mindrescu, Nicoleta, Morosanu, Magdalena, Morosoanu, Andrea, Mota, Maria, Moza, Anca, Nafornita, Valerica, Natea, Narcisa, Nicodim, Simona, Nita, Cristina, Onaca, Adriana, Onaca, Mircea, Pop, Cristina, Pop, Lavinia, Popa, Amorin, Popescu, Alexandrina, Pruna, Luchiana, Roman, Gabriela, Rosu, Mihaela, Sima, Alexandra, Sipciu, Doina, Sitterli-Natea, Carmen Narcisa, Szilagyi, Iosif, Tapurica, Minodora, Tase, Adrian, Tutescu, Adriana-Carmen, Vanghelie, Luminita, Verde, Ioana, Vlad, Adrian, Zarnescu, Mihaela, Akhmetov, Roman, Allenova, Irina, Avdeeva, Irina, Baturina, Oksana, Biserova, Irina, Bokovin, Nikolay, Bondar, Irina, Burova, Natalia, Chufeneva, Galina, Chumachek, Elena, Demidova, Marina, Demin, Alexander, Drobysheva, Vera, Egorova, Irina, Esenyan, Lev, Gelig, Ekaterina, Gilyarevsky, Sergey, Golshmid, Maria, Goncharov, Arseniy, Gorbunova, Anastasia, Gordeev, Ivan, Gorelysheva, Vera, Goryunova, Tatiana, Grebenshchikova, Irina, Ilchenko, Roman, Ivannikova, Maria, Karabalieva, Saule, Karpeeva, Juliya, Khaykina, Elena, Kobalava, Zhanna, Kononenko, Irina, Korolik, Oxana, Korshunova, Anna, Kostenko, Victor, Krasnopevtseva, Irina, Krylova, Ludmila, Kulkova, Polina, Kuzmina, Irina, Ledyaeva, Alla, Levashov, Sergey, Lokhovinina, Natalia, Lvov, Vadim, Martirosyan, Narine, Nedogoda, Sergey, Nilk, Rostislav, Osmolovskaya, Yulia, Panov, Alexey, Paramonova, Olga, Pavlova, Ekaterina, Pekareva, Elena, Petunina, Nina, Ponamareva, Svetlana, Reshedko, Galina, Salasyuk, Alla, Sepkhanyan, Malvina, Serebrov, Alexandr, Shabelnikova, Olesya, Skvortsov, Andrey, Smirnova, Olga, Spiridonova, Oxana, Strogova, Svetlana, Taratukhin, Evgeny, Tereschenko, Sergey, Trukhina, Lubov, Tsarkova, Olga, Tsoma, Vera, Tumarov, Farid, Tyan, Natalya, Tyurina, Tatiana, Villevalde, Svetlana, Yankovaya, Elena, Zarutskaya, Ludmila, Zenkova, Elena, Badat, Aysha, Bester, Frederik, Blignaut, Suzanne, Blom, Dirk, Booysen, Susan, Boyd, Warren, Brice, Brigitte, Brown, Susan, Burgess, Lesley, Cawood, Reina, Coetzee, Kathleen, Conradie, Hillet, Cronje, Tanja, de Jong, Douwe, Ellis, Graham, Emanuel, Shaunagh, Engelbrecht, Ingrid, Foulkes, Sharne, Fourie, Done, Gibson, Gilbert, Govender, Thirumani, Hansa, Sumayah, Hemus, Allana Colleen, Hendricks, Firzana, Heradien, Marshall, Holmgren, Chantelle, Hoosain, Zaheer, Horak, Emile, Howard, Johannes, Immink, Ignatius, Janari, E., Jivan, Daksha, Klusmann, Karl, Labuschagne, Weik, Lai, Yen-yu, Latiff, Gulam, Lombaard, J., Lottering, Hanlie, Meeding, Ronel, Middlemost, Shirley, Mitha, Haroon, Mitha, Ismail, Mkhwanazi, Sandile, Moodley, Rajendran, Murray, Almeri, Musungaie, Dany, Osman, Yasmin, Peacey, Kirsten, Pillay-Ramaya, Larisha, Pretorius, Catharina, Prozesky, Hans, Sarvan, Mahomed, Scholtz, E, Sebesteny, Attila, Skinner, Bianca, Skriker, Michael, Smit, M, Stapelberg, Anna-Marie, Swanepoel, Nicolaas, Urbach, Dorothea, van Aswegen, Dina, van Zyl, Francois, Van Zyl, Louis, Venter, Esme, Wadvalla, Shahid, Wing, Jeffrey, Wolmarans, Karen, Abreu, Cristina, Aguilà, Pilar, Aguilera, Eva, Alonso, Nuria, Alvarez, Carmen, Cajas, Priscila, Castro, Jose Carlos, Codinachs, Roger, Contreras, Jose, Coves, Maria Jose, Fajardo, Carmen, Ferrer, Juan Carlos, Font, Neus, Garcia, Mar, Gil, Maria Apolonia, Gomez, Fernando, Gomez, Lluis Alberto, Gonzalbez, Jose, Griera, Jose Luis, Masmiquel, Luís, Mauricio, Didac, Narejos Perez, Silvia, Nicolau, Juana Ana, Noheda Contreras, Olga, Olivan, Josefina, Olivares, Josefina, Ortega, Emilio, Pellitero, Silvia, Pertusa, Salvador, Rius, Ferran, Rodriguez, Irene, Sánchez-Juan, Carlos, Santos, Dolores, Soldevila, Berta, Subias, David, Terns, Manel, Trescoli, Carlos, Vilaplana, Judith, Villanueva, Alicia, Albo, Jaan, Antus, Kjell, Axelsson, Mattias, Bergström, Lisa, Binsell-Gerdin, Emil, Boman, Kurt, Botond, Fabian, Dotevall, Annika, Graipe, Anna, Jarnet, C, Kaminska, Jessica, Kempe, Anders, Korhonen, Michael, Linderfalk, Carina, Liu, Bo, Ljungstroem, Karl, Ljungström, Karl, Malmqvist, Lennart, Mellbin, Linda, Mooe, Thomas, Nicol, Peter, Norrby, Anders, Ohlsson, Ake, Rosengren, Annika, Saaf, Jan, Salmonsson, Staffan, Strandberg, Olof, Svensson, Karl-Axel, Tengmark, Bengt-Olov, Tsatsaris, Georgios, Ulvenstam, Anders, Vasko, Peter, Chang, Chwen-Tzuei, Chang, Hsin-Mei, Chen, Jung-Fu, Chen, To-Pang, Chung, Ming-Min, Fu, Chia-Po, Hsia, Te-Lin, Hua, Shih-Che, Kuo, Ming-Chun, Lee, Chia-ln, Lee, I-Te, Liang, Kae-Woei, Lin, Shih Yi, Lu, Chieh-Hsiang, Ma, Wen-Ya, Pei, Dee, Shen, Feng-Chih, Su, Ching-Chieh, Su, Shuo-Wei, Tai, Tsai-Sung, Tsai, Wan-Ni, Tsai, Yi-Ting, Tung, Shih-Chen, Wang, Jun-Sing, Yu, Hui-I, Al-Qaissi, Ahmed, Arutchelvam, Vijayaraman, Atkin, Stephen, Au, Simon, Aye, Myint Myint, Bain, Stephen, Bejnariu, Cristina, Bell, Patrick, Bhatnagar, Deepak, Bilous, Rudy, Black, Neil, Brennan, Ursula, Brett, Barbara, Bujanova, Jana, Chow, Elaine, Collier, Andrew, Combe, Amanda, Courtney, Christopher, Courtney, Hamish, Crothers, James, Eavis, Patrick, Elliott, Jackie, Febbraro, Salvatore, Finlayson, Jim, Gandhi, Rajiv, Gillings, Sharon, Hamling, Jonathan, Harper, Roy, Harris, Tim, Hassan, Kahal, Heller, Simon, Jane, Alison, Javed, Zeeshan, Johnson, Tim, Jones, Stephen, Kennedy, Adele, Kerr, David, Kilgallon, Brian, Konya, Judith, Lindsay, John, Lomova-Williams, Lina, Looker, Helen, MacFarlane, David, Macrury, Sandra, Malik, Iqbal, McCrimmon, Rory, McKeith, Douglas, McKnight, John, Mishra, Biswa, Mukhtar, Racha, Mulligan, Ciara, O'Kane, Maurice, Olateju, Tolu, Orpen, Ian, Richardson, Tristan, Rooney, Desmond, Ross, Shorsha Bae, Sathyapalan, Thozhukat, Siddaramaiah, Naveen, Sit, Lee Euan, Stephens, Jeffrey, Turtle, Frances, Wakil, Ammar, Walkinshaw, Emma, Ali, Asem, Anderson, Robert, Arakaki, Richard, Aref, Omar, Ariani, Mehrdad Kevin, Arkin, David, Banarer, Salomon, Barchini, George, Bhan, Arti, Branch, Kelley, Brautigam, Donald, Brietzke, Stephen, Brinas, Maridez, Brito, Yudit, Carter, Casey, Casagni, Kimberely, Casula, Sabina, Chakko, Simon, Charatz, Seth, Childress, Dale, Chow, Lisa, Chustecka, Malgorzata, Clarke, Subha, Cohen, Lisa, Collins, Barry, Colon Vega, Gildred, Comulada-Rivera, Angel, Cortes-Maisonet, Gregorio, Davis, Matthew, de Souza, Jose, Desouza, Cyrus, Dinnan, Mary, Duffy-Hidalgo, Bobbi, Dunn, Barbara, Dunn, Julia, Elman, Marshall, Felicetta, James, Finkelstein, Stuart, Fitz-Patrick, David, Florez, Hermes, Forker, Alan, Fowler, Wayne, Fredrickson, Sonja, Freedman, Zachary, Gainey Narron, Brooke, Gainey-Ferree, Kristin, Gardner, Michael, Gastelum, Christian, Giddings, Stephen, Gillespie, Eve, Gimness, Michael Paul, Goldstein, Gary, Gomes, Maria, Gomez, Nelson, Gorman, Timothy, Goswami, Ketan, Graves, Arthur, Hacking, Scott, Hall, Charles, Hanson, Lenita, Harman, Sherman, Heber, David, Henry, Robert, Hiner, Janette, Hirsch, Irl, Hollander, Priscilla, Hooker, Thomas, Horowitz, Barry, Hoste, Laura, Huang, Loli, Huynh, Minh, Hyman, Dan, Idriss, Soha, Iranmanesh, Ali, Karounos, Dennis, Kashyap, Moti, Katz, Lois, Kaye, William, Khaiton, Yevgeniy, Khardori, Romesh, Kitchen, Timothy, Klein, Andrew, Knffem, Wendi, Kosiborod, Mikhail, Kreglinger, Nicola, Kruger, Davida, Kumar, Anubhav, Laboy, Ivan, Larrabee, Patricia, Larrick, Laura, Lawson, Donna, Ledet, Mike, Lenhard, James, Levy, James, Li, George, Li, Zhaoping, Lieb, David, Limcolioc, April, Lions-Patterson, Jane, Lorber, Daniel, Lorch, Daniel, Lorrello, Michael, Lu, Peter, Lucas, Kathryn Jean, Ma, Siu-Ling, MacAdams, Michael, Magee, Michelle, Magno, Alexander, Mahakala, Aparna Reddy, Marks, Jennifer, McCall, Anthony, McClanahan, William, McClary, Carole, Melendez, Lydia, Melish, John, Michaud, Deanna, Miller, Christopher, Miller, Neil, Mora, Pablo, Moten, Marriyam, Mudaliar, Sunder, Myrick, Gregory, Narayan, Puneet, Nassif, Mike, Neri, Karena, Newton, Tabitha, Niblack, Patricia, Nicol, Philip, Nyenwe, Ebenezer, Odugbesan, A. Ola, Okorocha, Yolanda, Ortiz Carrasquillo, Ramón, Osei, Kwame, Palermo, Coromoto, Patel, Hiren, Patel, Krishna, Pau, Cindy, Perley, Michael, Plevin, Sanford, Plummer, Elena, Powell, Richard, Qintar, Mohammed, Rawls, Rex, Reyes-Castano, John, Reynolds, Lillian, Richards, Robert, Rosenstock, Julio, Rowe, Caroline, Saleh, Jahandar, Sam, Sony, Sanchez, Alfredo, Sander, Donald, Sanderson, Bruce, Savin, Virginia, Seaquist, Elizabeth, Shah, Jayendra, Shi, Serena, Shivaswamy, Vijay, Shlotzhauer, Tammi, Shore, David, Skukowski, Bobbie, Soe, Kyaw, Solheim, Vesna, Soufer, Joseph, Steinberg, Helmut, Steinsapir, Jaime, Tarkington, Phillip, Thayer, Debra, Thomson, Stephen, Thrasher, James, Tibaldi, Joseph, Tjaden, Jeff, Tores, Oberto, Trence, Dace, Trikudanathan, Subbulaxmi, Ullal, Jagdeesh, Uwaifo, Gabriel, Vo, Anthony, Vu, Kenny, Walia, Damandeep, Weiland, Karen, Whitehouse, Fred, Wiegmann, Thomas, Wyne, Kathleen, Wynne, Alan, Yuen, Kevin, Zaretzky, Joel, Zebrack, James, Zieve, Franklin, and Zigrang, William
- Abstract
Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk with high glycated haemoglobin A1c(HbA1c) concentrations. We assessed the effect of the GLP-1 receptor agonist dulaglutide on major adverse cardiovascular events when added to the existing antihyperglycaemic regimens of individuals with type 2 diabetes with and without previous cardiovascular disease and a wide range of glycaemic control.
- Published
- 2019
- Full Text
- View/download PDF
24. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial
- Author
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Gerstein, Hertzel C, Colhoun, Helen M, Dagenais, Gilles R, Diaz, Rafael, Lakshmanan, Mark, Pais, Prem, Probstfield, Jeffrey, Botros, Fady T, Riddle, Matthew C, Rydén, Lars, Xavier, Denis, Atisso, Charles Messan, Dyal, Leanne, Hall, Stephanie, Rao-Melacini, Purnima, Wong, Gloria, Avezum, Alvaro, Basile, Jan, Chung, Namsik, Conget, Ignacio, Cushman, William C, Franek, Edward, Hancu, Nicolae, Hanefeld, Markolf, Holt, Shaun, Jansky, Petr, Keltai, Matyas, Lanas, Fernando, Leiter, Lawrence A, Lopez-Jaramillo, Patricio, Cardona Munoz, Ernesto German, Pirags, Valdis, Pogosova, Nana, Raubenheimer, Peter J, Shaw, Jonathan E, Sheu, Wayne H-H, Temelkova-Kurktschiev, Theodora, Abella, Mercedes, Alebuena, Andrea, Almagro, Sandra, Amoroso, Eduardo, Anadon, Paula, Andreu, Elizabeth, Aristimuño, Guillermo, Arzadun, Maria, Barbieri, Maria, Barcudi, Raul, Bartolacci, Ines, Bolobanich, Gabriel, Bordonava, Anselmo, Bustamante Labarta, Miguel, Bustos, Betina, Caccavo, Alberto, Camino, Alejandra, Cantero, Maria, Carignano, Maria, Cartasegna, Luis, Cipullo, Marcela, Commendatore, Víctor, Conosciuto, Victoria, Costamagna, Osvaldo, Crespo, Claudia, Cuello, Jose, Cuneo, Carlos, Cusimano, Sandra, Dean, Sofia, Dituro, Claudio, Dominguez, Andrea, Farah, Miguel, Fernandez, Alberto, Fernandez, Florencia, Ferrari, Adriana, Flammia, Patricia, Fuentealba, Jose, Gallardo, Karina Beatriz, Garcia, Celso, Garcia Duran, Ruben, Garrido, Marcelo, Gavicola, Rodolfo, Gerbaudo, Claudio, Gilli, Graciela, Giotto, Ana Paula, Godoy Bolzán, Pedro, Gomez Vilamajo, Oscar, Guerlloy, Fernando, Guridi, Cristian, Gutierrez Garrido, Narcisa, Hasbani, Eduardo, Hermida, Sonia, Hominal, Miguel, Hrabar, Adrian, Ingaramo, Adrián, Izzicupo, Alejandra, Krynski, Mario, Lagrutta, Mariana, Lanchiotti, Paulina, Langhe, Maria, Leonard, Veronica, Llanos, Javier, Lopez Santi, Ricardo, Lowenstein, Jorge, Luquez, Cecilia, Mackinnon, Ignacio, Mana, Melina, Manzur, Sara, Marino, Javier, Martella, Carolina, Martinez, Roger, Matias, Re, Matkovich, Javier, Meritano, Monica, Montaña, Oscar, Mulazzi, María, Ochoa, Juan, Paterlini, Gustavo, Pelagagge, María, Peralta Lopez, Maria Elena, Prado, Aldo, Pruyas, Lorena, Racca, Martín, Ricotti, Carola, Rodriguez, Carolina, Romero Vidomlansky, Mariano, Ronderos, Ricardo, Sadowski, Ana Laura, Sala, Jorgelina, Sánchez, Alejandro, Santoro, Andrea, Schiavi, Lilia, Sein, Mariano, Sernia, Virginia, Serra, Leonardo, Sicer, Maximiliano, Smith, Tomas, Soso, Leonardo, Sposetti, Georgina, Steinacher, Andrea, Stival, Jorge, Tedesco, Jorge, Tonin, Hugo, Tortolo, Mauro, Ulla, Maria, Vallejos, Julio, Vico, Marisa, Virgillito, Luciana, Visco, Virginia, Vogel, Daniel, Waisman, Florencia, Zaidman, César, Zucchiatti, Noemi, Badshah, Imran, Cohen, Neale, Colman, Peter, Colquhoun, David, Davis, Timothy, Fourlanos, Spiros, Fulcher, Greg, Hamlyn, Jane, Haywood, Cilla, Hocking, Samantha, Huchinson, Maeve, Jeffries, William, Kyl, Mervyn, Lo, Clement, Mah, PeakMann, Makepeace, Ashley, Marope, Dolly, Nanayakkar, Natalie, Nankervis, Alison, Palmer, Neil, Palolus, Barbara, Pillai, Satish, Price, Sarah, Price, Sarah, Proietto, Joseph, Reutens, Anne, Rodrigo, Natassia, Sheikh, Abdul, Smith, Greg, So, Michelle, Soldatos, Georgia, Stuckey, Bronwyn, Sumithran, Priya, Teede, Helena, Vora, Parind, Williams, Lyn, Abib, Eduardo, Adão Poço, Christiani, Alves, Érica Ferreira, Andreatta Bernardi Barea, Janaina, Avezum Oliveira, Livia, Castro, Denise Ludovico da Costa de, Correa da Cruz, Ivan, Costa, Midiã, Cruz, Ivan, Cunha, Sidney, Da Silva, Marco Antonio Vieira, de Carvalho Camara Bona, Renata, de Paula, Bruna, Eliaschewitz, Freddy, Fazolli, Guilherme, Ferreira Filho, Carlos Alberto, Fortes, Jose, França, Cesar, Franco, Denise Reis, Genestreti, Paulo Roberto, Giorgeto, Flavio, Gonçalves, Rodrigo Marques, Grossman, Michele Elka, Henrique Marcelino, Ana Claudia, Hernandes, Mauro, Horta, Ana, Jaeger, Cristiano, Kaneblai, Midia, Kauffman Rutenberg, Cecilia, Kerr Saraiva, Jose Francisco, Lemos, Maria Angelica, Maia, Lilia, Manenti, Euler Roberto, Marques, Mariana, Melissa Valerio, Cynthia, Moreira, Rodrigo, Mothé, Flávia, Mouco, Osana Maria, Moura, Philip, Moura Jorge, José Carlos, Nakashima, Carlos, Nakazone, Marcelo, Napoli, Thiago, Nunes, Cristiane, Nunes Salles, Joao Eduardo, Oliveira, Karla, Oliveira, Marcela, Pantano, Gracielly de Souza, Petri, Fabio, Piazza, Leonardo, Pires, Andreia Carla, Pizzato, Patricia, Prata, Sergio, Precoma, Dalton, Rech, Rafael, Reis, Gilmar, Reis, Heleno, Resende, Elisabete, Ribas Fortes, Jose, Rodovalho, Sylka, Rossi dos Santos, Fabio, Salles, Joao Eduardo, Sampaio, Célia Regina, Santos, Thiago, Santos dos Santos, Vanessa, Silva e Quadros, Tulio, Silveira, Daniel, Siqueira, Katia Nunes, Teireira, M, Uehara, Marcelo, Valerio, C, Vianna, Henrique, Vidotti, Maria Helena, Visconti, Guilherme de Lima, Zanella, Maria Teresa, Andreeva, Viktoriya, Borisov, Radoslav, Botushanov, Nikolay, Dimitrov, Georgi, Dimova, Kameliya, Dragoychev, Tsvetan, Grigorova, Valentina, Gushterova, Valentina, Ivanov, Ivaylo, Kocelova, Tatyana, Kurktschiev, Dimo, Miletieva, Milena, Nenkova-Gugusheva, Neli, Pancheva, Ralitsa, Pavlova, Maria, Raev, Dimitar, Spasova, Vesela, Stoikov, Anastas, Troev, Dimitar, Yanev, Todor, Yoncheva-Mihaylova, Mariana, Abitbol, Alexander, Ajala, Buki, Alguwaihes, Abdullh, Ardilouze, Jean-Luc, Aris-Jilwan, Nahla, Arnaout, Amel, Aronson, Ronnie, Aslam, Nadeem, Babin, Sandra, Bailargeon, Jean-Patrice, Bailey, Allan, Bajaj, Harpreet, Beauchesne, Christian, Beca, Sorin, Belanger, Andre, Bell, Alan, Bellabarba, Diego, Berard, Lori, Berenbaum, Brian, Bergeron, Vincent, Berlingieri, Joseph, Bernier, Frédéric, Bishara, Phoebe, Blank, David, Blumer, Ian, Brault, Suzanne, Breton, Donald, Carpentier, André, Cha, James, Chandra, Prakash, Chiasson, Jean-Louis, Conway, James R, Couture, Ghyslaine, Couture, Nathalie, Dagenais, Gilles, Datta, Dyotirmoy, D'Ignazio, Giuseppe, Dumas, Richard, Fay, Didier, Frechette, Andre, Frenette, 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Oren, Sussman, Jack, Telner, Adam, Tobe, Sheldon, Twum-Barima, David-Yaw, Van Zanten, Audrey, VanRossum, Nicole, Vecchiarelli, Jonathan, Ward, Rick, Wessengel, John, Weisnagel, Stanley, Wilderman, Igor, Woo, Vincent, Yakubovich, Natalia, Yale, Jean-Francois, Yared, Zeina, Acevedo, Monica, Aguirre, Maria Loreto, Aizman, Andres, Barroso, Maria Soledad, Cobos, Leonardo, Danin Vargas, Alfredo, Descalzi, Barbara, Godoy, Gonzalo, Grumberg, Elio, Lahsen, Rodolfo, Larenas, Gladys, Ortiz, Eugenia, Paredes, Javier, Potthoff, Sergio, Retamal, Eva, Rojas, Luis, Salgado, Manuel, Santibanez, Claudio, Solis, Carmen, Stokins, Benjamin, Accini, Jose, Acebedo, Javier, Agudelo Baena, Lina Maria, Alarcon, Soraya, Angel, Juliana, Arcos, Edgar, Aroca Martinez, M, Atuesta, Leonor, Balaguera, Jose, Ballestas, Doris, Barrera, Sandra Isabel, Barrios Reyes, Rosmy, Bayona, Adolfo, Bermudez, Andres, Bernal, Diego Zarate, Blanquicett, Marco, Bravo, Victor, Bueno, Wendy, Burbano Delgado, Alvaro, Cadena, Alberto, Cadena, Andres, Caicedo, Sandra, Celemin, Carlos, Consuegra, Ricardo, Contreras Pimienta, Cristhian, Corredor, Kelly Johenis, Cure, Carlos, De La Hoz Rueda, Lizeth Dayana, Delgado, Erika, Diaz, Sarahy, Diego, Marta, Donado, Anabell, Encinales Sanabria, William, Escobar, Juliana, Escorcia, Gillian, Forero, Leonardo, Fuentes, Laura, Garcia, Maria, Garcia Lozada, Henry, Garcia Ortiz, Luis, Giraldo, Angela, Gomez Gonzalez, Laura, Granada, Javier, Gutierrez, Corina, Henao, Natalia, Hernandez, Edwin, Herrera Uejbe, Olga Maria, Higuera Cobos, Juan Diego, Ibarra Gómez, Jaime, Jaimes, Edwin Hernandez, Jaramillo, Monica, Jaramillo, Nicolas, Jaramillo Gomez, Carlos, Jaramillo Sanchez, Monica, Jarava Durán, Ivonne, Lopez Ceballos, Catalina, Madrid, Claudia, María Amastha, Elias, Mercado, Jennifer, Molina, Dora Ines, Molina Soto, Jessica, Montoya, Carlos, Morales, Alexander, Muñoz, Carolina, Orozco, Luis Alejandro, Osorio, Oscar, Palmera Sanchez, Jorge Mario, Peña, Adwar, Perez, Jose, Perez 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Dwojak, Marek, Grodzicka, Agnieszka, Janiec, Izabela, Jaruga, Joanna, Jazwinska-Tarnawska, Ewa Krystyna, Jedynasty, Krystyna, Juzwiak-Czapiewska, Danuta, Karczewicz-Janowska, Jadwiga, Konieczny, Jan, Konieczny, Marek, Korol, Marek, Kozina, Maciej, Krzyzagorska, Ewa, Kucharczyk-Petryka, Ewa, Laz, Roman, Majchrzak, Anna, Mrozowska, Zdzislawa, Mularczyk, Michal, Nowacka, Elzbieta, Peczynska, Jadwiga, Petryka, Robert, Pietrzak, Radoslaw, Pisarczyk-Wiza, Dorota, Rozanska, Aleksandra, Ruzga, Zofia, Rzeszotarska, Emilia, Sacha, Malgorzata, Sekulska, Marzenna, Sidorowicz-Bialynicka, Anna, Stasinska, Teresa, Strzelecka-Sosik, Agnieszka, Swierszcz, Teresa, Szymkowiak, Katarzyna Miroslawa, Turowska, Olga, Wisniewska, Krystyna, Wiza, Maciej, Wozniak, Iwona, Zelazowska, Katarzyna, Ziolkowska-Gawron, Bernadetta, Zytkiewicz-Jaruga, Danuta, Albota, Adrian, Alexandru, Carmina, Avram, Rodica, Bala, Cornelia, Barbonta, Diana, Barbu, Roxana, Braicu, Daniela, Calutiu, Nicoleta, Catrinoiu, Doina, Cerghizan, Anca, Ciorba, Alina, Craciun, Anca, Doros, Rodica, Duma, Livia, Dumitrache, Ancuta, Ferariu, Ioana, Ferician Moza, Anca, Ghergan, Alexandrina, Ghise, Gheorghe, Graur, Mariana, Gribovschi, Mihaela, Mihai, Bogdan, Mihalache, Laura, Mihalcea, Madalina, Mindrescu, Nicoleta, Morosanu, Magdalena, Morosoanu, Andrea, Mota, Maria, Moza, Anca, Nafornita, Valerica, Natea, Narcisa, Nicodim, Simona, Nita, Cristina, Onaca, Adriana, Onaca, Mircea, Pop, Cristina, Pop, Lavinia, Popa, Amorin, Popescu, Alexandrina, Pruna, Luchiana, Roman, Gabriela, Rosu, Mihaela, Sima, Alexandra, Sipciu, Doina, Sitterli-Natea, Carmen Narcisa, Szilagyi, Iosif, Tapurica, Minodora, Tase, Adrian, Tutescu, Adriana-Carmen, Vanghelie, Luminita, Verde, Ioana, Vlad, Adrian, Zarnescu, Mihaela, Akhmetov, Roman, Allenova, Irina, Avdeeva, Irina, Baturina, Oksana, Biserova, Irina, Bokovin, Nikolay, Bondar, Irina, Burova, Natalia, Chufeneva, Galina, Chumachek, Elena, Demidova, Marina, Demin, Alexander, Drobysheva, Vera, Egorova, Irina, Esenyan, Lev, Gelig, Ekaterina, Gilyarevsky, Sergey, Golshmid, Maria, Goncharov, Arseniy, Gorbunova, Anastasia, Gordeev, Ivan, Gorelysheva, Vera, Goryunova, Tatiana, Grebenshchikova, Irina, Ilchenko, Roman, Ivannikova, Maria, Karabalieva, Saule, Karpeeva, Juliya, Khaykina, Elena, Kobalava, Zhanna, Kononenko, Irina, Korolik, Oxana, Korshunova, Anna, Kostenko, Victor, Krasnopevtseva, Irina, Krylova, Ludmila, Kulkova, Polina, Kuzmina, Irina, Ledyaeva, Alla, Levashov, Sergey, Lokhovinina, Natalia, Lvov, Vadim, Martirosyan, Narine, Nedogoda, Sergey, Nilk, Rostislav, Osmolovskaya, Yulia, Panov, Alexey, Paramonova, Olga, Pavlova, Ekaterina, Pekareva, Elena, Petunina, Nina, Ponamareva, Svetlana, Reshedko, Galina, Salasyuk, Alla, Sepkhanyan, Malvina, Serebrov, Alexandr, Shabelnikova, Olesya, Skvortsov, Andrey, Smirnova, Olga, Spiridonova, Oxana, Strogova, Svetlana, Taratukhin, Evgeny, Tereschenko, Sergey, Trukhina, Lubov, Tsarkova, Olga, Tsoma, Vera, Tumarov, Farid, Tyan, Natalya, Tyurina, Tatiana, Villevalde, Svetlana, Yankovaya, Elena, Zarutskaya, Ludmila, Zenkova, Elena, Badat, Aysha, Bester, Frederik, Blignaut, Suzanne, Blom, Dirk, Booysen, Susan, Boyd, Warren, Brice, Brigitte, Brown, Susan, Burgess, Lesley, Cawood, Reina, Coetzee, Kathleen, Conradie, Hillet, Cronje, Tanja, de Jong, Douwe, Ellis, Graham, Emanuel, Shaunagh, Engelbrecht, Ingrid, Foulkes, Sharne, Fourie, Done, Gibson, Gilbert, Govender, Thirumani, Hansa, Sumayah, Hemus, Allana Colleen, Hendricks, Firzana, Heradien, Marshall, Holmgren, Chantelle, Hoosain, Zaheer, Horak, Emile, Howard, Johannes, Immink, Ignatius, Janari, E., Jivan, Daksha, Klusmann, Karl, Labuschagne, Weik, Lai, Yen-yu, Latiff, Gulam, Lombaard, J., Lottering, Hanlie, Meeding, Ronel, Middlemost, Shirley, Mitha, Haroon, Mitha, Ismail, Mkhwanazi, Sandile, Moodley, Rajendran, Murray, Almeri, Musungaie, Dany, Osman, Yasmin, Peacey, Kirsten, Pillay-Ramaya, Larisha, Pretorius, Catharina, Prozesky, Hans, Sarvan, Mahomed, Scholtz, E, Sebesteny, Attila, Skinner, Bianca, Skriker, Michael, Smit, M, Stapelberg, Anna-Marie, Swanepoel, Nicolaas, Urbach, Dorothea, van Aswegen, Dina, van Zyl, Francois, Van Zyl, Louis, Venter, Esme, Wadvalla, Shahid, Wing, Jeffrey, Wolmarans, Karen, Abreu, Cristina, Aguilà, Pilar, Aguilera, Eva, Alonso, Nuria, Alvarez, Carmen, Cajas, Priscila, Castro, Jose Carlos, Codinachs, Roger, Contreras, Jose, Coves, Maria Jose, Fajardo, Carmen, Ferrer, Juan Carlos, Font, Neus, Garcia, Mar, Gil, Maria Apolonia, Gomez, Fernando, Gomez, Lluis Alberto, Gonzalbez, Jose, Griera, Jose Luis, Masmiquel, Luís, Mauricio, Didac, Narejos Perez, Silvia, Nicolau, Juana Ana, Noheda Contreras, Olga, Olivan, Josefina, Olivares, Josefina, Ortega, Emilio, Pellitero, Silvia, Pertusa, Salvador, Rius, Ferran, Rodriguez, Irene, Sánchez-Juan, Carlos, Santos, Dolores, Soldevila, Berta, Subias, David, Terns, Manel, Trescoli, Carlos, Vilaplana, Judith, Villanueva, Alicia, Albo, Jaan, Antus, Kjell, Axelsson, Mattias, Bergström, Lisa, Binsell-Gerdin, Emil, Boman, Kurt, Botond, Fabian, Dotevall, Annika, Graipe, Anna, Jarnet, C, Kaminska, Jessica, Kempe, Anders, Korhonen, Michael, Linderfalk, Carina, Liu, Bo, Ljungstroem, Karl, Ljungström, Karl, Malmqvist, Lennart, Mellbin, Linda, Mooe, Thomas, Nicol, Peter, Norrby, Anders, Ohlsson, Ake, Rosengren, Annika, Saaf, Jan, Salmonsson, Staffan, Strandberg, Olof, Svensson, Karl-Axel, Tengmark, Bengt-Olov, Tsatsaris, Georgios, Ulvenstam, Anders, Vasko, Peter, Chang, Chwen-Tzuei, Chang, Hsin-Mei, Chen, Jung-Fu, Chen, To-Pang, Chung, Ming-Min, Fu, Chia-Po, Hsia, Te-Lin, Hua, Shih-Che, Kuo, Ming-Chun, Lee, Chia-ln, Lee, I-Te, Liang, Kae-Woei, Lin, Shih Yi, Lu, Chieh-Hsiang, Ma, Wen-Ya, Pei, Dee, Shen, Feng-Chih, Su, Ching-Chieh, Su, Shuo-Wei, Tai, Tsai-Sung, Tsai, Wan-Ni, Tsai, Yi-Ting, Tung, Shih-Chen, Wang, Jun-Sing, Yu, Hui-I, Al-Qaissi, Ahmed, Arutchelvam, Vijayaraman, Atkin, Stephen, Au, Simon, Aye, Myint Myint, Bain, Stephen, Bejnariu, Cristina, Bell, Patrick, Bhatnagar, Deepak, Bilous, Rudy, Black, Neil, Brennan, Ursula, Brett, Barbara, Bujanova, Jana, Chow, Elaine, Collier, Andrew, Combe, Amanda, Courtney, Christopher, Courtney, Hamish, Crothers, James, Eavis, Patrick, Elliott, Jackie, Febbraro, Salvatore, Finlayson, Jim, Gandhi, Rajiv, Gillings, Sharon, Hamling, Jonathan, Harper, Roy, Harris, Tim, Hassan, Kahal, Heller, Simon, Jane, Alison, Javed, Zeeshan, Johnson, Tim, Jones, Stephen, Kennedy, Adele, Kerr, David, Kilgallon, Brian, Konya, Judith, Lindsay, John, Lomova-Williams, Lina, Looker, Helen, MacFarlane, David, Macrury, Sandra, Malik, Iqbal, McCrimmon, Rory, McKeith, Douglas, McKnight, John, Mishra, Biswa, Mukhtar, Racha, Mulligan, Ciara, O'Kane, Maurice, Olateju, Tolu, Orpen, Ian, Richardson, Tristan, Rooney, Desmond, Ross, Shorsha Bae, Sathyapalan, Thozhukat, Siddaramaiah, Naveen, Sit, Lee Euan, Stephens, Jeffrey, Turtle, Frances, Wakil, Ammar, Walkinshaw, Emma, Ali, Asem, Anderson, Robert, Arakaki, Richard, Aref, Omar, Ariani, Mehrdad Kevin, Arkin, David, Banarer, Salomon, Barchini, George, Bhan, Arti, Branch, Kelley, Brautigam, Donald, Brietzke, Stephen, Brinas, Maridez, Brito, Yudit, Carter, Casey, Casagni, Kimberely, Casula, Sabina, Chakko, Simon, Charatz, Seth, Childress, Dale, Chow, Lisa, Chustecka, Malgorzata, Clarke, Subha, Cohen, Lisa, Collins, Barry, Colon Vega, Gildred, Comulada-Rivera, Angel, Cortes-Maisonet, Gregorio, Davis, Matthew, de Souza, Jose, Desouza, Cyrus, Dinnan, Mary, Duffy-Hidalgo, Bobbi, Dunn, Barbara, Dunn, Julia, Elman, Marshall, Felicetta, James, Finkelstein, Stuart, Fitz-Patrick, David, Florez, Hermes, Forker, Alan, Fowler, Wayne, Fredrickson, Sonja, Freedman, Zachary, Gainey Narron, Brooke, Gainey-Ferree, Kristin, Gardner, Michael, Gastelum, Christian, Giddings, Stephen, Gillespie, Eve, Gimness, Michael Paul, Goldstein, Gary, Gomes, Maria, Gomez, Nelson, Gorman, Timothy, Goswami, Ketan, Graves, Arthur, Hacking, Scott, Hall, Charles, Hanson, Lenita, Harman, Sherman, Heber, David, Henry, Robert, Hiner, Janette, Hirsch, Irl, Hollander, Priscilla, Hooker, Thomas, Horowitz, Barry, Hoste, Laura, Huang, Loli, Huynh, Minh, Hyman, Dan, Idriss, Soha, Iranmanesh, Ali, Karounos, Dennis, Kashyap, Moti, Katz, Lois, Kaye, William, Khaiton, Yevgeniy, Khardori, Romesh, Kitchen, Timothy, Klein, Andrew, Knffem, Wendi, Kosiborod, Mikhail, Kreglinger, Nicola, Kruger, Davida, Kumar, Anubhav, Laboy, Ivan, Larrabee, Patricia, Larrick, Laura, Lawson, Donna, Ledet, Mike, Lenhard, James, Levy, James, Li, George, Li, Zhaoping, Lieb, David, Limcolioc, April, Lions-Patterson, Jane, Lorber, Daniel, Lorch, Daniel, Lorrello, Michael, Lu, Peter, Lucas, Kathryn Jean, Ma, Siu-Ling, MacAdams, Michael, Magee, Michelle, Magno, Alexander, Mahakala, Aparna Reddy, Marks, Jennifer, McCall, Anthony, McClanahan, William, McClary, Carole, Melendez, Lydia, Melish, John, Michaud, Deanna, Miller, Christopher, Miller, Neil, Mora, Pablo, Moten, Marriyam, Mudaliar, Sunder, Myrick, Gregory, Narayan, Puneet, Nassif, Mike, Neri, Karena, Newton, Tabitha, Niblack, Patricia, Nicol, Philip, Nyenwe, Ebenezer, Odugbesan, A. Ola, Okorocha, Yolanda, Ortiz Carrasquillo, Ramón, Osei, Kwame, Palermo, Coromoto, Patel, Hiren, Patel, Krishna, Pau, Cindy, Perley, Michael, Plevin, Sanford, Plummer, Elena, Powell, Richard, Qintar, Mohammed, Rawls, Rex, Reyes-Castano, John, Reynolds, Lillian, Richards, Robert, Rosenstock, Julio, Rowe, Caroline, Saleh, Jahandar, Sam, Sony, Sanchez, Alfredo, Sander, Donald, Sanderson, Bruce, Savin, Virginia, Seaquist, Elizabeth, Shah, Jayendra, Shi, Serena, Shivaswamy, Vijay, Shlotzhauer, Tammi, Shore, David, Skukowski, Bobbie, Soe, Kyaw, Solheim, Vesna, Soufer, Joseph, Steinberg, Helmut, Steinsapir, Jaime, Tarkington, Phillip, Thayer, Debra, Thomson, Stephen, Thrasher, James, Tibaldi, Joseph, Tjaden, Jeff, Tores, Oberto, Trence, Dace, Trikudanathan, Subbulaxmi, Ullal, Jagdeesh, Uwaifo, Gabriel, Vo, Anthony, Vu, Kenny, Walia, Damandeep, Weiland, Karen, Whitehouse, Fred, Wiegmann, Thomas, Wyne, Kathleen, Wynne, Alan, Yuen, Kevin, Zaretzky, Joel, Zebrack, James, Zieve, Franklin, and Zigrang, William
- Abstract
Two glucagon-like peptide-1 (GLP-1) receptor agonists reduced renal outcomes in people with type 2 diabetes at risk for cardiovascular disease. We assessed the long-term effect of the GLP-1 receptor agonist dulaglutide on renal outcomes in an exploratory analysis of the REWIND trial of the effect of dulaglutide on cardiovascular disease.
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- 2019
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25. Guideline Alignment in Related Areas
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Dubrofsky, Lisa and Tobe, Sheldon W.
- Abstract
Clinical practice guidelines serve an important role in the primary and secondary prevention of cardiovascular disease. There is variability among guideline groups in the methods used to assess and grade clinical evidence, resulting in discrepancies in various guidelines. Multiple guidelines focused on different aspects of cardiovascular care can lead to recommendations that are out of sync. Discrepancies between a practice recommendation from 2 different Canadian guideline groups can lead to confusion among clinicians and patients, reducing the likelihood that the practice recommendation will be carried out. Assisting cardiovascular-focused guideline groups to align, to harmonize, and to score highly on appraisal has been a main function of the Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE). Validated appraisal tools, harmonized guideline initiatives, and continuous evaluation of the impact of guidelines on quality indicators and practice outcomes are crucial for improving cardiovascular care for all Canadians.
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- 2019
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26. Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
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Cheung, Alfred K., Chang, Tara I., Cushman, William C., Furth, Susan L., Ix, Joachim H., Pecoits-Filho, Roberto, Perkovic, Vlado, Sarnak, Mark J., Tobe, Sheldon W., Tomson, Charles R.V., Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., Mann, Johannes F.E., Bakris, George L., Damasceno, Albertino, Dwyer, Jamie P., Fried, Linda F., Haynes, Richard, Hirawa, Nobuhito, Holdaas, Hallvard, Ibrahim, Hassan N., Ingelfinger, Julie R., Iseki, Kunitoshi, Khwaja, Arif, Kimmel, Paul L., Kovesdy, Csaba P., Ku, Elaine, Lerma, Edgar V., Luft, Friedrich C., Lv, Jicheng, McFadden, Christopher B., Muntner, Paul, Myers, Martin G., Navaneethan, Sankar D., Parati, Gianfranco, Peixoto, Aldo J., Prasad, Ramesh, Rahman, Mahboob, Rocco, Michael V., Rodrigues, Cibele Isaac Saad, Roger, Simon D., Stergiou, George S., Tomlinson, Laurie A., Tonelli, Marcello, Toto, Robert D., Tsukamoto, Yusuke, Walker, Robert, Wang, Angela Yee-Moon, Wang, Jiguang, Warady, Bradley A., Whelton, Paul K., and Williamson, Jeff D.
- Abstract
In September 2017, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference titled Blood Pressure in Chronic Kidney Disease (CKD). The purpose of the meeting was to consider which recommendations from the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD should be reevaluated based on new evidence from clinical trials. Participants included a multidisciplinary panel of clinical and scientific experts. Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients. Consistent with the 2012 Guideline, the conference did not address BP management in patients on maintenance dialysis.
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- 2019
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27. Change of education strategy associated with slippage in Canadian hypertension awareness treatment and control rates
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Tobe, Sheldon W., Campbell, Norman R. C., Padwal, Raj S., Khan, Nadia A., and Singer, Julia
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- 2021
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28. The Influence of Marital Adjustment on 3-Year Left Ventricular Mass and Ambulatory Blood Pressure in Mild Hypertension
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Baker, Brian, Paquette, Miney, Szalai, John P., Driver, Helen, Perger, Tamara, Helmers, Karin, O'Kelly, Brian, and Tobe, Sheldon
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Cardiac patients -- Psychological aspects ,Coronary heart disease -- Psychological aspects ,Domestic relations -- Health aspects ,Health - Abstract
Background: Of psychosocial stressors, job strain has been associated with a sustained increase in blood pressure. The impact of marital factors on blood pressure and target organ has not been explored. Objectives: To evaluate whether marital adjustment, measured at baseline by self-report (Dyadic Adjustment Scale) influences left ventricular mass index (LVMI) and ambulatory blood pressure measured over 3 years in patients with mild hypertension. Methods: A prospective cohort study was conducted on 103 cohabiting males or females, including 72 with technically adequate echocardiograms, who at baseline were unmedicated, employed, and living with a significant other, all for a minimum of 6 months and had repeated elevated office diastolic blood pressure. Main Outcome Measures: Left ventricular mass by M-mode echocardiography indexed to body surface area and blood pressure were measured by ambulatory blood pressure every 15 minutes (daytime) and hourly between 11 PM and 7 AM. Results: Marital adjustment, smoking, drinking, and baseline LVMI contributed significantly to the prediction of 3-year LVMI (semipartial correlation, [sr.sup.2] = 0.04, 0.07, 0.03, and 0.22; P = .03, .008, .08, and [is less than] .001, respectively) together accounting for 36% of the total variability in follow-up LVMI. Three-year ambulatory blood pressure measures were not significantly related to marital adjustment but there were correlations with Dyadic Adjustment Scale subscales. Low or high levels of spousal contact during 3-year ambulatory blood pressure monitoring were associated with an increase or decrease of 3-year, 24-hour diastolic blood pressure, consistent with the quality of marital adjustment (P = .04) or marital satisfaction (Dyadic Adjustment Scale subscale, P = .008). Conclusions: In a cohort of subjects with mild essential hypertension, marital adjustment had an influence on 3-year LVMI. Depending on the quality of marital adjustment, spousal contact at 3 years was associated with an increase or decrease of 3-year diastolic blood pressure. Confirmation of these results, including objective marital assessment and the participation of normotensive subjects, is required. Arch Intern Med. 2000;160:3453-3458
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- 2000
29. Angiotensin Receptor-Neprilysin Inhibitor Therapy for Heart Failure With Preserved Ejection Fraction Improves Renal Outcomes
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Tobe, Sheldon W. and Poon, Stephanie
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- 2020
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30. Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children
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Nerenberg, Kara A., Zarnke, Kelly B., Leung, Alexander A., Dasgupta, Kaberi, Butalia, Sonia, McBrien, Kerry, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Padwal, Raj S., Tran, Karen C., Grover, Steven, Rabkin, Simon W., Moe, Gordon W., Howlett, Jonathan G., Lindsay, Patrice, Hill, Michael D., Sharma, Mike, Field, Thalia, Wein, Theodore H., Shoamanesh, Ashkan, Dresser, George K., Hamet, Pavel, Herman, Robert J., Burgess, Ellen, Gryn, Steven E., Grégoire, Jean C., Lewanczuk, Richard, Poirier, Luc, Campbell, Tavis S., Feldman, Ross D., Lavoie, Kim L., Tsuyuki, Ross T., Honos, George, Prebtani, Ally P.H., Kline, Gregory, Schiffrin, Ernesto L., Don-Wauchope, Andrew, Tobe, Sheldon W., Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Woo, Vincent, Hegele, Robert A., Selby, Peter, Pipe, Andrew, McFarlane, Philip A., Oh, Paul, Gupta, Milan, Bacon, Simon L., Kaczorowski, Janusz, Trudeau, Luc, Campbell, Norman R.C., Hiremath, Swapnil, Roerecke, Michael, Arcand, Joanne, Ruzicka, Marcel, Prasad, G.V. Ramesh, Vallée, Michel, Edwards, Cedric, Sivapalan, Praveena, Penner, S. Brian, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Dionne, Janis, Magee, Laura A., Logan, Alexander G., Côté, Anne-Marie, Rey, Evelyne, Firoz, Tabassum, Kuyper, Laura M., Gabor, Jonathan Y., Townsend, Raymond R., Rabi, Doreen M., and Daskalopoulou, Stella S.
- Abstract
Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension in adults and children. This year, the adult and pediatric guidelines are combined in one document. The new 2018 pregnancy-specific hypertension guidelines are published separately. For 2018, 5 new guidelines are introduced, and 1 existing guideline on the blood pressure thresholds and targets in the setting of thrombolysis for acute ischemic stroke is revised. The use of validated wrist devices for the estimation of blood pressure in individuals with large arm circumference is now included. Guidance is provided for the follow-up measurements of blood pressure, with the use of standardized methods and electronic (oscillometric) upper arm devices in individuals with hypertension, and either ambulatory blood pressure monitoring or home blood pressure monitoring in individuals with white coat effect. We specify that all individuals with hypertension should have an assessment of global cardiovascular risk to promote health behaviours that lower blood pressure. Finally, an angiotensin receptor-neprilysin inhibitor combination should be used in place of either an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in individuals with heart failure (with ejection fraction < 40%) who are symptomatic despite appropriate doses of guideline-directed heart failure therapies. The specific evidence and rationale underlying each of these guidelines are discussed.
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- 2018
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31. Thresholds and Targets for Hypertension Management in Adults With Type 2 Diabetes Should Remain at 130/80 mmHg: What's the Evidence?
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Shahi, Niharika and Tobe, Sheldon W.
- Abstract
Hypertension and diabetes are common comorbidities and are both modifiable risk factors for cardiovascular disease and death. Lowering blood pressure reduces target organ damage and prevents cardiovascular disease outcomes. The harmonized Canadian clinical practice guidelines for managing hypertension in people with diabetes provides health-behaviour advice and medical therapy recommendations for a threshold blood pressure of 130/80 mmHg and above and to target blood pressure to below 130/80 mmHg. We have reviewed the studies supporting these recommendations and others, and they appear to be at odds with the guidelines, including those for elderly people and patients with pre-existing cardiovascular disease.
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- 2018
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32. Treatment of Hypertension
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Tobe, Sheldon W., Gilbert, Richard E., Jones, Charlotte, Leiter, Lawrence A., Prebtani, Ally P.H., and Woo, Vincent
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- 2018
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33. Steady-State Pharmacokinetics of Oral Ciprofloxacin in Continuous Cycling Peritoneal Dialysis Patients: Brief Report
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Lee, Colin, Walker, Sandra A.N., Palmay, Lesley, Walker, Scott E., Tobe, Sheldon, and Simor, Andrew
- Abstract
Steady-state pharmacokinetics of oral ciprofloxacin in 3 continuous cycling peritoneal dialysis (CCPD) outpatients given ciprofloxacin 750 mg b.i.d. for 5 doses was determined. Mean steady-state maximum serum concentration and half-life were 4.4 ±1.5 mg/L and 10.3 ± 2.6 hours, respectively. Mean maximum dialysate concentration in the daytime long dwell and overnight continuous cycling dwell were 7.4 ± 1.2 mg/L and 3.3 ± 1.2 mg/L, respectively. Oral ciprofloxacin 750 mg b.i.d. may be reasonable for bloodstream and peritoneal infections caused by susceptible bacteria in CCPD patients.
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- 2018
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34. Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults
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Leung, Alexander A., Daskalopoulou, Stella S., Dasgupta, Kaberi, McBrien, Kerry, Butalia, Sonia, Zarnke, Kelly B., Nerenberg, Kara, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Gryn, Steven E., Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Penner, S. Brian, Burgess, Ellen, Sivapalan, Praveena, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Kline, Gregory, Leiter, Lawrence A., Jones, Charlotte, Côté, Anne-Marie, Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Tsuyuki, Ross T., Hiremath, Swapnil, Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Grégoire, Jean C., Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Lear, Scott A., Moullec, Gregory, Gupta, Milan, Magee, Laura A., Logan, Alexander G., Dionne, Janis, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Poirier, Luc, Padwal, Raj S., and Rabi, Doreen M.
- Abstract
Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension. This year, we introduce 10 new guidelines. Three previous guidelines have been revised and 5 have been removed. Previous age and frailty distinctions have been removed as considerations for when to initiate antihypertensive therapy. In the presence of macrovascular target organ damage, or in those with independent cardiovascular risk factors, antihypertensive therapy should be considered for all individuals with elevated average systolic nonautomated office blood pressure (non-AOBP) readings ≥ 140 mm Hg. For individuals with diastolic hypertension (with or without systolic hypertension), fixed-dose single-pill combinations are now recommended as an initial treatment option. Preference is given to pills containing an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in combination with either a calcium channel blocker or diuretic. Whenever a diuretic is selected as monotherapy, longer-acting agents are preferred. In patients with established ischemic heart disease, caution should be exercised in lowering diastolic non-AOBP to ≤ 60 mm Hg, especially in the presence of left ventricular hypertrophy. After a hemorrhagic stroke, in the first 24 hours, systolic non-AOBP lowering to < 140 mm Hg is not recommended. Finally, guidance is now provided for screening, initial diagnosis, assessment, and treatment of renovascular hypertension arising from fibromuscular dysplasia. The specific evidence and rationale underlying each of these guidelines are discussed.
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- 2017
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35. Acute change in glomerular filtration rate with inhibition of the renin-angiotensin system does not predict subsequent renal and cardiovascular outcomes
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Clase, Catherine M., Barzilay, Joshua, Gao, Peggy, Smyth, Andrew, Schmieder, Roland E., Tobe, Sheldon, Teo, Koon K., Yusuf, Salim, and Mann, Johannes F.E.
- Abstract
Initiation of blockade of the renin-angiotensin system may cause an acute decrease in glomerular filtration rate (GFR): the prognostic significance of this is unknown. We did a post hocanalysis of patients with, or at risk for, vascular disease, in two randomized controlled trials: Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and the Telmisartan Randomized AssessmeNt Study in ACE iNtolerant participants with cardiovascular Disease (TRANSCEND), whose median follow-up was 56 months. In 9340 patients new to renin-angiotensin system blockade, who were then randomized to renin-angiotensin system blockade, a fall in GFR of 15% or more at 2 weeks after starting renin-angiotensin system blockade was seen in 1480 participants (16%), with persistence at 8 weeks in 700 (7%). Both acute increases and decreases in GFR after initiation of renin-angiotensin system blockade were associated with tendencies, mostly not statistically significant, to increased risk of cardiovascular outcomes, which occurred in 1280 participants, and of microalbuminuria, which occurred in 864. Analyses of creatinine-based outcomes were suggestive of regression to the mean. In more than 3000 patients randomized in TRANSCEND to telmisartan or placebo, there was no interaction between acute change in GFR and renal or cardiovascular benefit from telmisartan. Thus, both increases and decreases in GFR on initiation of renin-angiotensin system blockade are common, and may be weakly associated with increased risk of cardiovascular and renal outcomes. Changes do not predict increased benefit from therapy.
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- 2017
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36. Innovative Approaches to Hypertension Control in Low- and Middle-Income Countries
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Vedanthan, Rajesh, Bernabe-Ortiz, Antonio, Herasme, Omarys I., Joshi, Rohina, Lopez-Jaramillo, Patricio, Thrift, Amanda G., Webster, Jacqui, Webster, Ruth, Yeates, Karen, Gyamfi, Joyce, Ieremia, Merina, Johnson, Claire, Kamano, Jemima H., Lazo-Porras, Maria, Limbani, Felix, Liu, Peter, McCready, Tara, Miranda, J. Jaime, Mohan, Sailesh, Ogedegbe, Olugbenga, Oldenburg, Brian, Ovbiagele, Bruce, Owolabi, Mayowa, Peiris, David, Ponce-Lucero, Vilarmina, Praveen, Devarsetty, Pillay, Arti, Schwalm, Jon-David, Tobe, Sheldon W., Trieu, Kathy, Yusoff, Khalid, and Fuster, Valentin
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Elevated blood pressure, a major risk factor for ischemic heart disease, heart failure, and stroke, is the leading global risk for mortality. Treatment and control rates are very low in low- and middle-income countries. There is an urgent need to address this problem. The Global Alliance for Chronic Diseases sponsored research projects focus on controlling hypertension, including community engagement, salt reduction, salt substitution, task redistribution, mHealth, and fixed-dose combination therapies. This paper reviews the rationale for each approach and summarizes the experience of some of the research teams. The studies demonstrate innovative and practical methods for improving hypertension control.
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- 2017
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37. What Can Declining Kidney Function Tell Us About Heart Failure?
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Tobe, Sheldon W.
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- 2018
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38. Prediction of the effect of atrasentan on renal and heart failure outcomes based on short-term changes in multiple risk markers
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Schievink, Bauke, de Zeeuw, Dick, Smink, Paul A, Andress, Dennis, Brennan, John J, Coll, Blai, Correa-Rotter, Ricardo, Hou, Fan Fan, Kohan, Donald, Kitzman, Dalane W, Makino, Hirofumi, Parving, Hans-Henrik, Perkovic, Vlado, Remuzzi, Giuseppe, Tobe, Sheldon, Toto, Robert, Hoekman, Jarno, and Lambers Heerspink, Hiddo J
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Background A recent phase II clinical trial (Reducing Residual Albuminuria in Subjects with Diabetes and Nephropathy with AtRasentan trial and an identical trial in Japan (RADAR/JAPAN)) showed that the endothelin A receptor antagonist atrasentan lowers albuminuria, blood pressure, cholesterol, hemoglobin, and increases body weight in patients with type 2 diabetes and nephropathy. We previously developed an algorithm, the Parameter Response Efficacy (PRE) score, which translates short-term drug effects into predictions of long-term effects on clinical outcomes.Design We used the PRE score on data from the RADAR/JAPAN study to predict the effect of atrasentan on renal and heart failure outcomes.Methods We performed a post-hoc analysis of the RADAR/JAPAN randomized clinical trials in which 211 patients with type-2 diabetes and nephropathy were randomly assigned to atrasentan 0.75 mg/day, 1.25 mg/day, or placebo. A PRE score was developed in a background set of completed clinical trials using multivariate Cox models. The score was applied to baseline and week-12 risk marker levels of RADAR/JAPAN participants, to predict atrasentan effects on clinical outcomes. Outcomes were defined as doubling serum creatinine or end-stage renal disease and hospitalization for heart failure.Results The PRE score predicted renal risk changes of −23% and −30% for atrasentan 0.75 and 1.25 mg/day, respectively. PRE scores also predicted a small non-significant increase in heart failure risk for atrasentan 0.75 and 1.25 mg/day (+2% vs. +7%). Selecting patients with >30% albuminuria reduction from baseline (responders) improved renal outcome to almost 50% risk reduction, whereas non-responders showed no renal benefit.Conclusions Based on the RADAR/JAPAN study, with short-term changes in risk markers, atrasentan is expected to decrease renal risk without increased risk of heart failure. Within this population albuminuria responders appear to contribute to the predicted improvements, whereas non-responders showed no benefit. The ongoing hard outcome trial (SONAR) in type 2 diabetic patients with >30% albuminuria reduction to atrasentan will allow us to assess the validity of these predictions.
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- 2016
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39. Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events
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Kim, Richard B., Morse, Bridget L., Djurdjev, Ognjenka, Tang, Mila, Muirhead, Norman, Barrett, Brendan, Holmes, Daniel T., Madore, Francois, Clase, Catherine M., Rigatto, Claudio, Levin, Adeera, Agharazii, Mohsen, Blouin, Joanne, Samson, France, Akbarii, Ayub, Cheesman, Judy, Courtney, Jennilea, Hamer, Sabrina, Delic, Edita, Cronin, Valerie, Barré, Paul, Golden, Jeffrey, Barrett, Brendan, Langille, Elizabeth, Adams, Sandra, Morgan, Janet, Clase, Catherine, Moreau, Cathy, Cooper, Susan, Forzley, Brian, Caron, Susan, Granger, Shauna, Valley, Susan, Sather, Helen, Cournoyer, Serge, Menard, Lorraine, Roy, Michèle, Skidmore, Hélène, Beaudry, Dolores, Dionne, Janis, Chow, Josephine, Sahraei, Valla, Donnelly, Sandra, Dacouris, Niki, Marticorena, Rosa, Hemmelgarn, Brenda, Gulewich, Sharon, Hamilton, Troy, Keown, Paul, Zalunardo, Nadia, Rogers, Daniel, Tut, Reena, Paquette, Matthew, Yung, Rossitta, Levin, Adeera, Ferguson, Nancy, Tang, Mila, Chiu, Helen, Carlson, Kathleen, Sioson, Lina, Perry, Taylor, Sheriff, Zainab, Rozen, Naama, Lok, Charmaine, Cross, Michelle, Forrester, Cathy, Cotoi, Alexandra, Madore, François, Maltais, Manon, Moist, Louise, Gallo, Kerri, Langford, Sarah, Slamen, Leah, Cram, Danielle, Muirhead, Norman, Edgar, Mary Jeanne, Gray, Taylor, Edgar, Cameron, Groeneweg, Karen, McKinnon, Eileen, McRae, Erin, Blackie, Kyla, Nathoo, Bharat, Lau, Kimmy, Parmar, Malvinder, Gelinas, Sylvie, Leblanc, Martine, Lépine, Lucie, Rigatto, Claudio, Friesen, Dolores, Soroka, Steven, Fleet, Susan, Squires, Jeanette, Thanamayooran, Siva, Binder, Michael, Hines, Christine, McNeil, Brenda, McDougall, Patrice, Howard, Joy, Gillis, Deborah, Hines, Kathleen, Tobe, Sheldon, Chessman, Mary, Perkins, Nancy, Agelopoulos, Martha, Knox, Stacey, Richards, Tiffany, Tonelli, Marcello, Szigety, Susan, Opgenorth, Dawn, Yeates, Karen, and Mahoney, Karen
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Cardiovascular disease is more common in patients with chronic kidney disease (CKD), and traditional risk factors do not adequately predict those at risk for cardiovascular (CV) events. Recent evidence suggests elevated trimethylamine N-oxide (TMAO), created by gut microflora from dietary L-carnitine and choline, is associated with CV events. We investigated the relationship of TMAO levels in patients with stages 3b and 4 CKD to ischemic CV events using the CanPREDDICT cohort, a Canada-wide observational study with prospective 3-year follow-up of adjudicated CV events. Baseline samples were obtained for 2529 CKD patients. TMAO, choline, and L-carnitine levels were measured using tandem mass spectrometry. Baseline median TMAO level was high for the whole cohort (20.41 μM;interquartile range [IQR]: 12.82–32.70 μM). TMAO was independently associated with CV events (hazard ratio 1.23; 95% confidence interval: 1.06–1.42 / 1 SD lnTMAO) after adjusting for all potential CV risk factors. Those in the highest TMAO quartile had significantly higher risk of CV events (adjusted hazard ratio 1.59; 95% confidence interval: 1.04–2.43; P = 0.0351) in the analysis of recurring ischemic events. Among those with stage 3b CKD (hazard ratio 1.45; 95% confidence interval: 1.12–1.87 / 1 SD lnTMAO), independent of kidney function, TMAO levels identified those at highest risk for events. Our results suggest that TMAO may represent a new potentially modifiable CV risk factor for CKD patients. Further studies are needed to determine sources of variability and if lowering of TMAO reduces CV risk in CKD.
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- 2016
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40. Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension
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Leung, Alexander A., Nerenberg, Kara, Daskalopoulou, Stella S., McBrien, Kerry, Zarnke, Kelly B., Dasgupta, Kaberi, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Penner, S. Brian, Burgess, Ellen, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Hiremath, Swapnil, Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Fodor, George, Grégoire, Jean C., Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Lear, Scott A., Moullec, Gregory, Gupta, Milan, Magee, Laura A., Logan, Alexander G., Harris, Kevin C., Dionne, Janis, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Poirier, Luc, Padwal, Raj S., and Rabi, Doreen M.
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Hypertension Canada's Canadian Hypertension Education Program Guidelines Task Force provides annually updated, evidence-based recommendations to guide the diagnosis, assessment, prevention, and treatment of hypertension. This year, we present 4 new recommendations, as well as revisions to 2 previous recommendations. In the diagnosis and assessment of hypertension, automated office blood pressure, taken without patient-health provider interaction, is now recommended as the preferred method of measuring in-office blood pressure. Also, although a serum lipid panel remains part of the routine laboratory testing for patients with hypertension, fasting and nonfasting collections are now considered acceptable. For individuals with secondary hypertension arising from primary hyperaldosteronism, adrenal vein sampling is recommended for those who are candidates for potential adrenalectomy. With respect to the treatment of hypertension, a new recommendation that has been added is for increasing dietary potassium to reduce blood pressure in those who are not at high risk for hyperkalemia. Furthermore, in selected high-risk patients, intensive blood pressure reduction to a target systolic blood pressure ≤ 120 mm Hg should be considered to decrease the risk of cardiovascular events. Finally, in hypertensive individuals with uncomplicated, stable angina pectoris, either a β-blocker or calcium channel blocker may be considered for initial therapy. The specific evidence and rationale underlying each of these recommendations are discussed. Hypertension Canada's Canadian Hypertension Education Program Guidelines Task Force will continue to provide annual updates.
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- 2016
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41. Preventing Cardiovascular and Renal Disease in Canada's Aboriginal Populations
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Tobe, Sheldon W., Maar, Marion, Roy, Meagan A., and Warburton, Darren E.R.
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Cardiovascular and renal disease are highly prevalent in Canada's Aboriginal population even though rates of cardiovascular disease are falling in the rest of the country. High and rising prevalence rates of diabetes must be addressed to impact significantly on global cardiovascular and renal risk. Type 2 diabetes is occurring in Aboriginal youth, putting them at greater risk of long-term complications. The reasons for the sudden upswing in diabetes rates in the past 60 years are a result in large part to social determinants of health, which for Aboriginal people include the multigenerational effects of colonization and consequences of the residential school system. Addressing cardiovascular and renal risk therefore requires the knowledge and skills to implement clinical practice guideline–based interventions, the ability to create culturally safe chronic disease management programs in partnership with Aboriginal communities, and advocacy across sectors for improvements in the social determinants of health.
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- 2015
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42. The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension
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Daskalopoulou, Stella S., Rabi, Doreen M., Zarnke, Kelly B., Dasgupta, Kaberi, Nerenberg, Kara, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, McKay, Donald W., Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Ramesh Prasad, G.V., Lebel, Marcel, Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Brian Penner, S., Burgess, Ellen, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Hiremath, Swapnil, Stone, James A., Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Fodor, George, Grégoire, Jean C., Fournier, Anne, Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Benoit, Geneviève, Feber, Janusz, Harris, Kevin C., Poirier, Luc, and Padwal, Raj S.
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The Canadian Hypertension Education Program reviews the hypertension literature annually and provides detailed recommendations regarding hypertension diagnosis, assessment, prevention, and treatment. This report provides the updated evidence-based recommendations for 2015. This year, 4 new recommendations were added and 2 existing recommendations were modified. A revised algorithm for the diagnosis of hypertension is presented. Two major changes are proposed: (1) measurement using validated electronic (oscillometric) upper arm devices is preferred over auscultation for accurate office blood pressure measurement; (2) if the visit 1 mean blood pressure is increased but < 180/110 mm Hg, out-of-office blood pressure measurements using ambulatory blood pressure monitoring (preferably) or home blood pressure monitoring should be performed before visit 2 to rule out white coat hypertension, for which pharmacologic treatment is not recommended. A standardized ambulatory blood pressure monitoring protocol and an update on automated office blood pressure are also presented. Several other recommendations on accurate measurement of blood pressure and criteria for diagnosis of hypertension have been reorganized. Two other new recommendations refer to smoking cessation: (1) tobacco use status should be updated regularly and advice to quit smoking should be provided; and (2) advice in combination with pharmacotherapy for smoking cessation should be offered to all smokers. The following recommendations were modified: (1) renal artery stenosis should be primarily managed medically; and (2) renal artery angioplasty and stenting could be considered for patients with renal artery stenosis and complicated, uncontrolled hypertension. The rationale for these recommendation changes is discussed.
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- 2015
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43. A New Algorithm for the Diagnosis of Hypertension in Canada
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Cloutier, Lyne, Daskalopoulou, Stella S., Padwal, Raj S., Lamarre-Cliche, Maxime, Bolli, Peter, McLean, Donna, Milot, Alain, Tobe, Sheldon W., Tremblay, Guy, McKay, Donald W., Townsend, Raymond, Campbell, Norm, and Gelfer, Mark
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Accurate blood pressure measurement is critical to properly identify and treat individuals with hypertension. In 2005, the Canadian Hypertension Education Program produced a revised algorithm to be used for the diagnosis of hypertension. Subsequent annual reviews of the literature have identified 2 major deficiencies in the current diagnostic process. First, auscultatory measurements performed in routine clinical settings have serious accuracy limitations that have not been overcome despite great efforts to educate health care professionals over several years. Thus, alternatives to auscultatory measurements should be used. Second, recent data indicate that patients with white coat hypertension must be identified earlier in the process and in a systematic manner rather than on an ad hoc or voluntary basis so they are not unnecessarily treated with antihypertensive medications. The economic and health consequences of white coat hypertension are reviewed. In this article evidence for a revised algorithm to diagnose hypertension is presented. Protocols for home blood pressure measurement and ambulatory blood pressure monitoring are reviewed. The role of automated office blood pressure measurement is updated. The revised algorithm strongly encourages the use of validated electronic digital oscillometric devices and recommends that out-of-office blood pressure measurements, ambulatory blood pressure monitoring (preferred), or home blood pressure measurement, should be performed to confirm the diagnosis of hypertension.
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- 2015
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44. Canadian Society of Nephrology Commentary on the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD
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Ruzicka, Marcel, Quinn, Robert R., McFarlane, Phil, Hemmelgarn, Brenda, Ramesh Prasad, G.V., Feber, Janusz, Nesrallah, Gihad, MacKinnon, Martin, Tangri, Navdeep, McCormick, Brendan, Tobe, Sheldon, Blydt-Hansen, Tom D., and Hiremath, Swapnil
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The KDIGO (Kidney Disease: Improving Global Outcomes) 2012 clinical practice guideline for the management of blood pressure (BP) in chronic kidney disease (CKD) provides the structural and evidence base for the Canadian Society of Nephrology (CSN) commentary on this guideline’s relevancy and application to the Canadian health care system. While in general agreement, we provide commentary on 13 of the 21 KDIGO guideline statements. Specifically, we agreed that nonpharmacological interventions should play a significant role in the management of hypertension in patients with CKD. We also agreed that the approach to the management of hypertension in elderly patients with CKD should be individualized and take into account comorbid conditions to avoid adverse outcomes from excessive BP lowering. In contrast to KDIGO, the CSN Work Group believes there is insufficient evidence to target a lower BP for nondiabetic CKD patients based on the presence and severity of albuminuria. The CSN Work Group concurs with the Canadian Hypertension Education Program (CHEP) recommendation of a target BP for all non–dialysis-dependent CKD patients without diabetes of ≤140mm Hg systolic and ≤90mm Hg diastolic. Similarly, it is our position that in diabetic patients with CKD and normal urinary albumin excretion, raising the threshold for treatment from <130mm Hg systolic BP to <140mm Hg systolic BP could increase stroke risk and the risk of worsening kidney disease. The CSN Work Group concurs with the CHEP and the Canadian Diabetic Association recommendation for diabetic patients with CKD with or without albuminuria to continue to be treated to a BP target similar to that of the overall diabetes population, aiming for BP levels < 130/80mm Hg. Consistent with this, the CSN Work Group endorses a BP target of <130/80mm Hg for diabetic patients with a kidney transplant. Finally, in the absence of evidence for a lower BP target, the CSN Work Group concurs with the CHEP recommendation to target BP<140/90mm Hg for nondiabetic patients with a kidney transplant.
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- 2014
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45. Contemporary Use of β-Blockers: Clinical Relevance of Subclassification
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Poirier, Luc and Tobe, Sheldon W.
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β-Adrenergic receptor blockers or β-blockers represent one of the oldest classes of cardiovascular agents and have been considered a cornerstone therapy for hypertension and heart disease for the past 5 decades. They are advocated as a first-line treatment for uncomplicated essential hypertension in patients younger than 60 years of age as recommended by the Canadian Hypertension Education Program. However, despite the well-established antihypertensive and cardiovascular benefits of β-blockers, a number of studies argue that they might not have the same clinical advantages of other classes of agents in terms of morbidity/mortality outcomes. This review will focus on the heterogeneity of the pharmacologic characteristics of β-blockers, and we will discuss the metabolic and hemodynamic differences within the β-blocker class and try to assess the potential implications of these differences for optimal selection in hypertension.
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- 2014
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46. Combining Other Antihypertensive Drugs With β-Blockers in Hypertension: A Focus on Safety and Tolerability
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Richards, Tiffany R. and Tobe, Sheldon W.
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Combining multiple classes of antihypertensive drugs together is one of the most important factors for achieving blood pressure control in most hypertensive patients. The benefits of combination therapy in comparison with monotherapy include: a synergistic enhancement of each drug's hypertensive effects and a potential reduction of side effects if each drug is used at a lower dose. Although long-acting dihydropyridine calcium channel blockers and β-blockers are a good fit for combination therapy, because of the risk of atrioventricular block and bradycardia, the combination of verapamil and β-blockers is not advised. In addition, the combination of higher-dose diltiazem and β-blockers is also not advised. β-blockers and diuretic agents as initial lone combination therapy are not the preferred combination to be used in uncomplicated hypertension. Using an angiotensin-converting enzyme inhibitor as initial combination therapy with most β-blockers is not recommended because of a lack of antihypertensive efficacy. Nebivolol, however, appears different in this regard and might provide an opportunity for combining these 2 classes of agents with proven cardiovascular benefits for better blood pressure control. Adding an α-blocker to a β-blocker is an effective combination.
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- 2014
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47. β-Blockers in Hypertension: Studies and Meta-analyses Over the Years
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Larochelle, Pierre, Tobe, Sheldon W., and Lacourcière, Yves
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β-Blockers are among the most commonly used medications in the treatment of hypertension. However, 45 years after their initial indication for that treatment, their place in the treatment of hypertensive patients is under evaluation and their usefulness has been questioned based on evidence from meta-analyses of clinical trials. The β-blocker class consists of various agents with diverse pharmacokinetic and pharmacodynamic properties including lipo- and hydrophilicity, duration of action, intrinsic sympathomimetic activity, vasodilation, and metabolism linked to genetic polymorphisms. Because of their various properties, some β-blockers are indicated for cardiovascular conditions such as angina, rate control of atrial fibrillation, chronic heart failure, and after myocardial infarction, and other indications such as migraine and essential tremor. There have been more than 17 large trials influencing the recommendations on the use of these agents in the treatment of hypertension. The results of these trials initially led to the widespread recommendation for the use of β-blockers in the management of hypertension. However, the recent multiple meta-analyses using these trials have raised a controversy on their place in that treatment. The Canadian Hypertension Education Program recommendations have included β-blockers as a first-line treatment option for patients younger than 60 years of age based on the evidence from these large trials, and this has been supported by 2 of the meta-analyses. This article reviews these studies to help clinicians better understand the role of β-blockers in managing hypertension.
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- 2014
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48. The 2014 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension
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Dasgupta, Kaberi, Quinn, Robert R., Zarnke, Kelly B., Rabi, Doreen M., Ravani, Pietro, Daskalopoulou, Stella S., Rabkin, Simon W., Trudeau, Luc, Feldman, Ross D., Cloutier, Lyne, Prebtani, Ally, Herman, Robert J., Bacon, Simon L., Gilbert, Richard E., Ruzicka, Marcel, McKay, Donald W., Campbell, Tavis S., Grover, Steven, Honos, George, Schiffrin, Ernesto L., Bolli, Peter, Wilson, Thomas W., Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Gelfer, Mark, Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, McLean, Donna, Arnold, J. Malcolm O., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Burns, Kevin D., Petrella, Robert J., Hiremath, Swapnil, Milot, Alain, Stone, James A., Drouin, Denis, Lavoie, Kim L., Lamarre-Cliche, Maxime, Tremblay, Guy, Hamet, Pavel, Fodor, George, Carruthers, S. George, Pylypchuk, George B., Burgess, Ellen, Lewanczuk, Richard, Dresser, George K., Penner, S. Brian, Hegele, Robert A., McFarlane, Philip A., Khara, Milan, Pipe, Andrew, Oh, Paul, Selby, Peter, Sharma, Mukul, Reid, Debra J., Tobe, Sheldon W., Padwal, Raj S., and Poirier, Luc
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Herein, updated evidence-based recommendations for the diagnosis, assessment, prevention, and treatment of hypertension in Canadian adults are detailed. For 2014, 3 existing recommendations were modified and 2 new recommendations were added. The following recommendations were modified: (1) the recommended sodium intake threshold was changed from ≤ 1500 mg (3.75 g of salt) to approximately 2000 mg (5 g of salt) per day; (2) a pharmacotherapy treatment initiation systolic blood pressure threshold of ≥ 160 mm Hg was added in very elderly (age ≥ 80 years) patients who do not have diabetes or target organ damage (systolic blood pressure target in this population remains at < 150 mm Hg); and (3) the target population recommended to receive low-dose acetylsalicylic acid therapy for primary prevention was narrowed from all patients with controlled hypertension to only those ≥ 50 years of age. The 2 new recommendations are: (1) advice to be cautious when lowering systolic blood pressure to target levels in patients with established coronary artery disease if diastolic blood pressure is ≤ 60 mm Hg because of concerns that myocardial ischemia might be exacerbated; and (2) the addition of glycated hemoglobin (A1c) in the diagnostic work-up of patients with newly diagnosed hypertension. The rationale for these recommendation changes is discussed. In addition, emerging data on blood pressure targets in stroke patients are discussed; these data did not lead to recommendation changes at this time. The Canadian Hypertension Education Program recommendations will continue to be updated annually.
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- 2014
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49. Renal Denervation Therapy for the Treatment of Resistant Hypertension: A Position Statement by the Canadian Hypertension Education Program
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Khan, Nadia A., Herman, Robert J., Quinn, Robert R., Rabkin, Simon W., Ravani, Pietro, Tobe, Sheldon W., Feldman, Ross D., Wijeysundera, Harindra C., and Padwal, Raj S.
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Renal denervation is a novel catheter-based, percutaneous procedure using radiofrequency energy to ablate nerves within the renal arteries. This procedure might help to significantly lower blood pressure (BP) in patients with resistant hypertension, defined as BP 140/90 mm Hg (130/80 mm Hg for those with diabetes) despite use of ≥ 3 optimally dosed antihypertensive agents, ideally including 1 diuretic agent. The Canadian Hypertension Education Program Recommendations Task Force reviewed the current evidence on safety and efficacy of this procedure. Eleven studies on renal denervation were examined and most of the evidence evaluating renal denervation was derived from the Symplicity studies. In patients with systolic BP ≥ 160 mm Hg (≥ 150 mm Hg for patients with type 2 diabetes) despite use of ≥ 3 antihypertensive agents, bilateral renal denervation was associated with significantly lower BP (−22/11 to −34/13 mm Hg) at 6 months with a low periprocedural complication rate. Few patients underwent 24-hour ambulatory BP monitoring and ambulatory BP monitoring showed more modest BP lowering (0 to −11/7 mm Hg). Although early results on short-term safety and blood pressure-lowering are encouraging, there are no long-term efficacy and safety data, or hard cardiovascular end point data. The discrepancy between office BP reductions and 24-hour ambulatory BP monitor reductions needs to be further investigated. Until more data are available, renal sympathetic denervation should be considered as a treatment option of last resort for patients with resistant hypertension who have exhausted all other available medical management options.
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- 2014
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50. The 2013 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension
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Hackam, Daniel G., Quinn, Robert R., Ravani, Pietro, Rabi, Doreen M., Dasgupta, Kaberi, Daskalopoulou, Stella S., Khan, Nadia A., Herman, Robert J., Bacon, Simon L., Cloutier, Lyne, Dawes, Martin, Rabkin, Simon W., Gilbert, Richard E., Ruzicka, Marcel, McKay, Donald W., Campbell, Tavis S., Grover, Steven, Honos, George, Schiffrin, Ernesto L., Bolli, Peter, Wilson, Thomas W., Feldman, Ross D., Lindsay, Patrice, Hill, Michael D., Gelfer, Mark, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, McLean, Donna, Arnold, J. Malcolm O., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Milot, Alain, Stone, James A., Drouin, Denis, Lavoie, Kim L., Lamarre-Cliche, Maxime, Godwin, Marshall, Tremblay, Guy, Hamet, Pavel, Fodor, George, Carruthers, S. George, Pylypchuk, George B., Burgess, Ellen, Lewanczuk, Richard, Dresser, George K., Penner, S. Brian, Hegele, Robert A., McFarlane, Philip A., Sharma, Mukul, Reid, Debra J., Tobe, Sheldon W., Poirier, Luc, and Padwal, Raj S.
- Abstract
We updated the evidence-based recommendations for the diagnosis, assessment, prevention, and treatment of hypertension in adults for 2013. This year's update includes 2 new recommendations. First, among nonhypertensive or stage 1 hypertensive individuals, the use of resistance or weight training exercise does not adversely influence blood pressure (BP) (Grade D). Thus, such patients need not avoid this type of exercise for fear of increasing BP. Second, and separately, for very elderly patients with isolated systolic hypertension (age 80 years or older), the target for systolic BP should be < 150 mm Hg (Grade C) rather than < 140 mm Hg as recommended for younger patients. We also discuss 2 additional topics at length (the pharmacological treatment of mild hypertension and the possibility of a diastolic J curve in hypertensive patients with coronary artery disease). In light of several methodological limitations, a recent systematic review of 4 trials in patients with stage 1 uncomplicated hypertension did not lead to changes in management recommendations. In addition, because of a lack of prospective randomized data assessing diastolic BP thresholds in patients with coronary artery disease and hypertension, no recommendation to set a selective diastolic cut point for such patients could be affirmed. However, both of these issues will be examined on an ongoing basis, in particular as new evidence emerges.
- Published
- 2013
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