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Increase in BNP in Response to Endothelin-Receptor Antagonist Atrasentan Is Associated With Incident Heart Failure

Authors :
Smeijer, J. David
Koomen, Jeroen
Kohan, Donald E.
McMurray, John J.V.
Bakris, George L.
Correa-Rotter, Ricardo
Hou, Fan-Fan
Januzzi, James L.
Kitzman, Dalane W.
Kolansky, Daniel M.
Makino, Hirofumi
Perkovic, Vlado
Tobe, Sheldon
Parving, Hans-Henrik
de Zeeuw, Dick
Heerspink, Hiddo J.L.
Source :
JACC: Heart Failure; July 2022, Vol. 10 Issue: 7 p498-507, 10p
Publication Year :
2022

Abstract

The endothelin receptor antagonist atrasentan reduced the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) in the SONAR (Study of Diabetic Nephropathy with Atrasentan) trial, although with a numerically higher incidence of heart failure (HF) hospitalization.

Details

Language :
English
ISSN :
22131779
Volume :
10
Issue :
7
Database :
Supplemental Index
Journal :
JACC: Heart Failure
Publication Type :
Periodical
Accession number :
ejs60234292
Full Text :
https://doi.org/10.1016/j.jchf.2022.03.004