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A recent study conducted by the Regional University of Cariri (URCA) in Crato, Brazil, focused on the potential of thiadiazine compounds as inhibitors of the NorA pump in Staphylococcus aureus. The NorA pump is responsible for reducing the effectiveness of fluoroquinolones, leading to antimicrobial resistance. The study involved various experiments, including direct activity assays, fluorescence assays, and molecular docking. While some thiadiazine derivatives did not show direct activity, compounds such as IJ11, IJ21, and IJ22 were found to inhibit the function of the NorA pump. This research represents the first investigation of thiadiazine derivatives against the NorA pump and provides a foundation for future experiments. [Extracted from the article]

A recent study conducted by the National Institute of Technology Calicut in Kerala, India, focused on the development of anticancer agents targeting the epidermal growth factor receptor (EGFR). The researchers designed and synthesized a novel series of compounds and tested their in vitro anticancer activity against three human breast cancer cell lines. Two compounds, 7f and 7h, showed superior activity against the cell lines compared to the standard drug Erlotinib. These compounds also demonstrated high efficacy in inhibiting EGFR. Both experimental and in silico investigations suggest that compounds 7f and 7h hold promise as lead compounds for further drug design and development. [Extracted from the article]

Researchers in Hyderabad, India have developed a new synthesis method for creating potent anti-breast cancer agents. The researchers synthesized a series of compounds containing fused [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine using a Cu(I)-catalyzed [3+2] cycloaddition method. These compounds were then tested in vitro against breast cancer cell lines, and several showed significant activity, surpassing the standard drug Erlotinib. In addition, molecular docking studies and ADMET predictions were performed to support the wet lab results. This research provides promising insights into potential treatments for breast cancer. [Extracted from the article]

A recent research study conducted at the University of Peshawar in Pakistan focused on the synthesis of a new series of thiadiazine thiones, which are sulfur compounds. The researchers characterized the structures of these compounds and evaluated their anti-nociceptive (pain-relieving) and bactericidal properties. Some of the compounds showed significant anti-nociceptive potential, particularly in targeting the m-opioid receptor. Additionally, two compounds demonstrated antibacterial activity against Pseudomonas aeruginosa and MSRA. The study suggests that further structural optimization could enhance the activity of these compounds. [Extracted from the article]

A study conducted at the National Institute of Technology Karnataka in India has discovered new compounds with antimicrobial properties. The compounds, called pyrazine-1,3,4-oxadiazole hybrids and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazine derivatives, showed promising activity against the M. tuberculosis H37Rv strain as well as antibacterial and antifungal activity. The compounds also exhibited low toxicity and were not harmful to normal cells. Further analysis was conducted to understand the compounds' electronic properties and pharmacological potential. The research has been peer-reviewed and more information can be found in the Journal of Molecular Structure. [Extracted from the article]

A recent study conducted by the Regional University of Cariri (URCA) in Crato, Brazil, focused on the antibacterial activity of thiadiazine derivatives against Staphylococcus aureus bacteria. The researchers synthesized compounds derived from thiadiazine and performed various tests to evaluate their antibacterial activity. Two compounds showed antibacterial activity against the examined strains, and all compounds showed activity when combined with the antibiotic norfloxacin. In-silico analysis indicated that the compounds have high lipophilicity and non-toxic characteristics. The study suggests that these compounds have the potential to be further studied as low-toxicity sources for multidrug-resistant bacteria. [Extracted from the article]

A recent study conducted at Port Said University in Egypt has investigated the potential anticancer activity of a compound called sodium 2-[(4-oxidobenzylidene) amino]-6H-1,3,4-thiadiazine-5-c (SOTA) against Ehrlich ascites carcinoma (EAC) cells in female mice. The study found that SOTA demonstrated a significant decrease in tumor cell viability and increased antioxidant capacity while decreasing malondialdehyde levels. Additionally, SOTA showed apoptotic activity by upregulating caspase-3 and p53 and downregulating PI3K and mTOR. The compound did not have any adverse effects on the liver, kidney, or heart, as supported by histological studies. The research suggests that SOTA has potential as a chemotherapeutic agent by targeting the PI3K/mTOR pathway. [Extracted from the article]

A recent study conducted by the School of Biological Sciences and Engineering explored the potential of alkyl-linked bis-thiadiazine derivatives as antimalarial drugs. The researchers evaluated the compounds in mice infected with two strains of Plasmodium, the parasites responsible for most cases of malaria. The results showed that some of the derivatives had an antimalarial effect, although none were as effective as chloroquine, a classic antimalarial drug. This research suggests that further investigation is needed to develop more effective treatments for malaria. [Extracted from the article]

Russia, Business, Diabetes Mellitus, Endocrine System Diseases and Conditions, Endocrinology, Glucose Metabolism Disorders, Health and Medicine, Hyperglycemia, Ekaterinburg, Metabolic Diseases and Conditions, Non-Insulin Dependent Diabetes Mellitus, Nutritional and Metabolic Diseases and Conditions, Thiadiazines, Sulfur Compounds, Type 2 Diabetes, Thiazines Keywords: Ekaterinburg; Russia; Business; Diabetes Mellitus; Endocrine System Diseases and Conditions; Endocrinology; Glucose Metabolism Disorders; Health and Medicine; Hyperglycemia; Metabolic Diseases and Conditions; Non-Insulin Dependent Diabetes Mellitus; Nutritional and Metabolic Diseases and Conditions; Sulfur Compounds; Thiadiazines; Thiazines; Type 2 Diabetes EN Ekaterinburg Russia Business Diabetes Mellitus Endocrine System Diseases and Conditions Endocrinology Glucose Metabolism Disorders Health and Medicine Hyperglycemia Metabolic Diseases and Conditions Non-Insulin Dependent Diabetes Mellitus Nutritional and Metabolic Diseases and Conditions Sulfur Compounds Thiadiazines Thiazines Type 2 Diabetes 245 245 1 07/17/23 20230717 NES 230717 2023 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Investigators publish new report on Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes. [Extracted from the article]

Russia, Antioxidants, Diabetes Mellitus, Drugs and Therapies, Endocrine System Diseases and Conditions, Endocrinology, Experimental Therapies, Glucose Metabolism Disorders, Health and Medicine, Metabolic Diseases and Conditions, Nutritional and Metabolic Diseases and Conditions, Protective Agents, Sulfur Compounds, Therapy, Thiadiazines, Ekaterinburg, Thiazines Keywords: Ekaterinburg; Russia; Antioxidants; Diabetes Mellitus; Drugs and Therapies; Endocrine System Diseases and Conditions; Endocrinology; Experimental Therapies; Glucose Metabolism Disorders; Health and Medicine; Metabolic Diseases and Conditions; Nutritional and Metabolic Diseases and Conditions; Protective Agents; Sulfur Compounds; Therapy; Thiadiazines; Thiazines EN Ekaterinburg Russia Antioxidants Diabetes Mellitus Drugs and Therapies Endocrine System Diseases and Conditions Endocrinology Experimental Therapies Glucose Metabolism Disorders Health and Medicine Metabolic Diseases and Conditions Nutritional and Metabolic Diseases and Conditions Protective Agents Sulfur Compounds Therapy Thiadiazines Thiazines 179 179 1 05/29/23 20230529 NES 230529 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Researchers detail new data in Nutritional and Metabolic Diseases and Conditions - Diabetes Mellitus. [Extracted from the article]

Keywords: Anticancer Agents; Cancer; Cancer Therapy; Drugs and Therapies; Health and Medicine; Nitric Oxide; Nitrogen Oxides; Oncology; Protective Agents; Sulfur Compounds; Thiadiazines; Thiazines; Thiones EN Anticancer Agents Cancer Cancer Therapy Drugs and Therapies Health and Medicine Nitric Oxide Nitrogen Oxides Oncology Protective Agents Sulfur Compounds Thiadiazines Thiazines Thiones 969 969 1 04/24/23 20230428 NES 230428 2023 APR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on anticancer agents have been published. Anticancer Agents, Cancer, Cancer Therapy, Drugs and Therapies, Health and Medicine, Nitric Oxide, Nitrogen Oxides, Oncology, Protective Agents, Sulfur Compounds, Thiadiazines, Thiazines, Thiones The news reporters obtained a quote from the research from University of Peshawar: "The anticancer activity of the compounds was evaluated against HeLa cell line and anti-inflammatory potential via nitric oxide (NO) inhibition. [Extracted from the article]

Antigens, Antimicrobials, Biological Factors, Drugs and Therapies, Health and Medicine, Immunology, Sulfur Compounds, Thiadiazines, Thiazines Keywords for this news article include: Yachay Tech University, Antigens, Antimicrobials, Thiazines, Immunology, Thiadiazines, Sulfur Compounds, Biological Factors, Drugs and Therapies, Health and Medicine. Keywords: Antigens; Antimicrobials; Biological Factors; Drugs and Therapies; Health and Medicine; Immunology; Sulfur Compounds; Thiadiazines; Thiazines EN Antigens Antimicrobials Biological Factors Drugs and Therapies Health and Medicine Immunology Sulfur Compounds Thiadiazines Thiazines 2086 2086 1 04/24/23 20230428 NES 230428 2023 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on antimicrobials. [Extracted from the article]