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The article explores the relationship between genetics and running performance, debunking the idea of a single "runner's gene" and highlighting the impact of gene variants on individual abilities. Dr. Chung's study found that certain gene variants significantly correlated with performance gains in runners over an eight-week training period. While genetic makeup plays a role in running ability, other factors such as training, diet, rest, and injury prevention are equally important for overall performance. The article also discusses the availability of genetic testing to help individuals tailor their training plans based on their unique genetic makeup. [Extracted from the article]

2024 NOV 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Life Science. According to news reporting originating [...]

2024 OCT 12 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 OCT 7 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- According to news reporting based on a preprint abstract, our journalists obtained the following [...]

With the increasing affordability of next-generation sequencing technologies, genotype-by-sequencing has become a cost-effective tool for ecologists and conservation biologists to describe a species' evolutionary history. For host–parasite interactions, genotype-by-sequencing can allow the simultaneous examination of host and parasite genomes and can yield insight into co-evolutionary processes. The eastern oyster, Crassostrea virginica , is among the most important aquacultured species in the United States. Natural and farmed oyster populations can be heavily impacted by 'dermo' disease caused by an alveolate protist, Perkinsus marinus. Here, we used restricted site-associated DNA sequencing (RADseq) to simultaneously examine spatial population genetic structure of host and parasite. We analysed 393 single-nucleotide polymorphisms (SNPs) for P. marinus and 52,100 SNPs for C. virginica from 36 individual oysters from the Gulf of Mexico (GOM) and mid-Atlantic coastline. All analyses revealed statistically significant genetic differentiation between the GOM and mid-Atlantic coast populations for both C. virginica and P. marinus , and genetic divergence between Chesapeake Bay and the outer coast of Virginia for C. virginica , but not for P. marinus. A co-phylogenetic analysis confirmed significant coupled evolutionary change between host and parasite across large spatial scales. The strong genetic divergence between marine basins raises the possibility that oysters from either basin would not be well adapted to parasite genotypes and phenotypes from the other, which would argue for caution with regard to both oyster and parasite transfers between the Atlantic and GOM regions. More broadly, our results demonstrate the potential of RADseq to describe spatial patterns of genetic divergence consistent with coupled evolution. [ABSTRACT FROM AUTHOR]

Entamoeba moshkovskii , according to recent studies, appears to exert a more significant impact on diarrhoeal infections than previously believed. The efficient identification and genetic characterization of E. moshkovskii isolates from endemic areas worldwide are crucial for understanding the impact of parasite genomes on amoebic infections. In this study, we employed a multilocus sequence typing system to characterize E. moshkovskii isolates, with the aim of assessing the role of genetic variation in the pathogenic potential of E. moshkovskii. We incorporated 3 potential genetic markers: KERP1, a protein rich in lysine and glutamic acid; amoebapore C (apc) and chitinase. Sequencing was attempted for all target loci in 68 positive E. moshkovskii samples, and successfully sequenced a total of 33 samples for all 3 loci. The analysis revealed 17 distinct genotypes, labelled M1–M17, across the tested samples when combining all loci. Notably, genotype M1 demonstrated a statistically significant association with diarrhoeal incidence within E. moshkovskii infection (P = 0.0394). This suggests that M1 may represent a pathogenic strain with the highest potential for causing diarrhoeal symptoms. Additionally, we have identified a few single-nucleotide polymorphisms in the studied loci that can be utilized as genetic markers for recognizing the most potentially pathogenic E. moshkovskii isolates. In our genetic diversity study, the apc locus demonstrated the highest H d value and π value, indicating its pivotal role in reflecting the evolutionary history and adaptation of the E. moshkovskii population. Furthermore, analyses of linkage disequilibrium and recombination within the E. moshkovskii population suggested that the apc locus could play a crucial role in determining the virulence of E. moshkovskii. [ABSTRACT FROM AUTHOR]

Parasitic gastrointestinal nematodes pose significant health risks to humans, livestock, and companion animals, and their control relies heavily on the use of anthelmintic drugs. Overuse of these drugs has led to the emergence of resistant nematode populations. Herein, a naturally occurring isolate (referred to as BCR) of the dog hookworm, Ancylostoma caninum , that is resistant to 3 major classes of anthelmintics is characterized. Various drug assays were used to determine the resistance of BCR to thiabendazole, ivermectin, moxidectin and pyrantel pamoate. When compared to a drug-susceptible isolate of A. caninum , BCR was shown to be significantly resistant to all 4 of the drugs tested. Multiple single nucleotide polymorphisms have been shown to impart benzimidazole resistance, including the F167Y mutation in the β -tubulin isotype 1 gene, which was confirmed to be present in BCR through molecular analysis. The frequency of the resistant allele in BCR was 76.3% following its first passage in the lab, which represented an increase from approximately 50% in the founding hookworm population. A second, recently described mutation in codon 134 (Q134H) was also detected at lower frequency in the BCR population. Additionally, BCR exhibits an altered larval activation phenotype compared to the susceptible isolate, suggesting differences in the signalling pathways involved in the activation process which may be associated with resistance. Further characterization of this isolate will provide insights into the mechanisms of resistance to macrocyclic lactones and tetrahydropyrimidine anthelmintics. [ABSTRACT FROM AUTHOR]

2024 AUG 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Life Science have been published. According to news [...]

2024 JUL 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on insulin resistance. According to news reporting originating [...]

2024 JUN 29 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JUN 22 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on genetics and breeding is now available. According to [...]

2024 MAY 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAY 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Life Science have been presented. According to news reporting [...]

2024 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Genome engineering presents therapeutic avenues for variants of age-related macular degeneration (AMD), according to an investigative team from the Nuffield Laboratory of Ophthalmology and Nuffield Department of Clinical Neurosciences, University [...]

2024 MAR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAR 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on type 1 diabetes. According to news originating [...]

2024 MAR 9 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

HKG epiTherapeutics Limited, a commercial-stage biotech company, announced the launch of its new product, MetaGen Mutations Panel, an innovative genetic methylation test, which evaluates specific genes that offer individuals unparalleled [...]

2024 JAN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JAN 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Alzheimer disease. According to news reporting out [...]

2023 DEC 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

The article in Dairy Mail discusses the importance of breeding for heat tolerance in high-producing dairy cows, particularly Holsteins, to mitigate the negative impacts of heat stress on reproduction, production, and overall physiological functions. The research emphasizes the need to prioritize heat tolerance as a trait in genetic and management strategies due to the escalating effects of global warming. Various studies cited in the article highlight the potential benefits of incorporating heat-resilient animals, candidate causal variants, and the 'slick' gene from Senepol cattle to improve heat tolerance in dairy cattle while maintaining productivity levels under hot and humid conditions. [Extracted from the article]

The National Institute on Drug Abuse is accepting research project cooperative agreement applications for the Animal Genomics Program. The program aims to identify genetic, genomic, and molecular variants that are related to Substance Use Disorders (SUD) risk, trajectory, and comorbidities. The deadline for proposals is February 11, 2025, and the number of awards will depend on the availability of funds and the quality of applications. Eligible applicants include colleges and universities, for-profit organizations, nonprofit organizations, and government entities. The program supports research that connects genetic and molecular mechanisms to neural circuit function and behavior, with a focus on identifying various types of genomic and epigenomic variants associated with addiction. [Extracted from the article]

2023 NOV 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 SEP 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Captain Richard Walker and Samuel Walker were among the earliest settlers of Reading, Massachusetts, established from Lynn Village on May 29, 1644. Mann found overwhelming evidence that Capt. Richard Walker was born in 1611 or 1612, not 1592 as previously thought.[14] This new information proved that Samuel Walker could not have been the son of Capt. Richard Walker. Because the STR mutation in Capt. Richard's line could have occurred between Capt. Richard and his grandson, the genetic distance across 111 STR markers between Capt. Richard and Samuel is at least two, but no more than three. [Extracted from the article]

The article discusses the impact of complex genetic interactions on susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci. It highlights the importance of considering nonadditive genetic effects beyond traditional single-nucleotide polymorphism (SNP) interactions in understanding Alzheimer's disease susceptibility. The study identifies significant genetic modulation mechanisms in these loci, expanding current knowledge of their contributions to Alzheimer's disease. The findings suggest that examining compound genotypes may uncover critical mechanisms not apparent when analyzing SNPs individually. [Extracted from the article]

The article discusses the development of a tool called PAV-spotter, which can identify presence/absence variation (PAV) in target capture data. This tool utilizes signal cross-correlation calculations to compare read counts per target between different sample classes. The study focuses on Triturus newts, which lack an annotated reference genome and suffer from a hereditary disease, demonstrating how PAV-spotter can identify structural variants even with low sequencing coverage levels. The code for PAV-spotter is available on the GitHub repository for further customization and use. [Extracted from the article]

The article discusses the development of a new tool called eXplainable PRS (XPRS) to enhance the interpretability of polygenic risk scores (PRS) in assessing genetic susceptibility to diseases. XPRS utilizes Shapley additive explanations (SHAPs) to break down PRS into genes/regions and single nucleotide polymorphism (SNP) contribution scores, providing insights into specific genetic factors. The tool includes visualization features such as Manhattan plots and tables to aid in understanding genetic data, aiming to improve communication between clinicians and patients. This preprint has not yet undergone peer review and is available for further exploration at medrxiv.org/content/10.1101/2024.10.24.24316050v1. [Extracted from the article]

A preprint abstract from medrxiv.org discusses the challenges in understanding the impact of non-coding single nucleotide polymorphisms (SNPs) on chronic immune-mediated inflammatory disorders (IMIDs). The study introduces a systems genomics approach to model the cumulative effects of non-coding SNPs on cellular signaling and gene regulatory networks in patients with Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD). By analyzing patient genomes, the study found that signals from non-coding SNPs influence disease-associated pathways and gene dysregulation, potentially aiding in the development of precision medicine for complex diseases. [Extracted from the article]

The University of Pennsylvania conducted research on chronic fatigue syndrome, focusing on the genetic variants associated with the condition and their impact on fatigue severity in the general population. The study found that individuals diagnosed with chronic fatigue syndrome exhibited differences in physical activity patterns and daily temperature rhythms compared to controls. Genetic overlap between chronic fatigue syndrome and fatigue symptoms at a broader population level suggests that understanding the biology of fatigue in general may inform our understanding of chronic fatigue syndrome pathophysiology. [Extracted from the article]

A study conducted by investigators from Seton Hill University in Greensburg, Pennsylvania, explored the relationship between genetic factors and external apical root resorption (EARR) in orthodontic patients. The study found a significant association between specific gene polymorphisms, such as rs678397 SNP of ACT3N and rs1051771 SNP of TSC2, and EARR. Patients with Class III malocclusion and longer treatment times were also identified as being at higher risk for EARR. The research suggests that assessing predisposing risk factors for EARR in each patient is crucial for clinical management. [Extracted from the article]

A recent study conducted at Beth Israel Deaconess Medical Center in Boston, Massachusetts, explored the role of the SLC25A48 protein in controlling mitochondrial choline import and metabolism. The research found that SLC25A48 is crucial for brown fat thermogenesis, mitochondrial respiration, and cell survival by facilitating the synthesis of choline-derived methyl donors. The study concluded that SLC25A48 plays a significant role in regulating mitochondrial choline catabolism, bioenergetics, and cell proliferation, shedding light on its importance in overall health and wellness. [Extracted from the article]

A study conducted at Wuhan University in China explored the genetic associations between gene polymorphisms on 3p25 and oral squamous cell carcinoma (OSCC) in the Chinese Han population. The research identified several single nucleotide polymorphisms (SNPs) in genes such as IQSEC1 and PPARG that were significantly associated with the clinical characteristics and prognosis of OSCC patients. The study concluded that multiple SNPs in IQSEC1 and PPARG genes may play a role in the clinical characteristics and prognosis of OSCC. [Extracted from the article]

A study conducted by researchers at Fujian Medical University in Fuzhou, China, focused on developing a novel barcode-based approach for highly sensitive single nucleotide recognition and mutation site sequencing. The method utilizes a dual-head folded complementary template probe and DNA ligase to identify target bases, followed by rolling circle amplification and fluorescence readout. The research demonstrated high accuracy and stability in sequencing a drug-resistant mutation site in Helicobacter pylori, showing promise as a next-generation sequencing method. For more information, the full article can be accessed for free at the Biosensors journal website. [Extracted from the article]

A recent study conducted by the Postgraduate Institute of Medical Education and Research focused on optimizing the Loop Mediated Isothermal Amplification Assay to detect chloroquine resistance in Plasmodium vivax malaria cases in India. The study found that the assay successfully detected single nucleotide polymorphisms in the Pvmdr1 gene, indicating a trend towards chloroquine resistance in Plasmodium vivax. This research could help identify emerging hubs of drug resistance and inform antimalarial drug policy in the future. [Extracted from the article]

A study conducted at the University of Catania in Italy explored the impact of follicle-stimulating hormone receptor gene polymorphisms on body mass index, metabolism, and bone mineral density in postmenopausal women. The research found that certain gene variants may play a role in protecting against obesity and influencing insulin metabolism. While no significant differences were observed in most parameters examined, women with specific gene variants showed lower glucose levels and higher bone mineral density scores. This study offers insights into the potential genetic factors influencing obesity and related metabolic conditions in postmenopausal women. [Extracted from the article]

A recent study from Keimyung University in Daegu, South Korea, explores the genetic basis of sweet taste preference and its potential implications for obesity. The research identified specific genes and single nucleotide polymorphisms (SNPs) associated with sweet taste preferences, highlighting their influence on dietary choices and obesity risk. The findings suggest that genetic factors play a role in personalized dietary recommendations and obesity management strategies, emphasizing the importance of understanding genetic influences on taste preferences. [Extracted from the article]

A recent study conducted at Mahidol University explored the impact of FTO gene variants on dietary habits contributing to obesity risk in Thai adults. The study found that individuals carrying certain risk alleles showed significantly higher intakes of sugar and saturated fat compared to others. These findings emphasize the importance of considering both genetic and dietary factors in obesity prevention strategies. For more information, the full article can be accessed for free at the link provided. [Extracted from the article]

Researchers have submitted a patent application for a novel method of detecting nucleic acids in samples without the need for intensive preparation or amplification. This method allows for rapid and sensitive detection of target nucleic acids, including viral RNA, with high specificity. The inventors have developed a technique that involves excising and detecting specific target probes from the nucleic acids, enabling multiplexing and quantification of target nucleic acids in a sample. [Extracted from the article]

Researchers from the Ministry of Agriculture and Rural Affairs conducted a study on Micropterus salmoides to identify growth-linked genes and SNP markers under a carbohydrate-rich diet and varying temperatures using RNA-seq and whole-genome re-sequencing. The study found that growth-related genes were enriched in fat digestion and absorption pathways, with temperature affecting carbohydrate transport and metabolism. Specific SNP markers were associated with body weight and growth performance, providing insights for developing M. salmoides strains that can better adapt to carbohydrate diets at different temperatures. The research was published in Scientific Reports and can be accessed for free online. [Extracted from the article]

The research conducted at the Hospital of Chengdu University of Traditional Chinese Medicine explored the potential causal connection between serum iron levels and female infertility in European populations. Utilizing Mendelian randomization analyses, the study found a positive correlation between serum iron levels and the risk of female infertility, while other iron markers did not significantly influence this risk. The findings suggest a need for further research into the relationship between serum iron status and female infertility risk. [Extracted from the article]

A study conducted at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida, explored how genetics may influence the effectiveness of the Mindfulness-Based Stress Reduction (MBSR) program for breast cancer survivors. The research found that genetic variants could moderate the program's impact on cognitive functioning and symptoms among participants. While the effects were small, the study suggests that personalized intervention programs tailored to individuals' genetic profiles could be developed for breast cancer survivors. The study was peer-reviewed and published in Biological Research For Nursing. [Extracted from the article]

A patent has been issued for Linked paired strand sequencing by Singular Genomics Systems Inc., focusing on innovative approaches to improve the accuracy and fidelity of high throughput sequencing methods. The method involves ligating adapters to a double-stranded nucleic acid, sequencing portions of the template, and distinguishing rare sequence variants from errors. This technology aims to enhance the efficiency and accuracy of next-generation sequencing techniques for personalized precision medicine applications. [Extracted from the article]

A recent study conducted by researchers at Hamad Bin Khalifa University in Qatar focused on genome sequencing to identify 13 novel candidate risk genes for Autism Spectrum Disorder (ASD) in a Qatari cohort. The study highlighted the genetic complexity of ASD, particularly in populations with high consanguinity, and identified variants in genes not previously associated with ASD. The findings underscore the importance of genetic counseling and screening programs in Qatar, emphasizing the impact of genetic diversity on neurodevelopmental conditions. The study was funded by Qatar Foundation and published in the International Journal of Molecular Sciences. [Extracted from the article]