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New research from the University of Washington explores the role of metabolic remodeling and mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF). The study found that HFpEF hearts had lower phosphocreatine content and reduced phosphocreatine/ATP ratio, similar to heart failure with reduced ejection fraction. Mitochondrial dysfunction and impaired mitochondrial quality control were observed in HFpEF hearts, contributing to the pathogenesis of the condition. The researchers suggest that stimulating fatty acid oxidation could improve HFpEF phenotypes. [Extracted from the article]

A study conducted by researchers at Mashhad University of Medical Sciences in Iran investigated the use of magnetic resonance spectrometry (MRS) as a prognostic tool for patients with diffuse axonal injury (DAI), a type of traumatic brain injury. The study involved 50 patients with DAI, and MRS scans were conducted on days 3 and 30 to assess the correlation between metabolites and patients' Glasgow Coma Scale (GCS) scores. The results showed that the levels of phosphocreatine, NAA/choline ratio, and hunter angle on day 3 were significantly correlated with patients' GCS scores on day 30. This research provides valuable insights into the potential use of MRS in predicting outcomes for patients with DAI. [Extracted from the article]

A patent application titled "Creatine Nutritional Supplement" has been published online. The inventor, Dylan Menter, has developed a nutritional food product in the form of a gummy that contains creatine. The supplement includes various ingredients such as sweeteners, a gelling agent, and water. The patent application also describes a method for producing the food product. The invention aims to provide an improved way to consume creatine, which is known for its potential benefits to the body. [Extracted from the article]

A study conducted in Dongying, People's Republic of China, investigated the effectiveness of sodium creatine phosphate (SCP) in treating pediatric viral myocarditis and its impact on cellular immune functions. The study included 83 children with viral myocarditis who were randomly assigned to a control group and a study group. The results showed that the study group, which received SCP in addition to conventional treatment, had a significantly higher total effective rate, improved cardiac function, reduced inflammation, and minimized myocardial damage compared to the control group. The researchers concluded that further evaluation is needed to assess the long-term efficacy and prognosis of SCP in treating pediatric viral myocarditis. [Extracted from the article]

A study conducted at Tianjin Children's Hospital in China examined the clinical effects of different doses of creatine phosphate sodium (CPS) combined with immunoglobulin in the treatment of pediatric viral myocarditis (VMC). The study involved 120 children with VMC who were divided into three groups and treated with varying doses of CPS and immunoglobulin for 14 days. The results showed that higher doses of CPS combined with immunoglobulin led to better therapeutic effects, improved cardiac and immune function, reduced inflammation, and fewer adverse effects. The study suggests that high-dose CPS in combination with immunoglobulin can be an effective treatment for children with VMC. [Extracted from the article]

A recent study conducted by researchers at the University of Aberdeen in the United Kingdom has found that breast cancer patients who receive epirubicin, a type of chemotherapy, may experience impaired cardiac and skeletal muscle energetics. The study involved 25 female patients with breast cancer and 25 age- and sex-matched healthy controls. After chemotherapy, the patients showed a reduction in cardiac phosphocreatine/gamma ATP ratio and an increase in skeletal muscle Pi/phosphocreatine ratio. Additionally, there were structural changes observed in both cardiac and skeletal muscle. These findings suggest that contemporary doses of epirubicin for breast cancer treatment can have significant effects on muscle metabolism and structure. [Extracted from the article]

A study conducted at Penn State College of Medicine aimed to determine if phosphocreatine (PCr) could decrease troponin I concentration after cardiac surgery. The study included 120 patients undergoing valve repair/replacement under cardiopulmonary bypass. The treatment group received PCr while the control group received a placebo. The study found no significant difference in troponin I concentration or other clinical outcomes between the two groups. The researchers concluded that PCr administration is safe but does not have a beneficial effect on clinical outcomes after surgery. [Extracted from the article]

Researchers at the Kennedy Krieger Research Institute in Baltimore, Maryland have conducted a study on the mapping of skeletal muscle using CEST MRI at 3T. The study aimed to confirm the slow-exchanging process of creatine (Cr) in muscle and obtain high-resolution maps of amide, creatine, and phosphocreatine (PCr) in skeletal muscle. The researchers used mouse hindlimbs and human calf muscle for their experiments and determined optimal saturation parameters for PCr/CrCEST signals. The study concluded that in vivo CrCEST is a slow-exchanging process and that amide, Cr, and PCr CEST in skeletal muscle can be mapped simultaneously at 3T using the PLOF CEST method. [Extracted from the article]

The article discusses the sources of muscular energy. An analogy between a muscle and an engine is presented. The role of adenosine triphosphate as the direct source of energy for the activity of a muscle is discussed. The ultimate sources of energy for the resynthesis of the phosphagens are enumerated.

Amino Acids, Angiology, Aortic Stenosis, Aortic Valve Stenosis, Cardiology, Cardiovascular Diseases and Conditions, Creatine, Disease Attributes, Disease Progression, Genetics, Health and Medicine, Phosphoamino Acids, Phosphocreatine, Stenosis Keywords: Amino Acids; Angiology; Aortic Stenosis; Aortic Valve Stenosis; Cardiology; Cardiovascular Diseases and Conditions; Creatine; Disease Attributes; Disease Progression; Genetics; Health and Medicine; Phosphoamino Acids; Phosphocreatine; Stenosis EN Amino Acids Angiology Aortic Stenosis Aortic Valve Stenosis Cardiology Cardiovascular Diseases and Conditions Creatine Disease Attributes Disease Progression Genetics Health and Medicine Phosphoamino Acids Phosphocreatine Stenosis 1504 1504 1 11/06/23 20231111 NES 231111 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- New research on disease progression is the subject of a new report. [Extracted from the article]

In the article, the author offers tips on how to improve egg fertility and hatchability of broiler breeders to enhance efficiency and productivity in broiler production. Also cited are the importance of using the spiking strategy to increase the mating of breeder hens to sustain their high fertility, and how creatine sources like the guanidinoacetic acid (GAA) feed can boost fertility of roosters and hatchability of eggs.

Keywords: Edmonton; Canada; North and Central America; Amino Acids; Brain Research; Central Nervous System; Cerebrum; Creatine; Depression; Diseases and Conditions; Drugs and Therapies; Frontal Lobe; Guanidines; Health and Medicine; Healthcare; Mental Health Diseases and Conditions; Phosphoamino Acids; Phosphocreatine; Prefrontal Cortex; Prosencephalon; Telencephalon EN Edmonton Canada North and Central America Amino Acids Brain Research Central Nervous System Cerebrum Creatine Depression Diseases and Conditions Drugs and Therapies Frontal Lobe Guanidines Health and Medicine Healthcare Mental Health Diseases and Conditions Phosphoamino Acids Phosphocreatine Prefrontal Cortex Prosencephalon Telencephalon 986 986 1 08/14/23 20230818 NES 230818 2023 AUG 18 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Mental Health Diseases and Conditions - Depression. We measured GABA+ (including homocarnosine and macromolecules), referenced to creatine and phosphocreatine, via magnetic resonance spectroscopy using a 3 Tesla magnet. [Extracted from the article]

Keywords: Amino Acids; Asparagine; Basic Amino Acids; Creatine; Diamino Amino Acids; Exercise Therapy; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo; Health and Medicine; Hypertrophy; Neutral Amino Acids; Phosphoamino Acids; Phosphocreatine; Physical Therapy and Rehabilitation Medicine EN Amino Acids Asparagine Basic Amino Acids Creatine Diamino Amino Acids Exercise Therapy Fundacao de Amparo a Pesquisa do Estado de Sao Paulo Health and Medicine Hypertrophy Neutral Amino Acids Phosphoamino Acids Phosphocreatine Physical Therapy and Rehabilitation Medicine 2370 2370 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Which kind of resistance training promotes more muscle growth: low load with many repetitions or high load with fewer repetitions? Keywords for this news article include: Asparagine, Hypertrophy, Phosphocreatine, Exercise Therapy, Basic Amino Acids, Phosphoamino Acids, Diamino Amino Acids, Health and Medicine, Neutral Amino Acids, Physical Therapy and Rehabilitation Medicine, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo. Amino Acids, Basic Amino Acids, Creatine, Diamino Amino Acids, Exercise Therapy, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Health and Medicine, Hypertrophy, Neutral Amino Acids, Phosphoamino Acids, Phosphocreatine, Physical Therapy and Rehabilitation Medicine, Asparagine. [Extracted from the article]

Keywords for this news article include: Asia, Guangdong, Pediatrics, Health and Medicine, People's Republic of China. According to the news editors, the research concluded: "The comprehensive nursing method used in the postoperative ICU of children with CHD can reduce the incidence of postoperative complications and improve nursing satisfaction." Keywords: Guangdong; People's Republic of China; Asia; Health and Medicine; Pediatrics EN Guangdong People's Republic of China Asia Health and Medicine Pediatrics 396 396 1 06/05/23 20230609 NES 230609 2023 JUN 10 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Health and Medicine is the subject of a report. [Extracted from the article]

Keywords: Amino Acids; Cholesterol; Creatine; Diet and Nutrition; Guanidines; Health and Medicine; Inflammation; Nutritional and Metabolic Diseases and Conditions; Obesity; Obesity and Diabetes; Patent Application; Vitamin D; Vitamins EN Amino Acids Cholesterol Creatine Diet and Nutrition Guanidines Health and Medicine Inflammation Nutritional and Metabolic Diseases and Conditions Obesity Obesity and Diabetes Patent Application Vitamin D Vitamins 271 271 1 04/24/23 20230424 NES 230424 2023 APR 24 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- A patent application by the inventors Parise, Gianni (Hamilton, CA); Phillips, Stuart (Hamilton, CA), filed on November 21, 2022, was made available online on April 6, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. "In a further embodiment, kit is provided comprising a first composition comprising a protein, creatine, vitamin D and calcium, and a second composition comprising an n-3 fatty acid. The kit of claim 1, wherein the creatine is selected from the group consisting of creatine monohydrate, creatine anhydrous, creatine citrate, creatine ethyl ester, creatine nitrate, creatine magnesium chelate, creatine hydrochloride, creatine malate, creatine pyruvate, creatine phosphate, creatine citrate malate, creatine tartrate, creatine HMB (b-hydroxy b-methylbutyrate), effervescent creatine, creatine titrate, buffered creatine, micronized creatine and any combination thereof. [Extracted from the article]

If you're an elite rider you might look at doing a morning ride to reduce muscle glycogen followed by several hours of reduced carbohydrate intake so that the evening session starts with low glycogen levels. To determine how increasing or decreasing glucose intake impacts performance, Southerland says, if you have a Tuesday afternoon set of intervals, try one fuelling strategy and see how you feel. Next time you're out for a ride, tip your cap to Andreas Marggraf, the German chemist who first isolated the simple sugar glucose in raisins in 1747. [Extracted from the article]

Phosphoarginine is a cell energy buffer molecule synthesized by the enzyme arginine kinase. In Trypanosoma cruzi, the aetiological agent of Chagas' disease, 2 different isoforms were identified by data mining, but only 1 was expressed during the parasite life cycle. The digitonin extraction pattern of arginine kinase differed from those obtained for reservosomes, glycosomes and mitochondrial markers, and similar to the cytosolic marker. Immunofluorescence analysis revealed that although arginine kinase is localized mainly in unknown punctuated structures and also in the cytosol, it did not co-localize with any of the subcelular markers. This punctuated pattern has previously been observed in many cytosolic proteins of trypanosomatids. The knowledge of the subcellular localization of phosphagen kinases is a crucial issue to understand their physiological role in protozoan parasites. [ABSTRACT FROM AUTHOR]

Phosphagenics Successful in Transdermal Insulin Clinical Trial. Prima Biomed and Burnet Institute Collaborate on Cell Therapies for Cancer. SciGen Acquires Shreya Biotech. Neuren's Third Lead Drug Candidate Proves Effective at Reversing Memory Loss. Living Cell Technologies Granted Diabetes Patent Across the EU. China's Most Profitability Biotech Company: GenSci. Japan Bioventures Today — BioMatrix Research. Prisma Biotech Corporation. [ABSTRACT FROM AUTHOR]

Presents information on several forms of creatine, a natural supplement and amino-acid derivative that aids in muscle and strength gains. Creatine monohydrate; Creatine anhydrous; Creatine citrate; Creatine phosphate.

Provides information on several creatine supplements. Creatine monohydrate; Creatine citrate; Creatine phosphate.

The article examines the three types of fitness and their role in dance. The classification of the three different systems depend on the intensity of the exercise and whether or not oxygen is used. The three types are adenosine tri phosphate-phosphocreatine (ATP-PCr), anaerobic system and aerobic system.

The article provides an answer to a question related to the use of dietary supplements in muscle-building, bodybuilding, and weight loss which further discusses how creatine phosphate, mainly found in muscle tissue, helps to exercisers by regulating ATP-PC energy producing system in body.

The article offers information on the effect of Bi-Carb soda and lactic acid accumulation over physical activeness. It discusses the energy metabolism carried out in human body which includes chemical energy in the form of adenosine triphosphate, creatine phosphate (CrP) as a readily available high-energy source, and anaerobic glycolysis. Also discussed are the topics including bicarbonate loading and gastrointestinal upset.

The article focuses on the evaluation on the use of energy during swimming. The Adenosine Triphosphate (ATP), Creatine Phosphate (CP) and glycogen are the potential chemical energy used in swimming. It highlights the classification of energy zones which are important to determine the anaerobic threshold.

The article discusses the aerobic training programs for volleyball players in the U.S. in order to endure continuous bouts of high-intensity levels during their games. One of the aerobic training programs is the phosphagen system which is an explosive mechanism used to provide the athlete with the majority of his/her energy. Another energy source used in volleyball is the anaerobic glycolysis which is the breakdown of blood glucose or muscle glycogen down to the lactic acid.

Presents several sports products and equipment. Features of Daewoo's Musso four-wheel drive automobile; Ray-Ban and Callaway sunglass designed for golfers; Sunbeam Pure Source Power Water Filter System; Blistex lip conditioner; Phosphagen, a creatine monohydrate dietary supplement from EAS.

Examines the physiological effect of creatine phosphate. Reason for the popularity of creatine as a nutritional supplement; Required dosage of creatine for muscle growth.

This article compares two different types of creatine. Creighton University researchers found that creatine phosphate improved performance three times as well as creatine monohydrate, the form most commonly used in creatine supplements. Although both creatine monohydrate and creatine phosphate improve strength and muscle-mass gains, the latter may give you a slight edge in performance.

Reports on the use of nuclear magnetic resonance (NMR) spectroscopy in detecting chemical compounds in intact muscle and changes resulting from drug treatment or disease. Technique used in NMR spectroscopy; Differences in the distribution of phosphate diesters between normal and diseased human and chicken muscle; Decreased levels of energy-storing molecule phosphocreatine in patients with a neuromuscular disease.