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A recent study conducted at the University of Toyama in Japan explored the impact of converting from conventional pemafibrate to a novel extended-release (XR) formulation on hypertriglyceridemia. The research found that the XR formulation may be more promising in improving hypertriglyceridemia due to enhanced medication adherence. The study involved 46 patients with hypertriglyceridemia, showing a significant decrease in serum triglyceride levels after the conversion to the XR formulation. This research provides valuable insights into potential advancements in treating lipid metabolism disorders. [Extracted from the article]

A study conducted by researchers at Sorbonne Universite explores the association between sleep and nighttime behavior disorders (SNBD) in older adults and pathological cholesterol and triglyceride levels. The study found that hypertriglyceridemia, but not hypercholesterolemia, was associated with higher odds of SNBD. This association was independent of body mass index (BMI). The researchers suggest that sleep disorders should prompt a systematic screening of dyslipidemia in older adults and vice versa. [Extracted from the article]

A recent study conducted at the Hayatabad Medical Complex examined the lipid abnormalities in patients with subclinical hypothyroidism. The study found that high triglyceride levels were the only abnormal findings in patients with subclinical hypothyroidism, while total cholesterol and high-density lipoproteins were not affected. The risk of hypertriglyceridemia was found to be moderately increased when the level of thyroid stimulating hormone (TSH) reached 10mIU/L. The study concluded that disorders of triglyceride metabolism in subclinical hypothyroidism are directly correlated with TSH levels, but do not affect total cholesterol and high-density lipoproteins. [Extracted from the article]

A study conducted in Zhejiang, People's Republic of China, has found that hypertriglyceridemia, a condition characterized by high levels of triglycerides in the blood, can interfere with the accurate measurement of hemoglobin (HGB) using colorimetric methods. The researchers used plasma exchange and formula substitution methods to establish a reliable calibration method for HGB determination in the presence of hypertriglyceridemia. The calibrated results provided accurate values for HGB and its related indexes, MCH and MCHC, in blood lipid samples, which can be useful for clinicians. This research has been peer-reviewed and published in Clinical Laboratory. [Extracted from the article]

A recent study compared patients with familial chylomicronemia syndrome (FCS) and multifactorial chylomicronemia syndrome (MCS), both of which are characterized by severe hypertriglyceridemia. The study found that FCS patients were significantly younger, had an earlier age of symptom onset, lower body mass index, and a higher prevalence of pancreatitis events compared to MCS patients. FCS patients also had a higher ratio of triglyceride to total cholesterol and lower plasma apolipoprotein B. The study suggests that some MCS patients with sustained refractory hypertriglyceridemia behave functionally as if they have FCS, which may impact their eligibility for novel therapies. [Extracted from the article]

A recent study on hypertriglyceridemia, conducted by researchers at the University of Bari in Italy, highlights the importance of therapy in preventing cardiovascular diseases. The study focuses on fibrates, a class of lipid-lowering drugs that lower triglyceride levels and increase high-density lipoprotein cholesterol. However, the use of fibrates in combination with statins may increase the risk of myopathy. The researchers also mention a new drug called pemafibrate, which is currently being considered for therapy. Overall, the study emphasizes the need for new therapies to reduce triglycerides and the risk of cardiovascular diseases. [Extracted from the article]

The article presents new findings on vitamin D deficiency and its association with cardiovascular risk factors in adult women from Morocco. Topics discussed include the correlation between low vitamin D levels and adverse atherogenic indices, such as hypertriglyceridemia and elevated atherogenic indices, the thresholds of vitamin D associated with increased cardiovascular risk, and the importance of raising awareness and taking preventive measures against cardiovascular disease.

A recent study suggests that hypertriglyceridemia, or high levels of triglycerides in the blood, may play a significant role in the development and rupture of abdominal aortic aneurysms (AAA). The study used genetic and experimental models to investigate the relationship between increased triglyceride levels and AAA risk. The findings indicate that elevated triglyceride concentrations can accelerate AAA development and rupture, and highlight the importance of managing triglyceride-rich lipoproteins in treating AAA. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

A new study conducted at Sorbonne Universite explores the capacity of high-density lipoprotein cholesterol (HDL) to acquire free cholesterol (FC) from triglyceride-rich lipoproteins during lipoprotein lipase-dependent lipolysis. The study found that the capacity of HDL to acquire FC increased progressively during the postprandial phase, reaching a maximum value after 6 hours. The researchers also identified individuals with reduced capacity of HDL to acquire FC, who exhibited exacerbated postprandial triglyceride response and reduced HDL cholesterol levels. The study suggests that to normalize postprandial triglyceride response, elevated FC transfer to HDL and increased levels of acceptor HDL particles are needed. [Extracted from the article]

Researchers from the University Hospital in Dijon, France have conducted a study on the mechanisms of hypertriglyceridemia associated with PLIN1-related familial partial lipodystrophy (FPL). The study found that patients with PLIN1-related FPL had decreased fat mass, insulin resistance, and diabetes, as well as higher plasma triglyceride levels compared to healthy controls and patients with type 2 diabetes. The researchers discovered that the hypertriglyceridemia in PLIN1-related FPL is a result of a decrease in the catabolism of triglyceride-rich lipoproteins, which may be due to a reduction in lipoprotein lipase availability related to decreased adipose tissue mass. This research provides insights into the understanding of obesity and diabetes. [Extracted from the article]

A recent study conducted at the University of Manchester in the United Kingdom explores the impact of severe hypertriglyceridemia (SHTG) and chylomicronemia on cardiovascular and pancreatic complications. The study highlights the challenges in diagnosing and treating SHTG, particularly familial chylomicronemia syndrome (FCS) and multifactorial chylomicronemia syndrome (MCS). The researchers emphasize the need for predictive models for complications and personalized treatment strategies. They also advocate for the establishment of national and international registries to enhance understanding of the disease and identify high-risk individuals. [Extracted from the article]

A study conducted by researchers at Johns Hopkins University aimed to describe the incidence of chronic kidney disease (CKD) and other comorbidities among young adults with perinatally acquired HIV (PHIV) in North America. The study analyzed electronic health records of 375 young adults with PHIV enrolled in routine HIV care. The findings showed a high incidence of diabetes mellitus type 2, hypercholesterolemia, hypertriglyceridemia, hypertension, and CKD among this population. The researchers suggest that earlier screening and intervention may be necessary to address these comorbidities in a timely manner. [Extracted from the article]

This document provides information about a clinical trial for the treatment of Generalized Lipodystrophy using a drug called Metreleptin. The trial is currently recruiting participants and aims to evaluate the effectiveness, safety, and pharmacokinetic parameters of Metreleptin in patients under 6 years of age with Generalized Lipodystrophy and associated diabetes mellitus and/or hypertriglyceridaemia. The trial is open-label and in Phase 3b, with primary outcome measures including changes in fasting serum TG levels and glycated haemoglobin (HbA1c) at Month 12. The trial is set to start on July 31, 2024, and is being conducted in Belgium, France, Germany, and Italy. [Extracted from the article]

A 49-year-old man developed hypertriglyceridemia while being treated with propofol for disseminated Coccidioidomycosis complicated by ARDS. The patient's plasma free Hb and triglyceride levels were significantly elevated, indicating hypertriglyceridemia. The hypertriglyceridemia was attributed to propofol, and the medication was discontinued and switched to midazolam. With insulin treatment, the patient's triglyceride levels decreased. [Extracted from the article]

A study conducted by researchers at Xi'an Jiaotong University in China aimed to understand the relationship between a healthy lifestyle and metabolic syndrome (MetS). The study found that individuals with a higher number of low-risk lifestyle factors had a lower risk of impaired glucose tolerance, high blood pressure, hypertriglyceridemia, and low levels of HDL cholesterol. The researchers also discovered that serum uric acid (SUA) mediated a portion of the effect of a healthy lifestyle on these components of MetS. This suggests that reducing SUA levels could be an important mechanism by which lifestyle influences MetS. [Extracted from the article]

A recent study conducted at the Royal Children's Hospital provides an update on the understanding of Familial Chylomicronemia Syndrome (FCS), a rare disorder of triglyceride metabolism. The study focuses on the diagnosis and stabilization of FCS in two infants who presented with hypertriglyceridemia-induced acute pancreatitis. The researchers found that FCS can be challenging to manage both acutely and in the long-term, and highlight the need for more evidence-based recommendations. The study emphasizes the importance of early diagnosis and appropriate management strategies for infants with FCS. [Extracted from the article]

This document provides information about a research study on the effects of dried barberry and a low-calorie diet on hypertriglyceridemia, a condition characterized by high levels of triglycerides in the blood. The study is an open-label, randomized, controlled clinical trial that will last for 8 weeks. Participants will be randomly assigned to either consume powdered seedless barberry or follow a low-calorie diet alone. The study aims to enroll 52 individuals and is being conducted by Shahid Beheshti University of Medical Sciences and Kashan University of Medical Sciences in Iran. The principal investigator is Javad Nasrollahzadeh. [Extracted from the article]

A recent study conducted by the University of Montreal focused on the use of plozasiran, an APOC3-targeted small interfering-RNA (siRNA) drug, for the treatment of severe hypertriglyceridemia (sHTG). The study aimed to determine the tolerability, efficacy, and dosage of plozasiran in lowering triglyceride and apolipoprotein C3 (APOC3) levels in patients with sHTG. The results showed that plozasiran significantly reduced triglyceride levels and improved other triglyceride-related lipoprotein parameters. Although there was an increase in LDL-C levels, there was no change in ApoB levels and a decrease in non-HDL-C levels. The safety profile of plozasiran was generally favorable. Further studies are needed to determine if plozasiran can effectively reduce the risk of sHTG-associated complications. [Extracted from the article]

A report from Fujian Medical University in Fuzhou, People's Republic of China, discusses the correlation between asparaginase enzyme activity (AEA) levels and clinical characteristics and adverse effects in Chinese pediatric patients with acute lymphoblastic leukemia (ALL). The study monitored AEA in 329 patients and found that AEA levels were higher in younger children and increased with cumulative dose numbers. The study also identified associations between AEA levels and adverse effects such as hypofibrinogenemia, hypertriglyceridemia, pancreatitis, thrombosis, and hypoglycemia. The researchers concluded that achieving sustained and adequate AEA levels should be the treatment target for PEG-asparaginase. [Extracted from the article]

A study conducted by the Shandong University of Traditional Chinese Medicine in China examined the association between serum uric acid (SUA) levels and hypertriglyceridemia (HTG) in adolescents in the United States. The study included 4,435 participants and found that male adolescents had higher SUA levels. After adjusting for various factors, the study revealed a positive correlation between SUA and HTG risk. The researchers recommend regular testing of SUA levels in children diagnosed with HTG and suggest including SUA in the comprehensive care of these children. [Extracted from the article]

In a retrospective study of seven neonates conducted between 2017 and 2022, five patients developed pneumonia or increased serum triglyceride levels while being treated with everolimus for giant cardiac rhabdomyomas. Additionally, these patients exhibited a lack of efficacy when treated with flecainide and propranolol for supraventricular tachycardia. The study provides specific cases of neonates experiencing these adverse effects and highlights the regression of cardiac rhabdomyomas in each case. It is important to note that the treatments used were off-label. [Extracted from the article]

A recent study from the University of Western Australia explores the treatment of hypertriglyceridemia (HTG), a condition associated with an increased risk of cardiovascular disease. The study focuses on the potential of targeting angiopoietin-like protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III) with monoclonal antibody and nucleic acid therapies. The findings suggest that these inhibitors can effectively lower plasma triglycerides and triglyceride-rich lipoproteins (TRLs), potentially reducing the risk of cardiovascular disease in patients with HTG. However, further research is needed to confirm the long-term safety and cost-effectiveness of these treatments. [Extracted from the article]

A recent study conducted at the University of Prishtina in Kosovo examined the patterns of presentation of patients with acute myocardial infarction (MI). The study found that ST-segment elevation MI (STEMI) was more common than non-ST-segment elevation MI (NSTEMI) in Kosovo, with STEMI patients being mostly male and more likely to have diabetes, hypertension, and a family history of coronary artery disease. Smoking and high triglycerides were identified as independent predictors of STEMI. The study highlights the need for better control of atherosclerosis risk factors and education strategies in Kosovo. [Extracted from the article]

A recent study conducted at Maulana Azad Medical College in New Delhi, India, explored the relationship between hemophagocytic lymphohistiocytosis (HLH) and systemic lupus erythematosus (SLE). HLH is a severe condition characterized by uncontrolled immune activity and hyperinflammation, and it can be either primary or secondary. The researchers presented three cases of unidentified autoimmune diseases that were later diagnosed as SLE manifesting as HLH. The study highlights the challenges in diagnosing HLH related to SLE and emphasizes the importance of early treatment for this life-threatening illness. [Extracted from the article]

A recent study conducted by researchers at the University of Brescia in Italy has found that high levels of serum uric acid (SUA) and triglycerides (TG) may contribute to the development of subclinical atherosclerosis, a precursor to cardiovascular disease. The study analyzed data from over 6,000 participants over a 20-year period and found that both SUA and TG were independently associated with the presence of carotid plaque, a marker of atherosclerosis. The study also found that the combination of hyperuricemia and hypertriglyceridemia was a stronger determinant of carotid plaque than either factor alone. These findings suggest that reducing SUA and TG levels may be important in preventing cardiovascular disease. [Extracted from the article]

In a study conducted between October 2017 and December 2021, three adult patients with rheumatoid arthritis (RA) developed various toxicities while being treated with baricitinib. The toxicities included grade 4 hypertriglyceridemia, grade 4 abnormal liver enzymes, grade 3 urticaria, increased platelet count, and central retinal vein occlusion. Baricitinib was discontinued in all three patients. The exact ages, sexes, dosages, duration of treatments, and outcomes were not provided in the study. [Extracted from the article]

A recent study conducted at Western University in London, Canada examined the association between severe hypertriglyceridemia (HTG) and carotid intima-media thickness (IMT), a marker for atherosclerotic cardiovascular disease (ASCVD) risk. The study compared three clinical cohorts: patients with severe HTG, patients with familial hypercholesterolemia (FH), and normolipidemic controls. The results showed that extreme triglyceride elevations in severe HTG patients were not significantly associated with carotid IMT, unlike the increased IMT observed in FH patients. These findings provide insight into the complex relationship between severe HTG and ASCVD risk. [Extracted from the article]

A new study published by researchers at the Department of Pediatrics explores the association between sleep onset time, sleep duration, and cardiometabolic health outcomes. The study included 6,696 adults aged 20 to 80 years and found that inappropriate sleep onset time and duration were associated with increased odds of hypertension, hypertriglyceridemia, and metabolic syndrome, particularly among participants aged 40 to 59 years. The research concludes that late sleep onset and insufficient or excessive sleep duration are linked to adverse cardiometabolic outcomes. Further information on the study can be found in the Journal of the American Heart Association. [Extracted from the article]

Researchers at Carol Davila University of Medicine and Pharmacy in Bucharest, Romania have conducted a study on acute pancreatitis, specifically focusing on hypertriglyceridemia-induced acute pancreatitis (HTG-AP). The study found that HTG-AP patients had a more severe course of the disease compared to patients with other known causes of pancreatitis. HTG-AP patients were typically middle-aged males with previous episodes of pancreatitis, and they had longer stays in the intensive care unit and hospital. They were also more likely to develop acute peripancreatic fluid collection and be cared for in a gastroenterology ward. This research provides valuable insights into the characteristics and outcomes of HTG-AP. [Extracted from the article]

A new report discusses the impact of lipid disorders on cardiovascular health, specifically focusing on hypertriglyceridemia. The research highlights the importance of triglycerides (TGs) in cardiovascular outcomes and comorbidities, with higher plasma concentrations of TGs associated with increased risk of coronary heart diseases, death, myocardial infarction, and stroke. However, the exact mechanisms underlying this relationship are not fully understood. The report aims to provide a comprehensive evaluation of TG metabolism, explore the physiological background of the relationship between TGs and cardiac and vascular damage, and emphasize the need for further research on therapies to reduce TG levels. [Extracted from the article]

A study explored the association between dyslipidemia (abnormal levels of cholesterol and triglycerides) and sleep and nighttime behavior disorders (SNBD) in older adults. The study found that hypertriglyceridemia (high triglyceride levels) was associated with higher odds of SNBD, while hypercholesterolemia (high cholesterol levels) was not. However, none of the dyslipidemia forms predicted the development of SNBD over a 12-month period. The study suggests that dyslipidemia may play a role in SNBD in older adults, particularly hypertriglyceridemia. Further research is needed to better understand this association. [Extracted from the article]

A new report from the Department of Obstetrics discusses a case of acute pancreatitis (AP) during pregnancy, which is a rare condition that can potentially lead to maternal-fetal mortality. The case involved a 35-year-old pregnant patient who presented with acute epigastric pain and was diagnosed with AP based on elevated lipase levels. The cause of the AP was severe hypertriglyceridemia (HTG), which also led to severe fetal distress (SFD) and necessitated an emergency cesarean section. The researchers emphasize the challenges in diagnosing and managing AP during pregnancy, particularly when it is secondary to HTG. They recommend a multidisciplinary approach and rapid fetal delivery in such cases to reduce the risk of fetal mortality. [Extracted from the article]

A recent study conducted at Aichi Medical University in Japan compared the effects of two treatments, pemafibrate and omega-3-acid ethyl ester, on hepatic function in patients with hypertriglyceridemia complicated by metabolic dysfunction-associated steatotic liver disease (MASLD). The study found that pemafibrate was more effective than omega-3-acid ethyl ester in improving hepatic function, lipid profiles, and hepatic fibrosis biomarkers. No adverse drug reactions or safety concerns were identified in either group. The researchers believe that these findings may contribute to the development of future treatment strategies for patients with MASLD. [Extracted from the article]

A patent application has been submitted for a method of treating lipid metabolism disorders by inhibiting the expression of the ANGPTL3 gene. The method involves using double-stranded ribonucleic acids (dsRNAs) to target and cleave the RNA transcripts of the gene. The application also includes information on modified nucleotides and the use of a ligand to enhance the effectiveness of the dsRNA. This information may be helpful for researchers studying lipid metabolism disorders and looking for potential treatments. [Extracted from the article]

A recent study conducted by Professor YIN Huiyong's team has uncovered a mechanism that links hyperuricemia (elevated levels of urate in the blood) to hypertriglyceridemia (high levels of triglycerides in the blood). Hyperuricemia affects over 185 million individuals in mainland China and is associated with various metabolic diseases, including gout, obesity, diabetes, cardiovascular and cerebrovascular diseases, hypertension, and kidney disease. The study found that fatty acid oxidation induces hepatic urate synthesis and hyperuricemia, offering potential strategies for the prevention and treatment of hyperlipidemia and hyperuricemia. The research was a collaboration between multiple institutions and was financially supported by various grants. [Extracted from the article]

A recent study conducted by researchers at Western University examined the association between severe hypertriglyceridemia (HTG) and carotid intima-media thickness (IMT), a marker for atherosclerotic cardiovascular disease (ASCVD) risk. The study compared three clinical cohorts: patients with severe HTG, patients with familial hypercholesterolemia (FH), and normolipidemic controls. The results showed that extreme triglyceride elevations in severe HTG patients were not significantly associated with carotid IMT, unlike the increased IMT observed in FH patients. These findings provide insight into the complex relationship between severe HTG and ASCVD risk. [Extracted from the article]

A study conducted in Porto, Portugal explored the association between maternal lipid profile and the risk of large-for-gestational-age (LGA) newborns in women with gestational diabetes mellitus (GDM). The study found that hypertriglyceridemia in the third trimester was independently associated with LGA, regardless of glycemic control, pre-pregnancy BMI, and pregnancy weight gain. The researchers concluded that further investigation is needed to confirm the role of triglycerides in excessive fetal growth in GDM pregnancies. [Extracted from the article]

A recent study conducted at Milano-Bicocca University in Milan, Italy, examined the prevalence of hypertriglyceridemia in patients with acute and chronic coronary syndrome (ACS and CCS) who were enrolled in a cardiac rehabilitation program. The study found that despite statin therapy and low-density lipoprotein (LDL) cholesterol targets, a significant proportion of patients still had elevated triglyceride levels. These patients also had higher body mass index (BMI), LDL cholesterol, and uric acid levels, as well as lower ejection fraction. The study suggests that Icosapent Ethyl may be effective in managing hypertriglyceridemia in these patients. [Extracted from the article]

A recent study conducted at Guru Gobind Singh Medical College and Hospital in Punjab, India, highlights the case of a 3-year-old girl with newly diagnosed and untreated type 1 diabetes mellitus (DM) who presented with severe hypertriglyceridemia and diabetic ketoacidosis (DKA). Despite treatment with insulin and supportive care, the patient's condition rapidly deteriorated and she ultimately succumbed to the illness. The study emphasizes the importance of early diagnosis and treatment of diabetes in children to prevent complications such as DKA and severe hypertriglyceridemia. [Extracted from the article]

A study conducted in Mexico has found that there is a positive association between high serum copper levels and overweight, obesity, hypertriglyceridemia, and insulin resistance in Mexican adults. The study collected anthropometrical and biochemical data from 346 participants and used the triglyceride-glucose index as a marker for insulin resistance. The results suggest that trace elements, such as copper, may play a role in the pathophysiology of obesity and metabolic diseases. This research provides new insights into the relationship between copper levels and cardiometabolic traits in Mexican adults. [Extracted from the article]

A recent study conducted in Chiapas, Mexico, aimed to analyze the association between dietary glycemic index (GI), glycemic load (GL), and dyslipidemia in adolescents. The study found that a high dietary GL was associated with a detrimental effect on high-density lipoprotein cholesterol (HDL-c) levels. Female adolescents with high dietary GL had higher odds of hypertriglyceridemia, while no association was found for males. Overall, the study suggests that dietary factors may play a role in abnormal blood lipid levels in youth, which can increase the risk of cardiovascular disease. [Extracted from the article]

A 13-year-old boy developed hypertriglyceridemia, pseudohyponatremia, and pseudohyperkalemia while being treated with pegaspargase for pre-B acute lymphoblastic leukemia. He experienced high triglyceride levels, low sodium levels, and high potassium levels. The boy was admitted to the hospital for monitoring and treatment to prevent thromboembolism. He was given glucose, insulin, fenofibrate, and omega-3 supplements to manage his hypertriglyceridemia. His triglyceride levels decreased within 24 hours, and he was discharged with fenofibrate for outpatient follow-up. [Extracted from the article]

A 13-year-old boy developed hypertriglyceridemia, pseudohyponatremia, and pseudohyperkalemia while being treated with pegaspargase for pre-B acute lymphoblastic leukemia. He experienced high triglyceride levels, low sodium levels, and high potassium levels. The boy was admitted to the hospital for monitoring and treatment to prevent thromboembolism. He was given glucose, insulin, fenofibrate, and omega-3 supplements to manage his hypertriglyceridemia. His triglyceride levels decreased within 24 hours and his sodium and potassium levels normalized. He was discharged with a prescription for fenofibrate and scheduled follow-up appointments. [Extracted from the article]

A recent study conducted by researchers at North Greenville University aimed to determine sex differences in poststroke hypertriglyceridemia and high stroke severity in patients with hyperlipidemia. The study analyzed data from 392 males and 373 females with hypertriglyceridemia and found that in male patients, diastolic blood pressure and ischemic stroke mortality were significantly associated with increased stroke severity. In female patients, age was associated with reduced stroke severity, while ischemic stroke mortality score was associated with increased stroke severity. These findings provide valuable information about sex differences in specific risk factors that can be managed to improve the care of male and female ischemic stroke patients with hypertriglyceridemia. [Extracted from the article]

A recent study conducted by researchers at Federal University Pernambuco aimed to evaluate the prevalence of abdominal obesity, hypercholesterolemia, and hypertriglyceridemia in low-income adults. The study found that there was a high prevalence of abdominal obesity, hypercholesterolemia, and hypertriglyceridemia in the population studied. Factors such as gender, age, race, and smoking were found to be associated with these conditions. The study highlights the importance of addressing these risk factors in order to prevent and manage abdominal obesity and lipid alterations in low-income adults. [Extracted from the article]

A recent study conducted at the Third People's Hospital in Fuyang, People's Republic of China, examined the relationship between major depressive disorder (MDD) in children and adolescents and abnormalities in lipid metabolism. The study found that dyslipidemia, including hypercholesterolemia and hypertriglyceridemia, were prevalent among individuals with MDD and were positively associated with suicidal ideation and suicide attempts. The research suggests that monitoring the incidence of suicidal thoughts and attempts in individuals with MDD could be useful in guiding therapy and promoting recovery. This study highlights the importance of addressing both mental health and metabolic disorders in children and adolescents. [Extracted from the article]

A clinical trial, NCT06402305, is currently recruiting participants to evaluate the lipid profile and ultrasound findings in patients with pancreaticobiliary diseases. The study aims to investigate the relationship between gall stones and multiple risk factors, including lifestyle factors, dietary factors, and serum lipids. It also examines the association between elevated serum triglyceride and low high-density lipoprotein cholesterol levels with persistent organ failure in acute pancreatitis. The study is being conducted in Egypt and is expected to be completed by May 2024. The primary contact for the study is Alaa M Mostafa from Sohag University. [Extracted from the article]

A new report from Cairo University discusses research findings on hypertriglyceridemia, a condition characterized by high levels of triglycerides in the blood. The study investigated the factors affecting clinical outcomes of continuous and intermittent plasmapheresis in patients with severe hypertriglyceridemia. The researchers found that shorter plasmapheresis procedures were associated with more effective triglyceride clearance, and continuous apheresis technology, particularly when using albumin as replacement fluid, was beneficial. The study also compared different anticoagulants and replacement fluids and found that heparin and albumin were associated with greater triglyceride reduction. The research suggests that optimizing plasmapheresis techniques can improve outcomes for patients with severe hypertriglyceridemia. [Extracted from the article]

A recent study conducted at Bharti Vidyapeeth Deemed University Medical College in Maharashtra, India, focused on the use of therapeutic plasma exchange (TPE) in treating hypertriglyceridemia-induced pancreatitis (HTGP). The study presented the case of a 35-year-old female patient who underwent TPE using the Spectra Optia Apheresis System. The patient experienced a significant reduction in serum triglyceride levels, which was life-saving. The researchers concluded that therapeutic plasma exchange should be considered as a treatment option for HTGP. This research has been peer-reviewed and published in the Indian Journal of Hematology and Blood Transfusion. [Extracted from the article]