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• Special platforms combining fluorescent dyes, biocompatible polymer and nanographene oxide were fabricated. • Nontoxic enzyme-nanocomposites in which GO x could possess and amplify its enzyme activities were firstly fabricated. • These enzyme-nanocomposites provide wider application potential in biosensing and tracing of glucose. Enzyme, produced and worked in all living things, could work as macromolecular biological catalysts in diverse biochemical processes with particular specificity, like glucose oxidase (GO X). The efficient use of enzyme properties has great importance in pharmaceutics and therapeutics. In this work, we could fabricate naive and effective electrochemical biosensors in the determination of glucose levels via utilizing GO X. Graphene oxide, as a water-soluble derivative of graphene, has shown great promise in a variety of biomedical applications including biosensors. Thus, we established a new-type special platform for GO X immobilization to perform its prosperities, in which nanographene oxide (nGO) was employed as an ideal base and poly(ethylene glycol) (PEG) was conjugated on the edge of nGO sheets to enhance its biocompatibility. Additionally, preferable functional dyes (Rhodamine B/fluorescein isothiocyanate) were also introduced to the platform. Enzyme-nanocomposites were then provided by locating GO X on the platform, i.e., GO X @nGO-PEG-RhB and GO X @nGO-PEG-FITC. The microstructure and composite of platforms and enzyme-nanocomposites were confirmed by diverse characterizations. Finally, on account of corresponding cyclic voltammetric and typical ready-state amperometric curves, it was informed that GO X @nGO-PEG-RhB and GO X @nGO-PEG-FITC could effectively respond to the fluctuation of glucose level as electrochemical biosensor. The present work presents special platforms for the immobilization of enzymes like GO X and provides new-type biosensors in the detection of glucose levels. [ABSTRACT FROM AUTHOR]

• A novel MOF-based binary heterojunction FMG has been fabricated. • Heterojunction strategy endows FMG with anti-tumor intelligence for the first time. • FMG achieved the enhanced chemodynamic/starvation therapy with enough safety. Chemodynamic therapy (CDT) as an emerging modality in cancer treatment, its implementation remains a daunting challenge by the lack of smart Fenton catalyst under acidic tumor microenvironments. Herein, we have successfully constructed a Fe 3 O 4 @MIL-100 heterojunction by growing Fe-based metal-organic framework (MIL-100) onto the surface of Fe 3 O 4 nanoparticles. The as-made heterojunction after encapsulating glucose oxidase (termed FMG) is demonstrated as a pH-responsive intelligent Fenton nanosystem with the synergistic effect of starvation therapy (ST). Density functional theory (DFT) calculations reveal that such heterojunction could greatly reduce the energy barrier of the Fenton reaction, which better explains the mechanism of Fenton performance improvement. Moreover, the encapsulated glucose oxidase has successfully activated the ST process, in which its generated H 2 O 2 and gluconic acid further improve the CDT efficiency. More O 2 from the enhanced CDT in turn promotes the enzymatic reaction of glucose oxidase. The Fenton/cascade enzymatic reaction operates in a self-feedback manner as proposed. In vitro and in vivo experiments demonstrate that such intelligent Fenton nanoreactors provide a powerful anticancer mechanism for effective tumor ablation with enough safety. This work provides insights into the developments of MOF-based heterojunctions as powerful anticancer treatment nanoreactors. [Display omitted] [ABSTRACT FROM AUTHOR]

A patent has been issued for a smart well device, multimodal system, and method for multi-analyte monitoring and processing. The invention aims to provide real-time, single-cell, and simultaneous multiple analyte measurements in a highly integrated system. It includes a well plate with multiple electrodes that have different sensitivities to different analytes, such as glucose, lactate, and oxygen. The well plate assembly can be used to measure abnormal or normal cell metabolism and can be easily incorporated into existing medical and biological technology. The patent was filed by inventors from Colorado State University Research Foundation. [Extracted from the article]

Southwest University in Chongqing, China has developed a biosensor for detecting the I27L gene variant associated with maturity-onset diabetes of the young (MODY). The biosensor utilizes a silver-metal organic gels (Ag MOGs)/K2S2O8-O2 system-based electrochemiluminescence resonance energy transfer (ECLRET) ratio to achieve sensitive and precise detection of the I27L gene. The Ag MOGs generate anodic ECL signals and facilitate electrocatalytic reduction, resulting in enhanced cathodic ECL emission. The biosensor has a linear detection range of 100 amol/L to 100 pmol/L and a detection limit of 72 amol/L. The researchers also suggest that the biosensor could be used for detecting other diabetes subtypes. The study was funded by the National Natural Science Foundation of China and the Chongqing Talents Program for Outstanding Scientists. [Extracted from the article]

The article focuses on the development of pH/ROS dual-sensitive nanoparticles for targeted cancer therapy, utilizing glucose oxidase to enhance starvation and oxidative treatments. Topics include the design and synthesis of the nanoparticles using zeolitic imidazolate framework-8 (ZIF-8) and hyaluronic acid (HA), the mechanism of action involving glucose consumption and H₂O₂ production, and the superior cytotoxicity of these enzyme-based nanoparticles compared to traditional drug carriers.

A researcher at Kangwon National University in South Korea has published new data on the therapy of oral squamous cell carcinoma. The study focuses on the development of nanofiber membrane systems that can induce cascade catalytic reactions and ferroptosis for oral cancer treatment. Glucose oxidase and aminoferrocene were incorporated into the nanofiber membrane, resulting in a fast disintegration and immediate drug-release properties. The study found that the nanofiber system exhibited higher cytotoxicity, antiproliferation potential, and apoptosis induction compared to other nanofiber groups. The research offers potential for starvation/chemodynamic therapy and ferroptosis induction in oral cancer treatment. [Extracted from the article]

A patent application titled "Method For Outputting Message Suggesting Behavior To User On Basis Of Blood Glucose Values Of User, And Electronic Device Performing Same" has been made available online. The application describes technology for an electronic device that can suggest behavior to a user based on their blood glucose values. The device includes a blood glucose sensor and a processor that generates logs for the user's blood glucose values, determines target events based on these values, and outputs messages suggesting target behaviors. The invention aims to provide useful services related to blood glucose management for diabetic patients and other users. [Extracted from the article]

A recent study conducted by researchers at Zhejiang Normal University in Jinhua, China, has explored the use of nanozymes in cancer therapy. Nanozymes are nanomaterials that mimic the catalytic activity of enzymes. The researchers designed a nanozyme called FeCo/PCP-GOx-DOX, which converted glucose into toxic hydroxyl radicals, effectively targeting tumor cells. The nanozyme demonstrated enhanced cytotoxicity in vitro when exposed to high glucose levels, suggesting the accumulation of hydrogen peroxide (H2O2) and its transformation into hydroxyl radicals for chemodynamic therapy. Additionally, the nanozyme integrated starvation therapy, chemodynamic therapy, and chemotherapy, resulting in improved therapeutic efficacy. This research has been peer-reviewed and published in Biomaterials Advances. [Extracted from the article]

A patent has been issued to the University of California for a pH modulation device architecture that enables the detection of metabolites without the use of enzymes. Current continuous glucose sensors use enzymes with a limited lifespan, requiring periodic replacement. Metal oxide sensors are an alternative, but they only function at high pH levels, while bodily fluids like sweat and tears have a neutral pH. The newly patented device addresses this issue by using a pH modifying contact that can change the pH of the fluid, enhancing the detection of substances of interest without the need for enzymes. This technology has the potential to improve continuous glucose monitoring for diabetic patients and reduce the discomfort associated with traditional blood glucose testing methods. [Extracted from the article]

Researchers at the Federal University of Ceara in Brazil have developed an Explainable Artificial Intelligence (XAI) system for predicting diabetes. The system uses Bi-directional Long Short-Term Memory (Bi-LSTM) and Convolutional Neural Network (CNN) to analyze abnormal glucose levels. The glucose levels are acquired through glucose oxidase (GOD) strips placed on the body and converted to spectrogram images. The XAI model effectively identifies individuals with elevated glucose levels. This research provides a potential solution for diabetes surveillance and monitoring. [Extracted from the article]

Researchers from Nanjing University of Science and Technology in China have developed a novel enzyme cascade biosensor for the detection of esophageal cancer biomarker miRNA-144. The biosensor utilizes glucose oxidase (GOX) mediated and FADH2 production to facilitate polymerization without the need for deoxygenation. The sensor demonstrates high sensitivity and selectivity, making it a promising tool for early disease detection and diagnosis. The method is cost-effective, environmentally friendly, and shows great potential in the field of high sensitivity detection of biomarkers. [Extracted from the article]

A patent has been issued for a method of mitigating cryptosporidiosis, a diarrheal disease caused by a parasite called Cryptosporidium. The patent describes compositions and methods for reducing the number and infectivity of Cryptosporidium oocysts, which are shed in the feces of infected animals and can spread through contaminated water and food. The compositions include a hydrogen peroxide-generating source, such as sodium percarbonate or glucose oxidase with dextrose, which can be added to animal feed. The method aims to reduce transmission and severity of cryptosporidiosis in food animals, potentially improving weight gain in infected animals. The patent was filed by inventors from Colchester, VT, and Fort Collins, CO, and is assigned to Purina Animal Nutrition LLC. [Extracted from the article]

Profusa Inc. has been issued a patent for oxygen sensors. The patent describes a method for detecting oxygen levels in tissue using luminescent dyes and polymers. The sensors are placed under the skin and generate a detectable luminescent signal. The invention aims to provide a non-invasive and accurate method for monitoring tissue oxygenation. The patent also discusses the need for stable and long-lasting sensors that can be implanted deep into tissue. [Extracted from the article]

Roche Diabetes Care Inc. has been issued a patent for a sensor device that can detect analytes in a user's body fluid, such as blood glucose levels. The device is designed for continuous monitoring and can be used in both home care and professional care settings. The sensor is applied under the skin, while the control part of the system is located outside the body. The patent describes various features and methods to ensure accurate measurements and protect the sensor from humidity and other substances. It also includes an evaluation device that compares the analyte concentration with threshold values and prepares a warning signal if the concentration exceeds the first threshold value. The device can communicate with a medication device to determine the dosage of insulin delivered to the user. The evaluation device can adjust the tolerance time interval and offset time interval based on user preferences or events that affect the analyte concentration. The patent was filed by Christian Ringemann and published in 2024. [Extracted from the article]

A new report from the University of Medical Sciences discusses the potential use of Ficus exasperata Vahl leaf extract (MEFE) as a remedy for diabetes. The study investigated the impact of MEFE on the expression of TGR5, GLP-1, and GIP in diabetic Wistar rats. The results showed that MEFE reduced blood glucose levels, increased expression of insulin and other genes related to blood glucose control, and had antioxidative effects. These findings suggest that MEFE may be beneficial in managing diabetes. Further research is needed to fully understand the mechanisms of action of MEFE. [Extracted from the article]

Researchers from Southwest University in Chongqing, China have developed gold nanodots-anchored cobalt ferrite nanoflowers (CFAP) as versatile tumor microenvironment modulators for reinforced redox dyshomeostasis. CFAP responds to tumor microenvironment cues and exacerbates redox dyshomeostasis for effective antineoplastic therapy under ultrasound irradiation. CFAP displays glucose oxidase-like activity, Fenton-like activity, and catalase-mimic activity, leading to the production of reactive oxygen species and the exhaustion of glutathione. Animal studies have shown the potency of CFAP for high-efficient tumor eradication. This research provides new insights into nanodots and their potential applications in cancer therapy. [Extracted from the article]

Researchers from Chongqing Medical University in China have developed a new nanoplatform called CMGH for targeted cancer treatment. The nanoplatform combines starvation therapy, chemodynamic therapy, and photothermal therapy to inhibit tumor growth. CMGH works by depleting glucose at tumor sites, leading to tumor cell starvation and the production of hydroxyl radicals. The nanoplatform also accumulates at tumor sites through surface modification with hyaluronic acid. In vitro and in vivo studies have shown promising results in inhibiting tumor growth. This research highlights the potential of CMGH as a targeted cancer therapeutic platform. [Extracted from the article]

A study conducted by researchers at Zhejiang University in Hangzhou, China, has developed a multifunctional wound dressing that utilizes self-assembling nanozymes to enhance diabetic wound healing. The dressing, made of a dual-dynamic bond cross-linked hydrogel, incorporates glucose oxidase and a pH-responsive nanozyme to generate hydroxyl radicals that attack biofilms and improve wound healing. The dressing also promotes collagen production and enhances the migration and proliferation of endothelial cells. This innovative approach to infected diabetic wound management may inspire new ideas for smart wound dressings. [Extracted from the article]

A patent application has been filed for an analyte sensor that could potentially revolutionize diabetes management. The sensor is designed to measure glucose levels in a non-invasive way, eliminating the need for uncomfortable finger pricking methods. It utilizes an electrochemical cell and a membrane with a non-smooth outer surface to control the influx of glucose. The sensor also includes an enzyme domain and an interference domain to ensure accurate measurements. The patent application includes various embodiments and methods for manufacturing and limiting the use of the sensor. [Extracted from the article]

The Queen Elizabeth Hospital King's Lynn Nhs Foundation Trust in the United Kingdom has been issued a patent for a safety warning system. The system is designed to detect glucose in arterial or venous monitoring or flush systems used in critical care areas. It includes a receptacle with a color change indicator that provides a visual indication of whether the fluid in the system contains glucose, alerting the user to potential harm. The patent was filed in 2016 and published online in 2024. [Extracted from the article]

A study conducted at Xinjiang Medical University in China has developed a new method for targeting bacterial persisters, which are a key factor in chronic infections. The researchers created a platform called reactive oxygen species (ROS) bomb, which uses hydrogel microspheres to generate hydroxyl radicals that destroy bacterial cell membranes. The system was found to be effective in reducing bacterial loads and alleviating inflammation and bone resorption damage. This research provides a new strategy for clearing bacterial persisters and has potential applications in other chronic infection-related diseases. [Extracted from the article]

Researchers at Nankai University in Tianjin, China have developed a new method for treating sepsis, a potentially life-threatening condition caused by bacterial infections. The researchers used a technique called in situ metabolic incorporation to load glucose-oxidase and Fe3O4 nanoparticles into the cell walls of bacteria. This allowed for the generation of reactive oxygen species (ROS) that effectively killed the bacteria without the use of antibiotics. The method was successful in treating sepsis in mice and showed promise for controlling other types of bacterial infections. [Extracted from the article]

A recent study conducted by researchers at the University of Porto in Portugal explores the production and health effects of low-alcohol and nonalcoholic wines. The study provides information on the methods used in the production of these wines and their impact on cardiovascular health. It also discusses the potential market for low-alcohol and nonalcoholic wines, highlighting a growing interest in healthier alternatives. From an economic perspective, the study suggests that the market for these wines is expected to expand and diversify, with the development of high-quality products that can command premium prices. The changing regulatory landscape in Europe, which emphasizes transparency in alcohol labeling and nutritional information, aligns with consumer preferences and regulatory standards. [Extracted from the article]

Researchers at Duy Tan University in Da Nang, Vietnam have discovered that Cassia grandis fruit extract can be used to synthesize and stabilize biogenic gold nanoparticles (AuNPs). The researchers optimized the synthesis conditions and characterized the properties of the AuNPs. They found that the AuNPs synthesized with the fruit extract demonstrated a high zeta potential and showed sensitivity and selectivity for glucose and vitamin C detection. This research provides insights into the synthesis mechanism, characterization, and potential applications of biogenic gold nanoparticles derived from Cassia grandis fruit extract. [Extracted from the article]

A recent study conducted by researchers at the University of Belgrade in Serbia examined the stability of basic biochemical parameters in samples under different storage conditions and freeze-thaw cycles. The study also investigated the presence of bacterial contamination in routine laboratory work. The results showed that urea and glucose concentrations remained stable, while lipid concentrations exhibited complex patterns of change. Additionally, no bacterial growth was observed in samples stored with sodium-fluoride/potassium oxalate plasma. The findings suggest that sodium-fluoride/potassium oxalate plasma may be a suitable option for analytical procedures where bacterial contamination can affect the quality of analysis. [Extracted from the article]

Researchers at Shanghai Jiao Tong University in Shanghai, China have developed a new biological scaffold material for repairing diabetic bone defects. The material, called a foam-like scaffold, is injectable and can be shaped to fit the specific defect. It incorporates glucose oxidase-integrated metal-organic framework hybrids, which help regulate the diabetic microenvironment within the bone defect site. The scaffold has shown promising results in blood sugar regulation, reactive oxygen species elimination, inflammation modulation, and the facilitation of bone and blood vessel growth. This research represents a significant advancement in the field of diabetic bone regeneration. [Extracted from the article]

A study conducted by researchers at Gachon University in Gyeonggi-do, South Korea, has developed a new sensor platform for glucose analysis in immune cells. The sensor platform combines an amine nobbled Platinum-Silver vanadate sensor with a recognition element called 3-mercapto phenylboronic acid. The study found that M1-type macrophages, which are associated with insulin resistance, uptake significantly larger amounts of glucose compared to other macrophage types. This research provides insights into how glucose impairment affects macrophage phenotypes. [Extracted from the article]

A recent study conducted at the University of Louisville explored the role of NADPH oxidoreductases NADH in neutrophils, which are blood cells that produce reactive oxygen species (ROS) to fight pathogens and regulate signaling. The researchers investigated how different metabolic pathways and mitochondrial activity affect the oxidative burst in neutrophils. They found that glycogen breakdown initiates the oxidative burst, while mitochondrial activity and the serine biosynthesis pathway control the magnitude and duration of ROS production. Glucose and glutamine are also necessary for the entire oxidative burst. Further research will focus on understanding the mechanisms of neutrophil metabolic plasticity and their relevance to wound healing, exercise, and chronic inflammatory diseases. [Extracted from the article]

Researchers at the City University of Hong Kong have developed a biosensor called graphene oxide (GO)-threose nucleic acid (TNA) that can accurately and rapidly detect and image target nucleic acids in vitro and in vivo. The biosensor addresses limitations in nucleic acid detection by offering improved reliability and specificity, distinguishing single nucleobase mismatches and avoiding false signals. The simplified preparation process enhances practicality and accessibility, enabling real-time analysis. The biosensor has potential applications in disease diagnosis, biomedical research, environmental analysis, and food safety. [Extracted from the article]

Medtronic MiniMed Inc. has been issued a patent for a colorimetric sensor that can screen glucose levels in sweat for pre and type 2 diabetes. The sensor is designed to be simple, low-cost, and suitable for use by non-medical personnel. It uses a glucose sensing complex and a colorimetric indicator to detect glucose levels in sweat. The sensor is non-invasive and painless, making it more convenient for individuals and reducing the risk of disease transmission and infection. The patent describes the composition of the sensor, which includes a glucose sensing enzyme complex, a colorimetric indicator, and a predefined concentration of glucose. The sensor is placed on human skin and sweat flows into the porous substrate, allowing it to detect glucose levels. This sensor can be used for screening glucose levels in individuals with pre and type 2 diabetes. [Extracted from the article]

A report from Qingdao Agricultural University in China discusses the inhibitory effects of DNase I and glucose oxidase (GOX) loaded chitosan nanoparticles (CSNPs) on dual-species biofilms of Salmonella enterica and Listeria monocytogenes. The researchers found that CSNP-DNase-GOX was more effective in inhibiting the biofilms compared to CSNP-GOX alone. The study used transmission electron microscopy (TEM), scanning electron microscopy (SEM), and fluorescence microscopy to observe the structure of the biofilms and confirm the disruption caused by CSNP-DNase-GOX. This research has been peer-reviewed and published in the International Journal of Biological Macromolecules. [Extracted from the article]

A recent study conducted by researchers from Nanjing Tech University in China has explored the potential of cancer starvation therapy as an effective treatment approach. The researchers synthesized nanoparticles called Au@BSA-L-wzb117, which were designed to target the altered metabolic requirements of cancer cells. These nanoparticles were found to exhibit high specificity and reduced side effects in inhibiting tumor growth through a two-pronged strategy that involved glucose consumption and energy crisis induction in cancer cells. The study provides promising insights into the development of tumor-specific starvation therapy. [Extracted from the article]

A study conducted by researchers at the University of Jinan in Guangzhou, China, has developed a functional biosensing composite that shows promise for sensitive glucose monitoring and collaborative wound healing in diabetic patients. The composite, made from self-prepared PTIGA elastomers with in situ synthesized AgNPs, exhibits excellent antibacterial properties, mechanical strength, and self-healing capabilities. The biosensor assembled from the composite demonstrates high glucose response sensitivity and stability, making it a potential tool for blood glucose monitoring. Additionally, the composite promotes the regeneration of skin and granulation tissue, indicating its therapeutic potential in diabetic wound healing. [Extracted from the article]

A patent application titled "Analyte Sensor" has been published online by the US Patent and Trademark Office. The inventors have developed a sensor for transcutaneous measurement of an analyte in a host, such as glucose levels in individuals with diabetes. The sensor includes an electrode with a membrane that controls the influx of the analyte and has a non-smooth outer surface. The membrane can be formed through a vapor deposition coating process and may include an enzyme domain. The patent application also describes methods for manufacturing the sensor and limiting its use to a predetermined time period. [Extracted from the article]

Researchers at Cheng Shiu University in Kaohsiung City, Taiwan have developed a novel method for non-enzymatic glucose sensing using a modified glassy carbon electrode. The electrode was modified with annealed Nickel carbide (Ni3C), which demonstrated high charge transfer efficiency and exceptional stability. The modified electrode showed superior electrocatalytic properties and was able to detect glucose in human blood and urine samples with a linear detection range and low detection limit. This research highlights the potential of Ni3C-modified electrodes for the non-enzymatic electrochemical sensing of glucose, offering new possibilities for diabetes monitoring. [Extracted from the article]

Researchers from Tsinghua University in Shenzhen, China have developed nano-enzymatic structures called Te-Au nanowires (NWs) that exhibit multiple enzyme-like activities for diabetes management. These nanozymes have advantages over natural enzymes, including a wider range of reaction conditions, reliable application stability, and flexible application to various paths of glucose detection. The researchers constructed three different colorimetric detection methods using the nanozymes, with the most optimal method achieving a linear range of 0.05-4 mM and a low limit of detection (LOD) of 2.11 mu M. This research provides a promising approach to address the limitations of natural enzymes in diabetes management. [Extracted from the article]

A recent report discusses research conducted at Kafrelsheikh University in Egypt on the use of nanomolecules as a surface for biosensors and drug delivery systems. The researchers synthesized a nanocomposite surface using nanoparticles of sodium butyrate, cellulose, and pycnogenol. The surface showed high efficiency in loading drugs and demonstrated safe interactions with cells. The researchers concluded that this nanocomposite surface could be an excellent nanocarrier for drug delivery and glucose biosensors for diabetes. The research has been peer-reviewed and published in the International Journal of Biological Macromolecules. [Extracted from the article]

Researchers from Southwest Jiaotong University in Chengdu, China have developed a new treatment strategy for diabetic wounds using nanozymes. The researchers loaded glucose oxidase (GO(X)) and catalase (CAT) into zinc sulfide (ZnS) particle spheres to create a treatment that responds to the high glucose microenvironment of diabetic wounds. When activated by glucose, the GO(X) and CAT undergo a catalytic reaction that improves the wound microenvironment, reduces toxic side effects, and promotes wound healing. This research has been peer-reviewed and offers a potential solution for diabetic wound healing. [Extracted from the article]

A recent study conducted by investigators from Shanghai University in China explores the use of 2D Ca2Mn8O16 nanosheets as a high-performance nanozyme for tumor therapy. These nanosheets mimic the activities of various enzymes and exhibit glucose oxidase-mimicking activities, which disrupt glucose supply and promote the generation of reactive oxygen species (ROS). The nanosheets also induce Ca2+ overload and trigger apoptosis, while simultaneously initiating the process of ferroptosis through ROS output and glutathione consumption. The researchers found that the application of ultrasound stimulation further enhances the effectiveness of this synergistic tumor treatment. This study highlights the importance of enzydynamic performance in ferroptosis-apoptosis therapy against tumors. [Extracted from the article]

A study conducted by investigators from Shandong University in Qingdao, China, focused on engineering the substrate preference of glucose oxidase (GOx) for the enzymatic oxidation of xylose. GOx is an enzyme that catalyzes the oxidation of glucose and has various applications in different industries. However, its strict substrate specificity limits its use in converting other sugars like xylose. The researchers engineered a mutant form of GOx that exhibited increased xylose oxidation activity, allowing for the co-oxidation of glucose and xylose. This study provides new insights into substrate recognition by GOx and offers a method for utilizing xylose from lignocellulosic feedstocks. [Extracted from the article]

A study conducted by researchers at Sichuan University in Chengdu, China, explores the use of a triple-combination therapy for the treatment of breast cancer. The therapy combines the effects of metformin, glucose oxidase (GOx), and a pH-responsive epigallocatechin gallate (EGCG)-conjugated low-molecular-weight chitosan (LC-EGCG) nanoparticle. The researchers found that this triple-combination therapy led to increased apoptosis and reduced proliferation of tumor cells in vivo. The study suggests that this approach shows promise for efficient and targeted cancer treatment. [Extracted from the article]

A study conducted in Nanning, People's Republic of China, has developed a novel electrochemical biosensor for detecting low-density lipoprotein (LDL) levels in biological samples. The biosensor utilizes a modified glassy carbon electrode coated with gold nanoparticles and poly-o-aminobenzenethiol films. The researchers employed antibody apolipoprotein B as a biorecognition element to capture LDL, and cholesterol esterase and cholesterol oxidase bi-enzymes to catalyze the oxidation of LDL. The biosensor demonstrated high specificity, reproducibility, and stability, making it a promising method for detecting LDL levels in human serum samples. [Extracted from the article]

A recent study conducted by researchers at Shandong University focused on Aspergillus niger, an industrially important fructooligosaccharides (FOS) producer. The researchers aimed to enhance the content of FOS by expressing glucose oxidase and peroxidase in engineered A. niger. The study successfully expressed glucose oxidase and peroxidase in A. niger, resulting in an increased purity of FOS. The researchers concluded that this strategy allows for obtaining high-content FOS without the need for additional purification processes, and it also demonstrates the potential of A. niger as an enzyme-producing cell factory. [Extracted from the article]

A study conducted by researchers at the Government College University of Lahore in Pakistan explores methods for extending the shelf life of mango fruit. The researchers developed a technique using silver nanoparticles and glucose oxidase to create a fine coating of hydrogen peroxide on the fruit's surface, acting as a barrier against the growth of microorganisms. The spray solution of silver nanoparticles significantly improved the quality parameters of the mango fruit, such as pH, DPPH activity, TSS, and weight loss. This innovative method has the potential to enhance food safety and sustainability. [Extracted from the article]

A study conducted by researchers at Zhejiang University in Hangzhou, China, explores the glucose oxidase-like activity of gold nanoparticles (Au NPs) and their potential applications in the biomedical field. The researchers analyzed 158 relevant publications from 2007 to 2023 and found that Au NPs have been used in glucose biosensors, glucose detection in human serum, and the detection of other carbohydrates and proteins. Recent research has focused on their application in oncotherapy and diabetic wound treatment, and there is potential for Au NPs to be used in the treatment of autoimmune illnesses, inflammation, and other diseases, possibly replacing insulin and antibiotics. The study concludes that the use of Au NPs is expected to increase in the future and hopes to guide future researchers in their application. [Extracted from the article]

A report from the University of Belgrade discusses the findings of research on gene therapy. The research focuses on the production of oxidoreductase (OXR) enzymes, which are in high demand for various applications in industries such as food, cosmetics, bioremediation, and medicine. The researchers explore different methods to increase the yield of these enzymes, including protein engineering, directed evolution, and strain engineering. They also discuss cutting-edge technologies like high-throughput screening methods and microfluidics. The report provides valuable insights into the current state-of-the-art technologies for the production of OXR enzymes in yeast. [Extracted from the article]

A patent application has been submitted for an analyte sensor that could potentially improve glucose monitoring for individuals with diabetes. The sensor aims to provide a more comfortable and convenient alternative to traditional self-monitoring blood glucose (SMBG) monitors, which require finger pricking. The sensor utilizes an electrochemical cell and a membrane with a non-smooth outer surface to control the influx of the analyte. The patent application also includes methods for manufacturing and limiting the use of the sensor. [Extracted from the article]

DexCom Inc. has been issued a patent for an analyte sensor. The patent describes a method for processing sensor data from a dual-electrode continuous analyte sensor that can detect glucose levels in a host's circulatory system. The sensor uses a first working electrode with an enzyme for detecting glucose and a second working electrode without an enzyme. The data from both electrodes is processed to obtain a signal without interference from non-analyte related compounds. This technology could improve glucose monitoring for individuals with diabetes. [Extracted from the article]

MicroTech Medical (Hangzhou) Co. Ltd. has filed a patent application for a glucose electrochemical sensor. The sensor is made of a hydrogel containing a cationic redox polymer and a transition metal complex medium. It accurately measures glucose levels and has a stable current signal that correlates well with glucose concentration. This sensor addresses the limitations of existing glucose sensors and has potential applications in continuous glucose measurement. The patent application provides detailed information on the sensor's preparation method. [Extracted from the article]

Researchers at Hebei University in China have developed a biodegradable bimetallic nanoreactor to enhance chemodynamic therapy (CDT). The nanoreactor, made of Fe-doped hollow mesoporous manganese dioxide (HMnO2), was loaded with doxorubicin (DOX) and modified with glucose oxidase (GOD) and hyaluronic acid (HA). The nanoreactor demonstrated improved catalytic efficiency and tumor accumulation, leading to enhanced antitumor efficacy. This research provides a new approach to enhancing CDT and has been peer-reviewed. [Extracted from the article]