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• Ti 3 C 2 MXene/semiconductor interface for room temperature NO 2 gas sensing. • Abundant 2D Ti 3 C 2 MXene surface area for NO 2 adsorption. • Widened electron depletion layer and Schottky barrier formation. • Highly stable NO 2 gas sensing and immune to humidity. • Limit of detection at ppt and ppb levels. Nowadays, there is a growing global demand for high-performance room temperature gas sensing devices. In this context, we aim to explore the advancements in two-dimensional (2D) Ti 3 C 2 MXene role for toxic NO 2 gas sensing at room temperature. The distinctive advantages of 2D Ti 3 C 2 MXene, including high electrical conductivity, ample surface area, surface termination groups, and layer structure have garnered significant attention towards NO 2 gas adsorption. Further, the compatible regularity of Ti 3 C 2 MXene at the interface of various semiconductors directed the development of potential room-temperature NO 2 gas sensing devices. Further, the leveraging gas sensing (selectivity, response, and recovery) characteristics become increasing attention on Ti 3 C 2 MXene/semiconductor interfaces than pure Ti 3 C 2 MXene. Elaborative control on the depletion layer through the Schottky barrier formation distinguished the room temperature NO 2 gas sensing and led to the evolution of electrophilic NO 2 gas molecule interaction. Remarkably, the great processability of Ti 3 C 2 MXene/semiconductor interface is sensitive to the low detection limit (LOD) of NO 2 gas at parts per billion (ppb) conditions. On the other hand, this review demonstrates the room temperature optoelectronic NO 2 gas sensing capabilities of Ti 3 C 2 -based composites for emphasizing selectivity and recovery. Interestingly, the Ti 3 C 2 MXene/semiconductor composite builds immunity against the atmosphere humidity and achieves stable NO 2 gas sensing. Finally, we have provided conclusions and key points to advance the research on room temperature NO 2 gas sensing of Ti 3 C 2 integrated semiconductors. [Display omitted] [ABSTRACT FROM AUTHOR]

• The C-BiOCl/Bi 2 S 3 (C-BOC/BS) composites are successfully prepared. • C-BOC/BS show good photoelectrochemical (PEC) and photocatalytic (PC) properties. • The optimized 5C-BOC/5BS composite is used as a PEC sensor for Cr(VI) detection. • Efficient Cr(VI) removal is achieved via adsorption and PC reduction by 5C-BOC/5BS. Novel C-BiOCl/Bi 2 S 3 composites are prepared by hydrothermal C doping in BiOCl and in-situ growth of Bi 2 S 3 on C-BiOCl. Compared with BiOCl, C-BiOCl has a larger exposed surface area and can effectively absorb visible light. The construction of a heterojunction in C-BiOCl/Bi 2 S 3 further promotes the separation and transfer of photogenerated carriers. With improved photoelectric properties, the optimized 5C-BiOCl/5Bi 2 S 3 is applied as a dual-functional composite for photoelectrochemical (PEC) detection and photocatalytic (PC) reduction of Cr(VI). The 5C-BiOCl/5Bi 2 S 3 shows a linear range of 0.02–80 μM for PEC cathodic detection of Cr(VI) with a detection limit of 0.01628 μM. Additionally, 99.5% of Cr(VI) can be removed via absorption and PC reduction by 5C-BiOCl/5Bi 2 S 3 , with the reduction rate constant (k) 336 times higher than that of BiOCl. [ABSTRACT FROM AUTHOR]

Copyright of China Pulp & Paper Industry is the property of China Pulp & Paper Industry Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article discusses the latest update to iZotope's RX software, which is a spectral editing and repair toolbox used in film and TV post-production, as well as by music producers, mastering engineers, and sound designers. The software allows users to select and edit specific time and frequency ranges in audio using various cursor tools. It also offers modules for analysis and processing, with the ability to transfer audio between a DAW and RX. The update includes new features such as an integrated processor called Repair Assistant, improved modules for dialogue isolation and music rebalancing, and tools for working with mid-side stereo. The article also mentions the pricing criticism of the software but concludes that RX 11 remains a powerful and intelligent tool. Additionally, the article discusses the new Loudness Optimize module, which addresses the issue of tracks sounding quieter on streaming platforms due to the measurement of integrated loudness. The module analyzes the audio's loudness and provides an upward compressor to lift the loudness of quieter passages. It also introduces a Streaming Preview module for comparing the audio with the transcoding and normalizing applied by streaming services. Overall, the article highlights the powerful features and improvements of RX 11 while acknowledging the pricing concerns and the usefulness of alternative software options. [Extracted from the article]

Concept evolution detection is an important but difficult task in streaming data analysis, and further the noise may seriously limit the detection performance gains. This paper proposed a concept evolution detection method based on noise reduction soft boundary (NRSB). To reduce the negative effect of noise samples near category boundary, the noise reduction soft boundaries are defined based on the introducing of extension distance, intension distance and corresponding noise reduction process. Then the sample space is divided into in-class, mixed-class and out-of-class areas corresponding to each category. For online new coming samples, three strategies of automatic labeling by model, active labeling by expert and multi-class collaborative labeling will be adopted respectively according to different areas they located in. Automatic model labeling does not need to update the model, which may improve the learning efficiency. Expert active labeling will help with difficult samples in mixed-class area. Multi-class collaborative labeling can change the sample label dynamically during online learning. The experimental results show that the proposed method can reflect the character of dynamic evolution of streaming data well and detect the concept evolution effectively. • Noise reduction soft boundary is proposed and then the category distribution can be described reasonably. • The negative effect of noise sample located near category boundary will be reduced effectively. • The proposed can effectively reflect the evolution character well and detect the concept evolution effectively. [ABSTRACT FROM AUTHOR]

A robust event-triggered distributed fusion algorithm is investigated in this paper for multi-sensor systems with unknown failure rates. A detection technique based on standard Gaussian distributed filtering innovation is designed and applied to judge whether the measurement is failed. This filtering innovation can also be used to construct the event-triggered condition. Specifically, the event condition is not triggered if the innovation is below the lower event-triggered threshold and the measurement is regarded as the failure measurement if the innovation exceeds the higher threshold. In the above two cases, the sensor measurement data is not transferred to the local estimator; otherwise, it will be transferred. Then, the sequential fast covariance intersection (SFCI) fusion algorithm is used for local estimation fusion. Besides, to analyze the estimation performance, sufficient conditions are given to demonstrate the boundness of the local estimation and fusion estimation covariance. Finally, a simulation example is given to show the usefulness of the presented algorithm. [ABSTRACT FROM AUTHOR]

A recent study conducted at Southwest University in Chongqing, People's Republic of China, has developed a novel chromophotometric biosensor for detecting pesticide residues, specifically diquat (DQ), in food products. This biosensor offers advantages such as high sensitivity, low detection limits, and minimal background interference, making it suitable for rapid clinical diagnostics. The research highlights the importance of innovative technologies in enhancing food safety by efficiently analyzing small molecule targets like pesticides. The study has been peer-reviewed and provides a new approach to in vitro detection of biological small molecules, showing potential applications in agricultural residue-related food safety. [Extracted from the article]

A recent study conducted by researchers at the Instituto de Agroquimica y Tecnologia de Alimentos in Valencia, Spain, focused on combating Listeria monocytogenes, a significant food safety risk globally. The researchers combined two enzyme-based antimicrobials, an endolysin from Listeria phage vB_LmoS_188 and an engineered glucose oxidase from Aspergillus niger, to create a potent treatment against the pathogenic bacterium. The synergistic effect of these enzymes resulted in a significant reduction in viable cells of Listeria monocytogenes, making it a promising eco-friendly antimicrobial treatment for this deadly food-borne pathogen. [Extracted from the article]

A patent application by Eximo Medical Ltd. for a "Smart Aspiration System And Laser Activation System" aims to improve the treatment of deadly diseases caused by blood clots in the circulatory system, such as myocardial infarction, stroke, pulmonary embolism, and deep venous thrombosis. The system involves a catheter, canister, pressure source, sensor, and computer system to control aspiration flow rate efficiently during the removal of undesirable intravascular material. This innovative system addresses the limitations of existing vascular treatment systems and offers a promising solution for saving lives of patients suffering from vascular conditions. [Extracted from the article]

Researchers have submitted a patent application for a waste water analysis system aimed at increasing sensitivity in detecting analytes, such as viruses and bacteria, in wastewater samples. The method involves collecting subsamples over a period of time, evaluating secondary analyte concentrations, and selecting samples with concentrations within a predetermined range for analysis. This innovative approach aims to improve detection efficiency, reduce costs, and enhance the overall workflow of wastewater analysis systems. [Extracted from the article]

A patent was issued for powered surgical instruments with smart reload capabilities, allowing for separately attachable exteriorly mounted wiring connections. The patent, filed by inventors from various locations in the US, was assigned to Cilag GmbH International in Switzerland. The modular surgical instrument system described in the patent includes unique identifier resistances and a control circuit to assess authenticity and functionality based on these identifiers. The system aims to improve surgical instrument safety and efficiency by ensuring proper configuration and authentication. [Extracted from the article]

A patent has been issued for the assessment of the performance of an implanted sensor by Senseonics Incorporated. The invention aims to monitor analytes in real-time and determine if the sensor's performance is suitable for monitoring. This technology could benefit patients with diabetes by providing more accurate and frequent glucose measurements, potentially improving their overall health outcomes. The patent details the system's ability to assess sensor performance, calculate analyte levels, and provide retirement indications if necessary. [Extracted from the article]

The article discusses a research paper from Universidad de Ciencias Aplicadas y Ambientales in Bogota, Colombia, outlining a method for validating quantitative-qualitative techniques used in detecting genetic material through qRT-PCR, with a focus on SARS-CoV-2 testing. The research emphasizes the need for comprehensive validation guidelines in genetic testing and describes statistical approaches and technical characterization profiles for the validation process. The study modified the gold standard method to establish a technical limit of detection of 5.09 copies/reaction at a 95% confidence interval. The research was supported by financial backers including Universidad De Ciencias Aplicadas Y Ambientales and Sistema General De Regalias De Colombia. [Extracted from the article]

Researchers at Sichuan University in Chengdu, People's Republic of China, have developed a new method for detecting multiple respiratory pathogens, including Influenza A Virus, using a CRISPR/Cas12a-enhanced DNA nanomachine. This innovative approach combines high sensitivity with elemental mass spectrometry analysis, allowing for accurate detection of pathogens in clinical samples with low concentrations. The study was supported by the National Natural Science Foundation of China and the Fundamental Research Funds for the Central Universities, and has been peer-reviewed for publication in Chemical Communications. [Extracted from the article]

Researchers have submitted a patent application titled "Methods For Pet Detector Afterglow Management" to address issues with scattered radiation interfering with PET detectors in radiation therapy systems. The application outlines methods for adjusting coincidence trigger thresholds of PET detectors, suspending communication between detectors and signal processors, and utilizing radiation-blocking shields to manage afterglow. The patent aims to enhance the acquisition of positron emission data during therapy sessions and improve the accuracy of radiation therapy systems. [Extracted from the article]

A patent application by inventor Peter Vincent Boesen from BRAGI GmbH in Germany proposes a system and method for utilizing wireless earpieces to populate electronic medical records. The invention aims to improve the collection and storage of biometric data from wearable devices for healthcare providers. The wireless earpieces include sensors for monitoring biometric levels, analyzing sensor measurements, associating them with the user's electronic medical record, and communicating them directly to medical professionals for validation. This innovation seeks to enhance the efficiency and accuracy of monitoring and recording patient health data. [Extracted from the article]

The University of Texas Southwestern researchers have developed a method to predict post-transplant relapse of myelodysplastic syndromes by evaluating stem cells. They created a high-throughput DNA sequencing assay capable of identifying mutated stem cells and found that detecting persistent disease-associated mutations in stem cells was highly specific for relapse after transplantation. This research provides a potential biomarker to improve the design of curative therapeutic strategies for myelodysplastic syndromes. [Extracted from the article]

A study conducted at Zhengzhou University in China focused on developing a new method for early diagnosis of tumorigenesis using ratiometric carbon dots with deep-red emissive fluorescence based on NAD+ dependence. The research aimed to improve the resolution and sensitivity of biomarkers for tumor diagnosis in living tissue. The study found that the proposed method showed high sensitivity to NAD+ and holds potential for NAD+-dependent tumor diagnosis in complex living systems. For more information, readers can refer to the article "Early Diagnosis of Tumorigenesis via Ratiometric Carbon Dots with Deep-Red Emissive Fluorescence Based on NAD+ Dependence" published in Molecules. [Extracted from the article]

A study conducted by the Minneapolis Heart Institute Foundation compared the incidences of procedure-related adverse events between two right ventricular leadless pacemakers, the Medtronic Micra VR and Abbott AVEIR VR, in the United States from 2022 to 2024. The research found that while both pacemakers had similar procedural safety profiles in terms of death and perforation, they differed significantly in device problems, possibly due to their design variances. AVEIR VR showed advantageous threshold measurement capability but was more prone to device dislodgement compared to Micra VR. The study has been peer-reviewed and provides valuable insights into the safety and efficacy of these leadless pacemakers. [Extracted from the article]

The article discusses the development of the EFP Analyzer, a software tool designed to analyze Extracellular Field Potentials from iPSC-derived cardiomyocytes. The tool can accurately measure intervals and detect changes in Field Potential Duration, making it useful for studying drug effects and disease models. The EFP Analyzer is available for download on Github and is intended to facilitate research using iPSC-CMs as a model. [Extracted from the article]

A recent study conducted at Changzhi Medical College in the People's Republic of China has developed an ultrasensitive electrochemical biosensor for detecting miRNA-21, a crucial biomarker for cancer diagnosis. The biosensor utilizes a hybrid polypyrrole/gold nanoelectrocatalyst for signal amplification, demonstrating a wide linear range and low detection limit. The research highlights the potential of this biosensor for accurate and selective detection of miRNA-21, showcasing promising applications in biotechnology and nanotechnology. For more information, readers can refer to the published article in Analytical Methods. [Extracted from the article]

A patent has been issued to Becton Dickinson and Company for a catheter dressing and securement device that includes temperature sensors for intravenous site condition detection. The device aims to detect temperature variations at catheter insertion sites, which can indicate infections or other issues. The patent outlines methods and systems for monitoring temperature changes and generating alerts for users based on the data collected. [Extracted from the article]

Sanofi has been issued a patent for systems and methods to control oxygen levels in bioreactors. The patent, filed in 2023 and published in 2024, outlines the importance of dissolved oxygen levels in bioreactors for cell growth and research. The system described in the patent includes sensors, a prediction model, and a control valve to regulate oxygen input based on measurements of dissolved oxygen and biomass levels. This technology aims to improve precision in regulating dissolved oxygen levels, enhance cell culture processes, and reduce sensor output noise. [Extracted from the article]

A recent study conducted by researchers at China Pharmaceutical University has developed a new method for the fast screening of retinoic acid in cosmetics. Retinoic acid is a banned cosmetic additive in the EU and China. The researchers used chemical derivatization combined with paper spray ionization mass spectrometry to detect retinoic acid in cosmetics. This method was found to be quick, sensitive, and accurate, with a detection limit of 0.0013 mg/mL and a limit of quantification of 0.0043 mg/mL. The study provides valuable insights for the detection of retinoic acid in complex matrices. [Extracted from the article]

A recent preprint abstract discusses the development of a genetically encoded fluorescent sensor called D2HGlo, which can detect the oncometabolite D-2-hydroxyglutarate (D-2-HG). D-2-HG is associated with mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) and can be used as a marker for IDH1/2 mutant cancers. D2HGlo has shown exceptional selectivity and can accurately quantify D-2-HG in various body fluids and glioma tumor supernatants. The sensor has the potential to be used as an in vitro diagnostic device for the detection and monitoring of IDH mutant cancers through liquid biopsies. The study also presents preliminary findings on the adaptation of D2HGlo to the cellular environment, specifically in immortalized glioma cells. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Sony Group Corporation has submitted a patent application for a sound processing device, sound processing method, and hearing aid device. The invention aims to address the problem of hearing loss by reducing noise and amplifying desired sounds. The device includes an information estimation unit that estimates control information based on hearing threshold information and input sound information, and a signal processing unit that processes the input sound signal based on the estimated control information. The patent application provides detailed information on the technical aspects and potential benefits of the invention. [Extracted from the article]

A patent has been issued for a system and method for managing crisis situations. The patent describes a user device, such as a wearable device, that can determine the probability and type of a crisis situation based on various measurements, including biometric signals and environmental characteristics. The device can then actuate mitigation steps, such as triggering an alarm, calling emergency numbers, or transmitting the user's location to emergency contacts. The system aims to address limitations of existing approaches, particularly in outdoor and incapacitated situations. The patent was filed by inventors from Georgia and assigned to Guardian-I LLC. [Extracted from the article]

Researchers at Maria Curie Sklodowska University in Lublin, Poland have developed a new method for determining trace levels of the antiviral drug acyclovir (ACV) using a boron-doped diamond electrode (BDDE) coupled with differential-pulse voltammetry (DPV). This method achieved the lowest detection limit reported in the literature for voltammetric procedures. The BDDE was found to be highly resistant to interfering agents and was successfully used to analyze pharmaceutical and municipal wastewater samples. The results obtained using this method were consistent with measurements made using chromatographic reference methods. [Extracted from the article]

A patent has been issued for a system and method that uses wireless earpieces to populate electronic medical records (EMRs). The inventor, Peter Vincent Boesen, recognized that wearable devices like wireless earpieces can provide biometric monitoring but often have limited utility. The system described in the patent aims to improve the use of biometric data from wireless earpieces in a medical context by linking the earpieces to a wireless device associated with a healthcare provider. The earpieces perform sensor measurements, including position, orientation, and biometric data, and populate the user's EMR with this information. The populated EMR can then be sent to the healthcare provider for validation and storage. [Extracted from the article]

A recent study conducted by researchers at Hacettepe University in Ankara, Turkey, aimed to investigate the effects of continuous theta burst stimulation (cTBS) on the occipital cortex in healthy individuals. The researchers found that cTBS led to an increase in phosphene threshold values, indicating a modulation of occipital cortex excitability. However, there were no significant differences observed in visual evoked potential habituation or P100 latency and N75-P100 amplitude values between sham and real cTBS sessions. This research provides insights into the neurophysiological alterations induced by cTBS in the occipital cortex. [Extracted from the article]

A patent application by inventor Felix Clarence Quintanar describes a negative pressure wound therapy apparatus that can detect blockages and leaks in multiple wound dressings. The apparatus includes a negative pressure source, fluid flow paths, a pressure sensor, and a controller. The controller measures pressure, determines fluid retention capacities, detects blockages and leaks, and provides indications of these issues. The invention aims to improve the healing rate of wounds and can be used for various types of wounds. The patent application was filed on May 2, 2024, and made available online on August 29, 2024. [Extracted from the article]

Researchers from Dalian University of Technology in China have developed a new host-guest platform for the detection of nitroreductase (NTR), an enzyme associated with hypoxia in tumors. The platform utilizes a fluorescent substrate encapsulated within a metal-organic capsule, allowing for rapid and quantitative detection of NTR activity. The platform also shows promise as an imaging tool for the early diagnosis of hypoxia-related tumors. This research provides a new avenue for the design and optimization of fluorescence detection platforms and offers potential applications in cancer diagnosis. [Extracted from the article]

Researchers from the University of Bristol have conducted a study on the detection of alpha emitters, such as plutonium, which can pose health risks when ingested. Traditional detection methods require close proximity to the contamination source, which can be unsafe and inefficient. The study demonstrates the successful detection of alpha emitters in open environments using a compact alpha camera. The camera incorporates a deep-cooled CCD and a low f-number lens system to minimize the effects of ambient light. The research highlights the potential for long-range optical detection of alpha emitters for environmental monitoring in real-world settings. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the development of a compact prism-based microscope for high sensitive measurements in fluid biopsy. The researchers aimed to address the need for sensitive, portable, and cost-effective disease detection methods. They presented a prism-based Total Internal Reflection system combined with surface functionalization techniques on gold nanoparticles, which achieved a remarkable limit of detection for specific analytes in synthetic liquids and real human samples. The researchers conducted scattering experiments in synthetic and human serum samples to validate the efficacy of their design. This preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted by the University of Murcia in Spain has developed and validated an assay for measuring cortisone levels in pig saliva. Cortisone is a biomarker of stress and the study aimed to determine if its concentration varies in stressful situations. The assay was found to be accurate and reliable, with a limit of detection of 0.006 ng/ml. The study also found that cortisone levels in pigs subjected to prolonged heat stress decreased significantly after treatment. This research suggests that measuring cortisone in pig saliva could be a non-invasive way to evaluate thermal stress in pigs. [Extracted from the article]

Researchers from the Gwangju Institute of Science and Technology (GIST) in South Korea have developed a new single-step, digital immunoassay that offers high sensitivity and accuracy. This immunoassay utilizes an imaging technique to differentiate between bound and unbound conjugates without the need for washing. The platform was able to detect the SARS-CoV-2 nucleocapsid protein with a sensitivity 103 times higher than that of a conventional lateral flow immunoassay. The researchers believe that this method has potential for highly sensitive and accurate point-of-care biosensors. [Extracted from the article]

Copyright of China Pulp & Paper Industry is the property of China Pulp & Paper Industry Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

• We synthesize a novel chitosan-PB nanocomposite for immunosensor preparation. • A urease-silica nanoprobe is prepared for the electrochemical signal transduction. • The urease-induced PDA deposition realizes the amplified signal inhibition to PB. • The multi-signal amplified mechanism leads to ultrahigh sensitivity of the method. The uncontrollable synthesis of Prussian blue (PB) and its weak stability toward OH– are great challenges affecting its electrochemical biosensing application. Herein we utilize the unique properties of chitosan (CS) to realize the facile and controllable synthesis of a CS-PB nanocomposite and combine it with the urease-catalyzed deposition of polydopamine (PDA) for amplifying the electrochemical signal inhibition of PB to develop a novel immunosensing method for protein detection. The immunosensor was constructed on a CS-PB modified electrode, and a urease-functionalized silica nanoprobe was prepared for tracing its sandwich immunoassay toward the model analyte of carcinoembryonic antigen. Besides the electrochemical impedance effect of the quantitatively captured nanoprobes, their enzymatic reaction can release numerous OH– to destroy the PB crystals and also induce the PDA deposition onto the immunosensor. These caused drastic electrochemical signal inhibition to PB. Based on the above multi-signal amplification mechanism, the method exhibits a very low detection limit of 0.042 pg mL–1 along with a very wide linear range of six-order of magnitude. In addition, the CS-PB based immunosensor has excellent specificity, repeatability, stability and reliability. Thus this PB nanocomposite and the proposed electrochemical immunosensing method reveal a promising potential for future applications. [Display omitted] [ABSTRACT FROM AUTHOR]

Researchers at the Indian Institute of Technology Guwahati have developed a portable smartphone platform for the sensitive and point-of-care detection of monoamine neurotransmitters. The platform uses a specially designed conjugated polymer to detect serotonin, a diagnostic biomarker for carcinoid tumors, in human blood plasma. The polymer displayed a high fluorescence quenching constant and an ultralow detection limit. A smartphone application was used to quantify the fluorescence response and provide real-time onsite detection. This technology has the potential to revolutionize clinical diagnosis and personalized healthcare devices. [Extracted from the article]

A patent has been issued for a method and system for automatically analyzing placenta insufficiency in a curved topographical ultrasound image slice. The patent describes a system that uses ultrasound imaging to analyze the placenta and detect conditions such as intrauterine growth restriction and placental infarct. The system extracts a curved ultrasound image slice and analyzes the color Doppler information to generate perfusion data. This technology aims to provide a more efficient and accurate method for diagnosing placenta insufficiency. The patent was filed by Ge Precision Healthcare LLC and published in August 2024. [Extracted from the article]

A preprint abstract from medrxiv.org discusses the validation of MyProstateScore 2.0 (MPS2), a urinary biomarker test aimed at improving the detection of clinically significant prostate cancer (csPCa) while minimizing unnecessary procedures. The study validates the analytical performance of MPS2, including detection limits, reproducibility, and robustness across potential interfering substances. The biomarker amplification of MPS2 was confirmed within defined limits, and most potential interfering substances had minimal impact on the assay. The study concludes that MPS2 exhibits reliable detection and quantitation limits, supporting its clinical use in accurately predicting csPCa and potentially reducing unnecessary biopsies and complications. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A new report published by researchers at the Hospital for Special Surgery in New York City discusses the use of a deep learning algorithm to measure angles associated with hip dysplasia. The algorithm was validated against manual measurements and applied to a large population to determine the prevalence of dysplasia. The study found that the reported prevalence of dysplasia varied depending on the measurement and threshold used, with 12.4% of patients having radiographic indices indicative of higher risk for total hip arthroplasty. This research provides valuable insights into the diagnosis and classification of mild hip dysplasia. [Extracted from the article]

This document provides information about a clinical trial for a drug called KD-025. The trial is currently recruiting participants and aims to study the effectiveness of KD-025 cell injections in patients with advanced solid tumors, such as ovarian, cholangiocarcinoma, and colorectal cancer. The trial has specific eligibility criteria, including age, expected survival, and certain organ and bone marrow functions. The study is being conducted in China, and the primary investigator is Dr. Ning Li. The document also includes administrative information about the trial, such as the NCT number and contact information for the primary investigator. [Extracted from the article]

A patent has been issued for a fog sensor for tailpipes, developed by Thermaco Incorporated. The invention aims to address the issue of fats, oils, and grease (FOG) waste materials clogging sewer systems, particularly from food handling facilities and apartment complexes. The sensor detects changes in capacitance caused by variations in the proportion of FOG in effluent flowing from a sink to a p-trap, allowing for the monitoring and control of FOG disposal. The patent includes details of the apparatus, monitoring system, and reporting system. [Extracted from the article]

A report from the National Institute of Environmental Health Sciences discusses the challenges of studying the impact of environmental mixtures on human health when exposure measurements are below the limit of detection (LOD). The researchers conducted extensive simulation studies and analyzed data from the National Health and Nutrition Examination Survey (NHANES) to understand the impact of different LOD accommodation approaches on mixture analysis results. They found that imputation by LOD/√2, truncated multiple imputation (MI), and censored accelerated failure time (AFT) models were the most effective methods for accommodating values below LOD. The study recommends using truncated MI and censored AFT models for the stability of downstream mixture analysis. [Extracted from the article]

A patent has been issued for a system and method to measure and calculate high-velocity blood flow in the microcirculation. The patent addresses the lack of understanding and recognition of high-velocity blood flow in critical care medicine. The system uses a data acquisition module to acquire microcirculatory blood vessel image data and a storage module to store the data. The method involves defining the high-velocity blood flow threshold, selecting observation regions, tracking the trajectory of blood particles, and calculating the average blood flow velocity. The invention aims to accurately measure high-velocity blood flow and provide indexes for its evaluation. The patent was filed by Xuzhou Lihua Electronic Technology Development Co. Limited. [Extracted from the article]

Since the detection of N-nitrosodimethylamine (NDMA) in a batch of valsartan in 2018, at levels exceeding ICH acceptable intake limits for mutagenic impurities, the analysis of nitrosamines has become an intense focus point for the pharmaceutical industry. The identification and low-level determination of nitrosamines in potentially affected materials is challenging and requires the application of highly sensitive analytical techniques. This article reviews the chronological development of the story and the regulatory landscape that has evolved. It will then discuss the development of analytical methods for the determination of a series of nitrosamines referenced by regulatory authorities, demonstrating separation of these compounds from the active pharmaceutical ingredient (API) and looking at how mass spectrometry (MS) can be applied to ensure that the required detection limits can be reached. [ABSTRACT FROM AUTHOR]

Mass spectrometry (MS), often termed mass selective detection, is the most powerful detector available for gas chromatography (GC). Multidimensional mass spectrometry (MS/MS) takes mass selective detection to another level on benchtop systems, offering both universal and selective detection along with low detection limits. In this instalment of "GC Connections", we review the fundamentals of MS/MS and how they relate to MS as a detector for GC. We see how using full-scan analyses can make the detector universal and how by using selected ion monitoring and multiple reaction monitoring the detector can be so selective and noise-free that femtogram quantitative analysis is commonplace. We then examine some scenarios that should lead analysts to consider using GC-MS/MS to solve complex problems. [ABSTRACT FROM AUTHOR]

Nanoporous metals prepared by dealloying have attracted increasing attention due to their interesting size-dependent physical, chemical, and biological properties. However, facile fabrication of metallic ultrathin freestanding nanoporous films (UF-NPFs) by dealloying is still challenging. Herein, we report a novel strategy of facile preparation of flexible Cu, Cu 3 Ag, and CuAg UF-NPFs by dealloying thick Mg-Cu(Ag)-Gd metallic glass ribbons. During dealloying, the local reaction latent heat-induced glass transition of the precursor ribbons leads to the formation of a solid/liquid interface between the initially dealloyed nanoporous layer and the underlying supercooled liquid layer. Due to the bulging effect of in situ generated H 2 on the solid/liquid interface, Cu, Cu 3 Ag, and CuAg UF-NPFs with thicknesses of ∼200 nm can self-peel off from the outer surface of the dealloying ribbons. Moreover, it was found that the surface-enhanced Raman scattering (SERS) detection limit of Rhodamine 6G (R6G) on the Cu and CuAg UF-NPF substrates are 10−6 M and 10−11 M, respectively, which are lower than most of the Cu and Cu-Ag substrates prepared by other methods. This work presents a reliable simple strategy to synthesize a variety of cost effective and flexible metallic UF-NPFs for functional applications. [ABSTRACT FROM AUTHOR]