A compact prism-based microscope for high sensitive measurements in fluid biopsy.

A preprint abstract from biorxiv.org discusses the development of a compact prism-based microscope for high sensitive measurements in fluid biopsy. The researchers aimed to address the need for sensitive, portable, and cost-effective disease detection methods. They presented a prism-based Total Internal Reflection system combined with surface functionalization techniques on gold nanoparticles, which achieved a remarkable limit of detection for specific analytes in synthetic liquids and real human samples. The researchers conducted scattering experiments in synthetic and human serum samples to validate the efficacy of their design. This preprint has not been peer-reviewed. [Extracted from the article]