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The article focuses on premature death of people due to effect of exposure of water and air pollution, synthetic chemicals and workplace carcinogens and mentions birth of the discipline of toxicology. Topics discussed include genomics moved from sequencing genes in Human Genome Project, causes of chronic illnesses and focus of study on barrier organs such as gut and skin to deal with environmental assaults.

The article addresses the escalating rates of cancer in individuals under fifty and explores potential causes such as obesity, sedentary lifestyles, disrupted microbiomes, stress, electromagnetic fields, and environmental pollutants. It suggests an anti-cancer action plan, including dietary recommendations like a modified ketogenic diet, increased physical activity, and ways to support gut health.

(Sources: TheHill.com, 14 July 2023, https://tinyurl.com/2m4jzp8a;AirforceTimes.com, 15 July 2023, https://tinyurl.com/2pxncgux.UAPNewCenter.com) TALIBAN ENDS CIA HEROIN TRADE IN AFGHANISTAN The Taliban has accomplished in one year what America's "war on drugs" failed to pull off in five decades - eliminating most all of Afghanistan's opium output. EARTH'S ROTATIONAL POLE HAS SHIFTED FROM ALL THE GROUNDWATER PUMPING A study conducted by researchers at Seoul National University has found that the Earth's rotational pole has shifted due to the extraction of groundwater. "In nations where the government is subservient to the elite, they will be able to establish popular resistance movements and committees of national liberation, including representatives of all sectors of society who propose a radical reform of politics inspired by the common good and fervently opposed to the neo-Malthusian project of the globalist agenda. With the US in control of Afghanistan in 2004, the Washington-backed government in Kabul set a goal of eliminating poppy cultivation within ten years. [Extracted from the article]

The article focuses on the Environmental Protection Agency's proposed regulation to reduce the use and prevent exposures to ethylene oxide (EtO ) gas sterilant to minimize the risk of cancer to healthcare workers, employees of commercial sterilizers, and surrounding communities. Topics include importance of EtO for sterilizing medical devices with the carcinogenic nature of EtO; and the EPA's provisions to protect both freestanding sterilization facilities and healthcare workers in hospitals.

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The article reports on the public safety issues concerning the Zantac ranitidine drug developed by GSK Plc (formerly Glaxo Laboratories) and approved by the U.S. Food and Drug Administration (FDA) as treatment for heartburn. Also cited are how Zantac increased the company's profits, and the discovery that the drug produces probable poisonous carcinogens that compelled the FDA to recall it from the market.

Antineoplastic drugs (ANDs) used for chemotherapy can cause secondary cancers in treated patients and can pose carcinogenic risks to health-sector workers anywhere along these drugs' life cycle in a facility, from production to patient administration. Several PAHO/WHO Collaborating Centers (CCs) have experience addressing these hazards in the health sector. The objectives of this report are four-fold: 1) Provide an overview of longstanding research and prevention efforts, led by PAHO/WHO and its Occupational Health CCs, aimed at reducing the burden of occupational cancer in the Americas; 2) Discuss how robust AND exposure assessment and educational/outreach work by PAHO CCs can form the basis of exposure mitigation efforts among health-sector workers; 3) Through the presentation of original AND exposure assessment data from a pharmaceutical compounding facility in Chile, highlight relatively inexpensive methods by which such data can be generated; and 4) Discuss how effective, periodic environmental surveillance in healthcare facilities results in the identification of AND contamination in the work environment and enables the implementation of low-cost, high-impact interventions to reduce the risk of occupational cancer in health-sector workers, including in limited-resource settings. The risk of health-sector worker exposure to ANDs and other hazardous drugs is an important issue for inclusion within PAHO/WHO's broader efforts at reducing the impact of occupational cancer in the Americas. This report demonstrates that a wide range of accessible AND-exposure mitigation strategies are feasible at both a facility and a national policy level across the hemisphere. [ABSTRACT FROM AUTHOR]

A preprint abstract from biorxiv.org discusses the discovery of mutational signatures in cancer research. The article proposes a new approach using a power posterior for a fully Bayesian NMF model to improve robustness in analyzing mutational signatures. The method is shown to accurately recover more true signatures than current leading methods in extensive simulation studies and on whole-genome sequencing data for six cancer types. This research has not yet been peer-reviewed and offers insights into cancer etiology and targeted therapies. [Extracted from the article]

Researchers at Southwest Medical University in Sichuan, China, have conducted a study on the role of tetraspanins in digestive system cancers, such as gastric, liver, colorectal, pancreatic, esophageal, and oral cancer. The study highlights the importance of tetraspanins as biomarkers and potential therapeutic targets in cancer treatment. The research also explores the molecular mechanisms underlying the involvement of tetraspanins in cancer progression and metastasis, while addressing current challenges and proposing future research directions. This peer-reviewed study provides valuable insights into the potential applications of tetraspanins in the context of digestive system malignancies. [Extracted from the article]

A recent study conducted at the University of Lille in France explored the functional interaction between receptor tyrosine kinase Met and Ets transcription factors in promoting the progression of prostate cancer. The research highlighted the role of these factors in inducing aggressive properties in prostate cancer cells and identified target genes that could play a significant role in this process. The study concluded that this interaction between ETS transcription factors and MET signaling contributes to the aggressiveness of prostate cancer, shedding light on a molecular signature characteristic of this combined action. [Extracted from the article]

A recent study from China Medical University explored the inhibitory effects of fruit powders on the formation of polycyclic aromatic hydrocarbons (PAHs) in charcoal-grilled pork. The research found that guava powder exhibited the highest phenolic content and antioxidant activity, leading to a significant reduction in PAH formation in grilled meats. Incorporating fruit powders in marination did not affect the sensory attributes of the meat and could potentially reduce health risks associated with consuming grilled meats. This study offers a promising strategy for inhibiting PAH formation in meat during charcoal grilling while maintaining sensory qualities. [Extracted from the article]

Researchers at the State Key Laboratory of Quality Research in Chinese Medicine have developed a novel small molecule, ZYZ384, that targets the protein SMYD3 for hepatocellular carcinoma treatment. The molecule reduces H3K4 trimethylation of the Rac1 promoter, leading to tumor cell cycle arrest through the AKT pathway. This study highlights the potential of ZYZ384 as a promising antitumor therapeutic for liver cancer. [Extracted from the article]

A recent study conducted by researchers from the Federal University of Bahia in Brazil explored the perception, knowledge, and consumption potential of crude and refined palm oil (CPO and RPO) in different regions of Brazil. The study found that while CPO is widely used in the food industry after refining, there is limited research on its consumption and perception in Brazil, particularly regarding its nutritional aspects. The results showed that most participants were unfamiliar with CPO but viewed its nutrients favorably. However, there was little awareness about the potential carcinogenic substances produced during the refining process. The study concluded that there is a need for better dissemination of information about CPO in Brazil, emphasizing its nutritional benefits and the importance of adhering to daily lipid intake limits. The researchers also recommended adding CPO at the end of cooking or consuming it raw to preserve thermosensitive compounds. [Extracted from the article]

A study conducted at Guangdong Medical University in China explored the role of folliculin interacting protein 1 (FNIP1) in colorectal cancer (CRC). The researchers found that FNIP1 is significantly downregulated in CRC and its absence is associated with shorter overall and disease-specific survival. FNIP1 inhibits CRC progression by suppressing the phosphorylation and nuclear translocation of signal transducer and activator of transcription-3 (STAT3). The study suggests that FNIP1 could be a potential prognostic indicator and therapeutic target for CRC. [Extracted from the article]

A patent has been issued to Cg Oncology Inc. for methods of treating solid or lymphatic tumors using combination therapy. The patent describes a method that involves locally administering an oncolytic virus to the tumor site and systemically administering an immunomodulator. The oncolytic virus is designed to replicate in cancer cells and contains a gene encoding an immune-related molecule. The immunomodulator helps activate the immune system to fight against the tumor. This method aims to improve the efficacy of cancer immunotherapy, which has faced challenges in the past. [Extracted from the article]

A new study has identified nearly 200 potential breast carcinogens in food contact materials (FCMs), such as plastics and paper, despite existing regulations. The research conducted by the Food Packaging Forum highlights the need for stronger preventative measures to reduce these chemicals in everyday products. The study found that 189 potential breast carcinogens have been detected in FCMs, with 143 in plastics and 89 in paper or board. The findings suggest that there is widespread exposure to these chemicals, indicating a need for more attention to cancer prevention by reducing hazardous chemicals in daily life. [Extracted from the article]

GSK Plc CEO Emma Walmsley is focused on moving past the ongoing litigation surrounding the company's heartburn drug Zantac, which has negatively impacted the stock for years. Walmsley stated that she works to ensure that the majority of the company is not preoccupied with the Zantac issue. GSK has denied claims that Zantac causes cancer and is working with its legal team to manage consumer claims. The potential settlement value for the Zantac cases is estimated to be between $3 billion and $4 billion, with GSK bearing half of that amount. Additionally, Walmsley discussed GSK's plans for growth in areas such as HIV treatments and potential opportunities in the obesity field. [Extracted from the article]

A recent study conducted at Huazhong University of Science and Technology in Wuhan, China, explores the relationship between CD151 and the progression of prostate cancer. Prostate cancer rates are increasing globally, including in China, and metastasis is becoming more common, which limits treatment effectiveness and prognosis. While previous research has linked CD151 to the progression of various malignancies, including prostate cancer, this study found that CD151 can actually inhibit the progression of prostate cancer. The research aims to provide a clearer understanding of the relationship between CD151 and prostate cancer progression for future studies. [Extracted from the article]

A recent research article from Guangdong Medical University explores the complicated role of ALKBH5 in gastrointestinal cancer. ALKBH5 is a type of RNA demethylase that has been found to exhibit abnormal expression in various gastrointestinal cancers. The article summarizes recent advances in understanding the role of ALKBH5 as either a tumor suppressor or promoter in gastrointestinal cancer, highlighting its potential as a therapeutic target. The research provides new perspectives and insights for further study in the field of gastrointestinal cancer. [Extracted from the article]

A recent study conducted by Eli Lilly and Company in Indianapolis, Indiana, examined the potential formation of nitrosamine drug substance related impurities (NDSRIs) in certain antidepressant drugs. NDSRIs can be carcinogenic, and the study aimed to assess their potency. The research found that NDSRIs formed from the drugs fluoxetine, duloxetine, and atomoxetine were 10-100-fold less potent than highly potent nitrosamines. The mutation response of these NDSRIs was also found to be higher than published regulatory limits. The study suggests that these approaches can help categorize NDSRIs and determine their potency. [Extracted from the article]

A recent study conducted by Emory University in Atlanta, Georgia, has identified a novel small-molecule compound called MX69-102 that shows promising results in the treatment of acute lymphoblastic leukemia (ALL). MX69-102 induces the degradation of the MDM2 protein, leading to the reactivation of p53 and inhibition of XIAP, resulting in cell growth inhibition and apoptosis in MDM2-overexpressing ALL. Importantly, MX69-102 demonstrated minimal toxicity to normal cells and tissues, making it a potential candidate for further development as a targeted therapeutic drug for refractory/MDM2-overexpressing ALL. The study was supported by the Andrew McDonough B + Foundation and Alex's Lemonade Stand Foundation. [Extracted from the article]

A comprehensive review conducted by researchers from Uttaranchal University in Dehradun, India, explores the various carcinogenic aspects of N-nitrosopiperidine (NPIP). NPIP is a potentially hazardous pollutant classified as a mutagenic and probable carcinogenic compound. It can be found in a variety of matrices, including latex products, agricultural chemicals, cosmetic items, chlorinated water, alcoholic beverages, spices, and food products. The review discusses the formation of NPIP, its stability, metabolic activation, and its role in inducing different types of cancers in animal models. The researchers also highlight preventive measures and removal techniques to limit exposure to NPIP. [Extracted from the article]

The article focuses on a study suggesting that having a tattoo may increase the risk of developing lymphoma, includes the higher lymphoma risk observed in tattooed individuals; the lack of evidence linking the risk to tattoo size; and the potential role of carcinogens in tattoo ink.

SR Timber has been awarded a Sun Safe Workplace Accreditation by SKCIN, a national charity that raises awareness of skin cancer prevention. Outdoor workers are at a high risk of developing skin cancer due to exposure to solar UV radiation. By participating in the Sun Safe Workplaces program, SR Timber has implemented a sun protection policy to reduce the risk of skin cancer for its employees. Skin cancer is the most commonly diagnosed cancer in the UK, with outdoor workers being at a 60% greater risk. [Extracted from the article]

The foodborne liver trematode Opisthorchis felineus (Rivolta, 1884) is a member of the triad of phylogenetically related epidemiologically important Opisthorchiidae trematodes, which also includes O. viverrini (Poirier, 1886) and Clonorchis sinensis (Loos, 1907). Despite similarity in the life cycle, Opisthorchiidae liver flukes also have marked differences. Two species (O. viverrini and C. sinensis) are recognized as Group 1A biological carcinogens, whereas O. felineus belongs to Group 3A. In this review, we focus on these questions: Are there actual differences in carcinogenicity among these 3 liver fluke species? Is there an explanation for these differences? We provide a recent update of our knowledge on the liver fluke O. felineus and highlight its differences from O. viverrini and C. sinensis. In particular, we concentrate on differences in the climate of endemic areas, characteristics of the life cycle, the range of intermediate hosts, genomic and transcriptomic features of the pathogens, and clinical symptoms and morbidity of the infections in humans. The discussion of these questions can stimulate new developments in comparative studies on the pathogenicity of liver flukes and should help to identify species-specific features of opisthorchiasis and clonorchiasis pathogenesis. [ABSTRACT FROM AUTHOR]

New research from Fujita Health University School of Medicine explores the role of adipocyte-cancer cell interactions in breast cancer development and progression. The study identifies adipsin-dependent adipocyte maturation as a key factor in promoting tumor invasion in breast cancers. The researchers found that mature adipocytes, but not their precursors, significantly induced breast tumor cell migration and invasion. These findings suggest that adipsin-dependent adipocyte maturation may play an important role in adipocyte-cancer cell interaction and breast cancer progression. [Extracted from the article]

B. Braun Melsungen AG, a medical technology company based in Germany, has been issued a patent for a coupling element for a closed fluid transfer system. The invention aims to improve the safety and simplicity of coupling systems used in the transfer of hazardous substances, such as cancer drugs, by ensuring dry-locking of the coupling surfaces. The coupling member includes a spike, a sealing member receptacle, and a movable coupling housing with a threaded portion. The patent also describes a coupling system that includes the coupling member and a mating coupling member. The invention addresses the limitations of current coupling systems, such as complexity, poor flow rates, and difficulties in disinfection. [Extracted from the article]

The article discusses research by the University of Amsterdam and, reported in the Supportive Care in Cancer issue, on August 20, 2024, on the risk of secondary oral cancer following hematopoietic cell transplantation. Topics include the significantly increased risk of oral cancer in allogeneic HCT recipients, particularly with chronic graft versus host disease, the importance of lifelong surveillance, and the need for further research on the role of HPV in these cancers.

The article focuses on an innovative cancer therapy using engineered Salmonella Typhimurium bacteria, which are designed to express collagenase to enhance tumor penetration and colonization. It addresses the limitations of current bacteria-based cancer treatments by improving bacterial delivery and efficacy through the degradation of the tumor's collagen matrix.

The article focuses on the patent for a fusion polypeptide comprising both a foreign antigen and a self-antigen, as issued to Stichting Amsterdam Umc under patent number 12049484. It highlights a novel approach to enhance cancer immunotherapy by designing a fusion protein that reduces the immune response to the foreign antigen while improving the response to the self-antigen, aiming to develop more effective anti-angiogenic cancer vaccines.

A researcher from Mars Incorporated has conducted a retrospective analysis of carcinogenicity assessments within FDA-notified GRAS determinations. The study aimed to understand the approaches used to evaluate the carcinogenic potential of food substances. The research found that different approaches were required due to the complexity of substances used in food, but all notifications supported the conclusion of safety. The study proposes an approach familiar to other product sectors and highlights the data commonly used to support the safety of different types of food substances. [Extracted from the article]

Amneal Pharmaceuticals Inc., the maker of store-brand Mucinex sold by CVS, Walmart, and other retailers, is reformulating its products to remove an ingredient that is made with a cancer-causing chemical. The company plans to submit testing data on its new formulation to the US Food and Drug Administration by the end of the year and expects to bring the updated products to market before August 2025. This decision comes after an analysis of government data revealed that store-brand generic versions of extended-release Mucinex made by Amneal contain a carbomer ingredient made with benzene, a potent carcinogen. The use of benzene in drugs has been allowed by US regulators for decades, despite international authorities advising against it. [Extracted from the article]

A recent report from researchers at Poznan University of Medical Sciences in Poland discusses the role of estrogen in the body and its impact on various tissues and organs. Estrogen is an important hormone that regulates reproductive functions and maintains non-reproductive tissues. However, imbalances in estrogen levels can lead to infertility, cancer, and other conditions. The report also highlights how exogenous compounds similar to estrogen can disrupt signaling pathways and contribute to the growth of cancer cells. The researchers emphasize the need to analyze the sources of estrogen and their effects on homeostasis. [Extracted from the article]

A study conducted in Henan, People's Republic of China, explored the role and mechanism of RHOXF2 and HOXC13 in the malignant progression of triple negative breast cancer (TNBC). The researchers found that RHOXF2 and HOXC13 expression was increased in TNBC cells, and that RHOXF2 knockdown suppressed the proliferation, invasion, migration, and induced cell cycle arrest and apoptosis of TNBC cells. Additionally, RHOXF2 was found to bind to HOXC13 and interfere with the Wnt2/beta-catenin pathway. The study suggests that RHOXF2 activated by H3K27ac functions as a tumor promoter in TNBC and provides insight into potential TNBC therapy. [Extracted from the article]

GSK Plc, a British drugmaker, has won a second trial in Illinois, convincing a jury that the former heartburn drug Zantac was not responsible for a woman's colorectal cancer. This follows a similar verdict in Chicago a few months ago. GSK's share price has risen slightly since the start of the year. The company is facing numerous lawsuits from individuals who claim that Zantac's active ingredient, ranitidine, can turn into a potential carcinogen. However, GSK maintains that there is no consistent or reliable evidence linking ranitidine to cancer. The company is still facing thousands of cases in the US and has settled some without admitting liability. Despite the ongoing litigation, GSK has made progress in other areas, including the success of its vaccine for a common respiratory virus. Under CEO Emma Walmsley, GSK has focused on prioritizing products in areas where it has existing strengths, such as vaccines, and has separated its consumer health business to concentrate on developing innovative new medicines. [Extracted from the article]

A recent study published in the journal eClinicalMedicine found a link between tattoo ink exposure and malignant lymphoma. Tattoo ink contains carcinogenic substances that can elicit an immune reaction and migrate to lymph nodes. The study revealed that tattooed individuals have a 21% higher chance of developing lymphoma compared to non-tattooed individuals. Laser therapy for tattoo removal was found to carry an even greater risk. Further research is needed to understand the long-term health effects of tattoo exposure and the implications of laser tattoo removal. Additionally, there have been claims that COVID-19 vaccines are causing excess deaths in Australia. However, the Australian Bureau of Statistics' data shows that the excess deaths began in week 14 of 2021, coinciding with the rollout of COVID-19 vaccines. The media in Australia has been accused of censoring medical experts who question the COVID-19 narrative, and some politicians have exempted themselves from receiving the vaccines. [Extracted from the article]

A patent application has been filed for a method of treating cancer, specifically glioblastoma and other cancers, by monitoring the methylation status of the STING promoter in tumor cells. If the promoter is found to be methylated, a demethylating agent can be administered to the patient. Conversely, if the promoter is unmethylated, immunotherapy can be administered. The method aims to improve treatment outcomes by increasing or normalizing STING expression and function. The patent application provides detailed claims and methods for predicting responsiveness to immunotherapy and identifying agents that modulate the methylation pattern of STING-silenced tumors. [Extracted from the article]

A recent report from the Wuhan Hospital of Traditional Chinese Medicine discusses the role of circular RNA circ_001621 in lung cancer. The study found that circ_001621 is significantly upregulated in lung cancer tissues and cells. Silencing circ_001621 reduced the viability and invasive ability of lung cancer cells and stimulated apoptosis. The study also identified the circ_001621/miR-199a-3p/GREM1 axis as a potential therapeutic target for lung cancer. Further research is needed to explore the diagnostic and treatment implications of these findings. [Extracted from the article]

The Federal Court has dismissed a class action against the makers of Roundup, stating that there is insufficient evidence to prove that the active ingredient, glyphosate, causes cancer. The court acknowledged that the scientific community has mixed views on the matter. While the International Agency for Research on Cancer classified glyphosate as "probably carcinogenic to humans" in 2015, other regulatory bodies have concluded that it is unlikely to pose a carcinogenic risk to humans. Epidemiological studies have not found evidence of a cancer association, and animal studies have shown no consistent evidence of cancer development. Additionally, there is currently no plausible mechanism for glyphosate to cause cancer at the levels humans are likely to be exposed to. [Extracted from the article]

A recent report from researchers at Ardabil University of Medical Sciences in Iran explores the potential protective effects of hesperidin, a compound with antioxidant and anticancer properties, against the development of cancer and congenital abnormalities induced by a chemical carcinogen. The study used mice as a model for glioma and found that pre-mating exposure to hesperidin reduced developmental toxicity, neurobehavioral dysfunction, neurotoxicity, oxidative stress, and histopathological abnormalities in the next generation. The researchers suggest that hesperidin may have potential for preventing primary brain cancer and minimizing the developmental and neurotoxicity effects of DNA alkylating agents. This research has been peer-reviewed. [Extracted from the article]

A report from the International Agency for Research on Cancer (IARC) discusses the advances in cancer research related to occupational exposure to carcinogens. The IARC Monographs now include a critical appraisal of exposure assessment quality in human cancer and mechanistic studies. The report describes the workflow of this procedure and provides examples of its application. Evaluating the quality of exposure assessment methods is crucial for judging study quality and improving transparency and consistency in evidence synthesis frameworks. For more information, refer to the journal article "Challenges And Opportunities in Occupational Exposure Characterization of Carcinogens For Cancer Hazard Identification" in Occupational Medicine. [Extracted from the article]

A recent study conducted by researchers at the University of Hong Kong has explored the molecular mechanisms underlying the increased risk of lung cancer associated with exposure to diesel engine exhaust (DEE). The study utilized an exposome approach to characterize the early biological effects of occupational DEE exposure. Through the analysis of plasma samples from DEE-exposed workers and non-exposed control workers, the researchers identified molecular features associated with DEE exposure, including compounds consistent with DEE exposure and alterations in oxidative stress and endothelial pathways. The study provides valuable insights into DEE biomarkers and biological response profiles in a high exposure setting. [Extracted from the article]

A report from Wuhan University in Hubei, China, discusses the role of N6-methyladenosine (m6A) modification and circular RNAs (circRNAs) in gastric cancer (GC). The study focuses on the circRNA hsa_circ_0112136 and its regulation by fat mass and obesity-associated protein (FTO). The researchers found that hsa_circ_0112136 functions as a tumor promoter, facilitating the malignant progression of GC through m6A modification and activation of the PI3K/AKT/mTOR pathway. Targeting FTO-m6A-hsa_circ_0112136-PI3K/AKT/mTOR may be a potential approach for GC intervention. This research has been peer-reviewed and published in Biotechnology and Applied Biochemistry. [Extracted from the article]

Researchers at University Hospital Bordeaux in France have conducted a study on lung cancer and occupational health surveillance for workers exposed to lung carcinogens. The study aimed to define the occupational health surveillance for workers exposed to pulmonary occupational carcinogens and issued 26 recommendations. The recommendations included the implementation of a feasibility study in two French departments, which would involve annual CT scans for two years in subjects aged 55 to 74 years who were occupationally exposed or previously exposed to lung carcinogens. The study was conducted in collaboration with various medical societies and organizations. [Extracted from the article]

A preprint abstract from biorxiv.org discusses a study on the dynamics of antigen-specific T cells in head and neck cancer. The study utilized a tobacco carcinogen mimetic model and genetically engineered mice. The findings showed that early ovalbumin expression did not impact cancer development and survival. However, the combination of an OVA synthetic long peptide vaccine and anti-PD-1 significantly reduced tumor burden and prolonged survival. The study highlights the potential of cancer vaccines to improve outcomes in head and neck cancer. Please note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at Birjand University of Medical Sciences in Iran explores the role of microRNA-98 (miR-98) in cancer progression and therapy. The study highlights the dual nature of miR-98, acting as both a tumor promoter and suppressor. The researchers discuss the potential of miR-98 as a diagnostic and prognostic biomarker and evaluate therapeutic avenues to modulate its expression. They also emphasize the need for further research on miR-98's involvement in tumor-stroma interactions, immune modulation, and metabolic regulation to develop novel strategies for cancer management. [Extracted from the article]

A recent study conducted by researchers at Case Western Reserve University in Cleveland, Ohio, has shed light on the role of the PML1 isoform in estrogen receptor-positive (ER+) breast cancers. The study found that PML1 is the most abundant isoform in all breast cancer subtypes and is associated with an unfavorable prognosis in ER+ breast cancers. The researchers also discovered that PML1 promotes cell proliferation, invasion, and stemness, and contributes to tumor growth and resistance to fulvestrant, an FDA-approved drug for ER+ breast cancer. These findings challenge the conventional understanding of PML as a tumor suppressor and provide new insights into the unique roles of PML isoforms in breast cancer. [Extracted from the article]

A recent study conducted by researchers from the University of the Witwatersrand in South Africa explores the intricacies of tumor heterogeneity in breast cancer. The study highlights the role of estrogen signaling and stemness in tumor processes and suggests that further investigation is needed to identify novel biomarkers for diagnostic, prognostic, and therapeutic purposes. The researchers also discuss the existence of various cell phenotypes that mediate stemness and contribute to tumor progression. This study provides valuable insights into potential prognostic breast cancer biomarkers and offers a deeper understanding of the complexity of tumor progression. [Extracted from the article]

A recent research article from the Francis Crick Institute discusses the role of environmental carcinogens in increasing cancer incidence. The study highlights that there are over 500 known or suspected carcinogens, and understanding how these substances cause cancer can support prevention efforts. The research suggests that recent advancements in understanding early tumorigenesis may open up new opportunities for molecular cancer prevention. The article provides further information on tumor promoters and opportunities for molecular cancer prevention. [Extracted from the article]